当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Altered RNA editing in 3' UTR perturbs microRNA-mediated regulation of oncogenes and tumor-suppressors.

Altered RNA editing in 3' UTR perturbs microRNA-mediated regulation of oncogenes and tumor-suppressors.

Abstract：

:RNA editing is a molecular event that alters specific nucleotides in RNA post-transcriptionally. RNA editing has the potential to impact a variety of cellular processes and is implicated in diseases such as cancer. Yet, the precise mechanisms by which RNA editing controls cellular processes are poorly understood. Here, we characterize sequences altered by RNA editing in patient samples from lymphoma, neuroblastoma and head and neck cancers. We show that A-to-I RNA editing sites are highly conserved across samples of the same tissue type and that most editing sites identified in tumors are also detectable in normal tissues. Next, we identify the significant changes in editing levels of known sites between tumor and paired "normal" tissues across 14 cancer types (627 pairs) from The Cancer Genome Atlas project and show that the complexity of RNA editing regulation cannot be captured by the activity of ADAR family genes alone. Our pan-cancer analysis confirms previous results on individual tumor types and suggests that changes of RNA editing levels in coding and 3'UTR regions could be a general mechanism to promote tumor growth. We also propose a model explaining how altered RNA editing levels affect microRNA-mediated post-transcriptional regulation of oncogenes and tumor-suppressors.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Zhang L,Yang CS,Varelas X,Monti S

doi

10.1038/srep23226

subject

Has Abstract

pub_date

2016-03-16 00:00:00

pages

23226

issn

2045-2322

pii

srep23226

journal_volume

6

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Inhibitory effect of thymol on pheromone-mediated attraction in two pest moth species.

    abstract：:Plant essential oils are considered as important bio-sources for the development of natural and environmentally safe pest control tools due to their multiple modes of action on insects. In this paper we have evaluated the activity of commercially available thyme oil and its constituents thymol, carvacrol, and p-cymene...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-79550-1

    authors： López S,Domínguez A,Guerrero Á,Quero C

    更新日期：2021-01-13 00:00:00

  • Recombinant Bri3 BRICHOS domain is a molecular chaperone with effect against amyloid formation and non-fibrillar protein aggregation.

    abstract：:Molecular chaperones assist proteins in achieving a functional structure and prevent them from misfolding into aggregates, including disease-associated deposits. The BRICHOS domain from familial dementia associated protein Bri2 (or ITM2B) probably chaperones its specific proprotein region with high β-sheet propensity ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-66718-y

    authors： Poska H,Leppert A,Tigro H,Zhong X,Kaldmäe M,Nilsson HE,Hebert H,Chen G,Johansson J

    更新日期：2020-06-17 00:00:00

  • Role of intestinal trefoil factor in protecting intestinal epithelial cells from burn-induced injury.

    abstract：:Although intestinal trefoil factor (ITF) can alleviate the burn-induced intestinal mucosa injury, the underlying mechanisms remains elusive. In this study, we investigated if ITF alters glutamine transport on the brush border membrane vesicles (BBMVs) of the intestines in Sprague-Dawley rats inflicted with 30% TBSA an...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-21282-4

    authors： Hu J,Shi Y,Wang C,Wan H,Wu D,Wang H,Peng X

    更新日期：2018-02-16 00:00:00

  • 3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained.

    abstract：:The potential of a spheroid tumor model composed of cells in different proliferative and metabolic states for the development of new anticancer strategies has been amply demonstrated. However, there is little or no information in the literature on the problems of reproducibility of data originating from experiments us...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep19103

    authors： Zanoni M,Piccinini F,Arienti C,Zamagni A,Santi S,Polico R,Bevilacqua A,Tesei A

    更新日期：2016-01-11 00:00:00

  • Chitosan coated cotton cloth supported zero-valent nanoparticles: Simple but economically viable, efficient and easily retrievable catalysts.

    abstract：:A simple, economically viable and fast method has been utilized for the preparation of highly active metal nanoparticles (MNPs) in coating layer of chitosan (CH) over cellulose microfibers of cotton cloth (CC). 2 wt% of CH solution was used for the coating of CC strips (CC-CH), and were kept in aqueous solutions of me...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-16815-2

    authors： Ali F,Khan SB,Kamal T,Alamry KA,Asiri AM,Sobahi TRA

    更新日期：2017-12-05 00:00:00

  • Adipose-derived Stem Cell Conditioned Media Extends Survival time of a mouse model of Amyotrophic Lateral Sclerosis.

    abstract：:Adipose stromal cells (ASC) secrete various trophic factors that assist in the protection of neurons in a variety of neuronal death models. In this study, we tested the effects of human ASC conditional medium (ASC-CM) in human amyotrophic lateral sclerosis (ALS) transgenic mouse model expressing mutant superoxide dism...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16953

    authors： Fontanilla CV,Gu H,Liu Q,Zhu TZ,Zhou C,Johnstone BH,March KL,Pascuzzi RM,Farlow MR,Du Y

    更新日期：2015-11-20 00:00:00

  • Association of admission serum levels of vitamin D, calcium, Phosphate, magnesium and parathormone with clinical outcomes in neurosurgical ICU patients.

    abstract：:To evaluate the association of admission serum levels of 25(OH)D, parathormone and the related electrolytes with severity of illness and clinical outcomes in neurosurgical critically ill patients, serum levels of 25(OH)D, parathormone, calcium, magnesium, and phosphate, along with APACHE II score were measured for 210...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-21177-4

    authors： Ardehali SH,Dehghan S,Baghestani AR,Velayati A,Vahdat Shariatpanahi Z

    更新日期：2018-02-14 00:00:00

  • A prospective, randomized, double-blind, placebo-controlled trial of acute postoperative pain treatment using opioid analgesics with intravenous ibuprofen after radical cervical cancer surgery.

    abstract：:This study assessed the efficacy and tolerability of intravenous ibuprofen in the improvement of post-operative pain control and the reduction of opioid usage. Patients were randomly divided into placebo, ibuprofen 400 mg and ibuprofen 800 mg groups. All patients received patient-controlled intravenous morphine analge...

    journal_title：Scientific reports

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/s41598-018-28428-4

    authors： Liu X,Wang X,Zhao W,Wei L,Zhang P,Han F

    更新日期：2018-07-05 00:00:00

  • A novel allele of L-galactono-1,4-lactone dehydrogenase is associated with enhanced drought tolerance through affecting stomatal aperture in common wheat.

    abstract：:In higher plants, L-galactono-1,4-lactone dehydrogenase (GLDH) plays important roles in ascorbic acid (AsA) biosynthesis and assembly of respiration complex I. Here we report three homoeologous genes (TaGLDH-A1, -B1 and -D1) encoding common wheat GLDH isozymes and a unique allelic variant (TaGLDH-A1b) associated with ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep30177

    authors： Zhang J,Li B,Yang Y,Mu P,Qian W,Dong L,Zhang K,Liu X,Qin H,Ling H,Wang D

    更新日期：2016-07-22 00:00:00

  • Use of a Lymphatic Drug Delivery System and Sonoporation to Target Malignant Metastatic Breast Cancer Cells Proliferating in the Marginal Sinuses.

    abstract：:Lymph node (LN) metastasis through the lymphatic network is a major route for cancer dissemination. Tumor cells reach the marginal sinuses of LNs via afferent lymphatic vessels (LVs) and form metastatic lesions that lead to distant metastasis. Thus, targeting of metastatic cells in the marginal sinuses could improve c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49386-5

    authors： Kato S,Shirai Y,Sakamoto M,Mori S,Kodama T

    更新日期：2019-09-13 00:00:00

  • CD147/EMMPRIN overexpression and prognosis in cancer: A systematic review and meta-analysis.

    abstract：:CD147/EMMPRIN (extracellular matrix metalloproteinase inducer) plays an important role in tumor progression and a number of studies have suggested that it is an indicator of tumor prognosis. This current meta-analysis systematically reevaluated the predictive potential of CD147/EMMPRIN in various cancers. We searched ...

    journal_title：Scientific reports

    pub_type： 杂志文章,评审

    doi：10.1038/srep32804

    authors： Xin X,Zeng X,Gu H,Li M,Tan H,Jin Z,Hua T,Shi R,Wang H

    更新日期：2016-09-09 00:00:00

  • Single Crystal Growth and Spin Polarization Measurements of Diluted Magnetic Semiconductor (BaK)(ZnMn)2As2.

    abstract：:Recently a new diluted magnetic semiconductor, (Ba,K)(Zn,Mn)2As2 (BZA), with high Curie temperature was discovered, showing an independent spin and charge-doping mechanism. This makes BZA a promising material for spintronics devices. We report the successful growth of a BZA single crystal for the first time in this st...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-08394-z

    authors： Zhao GQ,Lin CJ,Deng Z,Gu GX,Yu S,Wang XC,Gong ZZ,Uemura YJ,Li YQ,Jin CQ

    更新日期：2017-11-03 00:00:00

  • Analysis of inter-system variability of systolic and diastolic intraventricular pressure gradients derived from color Doppler M-mode echocardiography.

    abstract：:Assessment of intraventricular pressure gradients (IVPG) using color Doppler M-mode echocardiography has gained increasing interest in the evaluation of cardiac function. However, standardized analysis tools for IVPG quantification are missing. We aimed to evaluate the feasibility, the test-retest observer reproducibi...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41598-020-64059-4

    authors： Hodzic A,Bonnefous O,Langet H,Hamiche W,Chaufourier L,Tournoux F,Milliez P,Normand H,Saloux E

    更新日期：2020-04-28 00:00:00

  • Growth kinetics of plasma-polymerized films.

    abstract：:The growth kinetics of polymer thin films prepared by plasma-based deposition method were explored using atomic force microscopy. The growth behavior of the first layer of the polythiophene somewhat differs from that of the other layers because the first layer is directly deposited on the substrate, whereas the other ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep11201

    authors： Hwang S,Seo H,Jeong DC,Wen L,Han JG,Song C,Kim Y

    更新日期：2015-06-18 00:00:00

  • Hemidesmus indicus induces apoptosis via proteasome inhibition and generation of reactive oxygen species.

    abstract：:Proteasome inhibition represents an important anticancer strategy. Here, we studied the mechanisms at the basis of the pro-apoptotic activity of the standardized decoction of Hemidesmus indicus, a plant evoking a complex anticancer activity, and explored its inhibition of proteasome activity in human leukemia cells. A...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43609-5

    authors： Turrini E,Catanzaro E,Ferruzzi L,Guerrini A,Tacchini M,Sacchetti G,Paganetto G,Maffei F,Pellicioni V,Poli F,Hrelia P,Mandrone M,Sestili P,Brigotti M,Fimognari C

    更新日期：2019-05-10 00:00:00

  • Multiplex epitope mapping using bacterial surface display reveals both linear and conformational epitopes.

    abstract：:As antibody-based diagnosis and therapy grow at an increased pace, there is a need for methods which rapidly and accurately determine antibody-antigen interactions. Here, we report a method for the multiplex determination of antibody epitopes using bacterial cell-surface display. A protein-fragment library with 10(7) ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00706

    authors： Hudson EP,Uhlen M,Rockberg J

    更新日期：2012-01-01 00:00:00

  • Vibrio vulnificus VvhA induces autophagy-related cell death through the lipid raft-dependent c-Src/NOX signaling pathway.

    abstract：:VvhA, a virulent factor of Vibrio (V.) vulnificus, induces acute cell death in a destructive manner. Autophagy plays an important role in cell death, but the functional role of VvhA in autophagy-related cell death has not been elucidated yet. We found that rVvhA significantly increased LC3 puncta formation and autopha...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27080

    authors： Song EJ,Lee SJ,Lim HS,Kim JS,Jang KK,Choi SH,Han HJ

    更新日期：2016-06-02 00:00:00

  • Bloodstain Pattern Analysis: implementation of a fluid dynamic model for position determination of victims.

    abstract：:Bloodstain Pattern Analysis is a forensic discipline in which, among others, the position of victims can be determined at crime scenes on which blood has been shed. To determine where the blood source was investigators use a straight-line approximation for the trajectory, ignoring effects of gravity and drag and thus ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep11461

    authors： Laan N,de Bruin KG,Slenter D,Wilhelm J,Jermy M,Bonn D

    更新日期：2015-06-22 00:00:00

  • Heterogeneity of Diffusion-Weighted Imaging in Tumours and the Surrounding Stroma for Prediction of Ki-67 Proliferation Status in Breast Cancer.

    abstract：:Breast tissue heterogeneity is related to risk factors that lead to more aggressive tumour growth and worse prognosis, yet such heterogeneity has not been well characterized. The aim of this study is to reveal the heterogeneous signal patterns of the apparent diffusion coefficient (ADC) of a tumour and its surrounding...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03122-z

    authors： Fan M,He T,Zhang P,Zhang J,Li L

    更新日期：2017-06-06 00:00:00

  • Synergistic effect of N-decorated and Mn(2+) doped ZnO nanofibers with enhanced photocatalytic activity.

    abstract：:Here we report a high efficiency photocatalyst, i.e., Mn(2+)-doped and N-decorated ZnO nanofibers (NFs) enriched with vacancy defects, fabricated via electrospinning and a subsequent controlled annealing process. This nanocatalyst exhibits excellent visible-light photocatalytic activity and an apparent quantum efficie...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep32711

    authors： Wang Y,Cheng J,Yu S,Alcocer EJ,Shahid M,Wang Z,Pan W

    更新日期：2016-09-07 00:00:00

  • In silico investigation of a KCNQ1 mutation associated with short QT syndrome.

    abstract：:Short QT syndrome (SQTS) is a rare condition characterized by abnormally 'short' QT intervals on the ECG and increased susceptibility to cardiac arrhythmias and sudden death. This simulation study investigated arrhythmia dynamics in multi-scale human ventricle models associated with the SQT2-related V307L KCNQ1 'gain-...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-08367-2

    authors： Adeniran I,Whittaker DG,El Harchi A,Hancox JC,Zhang H

    更新日期：2017-08-16 00:00:00

  • Membrane topologies of the PGLa antimicrobial peptide and a transmembrane anchor sequence by Dynamic Nuclear Polarization/solid-state NMR spectroscopy.

    abstract：:Dynamic Nuclear Polarization (DNP) has been introduced to overcome the sensitivity limitations of nuclear magnetic resonance (NMR) spectroscopy also of supported lipid bilayers. When investigated by solid-state NMR techniques the approach typically involves doping the samples with biradicals and their investigation at...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep20895

    authors： Salnikov ES,Aisenbrey C,Aussenac F,Ouari O,Sarrouj H,Reiter C,Tordo P,Engelke F,Bechinger B

    更新日期：2016-02-15 00:00:00

  • Author Correction: Circulating Levels of Inflammatory Proteins and Survival in Patients with Gallbladder Cancer.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-59761-2

    authors： Liu Z,Kemp TJ,Gao YT,Corbel A,McGee EE,Roa JC,Wang B,Araya JC,Shen MC,Rashid A,Hsing AW,Hildesheim A,Ferreccio C,Pfeiffer RM,Pinto LA,Koshiol J

    更新日期：2020-02-11 00:00:00

  • Identification of a new cannabidiol n-hexyl homolog in a medicinal cannabis variety with an antinociceptive activity in mice: cannabidihexol.

    abstract：:The two most important and studied phytocannabinoids present in Cannabis sativa L. are undoubtedly cannabidiol (CBD), a non-psychotropic compound, but with other pharmacological properties, and Δ9-tetrahydrocannabinol (Δ9-THC), which instead possesses psychotropic activity and is responsible for the recreative use of ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-79042-2

    authors： Linciano P,Citti C,Russo F,Tolomeo F,Laganà A,Capriotti AL,Luongo L,Iannotta M,Belardo C,Maione S,Forni F,Vandelli MA,Gigli G,Cannazza G

    更新日期：2020-12-16 00:00:00

  • Rapid, topology-based particle tracking for high-resolution measurements of large complex 3D motion fields.

    abstract：:Spatiotemporal tracking of tracer particles or objects of interest can reveal localized behaviors in biological and physical systems. However, existing tracking algorithms are most effective for relatively low numbers of particles that undergo displacements smaller than their typical interparticle separation distance....

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-23488-y

    authors： Patel M,Leggett SE,Landauer AK,Wong IY,Franck C

    更新日期：2018-04-03 00:00:00

  • Optically Transparent Ferromagnetic Nanogranular Films with Tunable Transmittance.

    abstract：:Developing optically transparent magnets at room temperature is an important challenge. They would bring many innovations to various industries, not only for electronic and magnetic devices but also for optical applications. Here we introduce FeCo-(Al-fluoride) nanogranular films exhibiting ferromagnetic properties wi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep34227

    authors： Kobayashi N,Masumoto H,Takahashi S,Maekawa S

    更新日期：2016-09-28 00:00:00

  • Mechanistic insight into the functional transition of the enzyme guanylate kinase induced by a single mutation.

    abstract：:Dramatic functional changes of enzyme usually require scores of alterations in amino acid sequence. However, in the case of guanylate kinase (GK), the functional novelty is induced by a single (S→P) mutation, leading to the functional transition of the enzyme from a phosphoryl transfer kinase into a phosphorprotein in...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep08405

    authors： Zhang Y,Niu H,Li Y,Chu H,Shen H,Zhang D,Li G

    更新日期：2015-02-12 00:00:00

  • Author Correction: The Transcriptomic Signature Of Disease Development And Progression Of Nonalcoholic Fatty Liver Disease.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-65506-y

    authors： Cazanave S,Podtelezhnikov A,Jensen K,Seneshaw M,Kumar DP,Min HK,Santhekadur PK,Banini B,Mauro AG,Oseini AM,Vincent R,Tanis KQ,Webber AL,Wang L,Bedossa P,Mirshahi F,Sanyal AJ

    更新日期：2020-05-15 00:00:00

  • The effects of aquarium culture on coral oocyte ultrastructure.

    abstract：:As the world's oceans are currently threatened by anthropogenic pollution and climate change, coral breeding has become an important conservation method, since it can limit marine organisms' exposure to sub-optimal environment conditions. However, the aquarium environment is inherently different from the ocean, and th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-33341-x

    authors： Lin C,Zhuo JM,Chong G,Wang LH,Meng PJ,Tsai S

    更新日期：2018-10-11 00:00:00

  • Generation of genetically modified mice using SpCas9-NG engineered nuclease.

    abstract：:Although genetically modified mice can be generated with high efficiency by using CRISPR/Cas9-mediated genome editing in mouse zygotes, only the loci with a protospacer-adjacent motif (PAM) sequence are targetable. The present study investigated the usability of engineered Streptococcus pyogenes Cas9 (SpCas9-NG) in mo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49394-5

    authors： Fujii W,Ito H,Kanke T,Ikeda A,Sugiura K,Naito K

    更新日期：2019-09-09 00:00:00