A meta-analysis of gene expression data highlights synaptic dysfunction in the hippocampus of brains with Alzheimer's disease.

abstract：:Pressure therapy has been proved to be an effective treatment for hypertrophic scars in a clinical setting. However, evidence-based data are controversial and the precise mechanism of action of this technique remains unknown. The aim of this study was to investigate the potential molecular mechanisms of pressure thera...

journal_title：Scientific reports

authors： Liu B,Liu Y,Wang L,Hou C,An M

更新日期：2018-08-07 00:00:00

abstract：:Histone deacetylase inhibition (HDACi) has been suggested as a promising approach to bolster TLR-mediated induction of antimicrobial peptides such as human β-defensin 2 (hBD2). In inflammatory bowel disease (IBD), Crohn's disease (CD) patients display an attenuated expression of hBD2 as compared to ulcerative colitis ...

journal_title：Scientific reports

authors： Stebe-Frick S,Ostaff MJ,Stange EF,Malek NP,Wehkamp J

更新日期：2018-08-27 00:00:00

abstract：:Field electron emission (FEE) properties of vertically aligned hexagonal boron nitride nanowalls (hBNNWs) grown on Si have been markedly enhanced through the use of nitrogen doped nanocrystalline diamond (nNCD) films as an interlayer. The FEE properties of hBNNWs-nNCD heterostructures show a low turn-on field of 15.2 ...

journal_title：Scientific reports

authors： Sankaran KJ,Hoang DQ,Kunuku S,Korneychuk S,Turner S,Pobedinskas P,Drijkoningen S,Van Bael MK,D' Haen J,Verbeeck J,Leou KC,Lin IN,Haenen K

更新日期：2016-07-11 00:00:00

abstract：:Mitochondrial activity is central to tissue homeostasis. Mitochondria dysfunction constitutes a hallmark of many genetic diseases and plays a key role in tumor progression. The essential role of mitochondria, added to their recently documented capacity to transfer from cell to cell, obviously contributes to their curr...

journal_title：Scientific reports

authors： Caicedo A,Fritz V,Brondello JM,Ayala M,Dennemont I,Abdellaoui N,de Fraipont F,Moisan A,Prouteau CA,Boukhaddaoui H,Jorgensen C,Vignais ML

更新日期：2015-03-13 00:00:00

abstract：:Under the usual approximation of treating a biological particle as a spheroidal droplet, we consider the analysis of its size and shape with the high frequency photoacoustics and develop a numerical method which can simulate its characteristic photoacoustic waves. This numerical method is based on the calculation of s...

journal_title：Scientific reports

authors： Li Y,Fang H,Min C,Yuan X

更新日期：2015-10-07 00:00:00

abstract：:The celebrated Jordan-Wigner transformation provides an efficient mapping between spin chains and fermionic systems in one dimension. Here we extend this spin-fermion mapping to arbitrary tree structures, which enables mapping between fermionic and spin systems with nearest-neighbor coupling. The mapping is achieved w...

journal_title：Scientific reports

authors： Backens S,Shnirman A,Makhlin Y

更新日期：2019-02-22 00:00:00

abstract：:State-of-the-art of preoperative planning for forearm orthopaedic surgeries is currently limited to simple bone procedures. The increasing interest of clinicians for more comprehensive analysis of complex pathologies often requires dynamic models, able to include the soft tissue influence into the preoperative process...

journal_title：Scientific reports

authors： Carrillo F,Suter S,Casari FA,Sutter R,Nagy L,Snedeker JG,Fürnstahl P

更新日期：2020-04-14 00:00:00

abstract：:Automatic release and vertical transferring of silicon/silicon oxide nanowire arrays with a high integrity are demonstrated by an Ag-assisted ammonia etching method. By adding a water steaming step between Ag-assisted HF/H2O2 and ammonia etching to form a SiOx protective layer sheathing Si nanowires, we can tune the c...

journal_title：Scientific reports

authors： Wu L,Li S,He W,Teng D,Wang K,Ye C

更新日期：2014-02-03 00:00:00

abstract：:Axolotls have the amazing ability to regenerate. When compared to humans, axolotls display a very fast wound closure, no scarring and are capable to replace lost appendages perfectly. Understanding the signaling mechanism leading to this perfect healing is a key step to help develop regenerative treatments for humans....

journal_title：Scientific reports

authors： Sader F,Denis JF,Laref H,Roy S

更新日期：2019-02-04 00:00:00

abstract：:Recent genome-wide association studies (GWAS) of Parkinson's disease (PD) revealed at least 26 risk loci, with associated single nucleotide polymorphisms (SNPs) located in non-coding DNA having unknown functions in risk. In order to explore in which cell types these SNPs (and their correlated surrogates at r(2) ≥ 0.8)...

journal_title：Scientific reports

authors： Coetzee SG,Pierce S,Brundin P,Brundin L,Hazelett DJ,Coetzee GA

更新日期：2016-07-27 00:00:00

abstract：:In the era of precision medicine the treatment options for cancer patients and subsequent outcomes are expected to improve. We present a review of patients enrolled in first-in-human Phase1 trials at University of Alabama at Birmingham. Between 1/2015-6/2017, 162 cancer patients (whole cohort, WC) were enrolled on pha...

journal_title：Scientific reports

authors： Paluri RK,Li P,Anderson A,Nandagopal L,McArdle T,Young M,Robert F,Naik G,Saleh M

更新日期：2020-05-13 00:00:00

abstract：:Phase transition is a natural phenomenon happened around our daily life, represented by the process from ice to water. While melting and solidifying at a certain temperature, a high heat of fusion is accompanied, classified as the latent heat. Phase change material (PCM) has been widely applied to store and release la...

journal_title：Scientific reports

authors： Chen R,Cui Y,Tian H,Yao R,Liu Z,Shu Y,Li C,Yang Y,Ren T,Zhang G,Zou R

更新日期：2015-03-09 00:00:00

abstract：:This manuscript presents a detailed characterization of active control of bow shock waves via leading edge injection, including subsonic coolant ejection and the appearance of Coanda effects. The flow phenomena occurring at steady and pulsating flow injection regimes were analyzed using steady and unsteady two-dimensi...

journal_title：Scientific reports

authors： Lozano F,Paniagua G

更新日期：2020-12-14 00:00:00

abstract：:An orientation measurement method based on Hall-effect sensors is proposed for permanent magnet (PM) spherical actuators with three-dimensional (3D) magnet array. As there is no contact between the measurement system and the rotor, this method could effectively avoid friction torque and additional inertial moment exis...

journal_title：Scientific reports

authors： Yan L,Zhu B,Jiao Z,Chen CY,Chen IM

更新日期：2014-10-24 00:00:00

abstract：:Invasive infections caused by drug-resistant bacteria are frequently responsible for fatal sepsis, morbidity and mortality rates. In this work, we propose a new methodology based on nanosecond high frequency electric field bursts, which enables successful eradication of bacteria in vivo. High frequency (15 kHz) 15-25 ...

journal_title：Scientific reports

authors： Novickij V,Zinkevičienė A,Perminaitė E,Čėsna R,Lastauskienė E,Paškevičius A,Švedienė J,Markovskaja S,Novickij J,Girkontaitė I

更新日期：2018-09-28 00:00:00

abstract：:Negative diagonal magneto-conductivity/resistivity is a spectacular- and thought provoking-property of driven, far-from-equilibrium, low dimensional electronic systems. The physical response of this exotic electronic state is not yet fully understood since it is rarely encountered in experiment. The microwave-radiatio...

journal_title：Scientific reports

authors： Mani RG,Kriisa A

更新日期：2013-12-11 00:00:00

abstract：:The lack of bone morphological markers associated with the human control of wild animals has prevented the documentation of incipient animal domestication in archaeology. Here, we assess whether direct environmental changes (i.e. mobility reduction) could immediately affect ontogenetic changes in long bone structure, ...

journal_title：Scientific reports

authors： Harbers H,Zanolli C,Cazenave M,Theil JC,Ortiz K,Blanc B,Locatelli Y,Schafberg R,Lecompte F,Baly I,Laurens F,Callou C,Herrel A,Puymerail L,Cucchi T

更新日期：2020-11-04 00:00:00

abstract：:Outbreaks involving the Asian genotype Chikungunya virus (CHIKV) caused over one million infections in the Americas recently. The outbreak was preceded by a major nationwide outbreak in the Philippines. We examined the phylogenetic and phylogeographic relationships of representative CHIKV isolates obtained from the 20...

journal_title：Scientific reports

authors： Tan KK,Sy AK,Tandoc AO,Khoo JJ,Sulaiman S,Chang LY,AbuBakar S

更新日期：2015-07-23 00:00:00

abstract：:Diabetes is an independent risk factor for development of heart failure and has been associated with poor outcomes in these patients. The prevalence of diabetes continues to rise. Using routine HbA1c measurements on inpatients at a tertiary hospital, we aimed to investigate the prevalence of diabetes amongst patients ...

journal_title：Scientific reports

authors： Khoo K,Lew J,Neef P,Kearney L,Churilov L,Robbins R,Tan A,Hachem M,Owen-Jones L,Lam Q,Hart GK,Wilson A,Sumithran P,Johnson D,Srivastava PM,Farouque O,Burrell LM,Zajac JD,Ekinci EI

更新日期：2018-09-10 00:00:00

abstract：:Receipt of broad-spectrum antibiotics enhances Candida albicans colonization of the GI tract, a risk factor for haematogenously-disseminated candidiasis. To understand how antibiotics influence C. albicans colonization, we treated mice orally with vancomycin or a combination of penicillin, streptomycin, and gentamicin...

journal_title：Scientific reports

authors： Shankar J,Solis NV,Mounaud S,Szpakowski S,Liu H,Losada L,Nierman WC,Filler SG

更新日期：2015-02-03 00:00:00

abstract：:Being one of the most common trees in forests, Pinus sylvestris L. is a frequently used raw material for wood products. Its specific odour is, however, mostly unresolved to date. Accordingly, we investigated Scots pine wood samples grown in Germany for their main odorant composition. We employed dedicated odorant anal...

journal_title：Scientific reports

authors： Schreiner L,Bauer P,Buettner A

更新日期：2018-05-29 00:00:00

abstract：:Metastasis causes approximately 90% of breast cancer-related deaths in women. Previously, we have demonstrated that 2-dodecyl-6-methoxycyclohexa-2,5-diene- 1,4-dione (DMDD) remarkably inhibited the growth of human breast cancer cells with little toxicity. In this study, we investigated the toxicity and efficacy of DMD...

journal_title：Scientific reports

authors： Chen C,Nong Z,Xie Q,He J,Cai W,Tang X,Chen X,Huang R,Gao Y

更新日期：2017-07-27 00:00:00

abstract：:Infantile spasms (ISs) is a devastating form of an early infantile epileptic encephalopathy. The patterns of response of multiple regimens, and the difference in response rates for the cases who receive first-line therapies on time versus those who receive them after non-first-line therapies are unknown. We performed ...

journal_title：Scientific reports

authors： Mao L,Kessi M,Peng P,He F,Zhang C,Yang L,Wu L,Yin F,Peng J

更新日期：2020-07-13 00:00:00

abstract：:Despite the quintessential role that music plays in human societies by enabling us to release and share emotions with others, traces of its evolutionary origins in other species remain scarce. Drumming like humans whilst producing music is practically unheard of in our most closely related species, the great apes. Alt...

journal_title：Scientific reports

authors： Dufour V,Poulin N,Charlotte Curé,Sterck EH

更新日期：2015-06-17 00:00:00

abstract：:Silk suture material is primarily composed of silk fibroin and regarded as a non-resorbable material. It is slowly degraded by proteolysis when it is implanted into the body. 4-Hexylresorcinol (4HR) is a well-known antiseptic. In this study, the biodegradability of 4HR-incorporated silk sutures were compared to that o...

journal_title：Scientific reports

authors： Jo YY,Kweon H,Kim DW,Kim MK,Kim SG,Kim JY,Chae WS,Hong SP,Park YH,Lee SY,Choi JY

更新日期：2017-02-13 00:00:00

abstract：:Faithful DNA replication is a prerequisite for cell proliferation. Several cytological studies have shown that chromosome structures alter in the S-phase of the cell cycle. However, the molecular mechanisms behind the alteration of chromosome structures associated with DNA replication have not been elucidated. Here, w...

journal_title：Scientific reports

authors： Ruan K,Yamamoto TG,Asakawa H,Chikashige Y,Kimura H,Masukata H,Haraguchi T,Hiraoka Y

更新日期：2015-07-30 00:00:00

abstract：:Hfq is a bacterial RNA binding protein that carries out several roles in genetic expression regulation, mainly at the post-transcriptional level. Previous studies have shown its importance in growth and virulence of bacteria. Here, we provide the direct observation of its ability to interact with membranes. This was e...

journal_title：Scientific reports

authors： Malabirade A,Morgado-Brajones J,Trépout S,Wien F,Marquez I,Seguin J,Marco S,Velez M,Arluison V

更新日期：2017-09-06 00:00:00

abstract：:Large-scale studies have not been conducted to assess whether serum hypobicarbonatemia increases the risk for kidney function deterioration and mortality among East-Asians. We aimed to determine the association between serum total CO2 (TCO2) concentrations measured at the first outpatient visit and clinical outcomes. ...

journal_title：Scientific reports

authors： Yoo KD,An JN,Kim YC,Lee J,Joo KW,Oh YK,Kim YS,Lim CS,Oh S,Lee JP

更新日期：2021-01-18 00:00:00

abstract：:Schizophrenia is a common neuropsychiatric disorder with a lifetime risk of 1%. Accumulation of common polygenic variations has been found to be an important risk factor. Recent studies showed a role for the enrichment of minor alleles (MAs) of SNPs in complex diseases such as Parkinson's disease. Here we similarly st...

journal_title：Scientific reports

authors： He P,Lei X,Yuan D,Zhu Z,Huang S

更新日期：2017-09-15 00:00:00

abstract：:Conserving crop wild relatives (CWR) is critical for maintaining food security. However, CWR-focused conservation plans are lacking, and are often based on the entire genus, even though only a few taxa are useful for crop improvement. We used taxonomic and geographic prioritisation to identify the best locations for i...

journal_title：Scientific reports

authors： Moray C,Game ET,Maxted N

更新日期：2014-06-17 00:00:00