Chronic treatment with cisplatin induces chemoresistance through the TIP60-mediated Fanconi anemia and homologous recombination repair pathways.

Abstract:

:The Fanconi anemia pathway in coordination with homologous recombination is essential to repair interstrand crosslinks (ICLs) caused by cisplatin. TIP60 belongs to the MYST family of acetyltransferases and is involved in DNA repair and regulation of gene transcription. Although the physical interaction between the TIP60 and FANCD2 proteins has been identified that is critical for ICL repair, it is still elusive whether TIP60 regulates the expression of FA and HR genes. In this study, we found that the chemoresistant nasopharyngeal carcinoma cells, derived from chronic treatment of cisplatin, show elevated expression of TIP60. Furthermore, TIP60 binds to the promoters of FANCD2 and BRCA1 by using the chromatin immunoprecipitation experiments and promote the expression of FANCD2 and BRCA1. Importantly, the depletion of TIP60 significantly reduces sister chromatid exchange, a measurement of HR efficiency. The similar results were also shown in the FNACD2-, and BRCA1-deficient cells. Additionally, these TIP60-deficient cells encounter more frequent stalled forks, as well as more DNA double-strand breaks resulting from the collapse of stalled forks. Taken together, our results suggest that TIP60 promotes the expression of FA and HR genes that are important for ICL repair and the chemoresistant phenotype under chronic treatment with cisplatin.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Su WP,Ho YC,Wu CK,Hsu SH,Shiu JL,Huang JC,Chang SB,Chiu WT,Hung JJ,Liu TL,Wu WS,Wu PY,Su WC,Chang JY,Liaw H

doi

10.1038/s41598-017-04223-5

subject

Has Abstract

pub_date

2017-06-20 00:00:00

pages

3879

issue

1

issn

2045-2322

pii

10.1038/s41598-017-04223-5

journal_volume

7

pub_type

杂志文章
  • Large-scale semi-arid afforestation can enhance precipitation and carbon sequestration potential.

    abstract::Afforestation is an important approach to mitigate global warming. Its complex interactions with the climate system, however, makes it controversial. Afforestation is expected to be effective in the tropics where biogeochemical and biogeophysical effects act in concert; however, its potential in the large semi-arid re...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-19265-6

    authors: Yosef G,Walko R,Avisar R,Tatarinov F,Rotenberg E,Yakir D

    更新日期:2018-01-17 00:00:00

  • Ultra-short laser-accelerated proton pulses have similar DNA-damaging effectiveness but produce less immediate nitroxidative stress than conventional proton beams.

    abstract::Ultra-short proton pulses originating from laser-plasma accelerators can provide instantaneous dose rates at least 10(7)-fold in excess of conventional, continuous proton beams. The impact of such extremely high proton dose rates on A549 human lung cancer cells was compared with conventionally accelerated protons and ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep32441

    authors: Raschke S,Spickermann S,Toncian T,Swantusch M,Boeker J,Giesen U,Iliakis G,Willi O,Boege F

    更新日期:2016-08-31 00:00:00

  • Differential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice.

    abstract::Monosodium Glutamate (MSG) is used as flavour enhancer, with potential beneficial effects due to its nutritional value. Given the decline in kidney functions during aging, we investigated the impact of MSG voluntary intake on the kidney of male mice, aged 6 or 18 months. For 2 months, they freely consumed water (contr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-80048-z

    authors: Celestino M,Balmaceda Valdez V,Brun P,Castagliuolo I,Mucignat-Caretta C

    更新日期:2021-01-12 00:00:00

  • Tailoring the robust superhydrophobic silicon textures with stable photodetection properties.

    abstract::Surface hydrophobicity of silicon with sound durability under mechanical abrasion is highly desirable for practical needs. However, the reported micro-pyramid/nanowires structures suffer from the saturation characteristics of contact angle at around 132 degree, which impede the promotions toward reaching the state of ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37853-4

    authors: Hsiao M,Chen KY,Chen CY

    更新日期:2019-02-07 00:00:00

  • Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model.

    abstract::This study compared effects of five hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) inhibitors on PC12 cells and primary rat neurons following oxygen-glucose deprivation (OGD). At 100 µM, the PHD inhibitors did not cause cytotoxicity and apoptosis. MTT activity was only significantly reduced by FG4592 or Baye...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-58482-w

    authors: Singh A,Wilson JW,Schofield CJ,Chen R

    更新日期:2020-01-31 00:00:00

  • Ginseng oligopeptides protect against irradiation-induced immune dysfunction and intestinal injury.

    abstract::Intestinal injury and immune dysfunction are commonly encountered after irradiation therapy. While the curative abilities of ginseng root have been reported in prior studies, there is little known regarding its role in immunoregulation of intestinal repairability in cancer patients treated with irradiation. Our curren...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32188-6

    authors: He LX,Zhang ZF,Zhao J,Li L,Xu T,Bin Sun,Ren JW,Liu R,Chen QH,Wang JB,Salem MM,Pettinato G,Zhou JR,Li Y

    更新日期:2018-09-17 00:00:00

  • Robust high-Q filter with complete transmission by conjugated topological photonic crystals.

    abstract::High quality factor (High-Q) and transmission optical devices are required for various applications in the fields of physics and engineering. Critical for these applications is the realization of a structure with high-Q, complete transmission and small volume. A robust high-Q filter with complete transmission by conju...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-64076-3

    authors: Lin YC,Chou SH,Hsueh WJ

    更新日期:2020-04-27 00:00:00

  • The colors of biomass burning aerosols in the atmosphere.

    abstract::Biomass burning aerosols mainly consist of black carbon (BC) and organic aerosols (OAs), and some of OAs are brown carbon (BrC). This study simulates the colors of BrC, BC and their mixture with scattering OAs in the ambient atmosphere by using a combination of light scattering simulations, a two-stream radiative tran...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28267

    authors: Liu C,Chung CE,Zhang F,Yin Y

    更新日期:2016-06-16 00:00:00

  • Cytoplasmic Transport Machinery of the SPF27 Homologue Num1 in Ustilago maydis.

    abstract::In the phytopathogenic basidiomycete Ustilago maydis, the Num1 protein has a pivotal function in hyphal morphogenesis. Num1 functions as a core component of the spliceosome-associated Prp19/CDC5 complex (NTC). The interaction of Num1 with the kinesin motor Kin1 suggests a connection between a component of the splicing...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-21628-y

    authors: Zhou L,Obhof T,Schneider K,Feldbrügge M,Nienhaus GU,Kämper J

    更新日期:2018-02-26 00:00:00

  • Effect of Nitrate Leaching Caused by Swine Manure Application in Fields of the Yellow River Irrigation Zone of Ningxia, China.

    abstract::A five-year swine manure application trial and a study of nitrate leaching losses have been conducted. There were three treatments: traditional without manure (CK), traditional matched manure 4500 kg ha-2 (T1) and traditional matched manure 9000 kg ha-2 (T2). Nitrate nitrogen leaching losses at the 30-, 60-, and 90-cm...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12953-9

    authors: Yang S,Wang Y,Liu R,Zhang A,Yang Z

    更新日期:2017-10-20 00:00:00

  • Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans.

    abstract::How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each of seven genes that we...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep00487

    authors: Honda Y,Higashibata A,Matsunaga Y,Yonezawa Y,Kawano T,Higashitani A,Kuriyama K,Shimazu T,Tanaka M,Szewczyk NJ,Ishioka N,Honda S

    更新日期:2012-01-01 00:00:00

  • Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway.

    abstract::While the Wnt/β-catenin pathway plays a critical role in the maintenance of the zonation of ammonia metabolizing enzymes in the adult liver, the mechanisms responsible for inducing zonation in the embryo are not well understood. Herein we address the spatiotemporal role of the Wnt/β-catenin pathway in the development ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-20888-y

    authors: Burke ZD,Reed KR,Yeh SW,Meniel V,Sansom OJ,Clarke AR,Tosh D

    更新日期:2018-02-09 00:00:00

  • Unified and Exact Framework for Variance-Based Uncertainty Relations.

    abstract::We provide a unified and exact framework for the variance-based uncertainty relations. This unified framework not only recovers some well-known previous uncertainty relations, but also fixes the deficiencies of them. Utilizing the unified framework, we can construct the new uncertainty relations in both product and su...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-56803-2

    authors: Zheng X,Ma SQ,Zhang GF,Fan H,Liu WM

    更新日期:2020-01-10 00:00:00

  • Genetic architecture and mechanism of seed number per pod in rapeseed: elucidated through linkage and near-isogenic line analysis.

    abstract::Seed number per pod (SNPP) is one of the major yield components and breeding targets in rapeseed that shows great variation and is invaluable for genetic improvement. To elucidate the genetic architecture and uncover the mechanism of SNPP, we identified five quantitative trait loci (QTLs) using the BnaZNRIL population...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep24124

    authors: Yang Y,Shi J,Wang X,Liu G,Wang H

    更新日期:2016-04-12 00:00:00

  • Structural features distinguishing infectious ex vivo mammalian prions from non-infectious fibrillar assemblies generated in vitro.

    abstract::Seeded polymerisation of proteins forming amyloid fibres and their spread in tissues has been implicated in the pathogenesis of multiple neurodegenerative diseases: so called "prion-like" mechanisms. While ex vivo mammalian prions, composed of multichain assemblies of misfolded host-encoded prion protein (PrP), act as...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-36700-w

    authors: Terry C,Harniman RL,Sells J,Wenborn A,Joiner S,Saibil HR,Miles MJ,Collinge J,Wadsworth JDF

    更新日期:2019-01-23 00:00:00

  • Unique Molecular Identifiers reveal a novel sequencing artefact with implications for RNA-Seq based gene expression analysis.

    abstract::Attaching Unique Molecular Identifiers (UMI) to RNA molecules in the first step of sequencing library preparation establishes a distinct identity for each input molecule. This makes it possible to eliminate the effects of PCR amplification bias, which is particularly important where many PCR cycles are required, for e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-31064-7

    authors: Sena JA,Galotto G,Devitt NP,Connick MC,Jacobi JL,Umale PE,Vidali L,Bell CJ

    更新日期:2018-09-03 00:00:00

  • Olfactomedin 4 deficiency promotes prostate neoplastic progression and is associated with upregulation of the hedgehog-signaling pathway.

    abstract::Loss of olfactomedin 4 (OLFM4) gene expression is associated with the progression of human prostate cancer, but its role and the molecular mechanisms involved in this process have not been completely understood. In this study, we found that Olfm4-knockout mice developed prostatic intraepithelial neoplasia and prostati...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16974

    authors: Li H,Liu W,Chen W,Zhu J,Deng CX,Rodgers GP

    更新日期:2015-11-19 00:00:00

  • Optimization of Performance and Emission Characteristics of Catalytic Coated IC Engine with Biodiesel Using Grey-Taguchi Method.

    abstract::The performance and emission affected by piston catalytic coating have been analyzed in this study. The main contributing factors for improving performance such as load, fuel and speed have been preferred to reduce the emission and improve the performance of an IC engine. These specific standard parameters have been m...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-57129-9

    authors: Yessian S,Varthanan PA

    更新日期:2020-02-07 00:00:00

  • Ganoderma lucidum aqueous extract prevents hypobaric hypoxia induced memory deficit by modulating neurotransmission, neuroplasticity and maintaining redox homeostasis.

    abstract::Oxidative stress due to hypobaric hypoxia at extreme altitudes causes severe neuronal damage and irreversible cognitive loss. Owing to contraindications of current drug therapies, the aim of the study was to investigate memory enhancing potential of aqueous extract of Ganoderma lucidum (GLAQ) and underlying neuroprote...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65812-5

    authors: Sharma P,Tulsawani R

    更新日期:2020-06-02 00:00:00

  • Myosin phosphatase and RhoA-activated kinase modulate arginine methylation by the regulation of protein arginine methyltransferase 5 in hepatocellular carcinoma cells.

    abstract::Myosin phosphatase (MP) holoenzyme is a protein phosphatase-1 (PP1) type Ser/Thr specific enzyme that consists of a PP1 catalytic (PP1c) and a myosin phosphatase target subunit-1 (MYPT1). MYPT1 is an ubiquitously expressed isoform and it targets PP1c to its substrates. We identified the protein arginine methyltransfer...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40590

    authors: Sipos A,Iván J,Bécsi B,Darula Z,Tamás I,Horváth D,Medzihradszky KF,Erdődi F,Lontay B

    更新日期:2017-01-11 00:00:00

  • The Parkinson Disease gene SNCA: Evolutionary and structural insights with pathological implication.

    abstract::After Alzheimer, Parkinson's disease (PD) is the second most common neurodegenerative disorder. Alpha synuclein (SNCA) is deemed as a major component of Lewy bodies, a neuropathological feature of PD. Five point mutations in SNCA have been reported so far, responsible for autosomal dominant PD. This study aims to deci...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep24475

    authors: Siddiqui IJ,Pervaiz N,Abbasi AA

    更新日期:2016-04-15 00:00:00

  • Color image encryption based on chaotic compressed sensing and two-dimensional fractional Fourier transform.

    abstract::Combining the advantages of structured random measurement matrix and chaotic structure, this paper introduces a color image encryption algorithm based on a structural chaotic measurement matrix and random phase mask. The Chebyshev chaotic sequence is used in the algorithm to generate the flip permutation matrix, the s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-75562-z

    authors: Wang X,Su Y

    更新日期:2020-10-29 00:00:00

  • Association of BRCA1 promoter methylation with sporadic breast cancers: Evidence from 40 studies.

    abstract::Breast cancer susceptibility gene 1 (BRCA1) located at chromosome 17q12-21 is a classic tumor suppressor gene, and has been considered as a significant role in hereditary breast cancers. Moreover, numerous studies demonstrated the methylation status of CpG islands in the promoter regions of BRCA1 gene was aberrant in ...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析

    doi:10.1038/srep17869

    authors: Zhang L,Long X

    更新日期:2015-12-08 00:00:00

  • Discovery of Small Molecules that Inhibit the Disordered Protein, p27(Kip1).

    abstract::Disordered proteins are highly prevalent in biological systems, they control myriad signaling and regulatory processes, and their levels and/or cellular localization are often altered in human disease. In contrast to folded proteins, disordered proteins, due to conformational heterogeneity and dynamics, are not consid...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15686

    authors: Iconaru LI,Ban D,Bharatham K,Ramanathan A,Zhang W,Shelat AA,Zuo J,Kriwacki RW

    更新日期:2015-10-28 00:00:00

  • Chronic synaptic insulin resistance after traumatic brain injury abolishes insulin protection from amyloid beta and tau oligomer-induced synaptic dysfunction.

    abstract::Traumatic brain injury (TBI) is a risk factor for Alzheimer's disease (AD), although the mechanisms contributing to this increased risk are unknown. Insulin resistance is an additional risk factor for AD whereby decreased insulin signaling increases synaptic sensitivity to amyloid beta (Aβ) and tau. Considering this, ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-44635-z

    authors: Franklin W,Krishnan B,Taglialatela G

    更新日期:2019-06-03 00:00:00

  • An engineered opsin monomer scrambles phospholipids.

    abstract::The G protein-coupled receptor opsin is a phospholipid scramblase that facilitates rapid transbilayer phospholipid exchange in liposomes. The mechanism by which opsin scrambles lipids is unknown. It has been proposed that lipid translocation may occur at protein-protein interfaces of opsin dimers. To test this possibi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-16842-z

    authors: Pandey K,Ploier B,Goren MA,Levitz J,Khelashvili G,Menon AK

    更新日期:2017-12-01 00:00:00

  • Ancient hybridization and mtDNA introgression behind current paternal leakage and heteroplasmy in hybrid zones.

    abstract::Hybridization between heterospecific individuals has been documented as playing a direct role in promoting paternal leakage and mitochondrial heteroplasmy in both natural populations and laboratory conditions, by relaxing the egg-sperm recognition mechanisms. Here, we tested the hypothesis that hybridization can lead ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55764-w

    authors: Mastrantonio V,Urbanelli S,Porretta D

    更新日期:2019-12-16 00:00:00

  • Fermionic order by disorder in a van der Waals antiferromagnet.

    abstract::CeTe3 is a unique platform to investigate the itinerant magnetism in a van der Waals (vdW) coupled metal. Despite chemical pressure being a promising route to boost quantum fluctuation in this system, a systematic study on the chemical pressure effect on Ce3+(4f1) states is absent. Here, we report on the successful gr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-72300-3

    authors: Okuma R,Ueta D,Kuniyoshi S,Fujisawa Y,Smith B,Hsu CH,Inagaki Y,Si W,Kawae T,Lin H,Chuang FC,Masuda T,Kobayashi R,Okada Y

    更新日期:2020-09-17 00:00:00

  • A humanized anti-DLL4 antibody promotes dysfunctional angiogenesis and inhibits breast tumor growth.

    abstract::Blockage of Delta-like 4 (DLL4)-directed Notch signaling induces excessive tip cell formation and endothelial proliferation resulting in dysfunctional angiogenesis in tumors. MMGZ01, as a murine anti-human DLL4 monoclonal antibody, specifically binds to human DLL4 and blocks Notch pathway. Here, the structure of MMGZ0...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep27985

    authors: Jia X,Wang W,Xu Z,Wang S,Wang T,Wang M,Wu M

    更新日期:2016-06-15 00:00:00

  • GIS and AHP Techniques Based Delineation of Groundwater Potential Zones: a case study from Southern Western Ghats, India.

    abstract::Over-exploitation of groundwater and marked changes in climate over the years have imposed immense pressure on the global groundwater resources. As demand of potable water increases across the globe for human consumption, agriculture and industrial uses, the need to evaluate the groundwater potential and productivity ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-38567-x

    authors: Arulbalaji P,Padmalal D,Sreelash K

    更新日期:2019-02-14 00:00:00