Abstract：
:In this study, a design methodology for a multi-optical probe confocal imaging system was developed. To develop an imaging system that has the required resolving power and imaging area, this study focused on a design methodology to create a scalable and easy-to-implement confocal imaging system. This system overcomes the limitations of the optical complexities of conventional multi-optical probe confocal imaging systems and the short working distance using a micro-objective lens module composed of two microlens arrays and a telecentric relay optical system. The micro-objective lens module was fabricated on a glass substrate using backside alignment photolithography and thermal reflow processes. To test the feasibility of the developed methodology, an optical system with a resolution of 1 μm/pixel using multi-optical probes with an array size of 10 × 10 was designed and constructed. The developed system provides a 1 mm × 1 mm field of view and a sample scanning range of 100 μm. The optical resolution was evaluated by conducting sample tests using a knife-edge detecting method. The measured lateral resolution of the system was 0.98 μm.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Choi W,Shin R,Lim J,Kang Sdoi
10.1038/srep33278subject
Has Abstractpub_date
2016-09-12 00:00:00pages
33278issn
2045-2322pii
srep33278journal_volume
6pub_type
杂志文章abstract：:The flagellum is a rotary motor that enables bacteria to swim in liquids and swarm over surfaces. Numerous global regulators control flagellar assembly in response to cellular and environmental factors. Previous studies have also shown that flagellar assembly is affected by the growth-rate of the cell. However, a syst...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41189
更新日期：2017-01-24 00:00:00
abstract：:The TREX complex mediates the passage of bulk cellular mRNA export to the nuclear export factor TAP/NXF1 via the export adaptors ALYREF or UIF, which appear to act in a redundant manner. TREX complex recruitment to nascent RNA is coupled with 5' capping, splicing and polyadenylation. Therefore to facilitate expression...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33379-x
更新日期：2018-10-09 00:00:00
abstract：:EndMT has an important effect on metastasis and progression of tumor. This work will elucidate the effect of miR-494 on EndMT and development of HCC. Therefore, the differential miRNA expression among non-tumorous, para-tumorous and tumorous tissues was analyzed. Moreover, luciferase activities of SIRT3 3'UTR treated ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43731-4
更新日期：2019-05-10 00:00:00
abstract：:Airway smooth muscle (ASM) cells exhibit plastic phenotypic behavior marked by reversible modulation and maturation between contractile and proliferative phenotypic states. Integrins are a class of transmembrane proteins that have been implicated as novel therapeutic targets for asthma treatment. We previously showed ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46260-2
更新日期：2019-07-09 00:00:00
abstract：:An in vitro-transcribed RNA aptamer (trans-RA16) that targets non-small cell lung cancer (NSCLC) was previously identified through in vivo SELEX. Trans-RA16 can specifically target and inhibit human NCI-H460 cells in vitro and xenograft tumors in vivo. Here, in a follow-up study, we obtained a chemically-synthesized v...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55280-x
更新日期：2019-12-11 00:00:00
abstract：:It is now well established that at a superconductor/ferromagnet (S/F) interface an unconventional superconducting state arises in which the pairing is odd-frequency. The hallmark signature of this superconducting state is generally understood to be an enhancement of the electronic density of states (DoS) at subgap ene...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15483
更新日期：2015-10-27 00:00:00
abstract：:In photosynthesis Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) catalyses the often rate limiting CO2-fixation step in the Calvin cycle. This makes Rubisco both the gatekeeper for carbon entry into the biosphere and a target for functional improvement to enhance photosynthesis and plant growth. Encumbering...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22284
更新日期：2016-03-01 00:00:00
abstract：:We describe here a partial skull with associated mandible of a large felid from Monte Argentario, Italy (Early Pleistocene; ~1.5 million years). Propagation x-ray phase-contrast synchrotron microtomography of the specimen, still partially embedded in the rock matrix, allows ascribing it reliably to Acinonyx pardinensi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26698-6
更新日期：2018-05-29 00:00:00
abstract：:The 170 National Forests and Grasslands (NFs) in the conterminous United States are public lands that provide important ecosystem services such as clean water and timber supply to the American people. This study investigates the potential impacts of climate change on two key ecosystem functions (i.e., water yield and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24441
更新日期：2016-04-21 00:00:00
abstract：:High frequency oscillations (HFOs) are bursts of neural activity in the range of 80 Hz or higher, recorded from intracranial electrodes during epileptiform discharges. HFOs are a proposed biomarker of epileptic brain tissue and may also be useful for seizure forecasting. Despite such clinical utility of HFOs, the spat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76138-7
更新日期：2020-11-05 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-26061-9
更新日期：2018-05-15 00:00:00
abstract：:The objective of this study was to investigate the effects of slightly elevated atmospheric temperature in the spring on photosynthetic products in wheat seedlings and on organic compounds and biological activity in rhizosphere soil under cadmium (Cd) stress. Elevated temperature was associated with increased soluble ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14426
更新日期：2015-09-23 00:00:00
abstract：:Zebrafish embryos are translucent and develop rapidly in individual eggs ex utero; they are widely used as models for embryogenesis and organ development for human diseases and drug discovery. Lysine crotonylation (Kcr) is a type of histone post-translational modifications discovered in 2011. Kcr dynamics are involved...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22069-3
更新日期：2018-02-26 00:00:00
abstract：:During ice-free periods, the Northern Sea Route (NSR) could be an attractive shipping route. The decline in Arctic sea-ice extent, however, could be associated with an increase in the frequency of the causes of severe weather phenomena, and high wind-driven waves and the advection of sea ice could make ship navigation...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16868
更新日期：2015-11-20 00:00:00
abstract：:The ultrathin SmCo5 nanoflakes with average thickness smaller than 50 nm are prepared by a novel method of solid particle (NaCl) and surfactant co-assisted ball milling. The as-prepared nanoflakes exhibit a narrower thickness distribution of 10-50 nm and high coercivity of 23 kOe. The possible formation mechanism of n...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25805
更新日期：2016-05-13 00:00:00
abstract：:Thermoelectric properties of Graphene nano-ribbons (GNRs) with nanopores (NPs) are explored for a range of pore dimensions in order to achieve a high performance two-dimensional nano-scale thermoelectric device. We reduce thermal conductivity of GNRs by introducing pores in them in order to enhance their thermoelectri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11297
更新日期：2015-06-17 00:00:00
abstract：:Fertilizer application for rice production has increased significantly in southern China to raise yields, but has led to problems with lodging, quality decline and environmental pollution. Therefore, research on fertilizer-saving cultivation technologies for high-yielding rice is necessary. A two-factor experiment was...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36978-w
更新日期：2019-01-24 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-23597-8
更新日期：2018-04-11 00:00:00
abstract：:The stress distribution around endosseous implants is an important determinant of the surgical success. However, no method developed so far to determine the implant stability is sensitive to the loading conditions of the bone-implant interface (BII). The objective of this study is to investigate whether a quantitative...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50665-4
更新日期：2019-10-02 00:00:00
abstract：:Stimulated by a recent experiment observing successfully two superconducting states with even- and odd-number of electrons in a nanowire topological superconductor as expected from the existence of two end Majorana quasiparticles (MQs) [Albrecht et al., Nature 531, 206 (2016)], we propose a way to manipulate Majorana ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26324-5
更新日期：2018-05-21 00:00:00
abstract：:Discs Large Homolog 5 (DLG5) plays an important role in the maintenance of epithelial cell polarity. Recent research showed that DLG5 is decreased in Yes-associated protein (YAP)-overexpressing cells. However, the exact relationship between DLG5 and YAP is not clear. In this study, we showed that loss of DLG5 promoted...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42125
更新日期：2017-02-07 00:00:00
abstract：:Understanding Zn uptake dynamics is critical to rice grain Zn biofortification. Here we examined soil Zn availability and Zn uptake pathways as affected by genotype (high-grain Zn varieties IR69428 and IR68144), Zn fertilization and water management in two pot experiments. Results showed significant interactions (P < ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38301
更新日期：2016-12-02 00:00:00
abstract：:Trastuzumab combined with chemotherapy is standard of care for HER2 positive advanced gastro-esophageal cancers. The reported prevalence of HER2 discordance between primary tumors and corresponding metastases varies, hampering uniform patient selection for HER2 targeted therapy. This meta-analysis explores the influen...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-017-03304-9
更新日期：2017-06-09 00:00:00
abstract：:Nuclear factor κB (NF-κB) plays an essential role in regulation of innate immunity. In mammals, NF-κB factors can form homodimers and heterodimers to activate gene expression. In insects, three NF-κB factors, Dorsal, Dif and Relish, have been identified to activate antimicrobial peptide (AMP) gene expression. However,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20654
更新日期：2016-02-05 00:00:00
abstract：:The order Chlamydiales are biphasic intracellular bacterial pathogens infecting humans and domesticated animals. Wildlife infections have also been reported, with the most studied example being Chlamydia pecorum infections in the koala, an iconic Australian marsupial. In koalas, molecular evidence suggests that spill-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13164-y
更新日期：2017-10-09 00:00:00
abstract：:Sugarcane (Saccharum spp.) is a globally important crop for sugar and bioenergy production. Its highly polyploid, complex genome has hindered progress in understanding its molecular structure. Flow cytometric sorting and analysis has been used in other important crops with large genomes to dissect the genome into comp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55652-3
更新日期：2019-12-18 00:00:00
abstract：:Resolving the immunogenicity of cells derived from induced pluripotent stem cells (iPSCs) remains an important challenge for cell transplant strategies that use banked allogeneic cells. Thus, we evaluated the immunogenicity of mouse fetal neural stem/progenitor cells (fetus-NSPCs) and iPSC-derived neural stem/progenit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13522-w
更新日期：2017-10-11 00:00:00
abstract：:Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are desirable for diabetes, especially in patients with overweight/obesity. We aimed to determine whether GLP-1RAs exhibit different glucose-lowering efficacies between Asian type 2 diabetes (T2D) patients with and without overweight/obesity. Randomized controlled t...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-017-16018-9
更新日期：2017-11-22 00:00:00
abstract：:Reactive oxygen species (ROS) participate in various physiological and pathological functions following generation from different types of cells. Here we explore ROS functions on spontaneous tail regeneration using gecko model. ROS were mainly produced in the skeletal muscle after tail amputation, showing a temporal i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20752
更新日期：2016-02-08 00:00:00
abstract：:Nanomaterials are being extensively produced and applied in society. Human and environmental exposures are, therefore, inevitable and so increased attention is being given to nanotoxicity. While silica nanoparticles (NP) are one of the top five nanomaterials found in consumer and biomedical products, their toxicity pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37145
更新日期：2016-11-22 00:00:00
