Abstract：
:The flagellum is a rotary motor that enables bacteria to swim in liquids and swarm over surfaces. Numerous global regulators control flagellar assembly in response to cellular and environmental factors. Previous studies have also shown that flagellar assembly is affected by the growth-rate of the cell. However, a systematic study has not yet been described under controlled growth conditions. Here, we investigated the effect of growth rate on flagellar assembly in Escherichia coli using steady-state chemostat cultures where we could precisely control the cell growth-rate. Our results demonstrate that flagellar abundance correlates with growth rate, where faster growing cells produce more flagella. They also demonstrate that this growth-rate dependent control occurs through the expression of the flagellar master regulator, FlhD4C2. Collectively, our results demonstrate that motility is intimately coupled to the growth-rate of the cell.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sim M,Koirala S,Picton D,Strahl H,Hoskisson PA,Rao CV,Gillespie CS,Aldridge PDdoi
10.1038/srep41189subject
Has Abstractpub_date
2017-01-24 00:00:00pages
41189issn
2045-2322pii
srep41189journal_volume
7pub_type
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