Abstract:
:Breast tissue heterogeneity is related to risk factors that lead to more aggressive tumour growth and worse prognosis, yet such heterogeneity has not been well characterized. The aim of this study is to reveal the heterogeneous signal patterns of the apparent diffusion coefficient (ADC) of a tumour and its surrounding stromal tissue and to predict the Ki-67 proliferation status in oestrogen receptor (ER)-positive breast cancer patients. A dataset of 82 patients who underwent diffusion-weighted imaging (DWI) examination was collected. The ADC map was segmented into regions comprising the tumour and the surrounding stromal shells. To reflect correlations between each region in terms of its mean ADC value, a functional graph was constructed consisting of nodes as regions and edges as interactions between two nodes. Analysis of the graph revealed a higher average degree in samples over-expressing Ki-67 than in samples with low Ki-67 expression. In the low-Ki-67 group, most of the identified edges represented correlations between adjacent regions, whereas additional edges representing correlations between non-adjacent regions were found in the high-Ki-67 group. The ADC signal in various breast stromal regions surrounding the tumour showed a discriminative pattern and would be valuable for estimating the Ki-67 proliferation status by DWI.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Fan M,He T,Zhang P,Zhang J,Li Ldoi
10.1038/s41598-017-03122-zsubject
Has Abstractpub_date
2017-06-06 00:00:00pages
2875issue
1issn
2045-2322pii
10.1038/s41598-017-03122-zjournal_volume
7pub_type
杂志文章abstract::The Fanconi anemia pathway in coordination with homologous recombination is essential to repair interstrand crosslinks (ICLs) caused by cisplatin. TIP60 belongs to the MYST family of acetyltransferases and is involved in DNA repair and regulation of gene transcription. Although the physical interaction between the TIP...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04223-5
更新日期:2017-06-20 00:00:00
abstract::Unlike mammals, in palmipedes de novo lipogenesis from diet takes place mostly in the liver. The French Landes Goose is famous for its high capacity and susceptibility to fatty liver production. While miRNAs play a critical role in the posttranscriptional regulation of gene expression, miRNAs that are involved in the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16632-7
更新日期:2017-11-24 00:00:00
abstract::The relationship between biodiversity and ecological functioning is a central issue in freshwater ecology, but how this relationship is influenced by hydrological connectivity stress is still unknown. In this study we analyzed the dynamic of the phytoplankton alpha diversity indices and their relationships with trophi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78300-7
更新日期:2020-12-07 00:00:00
abstract::We aimed to determine if prematurity and lower birth weight are associated with poorer lung function in a non-western developed setting with less marked confounding by socioeconomic position. Using multivariable linear regression in Hong Kong's "Children of 1997" birth cohort, adjusted associations of prematurity and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56086-7
更新日期:2020-01-15 00:00:00
abstract::Multiple parasitic arthropods of medical importance depend on symbiotic bacteria. While the link between scabies and secondary bacterial infections causing post infective complications of Group A streptococcal and staphylococcal pyoderma is increasingly recognized, very little is known about the microbiota of Sarcopte...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47892-0
更新日期:2019-08-13 00:00:00
abstract::The study aims to evaluate the effectiveness of local injection of autologous platelet rich plasma (A-PRP) as a treatment for women suffering from stress urinary incontinence (SUI). In a prospective intervention study, twenty consecutive women suffering from SUI were treated with A-PRP injection at anterior vaginal wa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80598-2
更新日期:2021-01-15 00:00:00
abstract::Up to now, full tunability of waveforms was possible only in electronics, up to radio-frequencies. Here we propose a new concept of producing few-cycle terahertz (THz) pulses with widely tunable waveforms. It is based on control of the phase delay between different parts of the THz wavefront using linear diffractive o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43852-w
更新日期:2019-05-15 00:00:00
abstract::Isolated lung perfusion (ILP) is an ideal model to study treatment effects on a variety of pathologies. As published research mostly relies on rejected donor lungs or animal organs, this study investigates the use of surgically resected human lobes as an alternative and novel model for personalized experimental resear...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-019-48719-8
更新日期:2019-08-21 00:00:00
abstract::Carex buekii is a tall sedge, forming large stands in wetlands, particularly in river floodplains across Central Europe and thus on many sites determining the typical appearance of riverine habitats. Our paper aims at increasing the knowledge on ecology of C. buekii and its role in the wetlands. Field data were collec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47563-0
更新日期:2019-08-01 00:00:00
abstract::Pluripotency can be induced in vitro from adult somatic mammalian cells by enforced expression of defined transcription factors regulating and initiating the pluripotency network. Despite the substantial advances over the last decade to improve the efficiency of direct reprogramming, exact mechanisms underlying the co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15187-x
更新日期:2017-11-29 00:00:00
abstract::Growth in salmon aquaculture over the past two decades has raised concerns regarding the potential impacts of the industry on neighboring ecosystems and wild fish productivity. Despite limited evidence, sea lice have been identified as a major cause for the decline in some wild Pacific salmon populations on the west c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22458-8
更新日期:2018-03-05 00:00:00
abstract::The sedimentary record, and associated micropalaeontological proxies, is one tool that has been employed to quantify a region's tropical cyclone history. Doing so has largely relied on the identification of allochthonous deposits (sediments and microfossils), sourced from deeper water and entrained by tropical cyclone...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24846
更新日期:2016-04-29 00:00:00
abstract::Climate change significantly affects geographic distribution of plants pests and diseases worldwide. Understanding the influence of future climate change on the suitable areas of Diaphorina citri (Kuwayama) in our country and taking timely countermeasures are crucial for improving the effectiveness of control of pest....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66274-5
更新日期:2020-06-08 00:00:00
abstract::Accurate estimation of carrier probabilities of cancer susceptibility gene mutations is an important part of pre-test genetic counselling. Many predictive models are available but their applicability in the Asian population is uncertain. We evaluated the performance of five BRCA mutation risk predictive models in a Ch...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46707-6
更新日期:2019-07-15 00:00:00
abstract::The anisotropic hole and electron mobilities in N,N'-3,4,9,10-perylenediimide-1,7-phenoxy (PDIB-2OPh) and N,N'-3,4,9,10-perylenediimide (PDIB) were theoretically predicted using the Marcus-Hush theory. The substituent effect of phenoxy on their mobility rates, absorption spectra, electron affinities, and ionization po...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35555
更新日期:2016-10-19 00:00:00
abstract::NLRP3 inflammasomes recognize non-microbial danger signals and induce release of proinflammatory cytokine interleukin (IL)-1β, leading to sterile inflammation in cardiovascular disease. Because sterile inflammation is involved in doxorubicin (Dox)-induced cardiotoxicity, we investigated the role of NLRP3 inflammasomes...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26489
更新日期:2016-05-26 00:00:00
abstract::Light regulates cGMP concentration in the photoreceptor cytoplasm by activating phosphodiesterase (PDE) molecules through a G-protein signalling cascade. Spontaneous PDE activity is present in rod outer segments even in darkness. This basal PDE activity (βdark) has not been determined in wild type mammalian photorecep...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37661-w
更新日期:2019-02-04 00:00:00
abstract::Networks are widely used as a tool for describing diverse real complex systems and have been successfully applied to many fields. The distance between networks is one of the most fundamental concepts for properly classifying real networks, detecting temporal changes in network structures, and effectively predicting th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34944
更新日期:2016-10-11 00:00:00
abstract::After HSP70 binds to the J domain of the substrate and co-chaperone protein, ATP is hydrolyzed to ADP, and the nucleotide exchange factors (NEFs) promote the release of ADP. Under physiological conditions, the nucleotide exchange step is the rate-limiting step, which is accelerated by NEFs. In this study, the promoter...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74381-6
更新日期:2020-10-14 00:00:00
abstract::The effects of biogeographical separation and parent material differences in soil bacterial structure and diversity in offshore islands remain poorly understood. In the current study, we used next-generation sequencing to characterize the differences in soil bacterial communities in five offshore subtropical granite i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41170-9
更新日期:2019-03-20 00:00:00
abstract::Plasmonically enhanced metal-insulator-metal (MIM) type structures are popular among perfect absorbers and photodetectors in which the field enhancement (for increased absorption) mechanism is directly coupled with collection (photocurrent) processes. In this work we propose a device structure that decouples absorptio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42349
更新日期:2017-02-09 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-53737-7
更新日期:2019-11-13 00:00:00
abstract::Vanadium doped ZnO (VZO) thin films were grown by RF magnetron sputtering, starting from a ZnO:V ceramic target. The crystal structure, chemical composition, electric and piezoelectric properties of the films were investigated either on the as-grown thin films or after a post-deposition rapid thermal annealing (RTA) t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41957
更新日期:2017-02-06 00:00:00
abstract::The present study aimed to explore the value of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in differentiating hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma (ICC). This study included 65 patients with malignant hepatic nodules (55 with HCC, 10 with ICC), and 17 control pati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64804-9
更新日期:2020-05-07 00:00:00
abstract::High-quality, 25 nm octahedral-shaped Fe3O4 magnetite nanocrystals are epitaxially grown on 9 nm Au seed nanoparticles using a modified wet-chemical synthesis. These Fe3O4-Au Janus nanoparticles exhibit bulk-like magnetic properties. Due to their high magnetization and octahedral shape, the hybrids show superior in vi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29618-w
更新日期:2018-07-26 00:00:00
abstract::The concept of novel responsive materials with a displacement conversion capability was further developed through the design of new machine-augmented composites (MACs). Embedded converter machines and MACs with improved geometry were designed and fabricated by multi-material 3D printing. This technique proved to be ve...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03783
更新日期:2014-01-21 00:00:00
abstract::Geochemical discrimination has recently been recognised as a potentially useful proxy for identifying tsunami deposits in addition to classical proxies such as sedimentological and micropalaeontological evidence. However, difficulties remain because it is unclear which elements best discriminate between tsunami and no...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07077
更新日期:2014-11-17 00:00:00
abstract::The weak correlation between pain and structural changes in knee osteoarthritis is widely reported. In a previous within-person, knee-matched case-control study among Caucasians, the severity of radiographic osteoarthritis (ROA) was strongly associated with both the presence of frequent knee pain and pain severity. We...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19470-3
更新日期:2018-01-22 00:00:00
abstract::The plant selective autophagy cargo receptor neighbour of breast cancer 1 gene (NBR1) has been scarcely studied in the context of abiotic stress. We wanted to expand this knowledge by using Arabidopsis thaliana lines with constitutive ectopic overexpression of the AtNBR1 gene (OX lines) and the AtNBR1 Knock-Out (KO li...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64765-z
更新日期:2020-05-08 00:00:00
abstract::Ion pumps and channels are responsible for a wide variety of biological functions. Ion pumps transport only one ion during each stimulus-dependent reaction cycle, whereas ion channels conduct a large number of ions during each cycle. Ion pumping rhodopsins such as archaerhodopsin-3 (Arch) are often utilized as light-d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44308-x
更新日期:2019-05-27 00:00:00