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A pilot study: effectiveness of local injection of autologous platelet-rich plasma in treating women with stress urinary incontinence.

Abstract：

:The study aims to evaluate the effectiveness of local injection of autologous platelet rich plasma (A-PRP) as a treatment for women suffering from stress urinary incontinence (SUI). In a prospective intervention study, twenty consecutive women suffering from SUI were treated with A-PRP injection at anterior vaginal wall where mid-urethra locates. Self-reported questionnaires were used to measure pre-treatment, 1 month and 6 months post-treatment symptom severity. Secondary outcomes of sexual function and treatment effect sorted by age were analyzed with valid statistical methods. A-PRP is effective in relieving SUI symptoms at both 1 month and 6 months post-treatment without significant adverse reactions reported. It seems to have a trend that treatment success rate with cured and improved symptoms was slightly higher in the younger group, although it did not reach statistical significance (P = 0.07). No significant changes in sexual function before and after the treatment were reported by the patients. This pilot study is the first to report A-PRP treatment effect for SUI in women. The result suggested that A-PRP is a considerable treatment option for mild to moderate SUI cases. It also opens up further research opportunities for A-PRP's clinical applications.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Long CY,Lin KL,Shen CR,Ker CR,Liu YY,Loo ZX,Hsiao HH,Lee YC

doi

10.1038/s41598-020-80598-2

subject

Has Abstract

pub_date

2021-01-15 00:00:00

pages

1584

issue

1

issn

2045-2322

pii

10.1038/s41598-020-80598-2

journal_volume

11

pub_type

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