Dynamic mechanism for the transcription apparatus orchestrating reliable responses to activators.

abstract：:In this population-based retrospective study, we aimed to investigate the association between age at diagnosis and prognosis of pancreatic cancer (PC) patients using data from the National Cancer Institute's Surveillance, Epidemiology, and the End Results database. Different factors for stratification, like race, sex,...

journal_title：Scientific reports

authors： Wang H,Liu J,Xia G,Lei S,Huang X,Huang X

更新日期：2020-04-27 00:00:00

abstract：:Bronchiolitis, often caused by respiratory syncytial virus (RSV), is the commonest cause of hospitalisation in infancy. Serum transaminases are sometimes raised in children with bronchiolitis. We tested the hypothesis that raised transaminases are associated with increased disease severity in children ventilated for b...

journal_title：Scientific reports

authors： Thorburn K,Fulton C,King C,Ramaneswaran D,Alammar A,McNamara PS

更新日期：2018-01-29 00:00:00

abstract：:Of the 7-8 silk fibers making up an orb-web only the hierarchical structural organization of semicrystalline radial fibers -composed of major ampullate silk- has been studied in detail, given its fascinating mechanical features. While major ampullate silk's nanofibrillar morphology is well established, knowhow on meso...

journal_title：Scientific reports

authors： Riekel C,Burghammer M,Rosenthal M

更新日期：2020-10-23 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, ranging from steatosis to non-alcoholic steatohepatitis (NASH). Recently, cerium oxide nanoparticles (CeO2NPs) have emerged as a new antioxidant agent with hepatoprotective properties in experimental liver disease. T...

journal_title：Scientific reports

authors： Carvajal S,Perramón M,Oró D,Casals E,Fernández-Varo G,Casals G,Parra M,González de la Presa B,Ribera J,Pastor Ó,Morales-Ruíz M,Puntes V,Jiménez W

更新日期：2019-09-06 00:00:00

abstract：:Cyclin Y (CCNY) is a member of the cyclin protein family, known to regulate cell division in proliferating cells. Interestingly, CCNY is expressed in neurons that do not undergo cell division. Here, we report that CCNY negatively regulates long-term potentiation (LTP) of synaptic strength through inhibition of AMPA re...

journal_title：Scientific reports

authors： Cho E,Kim DH,Hur YN,Whitcomb DJ,Regan P,Hong JH,Kim H,Ho Suh Y,Cho K,Park M

更新日期：2015-07-29 00:00:00

abstract：:It has been suggested that an age-related loss of cognitive function might be driven by atherosclerotic effects associated with altered lipid patterns. However, the relationship between Lipoprotein (a) [Lp(a)] and healthy cognitive aging has not yet been sufficiently investigated. For the current analysis we used the ...

journal_title：Scientific reports

authors： Röhr F,Bucholtz N,Toepfer S,Norman K,Spira D,Steinhagen-Thiessen E,Lill CM,Bertram L,Demuth I,Buchmann N,Düzel S

更新日期：2020-06-30 00:00:00

abstract：:Decoders optimized offline to reconstruct intended movements from neural recordings sometimes fail to achieve optimal performance online when they are used in closed-loop as part of an intracortical brain-computer interface (iBCI). This is because typical decoder calibration routines do not model the emergent interact...

journal_title：Scientific reports

authors： Willett FR,Young DR,Murphy BA,Memberg WD,Blabe CH,Pandarinath C,Stavisky SD,Rezaii P,Saab J,Walter BL,Sweet JA,Miller JP,Henderson JM,Shenoy KV,Simeral JD,Jarosiewicz B,Hochberg LR,Kirsch RF,Bolu Ajiboye A

更新日期：2019-06-20 00:00:00

abstract：:Cellular locomotion is a central hallmark of eukaryotic life. It is governed by cell-extrinsic molecular factors, which can either emerge in the soluble phase or as immobilized, often adhesive ligands. To encode for direction, every cue must be present as a spatial or temporal gradient. Here, we developed a microfluid...

journal_title：Scientific reports

authors： Schwarz J,Bierbaum V,Merrin J,Frank T,Hauschild R,Bollenbach T,Tay S,Sixt M,Mehling M

更新日期：2016-11-07 00:00:00

abstract：:The anisotropic transport of thermal neutron in heterogeneous porous media is of great research interests in many fields. In this paper, it is the first time that a new model based on micron X-ray computed tomography (CT) has been proposed to simultaneously consider both the separation of matrix and pore and the distr...

journal_title：Scientific reports

authors： Wang Y,Yue W,Zhang M

更新日期：2016-06-08 00:00:00

abstract：:Plasmonics has established itself as a branch of physics which promises to revolutionize data processing, improve photovoltaics, and increase sensitivity of bio-detection. A widespread use of plasmonic devices is notably hindered by high losses and the absence of stable and inexpensive metal films suitable for plasmon...

journal_title：Scientific reports

authors： Kravets VG,Jalil R,Kim YJ,Ansell D,Aznakayeva DE,Thackray B,Britnell L,Belle BD,Withers F,Radko IP,Han Z,Bozhevolnyi SI,Novoselov KS,Geim AK,Grigorenko AN

更新日期：2014-07-01 00:00:00

abstract：:This paper proposes a novel "micro-gun" structure for laser pulse propulsion. The "micro-bullets" (glass microspheres) are irradiated by a laser pulse with a 10 ns duration in a dynamic process. Experimental parameters such as the microsphere diameter and the laser pulse energy are varied to investigate their influenc...

journal_title：Scientific reports

authors： Yu H,Li H,Cui L,Liu S,Yang J

更新日期：2017-11-24 00:00:00

abstract：:The study of the synchronization patterns of small neuron networks that control several biological processes has become an interesting growing discipline. Some of these synchronization patterns of individual neurons are related to some undesirable neurological diseases, and they are believed to play a crucial role in ...

journal_title：Scientific reports

authors： Lozano Á,Rodríguez M,Barrio R

更新日期：2016-03-29 00:00:00

abstract：:We investigate the Lorentz-covariant deformed algebra for Dirac oscillator problem, which is a generalization of Kempf deformed algebra in 3 + 1 dimension of space-time, where Lorentz symmetry are preserved. The energy spectrum of the system is analyzed by taking advantage of the corresponding wave functions with expl...

journal_title：Scientific reports

authors： Betrouche M,Maamache M,Choi JR

更新日期：2013-11-14 00:00:00

abstract：:Mechanotransduction is crucial for touch sensation, hearing, proprioception, and pain sensing. In C. elegans, male ray neurons have been implicated to be involved in the mechanosensation required for mating behavior. However, whether ray neurons directly sense mechanical stimulation is not yet known, and the underlyin...

journal_title：Scientific reports

authors： Zhang H,Yue X,Cheng H,Zhang X,Cai Y,Zou W,Huang G,Cheng L,Ye F,Kang L

更新日期：2018-05-08 00:00:00

abstract：:Geothermal waters from the Semi, Dagejia and Kawu hot springs in the Shiquanhe-Yarlung Zangbo geothermal field of southern Tibet (China) are highly enriched in rare alkali metals (RAM). However, the enrichment mechanism is still hotly debated. Here, we report the first silicon isotope data of these geothermal waters t...

journal_title：Scientific reports

authors： Wang W,Wei HZ,Jiang SY,Tan HB,Eastoe CJ,Williams-Jones AE,Hohl SV,Wu HP

更新日期：2019-05-27 00:00:00

abstract：:Kinetic restriction of a thermodynamically favourable equilibrium is a common theme in materials processing. The interfacial instability in systems where rate of material exchange is far greater than the mass transfer through respective bulk phases is of specific interest when tracking the transient interfacial area, ...

journal_title：Scientific reports

authors： Spooner S,Rahnama A,Warnett JM,Williams MA,Li Z,Sridhar S

更新日期：2017-10-30 00:00:00

abstract：:Control of parasite transmission is critical for the eradication of malaria. However, most antimalarial drugs are not active against P. falciparum gametocytes, responsible for the spread of malaria. Consequently, patients can remain infectious for weeks after the clearance of asexual parasites and clinical symptoms. H...

journal_title：Scientific reports

authors： Sun W,Tanaka TQ,Magle CT,Huang W,Southall N,Huang R,Dehdashti SJ,McKew JC,Williamson KC,Zheng W

更新日期：2014-01-17 00:00:00

abstract：:We present active manipulation of the structural vibrations of an elastic body to generate an acoustic illusion. The resultant illusion misrepresents the nature, size and number of objects in the exterior acoustic domain. We demonstrate our technique, herein termed active structural acoustic illusion, using an elastic...

journal_title：Scientific reports

authors： Eggler D,Kessissoglou N

更新日期：2020-06-17 00:00:00

abstract：:In this study, a design methodology for a multi-optical probe confocal imaging system was developed. To develop an imaging system that has the required resolving power and imaging area, this study focused on a design methodology to create a scalable and easy-to-implement confocal imaging system. This system overcomes ...

journal_title：Scientific reports

authors： Choi W,Shin R,Lim J,Kang S

更新日期：2016-09-12 00:00:00

abstract：:Surface-enhanced Raman scattering (SERS) can significantly boost the inherently weak Raman scattering signal and provide detailed structural information and binding nature of the molecules on the surface. Despite the long history of this technology, SERS has yet to become a sophisticated analytical tool in practical a...

journal_title：Scientific reports

authors： Liu X,Wang J,Wu Y,Fan T,Xu Y,Tang L,Ying Y

更新日期：2015-11-30 00:00:00

abstract：:Diagnosability is central to taxonomy as are type specimens which define taxa. New advances in technologies and the discovery of new informative traits must be matched with previous taxonomic decisions based on name-bearing type specimens. Consequently, the challenge of sequencing highly degraded DNA from historical t...

journal_title：Scientific reports

authors： Kehlmaier C,Zhang X,Georges A,Campbell PD,Thomson S,Fritz U

更新日期：2019-04-09 00:00:00

abstract：:KIBRA has been suggested as a key regulator of the hippo pathway, regulating organ size, cell contact inhibition as well as tissue regeneration and tumorigenesis. Recently, alterations of KIBRA expression caused by promotor methylation have been reported for several types of cancer. Our current study aimed to design a...

journal_title：Scientific reports

authors： Schelleckes K,Schmitz B,Lenders M,Mewes M,Brand SM,Brand E

更新日期：2018-03-09 00:00:00

abstract：:The time evolution of the distribution and shareability of quantum coherence of a tripartite system in a non-Markovian environment is examined. The total coherence can be decomposed into various contributions, ranging from local, global bipartite and global tripartite, which characterize the type of state. We identify...

journal_title：Scientific reports

authors： Radhakrishnan C,Chen PW,Jambulingam S,Byrnes T,Ali MM

更新日期：2019-02-20 00:00:00

abstract：:Environmentally persistent free radicals (EPFRs) have attracted increasing research interest in recent years. Herein, the generation of EPFRs during the hydrothermal carbonization of sewage sludge (SS) was studied. First, the surface morphology, functional groups, constituent elements and free radicals were characteri...

journal_title：Scientific reports

authors： Zhu Y,Wei J,Liu Y,Liu X,Li J,Zhang J

更新日期：2019-11-19 00:00:00

abstract：:Natural arches, pillars and other exotic sandstone formations have always been attracting attention for their unusual shapes and amazing mechanical balance that leave a strong impression of intelligent design rather than the result of a stochastic process. It has been recently demonstrated that these shapes could have...

journal_title：Scientific reports

authors： Ostanin I,Safonov A,Oseledets I

更新日期：2017-12-11 00:00:00

abstract：:Epigenetic variation is implicated in a range of non-communicable diseases, including those of the eye. However, investigating the role of epigenetic variation in central tissues, such as eye or brain, remains problematic and peripheral tissues are often used as surrogates. In this study, matched human blood and eye t...

journal_title：Scientific reports

authors： Hewitt AW,Januar V,Sexton-Oates A,Joo JE,Franchina M,Wang JJ,Liang H,Craig JE,Saffery R

更新日期：2017-04-13 00:00:00

abstract：:Obesity is one of the major risk factor for cardiovascular and metabolic diseases. A disproportional accumulation of fat at visceral (VAT) compared to subcutaneous sites (SAT) has been suspected as a key detrimental event. We used non-targeted metabolomics profiling to reveal metabolic pathways associated with higher ...

journal_title：Scientific reports

authors： Otto L,Budde K,Kastenmüller G,Kaul A,Völker U,Völzke H,Adamski J,Kühn JP,Krumsiek J,Artati A,Nauck M,Friedrich N,Pietzner M

更新日期：2020-01-30 00:00:00

abstract：:The effects of gradual vascular occlusion on the blood supply of perfused areas are poorly described. Information relating to the comparison of flap monitoring techniques is lacking. Varying stenotic conditions (0%, 25%, 50%, 75% and 100%) were generated on purpose at the A. and V. femoralis in the rat model. Analyses...

journal_title：Scientific reports

authors： Mücke T,Hapfelmeier A,Schmidt LH,Fichter AM,Kanatas A,Wolff KD,Ritschl LM

更新日期：2020-01-22 00:00:00

abstract：:We present detailed investigations on single crystals of quaternary EuRhAl4Si2 and EuIrAl4Si2. The two compounds order antiferromagnetically at TN1 = 11.7 and 14.7 K, respectively, each undergoing two magnetic transitions. The magnetic properties in the ordered state present a large anisotropy despite Eu(2+)being an S...

journal_title：Scientific reports

authors： Maurya A,Thamizhavel A,Dhar SK,Bonville P

更新日期：2015-07-09 00:00:00

abstract：:Micro/nanophotonic structures that are capable of optical wave-front shaping are implemented in optical waveguides and passive optical devices to alter the phase of the light propagating through them. The beam division directions and beam power distribution depend on the design of the micro/nanostructures. The ultimat...

journal_title：Scientific reports

authors： Li P,Han Y,Wang W,Liu Y,Jin P,Leng J

更新日期：2017-03-09 00:00:00