Continuous and automatic mortality risk prediction using vital signs in the intensive care unit: a hybrid neural network approach.

Abstract:

:Mortality risk prediction can greatly improve the utilization of resources in intensive care units (ICUs). Existing schemes in ICUs today require laborious manual input of many complex parameters. In this work, we present a scheme that uses variations in vital signs over a 24-h period to make mortality risk assessments for 3-day, 7-day, and 14-day windows. We develop a hybrid neural network model that combines convolutional (CNN) layers with bidirectional long short-term memory (BiLSTM) to predict mortality from statistics describing the variation of heart rate, blood pressure, respiratory rate, blood oxygen levels, and temperature. Our scheme performs strongly compared to state-of-the-art schemes in the literature for mortality prediction, with our highest-performing model achieving an area under the receiver-operator curve of 0.884. We conclude that the use of a hybrid CNN-BiLSTM network is highly effective in determining mortality risk for the 3, 7, and 14 day windows from vital signs. As vital signs are routinely recorded, in many cases automatically, our scheme could be implemented such that highly accurate mortality risk could be predicted continuously and automatically, reducing the burden on healthcare providers and improving patient outcomes.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Baker S,Xiang W,Atkinson I

doi

10.1038/s41598-020-78184-7

subject

Has Abstract

pub_date

2020-12-04 00:00:00

pages

21282

issue

1

issn

2045-2322

pii

10.1038/s41598-020-78184-7

journal_volume

10

pub_type

杂志文章
  • Close co-variation between soil moisture and runoff emerging from multi-catchment data across Europe.

    abstract::Soil moisture is an important variable for land-climate and hydrological interactions. To investigate emergent large-scale, long-term interactions between soil moisture and other key hydro-climatic variables (precipitation, actual evapotranspiration, runoff, temperature), we analyze monthly values and anomalies of the...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-61621-y

    authors: Ghajarnia N,Kalantari Z,Orth R,Destouni G

    更新日期:2020-03-16 00:00:00

  • Polyphyletic origin, intracellular invasion, and meiotic genes in the putatively asexual agamococcidians (Apicomplexa incertae sedis).

    abstract::Agamococcidians are enigmatic and poorly studied parasites of marine invertebrates with unexplored diversity and unclear relationships to other sporozoans such as the human pathogens Plasmodium and Toxoplasma. It is believed that agamococcidians are not capable of sexual reproduction, which is essential for life cycle...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-72287-x

    authors: Miroliubova TS,Simdyanov TG,Mikhailov KV,Aleoshin VV,Janouškovec J,Belova PA,Paskerova GG

    更新日期:2020-09-28 00:00:00

  • Acoustic tweezing cytometry for live-cell subcellular modulation of intracellular cytoskeleton contractility.

    abstract::Mechanical forces are critical to modulate cell spreading, contractility, gene expression, and even stem cell differentiation. Yet, existing tools that can apply controllable subcellular forces to a large number of single cells simultaneously are still limited. Here we report a novel ultrasound tweezing cytometry util...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep02176

    authors: Fan Z,Sun Y,Di Chen,Tay D,Chen W,Deng CX,Fu J

    更新日期:2013-01-01 00:00:00

  • A comparison study of radiation effective dose in ECG-Gated Coronary CT Angiography and calcium scoring examinations performed with a dual-source CT scanner.

    abstract::In this report we have evaluated radiation effective dose received by patients during ECG-gated CCTA examinations based on gender, heart rate, tube voltage protocol and body mass index (BMI). A total of 1,824 patients were retrospectively recruited (1,139 men and 685 women) and they were divided into Group 1 (CCTA wit...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40758-5

    authors: Sabarudin A,Siong TW,Chin AW,Hoong NK,Karim MKA

    更新日期:2019-03-13 00:00:00

  • Automated data cleaning of paediatric anthropometric data from longitudinal electronic health records: protocol and application to a large patient cohort.

    abstract::'Big data' in healthcare encompass measurements collated from multiple sources with various degrees of data quality. These data require quality control assessment to optimise quality for clinical management and for robust large-scale data analysis in healthcare research. Height and weight data represent one of the mos...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-66925-7

    authors: Phan HTT,Borca F,Cable D,Batchelor J,Davies JH,Ennis S

    更新日期:2020-06-23 00:00:00

  • Pretreatment brain volumes can affect the effectiveness of deep brain stimulation in Parkinson's disease patients.

    abstract::We aimed to assess whether brain volumes may affect the results of deep brain stimulation (DBS) in patients with Parkinson's disease (PD). Eighty-one consecutive patients with PD (male:female 40:41), treated with DBS between June 2012 and December 2017, were enrolled. Total and regional brain volumes were measured usi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-79138-9

    authors: Yim Y,Kim SJ,Jung SC,Kim HS,Choi CG,Lee JK,Lee CS,Lee SH,Shim WH,Cheong EN,Park SC

    更新日期:2020-12-16 00:00:00

  • In vivo cross-sectional imaging of the phonating larynx using long-range Doppler optical coherence tomography.

    abstract::Diagnosis and treatment of vocal fold lesions has been a long-evolving science for the otolaryngologist. Contemporary practice requires biopsy of a glottal lesion in the operating room under general anesthesia for diagnosis. Current in-office technology is limited to visualizing the surface of the vocal folds with fib...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep22792

    authors: Coughlan CA,Chou LD,Jing JC,Chen JJ,Rangarajan S,Chang TH,Sharma GK,Cho K,Lee D,Goddard JA,Chen Z,Wong BJ

    更新日期:2016-03-10 00:00:00

  • Unifying complexity and information.

    abstract::Complex systems, arising in many contexts in the computer, life, social, and physical sciences, have not shared a generally-accepted complexity measure playing a fundamental role as the Shannon entropy H in statistical mechanics. Superficially-conflicting criteria of complexity measurement, i.e. complexity-randomness ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep01585

    authors: Ke DG

    更新日期:2013-01-01 00:00:00

  • Comparison of DNA repair and radiosensitivity of different blood cell populations.

    abstract::Despite the frequent use of ionising radiation (IR) in therapy and diagnostics and the unavoidable exposure to external radiation sources, our knowledge regarding the radiosensitivity of human blood cell populations is limited and published data, obtained under different experimental conditions, are heterogeneous. To ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-81058-1

    authors: Heylmann D,Ponath V,Kindler T,Kaina B

    更新日期:2021-01-28 00:00:00

  • Carbon black as an alternative cathode material for electrical energy recovery and transfer in a microbial battery.

    abstract::Rather than the conventional concept of viewing conductive carbon black (CB) to be chemically inert in microbial electrochemical cells (MECs), here we confirmed the redox activity of CB for its feasibility as an electron sink in the microbial battery (MB). Acting as the cathode of a MB, the solid-state CB electrode sh...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-07174-z

    authors: Zhang X,Guo K,Shen D,Feng H,Wang M,Zhou Y,Jia Y,Liang Y,Zhou M

    更新日期:2017-08-01 00:00:00

  • Biological significance and prognostic relevance of peripheral blood neutrophil-to-lymphocyte ratio in soft tissue sarcoma.

    abstract::Peripheral blood indices of systemic inflammation such as the neutrophil-lymphocyte ratio (NLR) have been shown to be prognostic in various cancers. We aim to investigate the clinical significance of these indices in patients with soft tissue sarcoma (STS). Seven hundred and twelve patients with available blood counts...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-30442-5

    authors: Chan JY,Zhang Z,Chew W,Tan GF,Lim CL,Zhou L,Goh WL,Poon E,Somasundaram N,Selvarajan S,Sittampalam K,Chin F,Teh J,Tan MH,Soo KC,Teo M,Farid M,Quek R

    更新日期:2018-08-10 00:00:00

  • Extended 3D-PTV for direct measurements of Lagrangian statistics of canopy turbulence in a wind tunnel.

    abstract::Direct estimation of Lagrangian turbulence statistics is essential for the proper modeling of dispersion and transport in highly obstructed canopy flows. However, Lagrangian flow measurements demand very high rates of data acquisition, resulting in bottlenecks that prevented the estimation of Lagrangian statistics in ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43555-2

    authors: Shnapp R,Shapira E,Peri D,Bohbot-Raviv Y,Fattal E,Liberzon A

    更新日期:2019-05-15 00:00:00

  • Feasibility and accuracy of a robotic guidance system for navigated spine surgery in a hybrid operating room: a cadaver study.

    abstract::The combination of navigation and robotics in spine surgery has the potential to accurately identify and maintain bone entry position and planned trajectory. The goal of this study was to examine the feasibility, accuracy and efficacy of a new robot-guided system for semi-automated, minimally invasive, pedicle screw p...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-64462-x

    authors: Burström G,Balicki M,Patriciu A,Kyne S,Popovic A,Holthuizen R,Homan R,Skulason H,Persson O,Edström E,Elmi-Terander A

    更新日期:2020-05-05 00:00:00

  • Author Correction: Elevated numbers of PD-L1 expressing B cells are associated with the development of AIDS-NHL.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-57442-8

    authors: Epeldegui M,Conti DV,Guo Y,Cozen W,Penichet ML,Martínez-Maza O

    更新日期:2020-01-15 00:00:00

  • Recruitment of parvalbumin and somatostatin interneuron inputs to adult born dentate granule neurons.

    abstract::GABA is a key regulator of adult-born dentate granule cell (abDGC) maturation so mapping the functional connectivity between abDGCs and local interneurons is required to understand their development and integration into the hippocampal circuit. We recorded from birthdated abDGCs in mice and photoactivated parvalbumin ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-74385-2

    authors: Remmers CL,Castillon CCM,Armstrong JN,Contractor A

    更新日期:2020-10-16 00:00:00

  • Corrigendum: Mechanisms underlying the activity-dependent regulation of locomotor network performance by the Na+ pump.

    abstract::This corrects the article DOI: 10.1038/srep16188. ...

    journal_title:Scientific reports

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/srep46909

    authors: Zhang HY,Picton L,Li WC,Sillar KT

    更新日期:2017-12-22 00:00:00

  • Focusing on Plates: Controlling Guided Waves using Negative Refraction.

    abstract::Elastic waves are guided along finite structures such as cylinders, plates, or rods through reflection, refraction, and mode conversion at the interfaces. Such wave propagation is ubiquitous in the world around us, and studies of elastic waveguides first emerged in the later part of the 19(th) century. Early work on e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep11112

    authors: Philippe FD,Murray TW,Prada C

    更新日期:2015-06-08 00:00:00

  • Vitamin A and E Nutritional Status in Relation to Leptin, Adiponectin, IGF-I and IGF-II in Early Life - a Birth Cohort Study.

    abstract::The metabolic health effects of vitamin A and E nutritional status in early life are largely unknown. We assessed whether vitamin A and vitamin E nutritional status may affect circulating leptin, adiponectin, insulin-like growth factor (IGF)-I and IGF-II levels in early life in humans. In a singleton birth cohort (n =...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18531-3

    authors: Du Q,Luo ZC,Nuyt AM,Audibert F,Julien P,Wei SQ,Zhang DL,Fraser W,Levy E

    更新日期:2018-01-08 00:00:00

  • Homodyne detection of short-range Doppler radar using a forced oscillator model.

    abstract::This article presents the homodyne detection in a self-oscillation system, which represented by a short-range radar (SRR) circuit, that is analysed using a multi-time forced oscillator (MTFO) model. The MTFO model is based on a forced oscillation perspective with the signal and system theory, a second-order differenti...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep43680

    authors: Kittipute K,Saratayon P,Srisook S,Wardkein P

    更新日期:2017-03-02 00:00:00

  • Molecular imaging of oxidative stress using an LED-based photoacoustic imaging system.

    abstract::LED-based photoacoustic imaging has practical value in that it is affordable and rugged; however, this technology has largely been confined to anatomic imaging with limited applications into functional or molecular imaging. Here, we report molecular imaging reactive oxygen and nitrogen species (RONS) with a near-infra...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47599-2

    authors: Hariri A,Zhao E,Jeevarathinam AS,Lemaster J,Zhang J,Jokerst JV

    更新日期:2019-08-06 00:00:00

  • PEGylated insulin-like growth factor-I affords protection and facilitates recovery of lost functions post-focal ischemia.

    abstract::Insulin-like growth factor-I (IGF-I) is involved in the maturation and maintenance of neurons, and impaired IGF-I signaling has been shown to play a role in various neurological diseases including stroke. The aim of the present study was to investigate the efficacy of an optimized IGF-I variant by adding a 40 kDa poly...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-00336-z

    authors: Parker K,Berretta A,Saenger S,Sivaramakrishnan M,Shirley SA,Metzger F,Clarkson AN

    更新日期:2017-03-21 00:00:00

  • Discordance in HER2 Status in Gastro-esophageal Adenocarcinomas: A Systematic Review and Meta-analysis.

    abstract::Trastuzumab combined with chemotherapy is standard of care for HER2 positive advanced gastro-esophageal cancers. The reported prevalence of HER2 discordance between primary tumors and corresponding metastases varies, hampering uniform patient selection for HER2 targeted therapy. This meta-analysis explores the influen...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析

    doi:10.1038/s41598-017-03304-9

    authors: Creemers A,Ter Veer E,de Waal L,Lodder P,Hooijer GKJ,van Grieken NCT,Bijlsma MF,Meijer SL,van Oijen MGH,van Laarhoven HWM

    更新日期:2017-06-09 00:00:00

  • Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system.

    abstract::IgG is an indispensable biological experimental tool as well as a widely-used therapeutic protein. However, cell culture-based expression of monoclonal IgG is costly and time-consuming, making this process difficult to use for high-throughput screening in early-stage evaluation of biologics. With the goal of establish...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-36691-8

    authors: Murakami S,Matsumoto R,Kanamori T

    更新日期:2019-01-24 00:00:00

  • Integrated deep visual and semantic attractor neural networks predict fMRI pattern-information along the ventral object processing pathway.

    abstract::Recognising an object involves rapid visual processing and activation of semantic knowledge about the object, but how visual processing activates and interacts with semantic representations remains unclear. Cognitive neuroscience research has shown that while visual processing involves posterior regions along the vent...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-28865-1

    authors: Devereux BJ,Clarke A,Tyler LK

    更新日期:2018-07-13 00:00:00

  • Canine morbillivirus (canine distemper virus) with concomitant canine adenovirus, canine parvovirus-2, and Neospora caninum in puppies: a retrospective immunohistochemical study.

    abstract::A retrospective immunohistochemical study was designed to investigate the frequency of concomitant traditional infectious disease pathogens in puppies that died suddenly and review the aspects of associated pathogenesis. Fifteen puppies were evaluated; the pathology reports and histopathologic slides of these animals ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-31540-0

    authors: Headley SA,Oliveira TES,Pereira AHT,Moreira JR,Michelazzo MMZ,Pires BG,Marutani VHB,Xavier AAC,Di Santis GW,Garcia JL,Alfieri AA

    更新日期:2018-09-07 00:00:00

  • Greenhouse gas emissions and carbon sequestration by agroforestry systems in southeastern Brazil.

    abstract::Agrosilvopastoral and silvopastoral systems can increase carbon sequestration, offset greenhouse gas (GHG) emissions and reduce the carbon footprint generated by animal production. The objective of this study was to estimate GHG emissions, the tree and grass aboveground biomass production and carbon storage in differe...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-16821-4

    authors: Torres CMME,Jacovine LAG,Nolasco de Olivera Neto S,Fraisse CW,Soares CPB,de Castro Neto F,Ferreira LR,Zanuncio JC,Lemes PG

    更新日期:2017-12-01 00:00:00

  • The interplay of the Notch signaling in hepatic stellate cells and macrophages determines the fate of liver fibrogenesis.

    abstract::Hepatic stellate cells (HSCs) known as "master producers" and macrophages as "master regulators", are the key cell types that strongly contribute to the progression of liver fibrosis. Since Notch signaling regulates multiple cellular processes, we aimed to study the role of Notch signaling in HSCs differentiation and ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep18272

    authors: Bansal R,van Baarlen J,Storm G,Prakash J

    更新日期:2015-12-14 00:00:00

  • Protecting quantum resources via frequency modulation of qubits in leaky cavities.

    abstract::Finding strategies to preserve quantum resources in open systems is nowadays a main requirement for reliable quantum-enhanced technologies. We address this issue by considering structured cavities embedding qubits driven by a control technique known as frequency modulation. We first study a single qubit in a lossy cav...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32661-2

    authors: Mortezapour A,Lo Franco R

    更新日期:2018-09-24 00:00:00

  • Improving understanding of the functional diversity of fisheries by exploring the influence of global catch reconstruction.

    abstract::Functional diversity is thought to enhance ecosystem resilience, driving research focused on trends in the functional composition of fisheries, most recently with new reconstructions of global catch data. However, there is currently little understanding of how accounting for unreported catches (e.g. small-scale and il...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-10723-1

    authors: Nash KL,Watson RA,Halpern BS,Fulton EA,Blanchard JL

    更新日期:2017-09-06 00:00:00

  • A Multiwell-Based Detection Platform with Integrated PDMS Concentrators for Rapid Multiplexed Enzymatic Assays.

    abstract::We report an integrated system for accelerating assays with concentrators in a standard 12-well plate (ISAAC-12) and demonstrate its versatility for rapid detection of matrix metalloproteinase (MMP)-9 expression in the cell culture supernatant of breast cancer cell line MDA-MB-231 by accelerating the enzymatic reactio...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-29065-7

    authors: Wei X,Do VQ,Pham SV,Martins D,Song YA

    更新日期:2018-07-17 00:00:00