Abstract:
:Silicon is the second most common element on the Earth's crust and its oxide (SiO(2)) the most abundant mineral. Silica and silicates are widely used in medicine and industry as well as in micro- and nano-optics and electronics. However, the fabrication of glass fibres and components requires high temperature and non-physiological conditions, in contrast to biosilica structures in animals and plants. Here, we show for the first time the use of recombinant silicatein-α, the most abundant subunit of sponge proteins catalyzing biosilicification reactions, to direct the formation of optical waveguides in-vitro through soft microlithography. The artificial biosilica fibres mimic the natural sponge spicules, exhibiting refractive index values suitable for confinement of light within waveguides, with optical losses in the range of 5-10 cm(-1), suitable for application in lab-on-chips systems. This method extends biosilicification to the controlled fabrication of optical components by physiological processing conditions, hardly addressed by conventional technologies.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Polini A,Pagliara S,Camposeo A,Cingolani R,Wang X,Schröder HC,Müller WE,Pisignano Ddoi
10.1038/srep00607subject
Has Abstractpub_date
2012-01-01 00:00:00pages
607issn
2045-2322journal_volume
2pub_type
杂志文章abstract::Fibrillar collagen COL6α3 in adipose tissue has been associated with obesity, inflammation, insulin resistance and cancer. We here aimed to identify novel transcriptional regulators of COL6A3 expression. Based on a transcriptome dataset of adipose tissue, we identified strong correlations for 56 genes with COL6A3 mRNA...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77406-2
更新日期:2020-11-19 00:00:00
abstract::Pigeons learned to discriminate two different patterns displayed with miniature light-emitting diode arrays. They were then tested with 84 interspersed, non-reinforced degraded pattern pairs. Choices ranged between 100% and 50% for one or other of the patterns. Stimuli consisting of few pixels yielded low choice score...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50212-1
更新日期:2019-09-26 00:00:00
abstract::Transcranial focused ultrasound (US) has been demonstrated to stimulate neurons in animals and humans, but the mechanism of this effect is unknown. It has been hypothesized that US, a mechanical stimulus, may mediate cellular discharge by activating mechanosensitive ion channels embedded within cellular membranes. To ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24170
更新日期:2016-04-26 00:00:00
abstract::Multidrug-resistant organisms are increasing in healthcare settings, and there are few antimicrobials available to treat infections from these bacteria. Pseudomonas aeruginosa is an opportunistic pathogen in burn patients and individuals with cystic fibrosis (CF), and a leading cause of nosocomial infections. P. aerug...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43060-6
更新日期:2019-04-30 00:00:00
abstract::Recent studies reveal that tonal language speakers with autism have enhanced neural sensitivity to pitch changes in nonspeech stimuli but not to lexical tone contrasts in their native language. The present ERP study investigated whether the distinct pitch processing pattern for speech and nonspeech stimuli in autism w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43254
更新日期:2017-02-22 00:00:00
abstract::In the research field of extracellular vesicles (EVs), the use of fetal bovine serum (FBS) depleted of EVs for in vitro studies is advocated to eliminate the confounding effects of media derived EVs. EV-depleted FBS may either be prepared by ultracentrifugation or purchased commercially. Nevertheless, these preparatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41772-3
更新日期:2019-04-02 00:00:00
abstract::Corticosteroids have been proved to be ineffective for Guillain-Barré syndrome, but the mechanism remains unknown. In a rabbit model of axonal Guillain-Barré syndrome, treatment with corticosteroids significantly reduced macrophage infiltration in the spinal ventral roots and the survival rate as well as clinical impr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13931
更新日期:2015-09-10 00:00:00
abstract::The development is reported of an ultra-rapid, point-of-care diagnostic device which harnesses surface acoustic wave (SAW) biochips, to detect HIV in a finger prick of blood within 10 seconds (sample-in-result-out). The disposable quartz biochip, based on microelectronic components found in every consumer smartphone, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11887-6
更新日期:2017-09-20 00:00:00
abstract::Recent research tried to analyze the conjugation of some chemotherapeutic drugs to the biologically produced gold nanoparticles (GNPs) in one step, without the use of any additional linkers. GNPs was produced using Fusarium oxysporum and their presence was confirmed using spectrophotometer, transmission electron micro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46602-0
更新日期:2019-07-15 00:00:00
abstract::SERS spectra excited at 785 nm of the bacteria Chlamydia trahomatis (elementary bodies, EB) and Neisseria gonorrheoae, the causative pathogens for the two most common sexually transmitted diseases (STD), chlamydia and gonorrhea, respectively, are reported. Although both are Gram-negative bacteria, the SERS signatures ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23562-5
更新日期:2018-03-26 00:00:00
abstract::Interleukin-8 (IL-8) as an important cytokine involving in inflammatory and immune response, has been studied as effective adjuvants for vaccines in mammals. However, there are fewer reports about the characterization and adjuvant effects of IL-8 in fish. In this study, cloning and sequence analysis of IL-8 coding reg...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29310
更新日期:2016-07-04 00:00:00
abstract::Abnormal expression of microRNAs (miRNAs) contributes to glioma initiation. However, the expression of miRNAs in tumour tissue or blood of spinal cord glioma (SCG) patients, particularly in high-grade spinal gliomas (Grade IV) known as glioblastoma (GBM), remains largely unknown. In this study we aimed to determine di...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42364-x
更新日期:2019-06-24 00:00:00
abstract::The CRISPR/Cas9 system is a powerful method of editing genes by randomly introducing errors into the target sites. Here, we describe a CRISPR-based test for gene essentiality (CRISPR-E test) that allows the identification of essential genes. Specifically, we use sgRNA-mediated CRISPR/Cas9 to target the open reading fr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71690-8
更新日期:2020-09-08 00:00:00
abstract::Circular RNA (circRNA) is a newly discovered non-coding RNA, which play significant roles in the function and transcriptional regulation of microRNA. To date, in Chinese cabbage, the functional characteristic of circRNAs in response to calcium deficiency-induced tip-burn have not been reported. In this study, 730 circ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51190-0
更新日期:2019-10-10 00:00:00
abstract::The recent surge in research on metal-halide-perovskite solar cells has led to a seven-fold increase of efficiency, from ~3% in early devices to over 22% in research prototypes. Oft-cited reasons for this increase are: (i) a carrier diffusion length reaching hundreds of microns; (ii) a low exciton binding energy; and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36108
更新日期:2016-11-08 00:00:00
abstract::Mesenchymal stem cells (MSC) are osteoblasts progenitors and a variety of studies suggest that they may play an important role for the health in the field of bone regeneration. Magnesium supplementation is gaining importance as adjuvant treatment to improve osteogenesis, although the mechanisms involving this process ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08379-y
更新日期:2017-08-10 00:00:00
abstract::Sigma-1 and sigma-2 receptors are emerging therapeutic targets. We have identified that simple ammonium salts bind to these receptors and are effective in vivo. Radioligand binding assays were used to obtain structure-activity relationships of these salts. MTS assays were performed to determine their effect on growth ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65849-6
更新日期:2020-06-08 00:00:00
abstract::Insects are a promising alternative protein source. One of the bottlenecks in applying insects in food is the fast darkening initiated during grinding. Besides enzymatic browning, non-enzymatic factors can cause off-colour formation, which differs between species. This study investigates the impact of iron, phenoloxid...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38923-x
更新日期:2019-02-27 00:00:00
abstract::Connectivity is fundamentally important for shaping the resilience of complex human and natural networks when systems are disturbed. Ecosystem resilience is, in part, shaped by the spatial arrangement of habitats, the permeability and fluxes between them, the stabilising functions performed by organisms, their dispers...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-80987-1
更新日期:2021-01-13 00:00:00
abstract::Loss of anorectal resting pressure due to internal anal sphincter (IAS) dysfunctionality causes uncontrolled fecal soiling and leads to passive fecal incontinence (FI). The study is focused on immediate and long-term safety and potential efficacy of bioengineered IAS BioSphincters to treat passive FI in a clinically r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54440-3
更新日期:2019-12-02 00:00:00
abstract::Receptor tyrosine kinases (RTKs) are key regulators of normal cellular processes and have a critical role in the development and progression of many diseases. RTK ligand-induced stimulation leads to activation of the cytoplasmic kinase domain that controls the intracellular signalling. Although the kinase domain of RT...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62460-7
更新日期:2020-03-25 00:00:00
abstract::The strong age dependency of neonatal systemic infection with Escherichia coli K1 can be replicated in the neonatal rat. Gastrointestinal (GI) colonization of two-day-old (P2) rats leads to invasion of the blood within 48 h of initiation of colonization; pups become progressively less susceptible to infection over the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00123-w
更新日期:2017-03-06 00:00:00
abstract::LL37 exerts a dual pathogenic role in psoriasis. Bound to self-DNA/RNA, LL37 licenses autoreactivity by stimulating plasmacytoid dendritic cells-(pDCs)-Type I interferon (IFN-I) and acts as autoantigen for pathogenic Th17-cells. In systemic lupus erythematosus (SLE), LL37 also triggers IFN-I in pDCs and is target of p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62480-3
更新日期:2020-04-03 00:00:00
abstract::In 2010, a new rabbit hemorrhagic disease virus (RHDV) variant, designated RHDV2, was identified for the first time in Italy. Studies have shown that RHDV2 differs from RHDV1 (traditional RHDV) in terms of its antigenic profile and genetic characteristics. The VP60 protein of RHDV is a structural protein that plays im...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20857
更新日期:2016-02-16 00:00:00
abstract::Mt. Spurr is the largest active volcano in Alaska of high explosive potential. The most recent activity, including two recent magmatic eruptions in 1953 and 1992, has occurred via the flanking Crater Peak. From 2004 to 2006, strong seismicity, gas flux, and heating were observed in the summit area, which had remained ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35453-w
更新日期:2018-11-30 00:00:00
abstract::Despite advances in renovascular disease (RVD) research, gaps remain between experimental and clinical outcomes, translation of results, and the understanding of pathophysiological mechanisms. A predictive tool to indicate support (or lack of) for biological findings may aid clinical translation of therapies. We creat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57386-8
更新日期:2020-01-16 00:00:00
abstract::This study analyses spatially resolved estimates of mass budget and surface velocity of glaciers in the Zanskar Basin of Western Himalaya in the context of varying debris cover, glacier hypsometry and orientation. The regional glacier mass budget for the period of 1999-2014 is -0.38 ± 0.09 m w.e./a. Individual mass bu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27014-y
更新日期:2018-06-11 00:00:00
abstract::β-lactam antibiotics act as suicide substrates of transpeptidases responsible for the last cross-linking step of peptidoglycan synthesis in the bacterial cell wall. Nucleophilic attack of the β-lactam carbonyl by the catalytic residue (Ser or Cys) of transpeptidases results in the opening of the β-lactam ring and in t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09341-8
更新日期:2017-08-22 00:00:00
abstract::The nitrogen-vacancy (NV) centre in diamond is a promising candidate for quantum computing applications and magnetic sensing applications, because it is an atomic-scale defect with stable coherence time (T2) and reliable accessibility at room temperature. We demonstrated a method for improving the NV spin properties (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34158-4
更新日期:2018-10-26 00:00:00
abstract::The importance of evaluating physical cues in cancer research is gradually being realized. Assessment of cancer cell physical appearance, or phenotype, may provide information on changes in cellular behavior, including migratory or communicative changes. These characteristics are intrinsically different between malign...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12083
更新日期:2015-07-13 00:00:00