Abstract：
:Mitochondria distribution in cells controls cellular physiology in health and disease. Here we describe the mitochondrial morphology and positioning found in the different stages of the lytic cycle of the eukaryotic single-cell parasite Toxoplasma gondii. The lytic cycle, driven by the tachyzoite life stage, is responsible for acute toxoplasmosis. It is known that whilst inside a host cell the tachyzoite maintains its single mitochondrion at its periphery. We found that upon parasite transition from the host cell to the extracellular matrix, mitochondrion morphology radically changes, resulting in a reduction in peripheral proximity. This change is reversible upon return to the host, indicating that an active mechanism maintains the peripheral positioning found in the intracellular stages. Comparison between the two states by electron microscopy identified regions of coupling between the mitochondrion outer membrane and the parasite pellicle, whose features suggest the presence of membrane contact sites, and whose abundance changes during the transition between intra- and extra-cellular states. These novel observations pave the way for future research to identify molecular mechanisms involved in mitochondrial distribution in Toxoplasma and the consequences of these mitochondrion changes on parasite physiology.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ovciarikova J,Lemgruber L,Stilger KL,Sullivan WJ,Sheiner Ldoi
10.1038/srep42746subject
Has Abstractpub_date
2017-02-16 00:00:00pages
42746issn
2045-2322pii
srep42746journal_volume
7pub_type
杂志文章abstract：:In eusocial Hymenoptera (ants, bees and wasps), queen and worker adult castes typically arise via environmental influences. A fundamental challenge is to understand how a single genome can thereby produce alternative phenotypes. A powerful approach is to compare the molecular basis of caste determination and different...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45674
更新日期：2017-03-31 00:00:00
abstract：:Perhaps, oxidative stress progresses pupation in some Lepidopteran insects; however, the reasons for this remain obscure. In our previous study, we clarified Bombyx mori SOD1 (BmSOD1) and B. mori SOD2 (BmSOD2) proteins respond in common to ultraviolet irradiation (UV) oxidative stress and metamorphosis. This result st...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51163-3
更新日期：2019-10-11 00:00:00
abstract：:Oral microbiome dysbiosis has been associated with various local and systemic human diseases such as dental caries, periodontal disease, obesity, and cardiovascular disease. Bacterial composition may be affected by age, oral health, diet, and geography, although information about the natural variation found in the gen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59016-0
更新日期：2020-02-07 00:00:00
abstract：:Adolescent idiopathic scoliosis (AIS) patients have been reported to be taller and more slender than normal controls, suggesting less mechanical stiffness of their trunk and spine. For assessment of mechanical stiffness, to our best knowledge this is the first to study height-width-depth relations at the level of the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46448
更新日期：2017-04-18 00:00:00
abstract：:The proteolytic system of Lactobacillus plays an essential role in bacterial growth, contributes to the flavor development of fermented products, and can release bioactive health-beneficial peptides during milk fermentation. In this work, a genomic analysis of all genes involved in the proteolytic system of L. delbrue...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09124-1
更新日期：2017-08-17 00:00:00
abstract：:In large random networks, each eigenvector of the Laplacian matrix tends to localize on a subset of network nodes having similar numbers of edges, namely, the components of each Laplacian eigenvector take relatively large values only on a particular subset of nodes whose degrees are close. Although this localization p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01010-0
更新日期：2017-04-25 00:00:00
abstract：:Metal pollution in drinking water source has been under scrutiny as it seriously affects human health. This work examined 12 dissolved metals in the surface and overlying water of the Xiangjiang River, an important drinking water source in southern China, and characterized their distribution, identified their possible...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80403-0
更新日期：2021-01-08 00:00:00
abstract：:Development of cost-effective counter electrode (CE) materials is a key issue for practical applications of photoelectrochemical solar energy conversion. Kesterite Cu2ZnSnS4 (CZTS) has been recognized as a potential CE material, but its electrocatalytic activity is still insufficient for the recovery of I-/I3- electro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26770-1
更新日期：2018-06-07 00:00:00
abstract：:This work reports the oxygen reduction reaction (ORR) kinetics of metal nanoparticle catalysts between 500 and 600 °C at low oxygen partial pressures. Ex situ and in situ TEM measurements demonstrate catalyzed nanowire growth initially follows linear kinetics; characteristic of being ORR rate limited. The ORR rates of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07717-4
更新日期：2017-08-01 00:00:00
abstract：:On an SiO2-patterned c-plane sapphire substrate, GaN domains were grown with their polarity controlled in accordance with the pattern. While N-polar GaN was grown on hexagonally arranged circular openings, Ga-polar GaN was laterally overgrown on mask regions due to polarity inversion occurring at the boundary of the c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22424-4
更新日期：2018-03-07 00:00:00
abstract：:Personal values developed in adolescence may influence mental health and well-being over the life course. Using data from 684 respondents in the Youth Development Study (61.9% of respondents in the baseline survey), we explored the effects of work values at ages 14-15 on positive and negative emotions, as well as psyc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70507-y
更新日期：2020-08-11 00:00:00
abstract：:Large classes of electronic, photonic, and acoustic crystals and quasi-crystals have been predicted to support topological wave-modes. Some of these modes are stabilized by certain symmetries but others occur as pure wave phenomena, hence they can be observed in many other media that support wave propagation. Surface ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21462-2
更新日期：2018-02-20 00:00:00
abstract：:Gliomas are heterogeneous, primary brain tumours that originate from glial cells. The main type of gliomas is astrocytomas. There are four grades (I-IV) of astrocytoma malignancy. Astrocytoma grade IV known as glioblastoma multiforme (GBM) is the most common and aggressive type of astrocytic gliomas. Metallothioneins ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41974-9
更新日期：2019-04-01 00:00:00
abstract：:In this article a new spent catalyst sample preparation method was implemented for the purpose of molybdenum leaching in a single step. Further molybdenum and vanadium in the leach liquor were separated and their concentrations were enriched using the solvent extraction and stripping techniques. The impervious sulfur ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58972-x
更新日期：2020-02-06 00:00:00
abstract：:The therapeutic management and health challenges caused by atrial fibrillation (AF) differ between different groups. The purpose of this study was to investigate the clinical features of patients hospitalized with AF and to explore the use of anticoagulation treatments in Han and Uygur patients in Xinjiang, northwest ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45884
更新日期：2017-04-10 00:00:00
abstract：:Microtus fortis exhibits natural resistance against Schistosoma japonicum, and the parasite cannot grow and develop in M. fortis. Extensive research has been carried out, however, the associated mechanism remains unclear. In the present study, we analysed the combined data obtained from a cytokine chip assay, transcri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11532-2
更新日期：2017-09-12 00:00:00
abstract：:There are no clinical guidelines for the timing of cholecystectomy (CCY) after performing therapeutic endoscopic retrograde cholangiopancreatography (ERCP) for choledocholithiasis. We tried to analyze the clinical practice patterns, medical expenses, and subsequent outcomes between the early CCY, delayed CCY, and no C...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38428-z
更新日期：2019-02-18 00:00:00
abstract：:Geochemical discrimination has recently been recognised as a potentially useful proxy for identifying tsunami deposits in addition to classical proxies such as sedimentological and micropalaeontological evidence. However, difficulties remain because it is unclear which elements best discriminate between tsunami and no...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07077
更新日期：2014-11-17 00:00:00
abstract：:Post-glycosylphosphatidylinositol (GPI) attachment to proteins 3, also known as PGAP3 or PERLD1 (PER1-like domain-containing protein 1), participates in the lipid remodeling process of glycosylphosphatidylinositol (GPI) anchor proteins during post-translational modification. Functional defect in PERLD1 was previously ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57592-9
更新日期：2020-01-20 00:00:00
abstract：:Living organisms in drying environments build anisotropic structures and exhibit directionality through self-organization of biopolymers. However, the process of macro-scale assembly is still unknown. Here, we introduce a dissipative structure through a non-equilibrium process between hydration and deposition in the d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05883-z
更新日期：2017-07-21 00:00:00
abstract：:This work introduces a new population-based stochastic search technique, named multi-variant differential evolution (MVDE) algorithm for solving fifteen well-known real world problems from UCI repository and compared to four popular optimization methods. The MVDE proposes a new self-adaptive scaling factor based on co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74228-0
更新日期：2020-10-14 00:00:00
abstract：:Since the world population is ageing, dementia is going to be a growing concern. Alzheimer's disease is the most common form of dementia. The pathogenesis of Alzheimer's disease is extensively studied, yet unknown remains. Therefore, we aimed to extract new knowledge from existing data. We analysed about 2700 upregula...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-020-64452-z
更新日期：2020-05-20 00:00:00
abstract：:Sub-retinal fluid (SRF) has been discussed as a protective factor against macular atrophy in eyes with neovascular age-related macular degeneration (nAMD).To gauge the impact of SRF on macular atrophy, a database of 310 nAMD eyes was screened for eyes manifesting an SRF-only phenotype under treat & extend anti-VEGF tr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64901-9
更新日期：2020-05-15 00:00:00
abstract：:This study aimed to define the width and length of the dental arch in 12-year-old Vietnamese children, and to elucidate differences between genders and among ethnic groups. A cross-sectional study was conducted in 4565 12 years-old children from the 4 major ethnic groups in Vietnam (Kinh, Muong, Thai, and Tay), with a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39710-4
更新日期：2019-02-28 00:00:00
abstract：:Electroporation (EP), the increase of cell membrane permeability due to the application of electric pulses, is a universal phenomenon with a broad range of applications. In medicine, some of the foremost EP-based tumor treatments are electrochemotherapy (ECT), irreversible electroporation, and gene electrotransfer (GE...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79858-y
更新日期：2021-01-14 00:00:00
abstract：:A novel design of thin-film crystalline silicon solar cell (TF C-Si-SC) is proposed and numerically analyzed. The reported SC has 1.0 µm thickness of C-Si with embedded dielectric silicon dioxide nanowires (NWs). The introduced NWs increase the light scattering in the active layer which improves the optical path lengt...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74453-7
更新日期：2020-10-16 00:00:00
abstract：:Respiratory syncytial virus (RSV) is a major cause of diseases of the respiratory tract in young children and babies, being mainly associated with bronchiolitis. RSV infection occurs primarily in pulmonary epithelial cells and, once infection is established, an immune response is triggered and neutrophils are recruite...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32576-y
更新日期：2018-09-21 00:00:00
abstract：:Apparently mundane, amorphous nanostructures of carbon have optical properties which are as exotic as their crystalline counterparts. In this work we demonstrate a simple and inexpensive mechano-chemical method to prepare bulk quantities of self-passivated, amorphous carbon dots. Like the graphene quantum dots, the wa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28021-9
更新日期：2018-06-27 00:00:00
abstract：:Biomimetic scaffolds are of great interest to tissue engineering (TE) and tissue repair as they support important cell functions. Scaffold coating with soluble collagen-I has been used to achieve better tissue integration in orthopaedy, however, as collagen persistence was only temporary such efforts were limited. Ade...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27760-z
更新日期：2018-06-20 00:00:00
abstract：:In 2010, a new rabbit hemorrhagic disease virus (RHDV) variant, designated RHDV2, was identified for the first time in Italy. Studies have shown that RHDV2 differs from RHDV1 (traditional RHDV) in terms of its antigenic profile and genetic characteristics. The VP60 protein of RHDV is a structural protein that plays im...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20857
更新日期：2016-02-16 00:00:00
