Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice.

Abstract:

:Modern society characterized by a 24/7 lifestyle leads to misalignment between environmental cycles and endogenous circadian rhythms. Persisting circadian misalignment leads to deleterious effects on health and healthspan. However, the underlying mechanism remains not fully understood. Here, we subjected adult, wild-type mice to distinct chronic jet-lag paradigms, which showed that long-term circadian misalignment induced significant early mortality. Non-biased RNA sequencing analysis using liver and kidney showed marked activation of gene regulatory pathways associated with the immune system and immune disease in both organs. In accordance, we observed enhanced steatohepatitis with infiltration of inflammatory cells. The investigation of senescence-associated immune cell subsets from the spleens and mesenteric lymph nodes revealed an increase in PD-1+CD44high CD4 T cells as well as CD95+GL7+ germinal center B cells, indicating that the long-term circadian misalignment exacerbates immune senescence and consequent chronic inflammation. Our results underscore immune homeostasis as a pivotal interventional target against clock-related disorders.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Inokawa H,Umemura Y,Shimba A,Kawakami E,Koike N,Tsuchiya Y,Ohashi M,Minami Y,Cui G,Asahi T,Ono R,Sasawaki Y,Konishi E,Yoo SH,Chen Z,Teramukai S,Ikuta K,Yagita K

doi

10.1038/s41598-020-59541-y

subject

Has Abstract

pub_date

2020-02-13 00:00:00

pages

2569

issue

1

issn

2045-2322

pii

10.1038/s41598-020-59541-y

journal_volume

10

pub_type

杂志文章
  • L-proline: a highly effective cryoprotectant for mouse oocyte vitrification.

    abstract::Recent studies have shown that L-proline is a natural osmoprotectant and an antioxidant to protect cells from injuries such as that caused by freezing and thawing in many species including plant, ram sperm and human endothelial cells. Nevertheless, this nontoxic cryoprotectant has not yet been applied to mammalian ooc...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26326

    authors: Zhang L,Xue X,Yan J,Yan LY,Jin XH,Zhu XH,He ZZ,Liu J,Li R,Qiao J

    更新日期:2016-07-14 00:00:00

  • Accelerating forest growth enhancement due to climate and atmospheric changes in British Colombia, Canada over 1956-2001.

    abstract::Changes in climate and atmospheric CO2 and nitrogen (N) over the last several decades have induced significant effects on forest carbon (C) cycling. However, contributions of individual factors are largely unknown because of the lack of long observational data and the undifferentiating between intrinsic factors and ex...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04461

    authors: Wu C,Hember RA,Chen JM,Kurz WA,Price DT,Boisvenue C,Gonsamo A,Ju W

    更新日期:2014-03-25 00:00:00

  • A bacterial acetyltransferase triggers immunity in Arabidopsis thaliana independent of hypersensitive response.

    abstract::Type-III secreted effectors (T3Es) play critical roles during bacterial pathogenesis in plants. Plant recognition of certain T3Es can trigger defence, often accompanied by macroscopic cell death, termed the hypersensitive response (HR). Economically important species of kiwifruit are susceptible to Pseudomonas syringa...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-03704-x

    authors: Jayaraman J,Choi S,Prokchorchik M,Choi DS,Spiandore A,Rikkerink EH,Templeton MD,Segonzac C,Sohn KH

    更新日期:2017-06-15 00:00:00

  • Iron Pyrite/Titanium Dioxide Photoanode for Extended Near Infrared Light Harvesting in a Photoelectrochemical Cell.

    abstract::The design of active and stable semiconducting composites with enhanced photoresponse from visible light to near infrared (NIR) is a key to improve solar energy harvesting for photolysis of water in photoelectrochemical cell. In this study, we prepared earth abundant semiconducting composites consisting of iron pyrite...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20397

    authors: Wang DY,Li CH,Li SS,Kuo TR,Tsai CM,Chen TR,Wang YC,Chen CW,Chen CC

    更新日期:2016-02-08 00:00:00

  • Aspirin might reduce the incidence of pancreatic cancer: A meta-analysis of observational studies.

    abstract::Although there is evidence that non-steroidal anti-inflammatory drugs (NSAIDs) might be able to prevent pancreatic cancer, the findings from epidemiological studies have been inconsistent. In this paper, we conducted a meta-analysis of observational studies to examine this possibility. We searched PubMed and Embase fo...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析

    doi:10.1038/srep15460

    authors: Zhang YP,Wan YD,Sun YL,Li J,Zhu RT

    更新日期:2015-10-21 00:00:00

  • Comparing distress of mouse models for liver damage.

    abstract::In order to foster animal welfare as well as high quality of research, many countries regulate by law that the severity of animal experiments must be evaluated and considered when performing biomedical research. It is well accepted that multiple parameters rather than a single readout parameter should be applied to de...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76391-w

    authors: Tang G,Seume N,Häger C,Kumstel S,Abshagen K,Bleich A,Vollmar B,Talbot SR,Zhang X,Zechner D

    更新日期:2020-11-13 00:00:00

  • Dosimetric analysis of isocentrically shielded volumetric modulated arc therapy for locally recurrent nasopharyngeal cancer.

    abstract::This study aimed to investigate the dosimetric characteristics of an isocentrically shielded RapidArc (IS-RA) technique for treatment of locally recurrent nasopharyngeal cancer (lrNPC). In IS-RA, the isocenter was placed at the center of the pre-irradiated brainstem (BS)/spinal cord (SC) and the jaws were set to shiel...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25959

    authors: Lu JY,Huang BT,Xing L,Chang DT,Peng X,Xie LX,Lin ZX,Li M

    更新日期:2016-05-13 00:00:00

  • Production of genetically engineered mice with higher efficiency, lower mosaicism, and multiplexing capability using maternally expressed Cas9.

    abstract::The CRISPR/Cas9 system is widely used to generate gene-edited animals. Here, we developed an efficient system for generating genetically modified mice using maternal Cas9 from Cas9 transgenic mice. Using this system, we achieved lower mosaicism and higher rates of knock-in success, gene-editing, and birth compared to ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-57996-7

    authors: Sakurai T,Kamiyoshi A,Kawate H,Watanabe S,Sato M,Shindo T

    更新日期:2020-01-23 00:00:00

  • Droplet digital PCR-based EGFR mutation detection with an internal quality control index to determine the quality of DNA.

    abstract::In clinical translational research and molecular in vitro diagnostics, a major challenge in the detection of genetic mutations is overcoming artefactual results caused by the low-quality of formalin-fixed paraffin-embedded tissue (FFPET)-derived DNA (FFPET-DNA). Here, we propose the use of an 'internal quality control...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18642-x

    authors: Kim SS,Choi HJ,Kim JJ,Kim MS,Lee IS,Byun B,Jia L,Oh MR,Moon Y,Park S,Choi JS,Chae SW,Nam BH,Kim JS,Kim J,Min BS,Lee JS,Won JK,Cho SY,Choi YL,Shin YK

    更新日期:2018-01-11 00:00:00

  • Guidelines to electrode positioning for human and animal electrical impedance myography research.

    abstract::The positioning of electrodes in electrical impedance myography (EIM) is critical for accurately assessing disease progression and effectiveness of treatment. In human and animal trials for neuromuscular disorders, inconsistent electrode positioning adds errors to the muscle impedance. Despite its importance, how the ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep32615

    authors: Sanchez B,Pacheck A,Rutkove SB

    更新日期:2016-09-02 00:00:00

  • Structure-Property-Function Relationship in Humic Substances to Explain the Biological Activity in Plants.

    abstract::Knowledge of the structure-property-function relationship of humic substances (HSs) is key for understanding their role in soil. Despite progress, studies on this topic are still under discussion. We analyzed 37 humic fractions with respect to their isotopic composition, structural characteristics, and properties resp...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20798

    authors: García AC,de Souza LG,Pereira MG,Castro RN,García-Mina JM,Zonta E,Lisboa FJ,Berbara RL

    更新日期:2016-02-10 00:00:00

  • Pathologist-level classification of histologic patterns on resected lung adenocarcinoma slides with deep neural networks.

    abstract::Classification of histologic patterns in lung adenocarcinoma is critical for determining tumor grade and treatment for patients. However, this task is often challenging due to the heterogeneous nature of lung adenocarcinoma and the subjective criteria for evaluation. In this study, we propose a deep learning model tha...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40041-7

    authors: Wei JW,Tafe LJ,Linnik YA,Vaickus LJ,Tomita N,Hassanpour S

    更新日期:2019-03-04 00:00:00

  • Oxidative status and metabolic profile in a long-lived bird preparing for extreme endurance migration.

    abstract::The high metabolic activity associated with endurance flights and intense fuelling of migrant birds may produce large quantities of reactive oxygen species, which cause oxidative damage. Yet it remains unknown how long-lived birds prepare for oxidative challenges prior to extreme flights. We combined blood measurement...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-54057-6

    authors: Gutiérrez JS,Sabat P,Castañeda LE,Contreras C,Navarrete L,Peña-Villalobos I,Navedo JG

    更新日期:2019-11-26 00:00:00

  • Quantum Engineering of Atomically Smooth Single-Crystalline Silver Films.

    abstract::There is a demand for ultra low-loss metal films with high-quality single crystals and perfect surface for nanophotonics and quantum information processing. Many researches are devoted to alternative materials, but silver is by far theoretically the most preferred low-loss material at optical and near-IR frequencies. ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48508-3

    authors: Rodionov IA,Baburin AS,Gabidullin AR,Maklakov SS,Peters S,Ryzhikov IA,Andriyash AV

    更新日期:2019-08-22 00:00:00

  • Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic Acids.

    abstract::Adipose tissue dysfunction is considered an important contributor to systemic insulin resistance and Type 2 diabetes (T2D). Recently, a novel family of endogenous lipids, palmitic acid hydroxy stearic acids (PAHSAs), was discovered. These have anti-diabetic and anti-inflammatory effects in mice and are reduced in seru...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-34113-3

    authors: Hammarstedt A,Syed I,Vijayakumar A,Eliasson B,Gogg S,Kahn BB,Smith U

    更新日期:2018-10-25 00:00:00

  • Superresolution microscopy reveals distinct localisation of full length IRSp53 and its I-BAR domain protein within filopodia.

    abstract::Superresolution microscopy offers the advantage of imaging biological structures within cells at the nano-scale. Here we apply two superresolution microscopy techniques, specifically 3D structured illumination microscopy (3D-SIM) and direct stochastic optical reconstruction microscopy (dSTORM), a type of single molecu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-38851-w

    authors: Sudhaharan T,Hariharan S,Lim JSY,Liu JZ,Koon YL,Wright GD,Chiam KH,Ahmed S

    更新日期:2019-02-21 00:00:00

  • Distribution and the origin of invasive apple snails, Pomacea canaliculata and P. maculata (Gastropoda: Ampullariidae) in China.

    abstract::Species of Pomacea, commonly known as apple snails, are native to South America, and have become widely distributed agricultural and environmental pests in southern China since their introduction in the 1980s. However, only since 2010 have researchers recognized that at least two species, P. canaliculata and P. macula...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-19000-7

    authors: Yang QQ,Liu SW,He C,Yu XP

    更新日期:2018-01-19 00:00:00

  • Linearly polarized photoluminescence of InGaN quantum disks embedded in GaN nanorods.

    abstract::We have investigated the emission from InGaN/GaN quantum disks grown on the tip of GaN nanorods. The emission at 3.21 eV from the InGaN quantum disk doesn't show a Stark shift, and it is linearly polarized when excited perpendicular to the growth direction. The degree of linear polarization is about 39.3% due to the a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-26642-8

    authors: Park Y,Chan CCS,Nuttall L,Puchtler TJ,Taylor RA,Kim N,Jo Y,Im H

    更新日期:2018-05-25 00:00:00

  • Targeting intracellular p-aminobenzoic acid production potentiates the anti-tubercular action of antifolates.

    abstract::The ability to revitalize and re-purpose existing drugs offers a powerful approach for novel treatment options against Mycobacterium tuberculosis and other infectious agents. Antifolates are an underutilized drug class in tuberculosis (TB) therapy, capable of disrupting the biosynthesis of tetrahydrofolate, an essenti...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep38083

    authors: Thiede JM,Kordus SL,Turman BJ,Buonomo JA,Aldrich CC,Minato Y,Baughn AD

    更新日期:2016-12-01 00:00:00

  • A nomogram for predicting cancer-specific survival in patients with osteosarcoma as secondary malignancy.

    abstract::The prognostic factors for survival among patients with secondary osteosarcoma remain unclear. The aim of this study was to develop a practical nomogram for predicting cancer-specific survival (CSS) in patients with osteosarcoma as a secondary malignancy. The surveillance, epidemiology, and end results database was us...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69740-2

    authors: He Y,Liu H,Wang S,Zhang J

    更新日期:2020-07-30 00:00:00

  • High sensitive space electric field sensing based on micro fiber interferometer with field force driven gold nanofilm.

    abstract::The traditional electrical field sensing can be realized by utilizing electro-optic materials or liquid crystals, and has limitations of easy breakdown, free assembly and difficult measurement of low-frequency. Here, we propose a new method to realize safe measurement of spatial dynamic electric field by using a micro...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15802

    authors: Zhu T,Zhou L,Liu M,Zhang J,Shi L

    更新日期:2015-10-28 00:00:00

  • Skin Carotenoid Index in a large Japanese population sample.

    abstract::Carotenoids are anti-oxidative agents. Human skin and eyes contain specific carotenoid species known to prevent various pathologies caused by oxidative stress. We quantified skin and eye carotenoid levels and investigated their potential correlation in a population including 985 Japanese patients and staff members of ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45751-6

    authors: Obana A,Gohto Y,Gellermann W,Ermakov IV,Sasano H,Seto T,Bernstein PS

    更新日期:2019-06-27 00:00:00

  • Crystal structure of SEL1L: Insight into the roles of SLR motifs in ERAD pathway.

    abstract::Terminally misfolded proteins are selectively recognized and cleared by the endoplasmic reticulum-associated degradation (ERAD) pathway. SEL1L, a component of the ERAD machinery, plays an important role in selecting and transporting ERAD substrates for degradation. We have determined the crystal structure of the mouse...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20261

    authors: Jeong H,Sim HJ,Song EK,Lee H,Ha SC,Jun Y,Park TJ,Lee C

    更新日期:2016-02-09 00:00:00

  • An interspecific variation in rhizosphere effects on soil anti-erodibility.

    abstract::Soil erosion due to underground leakage is a major factor causing land degradation in karst regions. Rhizosphere effects (REs) on soil anti-erodibility (SAE) can alleviate this type of soil erosion by improving soil physical processes such as aggregate stability. However, the magnitudes and causes of interspecific var...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-58784-z

    authors: Wang Z,Chiarucci A,Fang H,Chen M

    更新日期:2020-02-12 00:00:00

  • Drawing circuits with carbon nanotubes: scratch-induced graphoepitaxial growth of carbon nanotubes on amorphous silicon oxide substrates.

    abstract::Controlling the orientations of nanomaterials on arbitrary substrates is crucial for the development of practical applications based on such materials. The aligned epitaxial growth of single-walled carbon nanotubes (SWNTs) on specific crystallographic planes in single crystalline sapphire or quartz has been demonstrat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep05289

    authors: Choi WJ,Chung YJ,Kim YH,Han J,Lee YK,Kong KJ,Chang H,Lee YK,Kim BG,Lee JO

    更新日期:2014-06-13 00:00:00

  • Electrophysiology of the rhythmic defecation program in nematode Heterorhabditis megidis.

    abstract::The nervous system controls most rhythmic behaviors, with a remarkable exception. In Caenorhabditis elegans periodic defecation rhythm does not appear to involve the nervous system. Such oscillations are studied in detail with genetic and molecular biology tools. The small size of C. elegans cells impairs the use of s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18118-y

    authors: Kuznetsov VP,Slivko-Koltchik GA,Voronov DA,Panchin YV

    更新日期:2017-12-19 00:00:00

  • Mesenchymal stem cell-laden anti-inflammatory hydrogel enhances diabetic wound healing.

    abstract::The purpose of this study was to permit bone marrow mesenchymal stem cells (BMSCs) to reach their full potential in the treatment of chronic wounds. A biocompatible multifunctional crosslinker based temperature sensitive hydrogel was developed to deliver BMSCs, which improve the chronic inflammation microenvironments ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep18104

    authors: Chen S,Shi J,Zhang M,Chen Y,Wang X,Zhang L,Tian Z,Yan Y,Li Q,Zhong W,Xing M,Zhang L,Zhang L

    更新日期:2015-12-08 00:00:00

  • The Arabidopsis defensin gene, AtPDF1.1, mediates defence against Pectobacterium carotovorum subsp. carotovorum via an iron-withholding defence system.

    abstract::Plant defensins (PDFs) are cysteine-rich peptides that have a range of biological functions, including defence against fungal pathogens. However, little is known about their role in defence against bacteria. In this study, we showed that the protein encoded by ARABIDOPSIS THALIANA PLANT DEFENSIN TYPE 1.1 (AtPDF1.1) is...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08497-7

    authors: Hsiao PY,Cheng CP,Koh KW,Chan MT

    更新日期:2017-08-23 00:00:00

  • Whole genome sequencing for investigations of meningococcal outbreaks in the United States: a retrospective analysis.

    abstract::Although rare in the U.S., outbreaks due to Neisseria meningitidis do occur. Rapid, early outbreak detection is important for timely public health response. In this study, we characterized U.S. meningococcal isolates (N = 201) from 15 epidemiologically defined outbreaks (2009-2015) along with temporally and geographic...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-33622-5

    authors: Whaley MJ,Joseph SJ,Retchless AC,Kretz CB,Blain A,Hu F,Chang HY,Mbaeyi SA,MacNeil JR,Read TD,Wang X

    更新日期:2018-10-25 00:00:00

  • Optomechanical interface for probing matter-wave coherence.

    abstract::We combine matter-wave interferometry and cavity optomechanics to propose a coherent matter-light interface based on mechanical motion at the quantum level. We demonstrate a mechanism that is able to transfer non-classical features imprinted on the state of a matter-wave system to an optomechanical device, transducing...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep03378

    authors: Xuereb A,Ulbricht H,Paternostro M

    更新日期:2013-11-29 00:00:00