Ganoderma lucidum aqueous extract prevents hypobaric hypoxia induced memory deficit by modulating neurotransmission, neuroplasticity and maintaining redox homeostasis.

abstract：:Childhood obesity and early rapid growth increase the risk for type 2 diabetes. Such early overnutrition can be modeled in mice by reducing litter size. We investigated the effects of early overnutrition and increased dietary fat intake on β cell function in Swiss Webster mice. On a moderate-fat diet, early overnutrit...

journal_title：Scientific reports

authors： Glavas MM,Hui Q,Tudurí E,Erener S,Kasteel NL,Johnson JD,Kieffer TJ

更新日期：2019-03-06 00:00:00

abstract：:Poly(N-isopropylacrylamide) (PNIPAm) is widely used to fabricate cell sheet surfaces for cell culturing, however copolymer and interpenetrated polymer networks based on PNIPAm have been rarely explored in the context of tissue engineering. Many complex and expensive techniques have been employed to produce PNIPAm-base...

journal_title：Scientific reports

authors： Sanzari I,Buratti E,Huang R,Tusan CG,Dinelli F,Evans ND,Prodromakis T,Bertoldo M

更新日期：2020-04-09 00:00:00

abstract：:Vaccine platforms that can be flexibly loaded with antigens can contribute to decrease response time to emerging infections. For many pathogens and chronic infections, induction of a robust cytotoxic T lymphocytes-mediated response is desirable to control infection. Antigen delivery into the cytoplasm of antigen prese...

journal_title：Scientific reports

authors： Akhras S,Toda M,Boller K,Himmelsbach K,Elgner F,Biehl M,Scheurer S,Gratz M,Vieths S,Hildt E

更新日期：2017-08-29 00:00:00

abstract：:Vermetids form reefs in sub-tropical and warm-temperate waters that protect coasts from erosion, regulate sediment transport and accumulation, serve as carbon sinks and provide habitat for other species. The gastropods that form these reefs brood encapsulated larvae; they are threatened by rapid environmental changes ...

journal_title：Scientific reports

authors： Milazzo M,Rodolfo-Metalpa R,Chan VB,Fine M,Alessi C,Thiyagarajan V,Hall-Spencer JM,Chemello R

更新日期：2014-02-28 00:00:00

abstract：:Mammalian cytokinetic abscission is mediated by the ESCRT membrane fission machinery. While much has been clarified on the topology and kinetics of abscission through high-resolution microscopy, key questions regarding the mechanism of abscission remain open. Here we apply cryogenic soft-X-ray tomography to elucidate ...

journal_title：Scientific reports

authors： Sherman S,Kirchenbuechler D,Nachmias D,Tamir A,Werner S,Elbaum M,Elia N

更新日期：2016-06-10 00:00:00

abstract：:The possibility of producing transgenic cloned buffalos by nuclear transfer of fetal fibroblasts expressing enhanced green fluorescent protein (EGFP) was explored in this study. When buffalo fetal fibroblasts (BFFs) isolated from a male buffalo fetus were transfected with pEGFP-N1 (EGFP is driven by CMV and Neo is dri...

journal_title：Scientific reports

authors： Lu F,Luo C,Li N,Liu Q,Wei Y,Deng H,Wang X,Li X,Jiang J,Deng Y,Shi D

更新日期：2018-05-03 00:00:00

abstract：:China's reported cases of Human Immunodeficiency Virus (HIV) and AIDS increased from over 50000 in 2011 to more than 130000 in 2017, while AIDS related search indices on Baidu from 2.1 million to 3.7 million in the same time periods. In China, people seek AIDS related knowledge from Baidu which one of the world's larg...

journal_title：Scientific reports

authors： Li K,Liu M,Feng Y,Ning C,Ou W,Sun J,Wei W,Liang H,Shao Y

更新日期：2019-01-23 00:00:00

abstract：:Sphingolipids are essential constituents of the plasma membrane (PM) and play an important role in signal transduction by modulating clustering and dynamics of membrane receptors. Changes in lipid composition are therefore likely to influence receptor organisation and function, but how this precisely occurs is difficu...

journal_title：Scientific reports

authors： Eich C,Manzo C,de Keijzer S,Bakker GJ,Reinieren-Beeren I,García-Parajo MF,Cambi A

更新日期：2016-02-12 00:00:00

abstract：:In the following article, we present a simple, two-step method of creating spaced, hollow nanopillars, from the titania nanotube arrays via pulsed laser-treatment. Due to the high ordering of the structure, the prepared material exhibits photonic properties, which has been shown to increase the overall photoefficiency...

journal_title：Scientific reports

authors： Wawrzyniak J,Karczewski J,Kupracz P,Grochowska K,Coy E,Mazikowski A,Ryl J,Siuzdak K

更新日期：2020-11-19 00:00:00

abstract：:The transcription apparatus (TA) is a huge molecular machine. It detects the time-varying concentrations of transcriptional activators and initiates mRNA transcripts at appropriate rates. Based on the general structural organizations of the TA, we propose how the TA dynamically orchestrates transcriptional responses. ...

journal_title：Scientific reports

authors： Wang Y,Liu F,Wang W

更新日期：2012-01-01 00:00:00

abstract：:Cancer stem-like cells (CSCs) play a key role in maintaining the aggressiveness of hepatocellular carcinoma (HCC), but the cell-biological regulation of CSCs is unclear. In the study, we report that thyroid hormone (TH) promotes cell self-renewal in HCC cells. TH also increases the percentage of CD90 + HCC cells and p...

journal_title：Scientific reports

authors： Wang T,Xia L,Ma S,Qi X,Li Q,Xia Y,Tang X,Cui D,Wang Z,Chi J,Li P,Feng YX,Xia Q,Zhai B

更新日期：2016-05-12 00:00:00

abstract：:Chemotherapy can cause cachexia, which consists of weight loss associated with muscle atrophy. The exact mechanisms underlying this skeletal muscle toxicity are largely unknown and co-therapies to attenuate chemotherapy-induced side effects are lacking. By using a rat model of cisplatin-induced cachexia, we here chara...

journal_title：Scientific reports

authors： Sirago G,Conte E,Fracasso F,Cormio A,Fehrentz JA,Martinez J,Musicco C,Camerino GM,Fonzino A,Rizzi L,Torsello A,Lezza AMS,Liantonio A,Cantatore P,Pesce V

更新日期：2017-10-12 00:00:00

abstract：:Neuropathic pain is a complex, chronic pain state that often accompanies tissue damage, inflammation or injury of the nervous system. However the underlying molecular mechanisms still remain unclear. Here, we showed that CXCL12 and CXCR4 were upregulated in the dorsal root ganglion (DRG) after chronic compression of D...

journal_title：Scientific reports

authors： Yu Y,Huang X,Di Y,Qu L,Fan N

更新日期：2017-07-18 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Robertson KE,Truong CD,Craciunescu FM,Yang JH,Chiu PL,Fromme P,Hansen DT

更新日期：2020-03-02 00:00:00

abstract：:A positive Indian Ocean Dipole (IOD) and a warm phase of the El Niño-Southern Oscillation (ENSO) reduce rainfall over the Indian subcontinent and southern Australia. However, since the 1980s, El Niño's influence has been decreasing, accompanied by a strengthening in the IOD's influence on southern Australia but a reve...

journal_title：Scientific reports

authors： Li Z,Cai W,Lin X

更新日期：2016-08-22 00:00:00

abstract：:Diabetic nephropathy is characterised by the excessive amount of extracellular matrix in glomeruli and tubulointerstitial space. Lysyl oxidase-like 2 (LOXL2) is elevated in renal fibrosis and known to play key roles in ECM stabilisation by facilitating collagen cross-links, epithelial to mesenchymal transition and myo...

journal_title：Scientific reports

authors： Stangenberg S,Saad S,Schilter HC,Zaky A,Gill A,Pollock CA,Wong MG

更新日期：2018-06-21 00:00:00

abstract：:Development of artificial materials for the facilitation of cartilage regeneration remains an important challenge in orthopedic practice. Our study investigates the potential for neocartilage formation within a synthetic polyester scaffold based on the polymerization of high internal phase emulsions. The fabrication o...

journal_title：Scientific reports

authors： Naranda J,Sušec M,Maver U,Gradišnik L,Gorenjak M,Vukasović A,Ivković A,Rupnik MS,Vogrin M,Krajnc P

更新日期：2016-06-24 00:00:00

abstract：:This paper examines how a move from traditional post-harvest operations of smallholder rice farms in the Ayeyarwaddy delta, Myanmar, to improved post-harvest operations affected income, energy efficiency and greenhouse gas emissions (GHGE). Harvest and post-harvest losses were investigated in a field experiment with 5...

journal_title：Scientific reports

authors： Gummert M,Nguyen-Van-Hung,Cabardo C,Quilloy R,Aung YL,Thant AM,Kyaw MA,Labios R,Htwe NM,Singleton GR

更新日期：2020-11-13 00:00:00

abstract：:We introduce QuEST, the Quantum Exact Simulation Toolkit, and compare it to ProjectQ, qHipster and a recent distributed implementation of Quantum++. QuEST is the first open source, hybrid multithreaded and distributed, GPU accelerated simulator of universal quantum circuits. Embodied as a C library, it is designed so ...

journal_title：Scientific reports

authors： Jones T,Brown A,Bush I,Benjamin SC

更新日期：2019-07-24 00:00:00

abstract：:Microtubules (MTs) are cytoskeletal structures that play a central role in a variety of cell functions including cell division and cargo transfer. MTs are also nonlinear electrical transmission lines that produce and conduct electrical oscillations elicited by changes in either electric field and/or ionic gradients. T...

journal_title：Scientific reports

authors： Cantero MDR,Perez PL,Scarinci N,Cantiello HF

更新日期：2019-08-27 00:00:00

abstract：:Biological control mechanisms of plant diseases have been intensively studied. However, how plant pathogens respond to and resist or alleviate biocontrol agents remains largely unknown. In this study, a comparative transcriptome analysis was performed to elucidate how the pathogen of sclerotinia stem rot, Sclerotinia ...

journal_title：Scientific reports

authors： Yang X,Zhang L,Xiang Y,Du L,Huang X,Liu Y

更新日期：2020-07-28 00:00:00

abstract：:Tropical Pacific stalagmites are commonly affected by dating uncertainties because of their low U concentration and/or elevated initial 230Th content. This poses problems in establishing reliable trends and periodicities for droughts and pluvial episodes in a region vulnerable to climate change. Here we constrain the ...

journal_title：Scientific reports

authors： Faraji M,Borsato A,Frisia S,Hellstrom JC,Lorrey A,Hartland A,Greig A,Mattey DP

更新日期：2021-01-26 00:00:00

abstract：:New Delhi metallo-β-lactamase (NDM) had been reported to be the predominant carbapenemase among Escherichia coli in Taiwan. However, studies focusing on the clonal background and epidemiology of plasmids carrying NDM genes were limited. Between 2016 and 2018, all clinical E. coli and Klebsiella pneumoniae isolates tha...

journal_title：Scientific reports

authors： Huang YS,Tsai WC,Li JJ,Chen PY,Wang JT,Chen YT,Chen FJ,Lauderdale TL,Chang SC

更新日期：2021-01-28 00:00:00

abstract：:The availability of iron (Fe) can seasonally limit phytoplankton growth in the High Latitude North Atlantic (HLNA), greatly reducing the efficiency of the biological carbon pump. However, the spatial extent of seasonal iron limitation is not yet known. We present autumn nutrient and dissolved Fe measurements, combined...

journal_title：Scientific reports

authors： Birchill AJ,Hartner NT,Kunde K,Siemering B,Daniels C,González-Santana D,Milne A,Ussher SJ,Worsfold PJ,Leopold K,Painter SC,Lohan MC

更新日期：2019-02-05 00:00:00

abstract：:Naturally occurring metals and metalloids [metal(loid)s] are essential for the physiological functioning of wildlife; however, environmental contamination by metal(loid) and plastic pollutants is a health hazard. Metal(loid)s may interact with plastic in the environment and there is mixed evidence about whether plasti...

journal_title：Scientific reports

authors： Roman L,Kastury F,Petit S,Aleman R,Wilcox C,Hardesty BD,Hindell MA

更新日期：2020-10-22 00:00:00

abstract：:The recent discovery that human noroviruses (huNoVs) recognize sialic acids (SAs) in addition to histo-blood group antigens (HBGAs) pointed to a new direction in studying virus-host interactions during calicivirus infection. HuNoVs remain difficult to study due to the lack of an effective cell culture model. In this s...

journal_title：Scientific reports

authors： Tan M,Wei C,Huang P,Fan Q,Quigley C,Xia M,Fang H,Zhang X,Zhong W,Klassen JS,Jiang X

更新日期：2015-07-06 00:00:00

abstract：:Periodontal ligament stem cells (PDLSCs) are a major source of mesenchymal stem cells (MSCs) in adults and are effective for tissue engineering, like promoting angiogenesis and bone regeneration. CXCL12 has been reported to be involved in the recruitment and engraftment of MSCs in wound sites. However, whether CXCL12 ...

journal_title：Scientific reports

authors： Zhang L,Zhou Y,Sun X,Zhou J,Yang P

更新日期：2017-08-31 00:00:00

abstract：:Alzheimer's disease (AD) is mainly characterized by the deposition of extracellular amyloid plaques and intracellular accumulation of neurofibrillary tangles (NFTs). While the recent 5xFAD AD mouse model exhibits many AD-related phenotypes and a relatively early and aggressive amyloid β production, it does not show NF...

journal_title：Scientific reports

authors： Kang S,Kim J,Chang KA

更新日期：2021-01-14 00:00:00

abstract：:Corals access inorganic seawater nutrients through their autotrophic endosymbiotic dinoflagellates, but also capture planktonic prey through heterotrophic feeding. Correlating NanoSIMS and TEM imaging, we visualized and quantified the subcellular fate of autotrophic and heterotrophic C and N in the coral Stylophora pi...

journal_title：Scientific reports

authors： Krueger T,Bodin J,Horwitz N,Loussert-Fonta C,Sakr A,Escrig S,Fine M,Meibom A

更新日期：2018-08-23 00:00:00

abstract：:Several studies provide evidence of a link between vector-borne disease outbreaks and El Niño driven climate anomalies. Less investigated are the effects of the North Atlantic Oscillation (NAO). Here, we test its impact on outbreak occurrences of 13 infectious diseases over Europe during the last fifty years, controll...

journal_title：Scientific reports

authors： Morand S,Owers KA,Waret-Szkuta A,McIntyre KM,Baylis M

更新日期：2013-01-01 00:00:00