Abstract：
:Helicobacter pylori is presumed to infect gastric tissue via the oral cavity in childhood, whereas risk factors for H. pylori infection in the oral cavity are unknown. In this study, we analysed the effects of Streptococcus mutans, a major cariogenic bacterial species, on H. pylori colonisation in the oral cavity, as well as gastric tissue. Rats in the weaning period were infected with S. mutans in the oral cavity, then fed a caries-inducing diet to facilitate S. mutans colonisation. One month after S. mutans infection, rats were infected with H. pylori in the oral cavity; rats were then euthanised at 1 month after H. pylori infection. H. pylori was detected in the oral cavities of rats infected with both S. mutans and H. pylori, but not in rats infected with H. pylori alone. In addition, H. pylori colonisation in the gastric tissue and typical gastrointestinal damage were observed in rats infected with both S. mutans and H. pylori. When H. pylori was co-cultured with in vitro biofilm formed by S. mutans, a large number of H. pylori bacteria invaded the biofilm formed by S. mutans. Our results suggest that S. mutans is involved in the establishment of H. pylori infection.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Nomura R,Kadota T,Ogaya Y,Matayoshi S,Iwashita N,Okawa R,Nakano Kdoi
10.1038/s41598-020-69368-2subject
Has Abstractpub_date
2020-07-27 00:00:00pages
12540issue
1issn
2045-2322pii
10.1038/s41598-020-69368-2journal_volume
10pub_type
杂志文章abstract：:Staphylococcus aureus colonizes the skin of atopic dermatitis (AD) individuals, but the impact of its enterotoxins on the chronic activation of CD4+ T cells demands further analysis. We aimed to analyze the CD4+ T cell anergy profile and their phenotypic and functional features through differential expression of cellu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49421-5
更新日期：2019-09-11 00:00:00
abstract：:Neuropathic pain is characterized by an uncertain etiology and by a poor response to common therapies. The ineffectiveness and the frequent side effects of the drugs used to counteract neuropathic pain call for the discovery of new therapeutic strategies. Laser therapy proved to be effective for reducing pain sensitiv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45469-5
更新日期：2019-06-26 00:00:00
abstract：:Hematopoietic stem/progenitor cells (HSPC) in zebrafish emerge from the aortic hemogenic endothelium (HE) and migrate towards the caudal hematopoietic tissue (CHT), where they expand and differentiate during definitive hematopoiesis. Phospholipase C gamma 1 (Plcγ1) has been implicated for hematopoiesis in vivo and in ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36338-8
更新日期：2019-01-21 00:00:00
abstract：:ABX464 is a first-in-class, clinical-stage, small molecule for oral administration that has shown strong anti-inflammatory effects in the DSS-model for inflammatory bowel disease (IBD) and also prevents replication of the HIV virus. ABX464 which binds to cap binding complex (CBC) has demonstrated safety and efficacy i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37813-y
更新日期：2019-01-28 00:00:00
abstract：:No international consensus regarding the resection of the para-aortic lymph node (PALN) station Ln16b1 during pancreatoduodenectomy for pancreatic ductal adenocarcinoma (PDAC) has been reached. The present retrospectively investigated 264 patients with PDAC who underwent curative pancreatoduodenectomy or total pancrea...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08165-w
更新日期：2017-08-09 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-63859-y
更新日期：2020-04-22 00:00:00
abstract：:Geometric mean concentrations of fecal indicator bacteria E. coli and enterococci are commonly used to evaluate the microbial quality of irrigation, recreation, and other types of waters, as well in watershed-scale microbial water quality modeling. It is not known how the uncertainty of those geometric mean concentrat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58603-5
更新日期：2020-02-03 00:00:00
abstract：:Photoluminescence (PL) was used to estimate the concentration of carbon in GaN grown by hydride vapor phase epitaxy (HVPE). The PL data were compared with profiles of the impurities obtained from secondary ion mass spectrometry (SIMS) measurements. Comparison of PL and SIMS data has revealed that apparently high conce...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59033-z
更新日期：2020-02-10 00:00:00
abstract：:Although cisplatin plays a central role in cancer chemotherapy, the mechanisms of cell response to this drug have been unexplored. The present study demonstrates the relationships between the intracellular pH (pHi), cell bioenergetics and the response of cervical cancer to cisplatin. pHi was measured using genetically...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09426-4
更新日期：2017-08-21 00:00:00
abstract：:Oxide heterointerfaces are ideal for investigating strong correlation effects to electron transport, relevant for oxide-electronics. Using hot-electrons, we probe electron transport perpendicular to the La₀.₇Sr₀.₃MnO₃ (LSMO)- Nb-doped SrTiO₃ (Nb:STO) interface and find the characteristic hot-electron attenuation lengt...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01274
更新日期：2013-01-01 00:00:00
abstract：:Biological networks play a key role in determining biological function and therefore, an understanding of their structure and dynamics is of central interest in systems biology. In Boolean models of such networks, the status of each molecule is either "on" or "off" and along with the molecules interact with each other...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20067
更新日期：2016-01-29 00:00:00
abstract：:Psychological factors, specific lifestyles and environmental stressors may influence etiopathogenesis and evolution of chronic diseases. We investigate the association between Chronic Inflammatory Bowel Diseases (IBD) and psychological dimensions such as personality traits, defence mechanisms, and Alexithymia, i.e. de...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41786
更新日期：2017-02-02 00:00:00
abstract：:Obesity is a major cause of type 2 diabetes mellitus (T2DM) in mammals. We have previously established a zebrafish model of diet-induced obesity (DIO zebrafish) by overfeeding Artemia. Here we created DIO zebrafish using a different method to induce T2DM. Zebrafish were overfed a commercially available fish food using...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01432-w
更新日期：2017-05-03 00:00:00
abstract：:Miscanthus is a rhizomatous C4 grass which is considered as potential high-yielding energy crop with the low-nutrient requirements, high water-use efficiency, and capability of C mitigation. To better understand the genetic basis, an integrative analysis of the transcriptome and proteome was performed to identify impo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14151-z
更新日期：2017-10-23 00:00:00
abstract：:At the moment it is unknown to what extent the impaired function of T lymphocytes in ESRD patients depends on uremia, and to what extent on hemodialysis (HD) procedure. Therefore, the purpose of the study was to evaluate percentages of T lymphocyte subpopulations ex vivo, plasma concentrations of IL12p70, TNF, IL-10, ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-019-41619-x
更新日期：2019-03-25 00:00:00
abstract：:We study the local indistinguishability problem of quantum states. By introducing an easily calculated quantity, non-commutativity, we present an criterion which is both necessary and sufficient for the local indistinguishability of a complete set of pure orthogonal product states. A constructive distinguishing proced...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06336
更新日期：2014-09-11 00:00:00
abstract：:A bistable toggle switch is a paradigmatic model in the field of biology. The dynamics of the system induced by Gaussian noise has been intensively investigated, but Gaussian noise cannot incorporate large bursts typically occurring in real experiments. This paper aims to examine effects of variations from one protein...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31505
更新日期：2016-08-19 00:00:00
abstract：:Climate change is expected to have profound, partly unforeseeable effects on the composition of functional traits of complex ecosystems, such as coral reefs, and some ecosystem properties are at risk of disappearing. This study applies a novel spatially explicit, individual-based model to explore three critical life h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38962-4
更新日期：2019-03-06 00:00:00
abstract：:Streptococcus pneumoniae (S. pneumoniae) is a leading human pathogen, which takes large responsibility for severe otitis media, acute meningitis and septicaemia. It encodes up to three distinct sialidases: NanA, NanB and NanC, which are promising drug targets. Recent experimental studies have shown that these three si...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38131-z
更新日期：2019-02-15 00:00:00
abstract：:Activation of G protein-gated inwardly rectifying potassium (GIRK) channels leads to a hyperpolarization of the neuron's membrane potential, providing an important component of inhibition in the brain. In addition to the canonical G protein-activation pathway, GIRK channels are activated by small molecules but less is...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04681-x
更新日期：2017-07-04 00:00:00
abstract：:Plant seed germination is a crucial developmental event that has significant effects on seedling establishment and yield production. This process is controlled by multiple intrinsic signals, particularly phytohormones. The gaseous hormone ethylene stimulates seed germination; however, the genetic basis of ethylene pro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58607-1
更新日期：2020-02-03 00:00:00
abstract：:Extravillous trophoblasts (EVTs) have the potential to provide the entire fetal genome for prenatal testing. Previous studies have demonstrated the presence of EVTs in the cervical canal and the ability to retrieve a small quantity of these cells by cervical sampling. However, these small quantities of trophoblasts ar...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48346-3
更新日期：2019-08-20 00:00:00
abstract：:Separation of CO2 from other gasses offers environmental benefits since CO2 gas is the main contributor to global warming. Recently, graphene oxide (GO) based gas separation membranes are of interest due to their selective barrier properties. However, maintaining selectivity without sacrificing permeance is still chal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00433-z
更新日期：2017-03-28 00:00:00
abstract：:Silicene is an exciting two-dimensional material that shares many of graphene's electronic properties, but differs in its structural buckling. This buckling allows opening a bandgap in silicene through the application of a perpendicular electric field. Here we show that this buckling also enables highly effective modu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14815
更新日期：2015-10-06 00:00:00
abstract：:Investigation of climatic conditions prior to the Sturtian glaciations is critical to understanding the trigger mechanism for the series of Neoproterozoic global glaciations. In this study, we report high-resolution chemical index of alteration (CIA) records in the sediments of South China prior to the Sturtian glacia...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06868
更新日期：2014-10-31 00:00:00
abstract：:Theory predicts that social interactions can induce an alignment of behavioral asymmetries between individuals (i.e., population-level lateralization), but evidence for this effect is mixed. To understand how interaction with other individuals affects behavioral asymmetries, we systematically manipulated the social en...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61410-7
更新日期：2020-03-11 00:00:00
abstract：:The aims of this study were, firstly, to assess the effect of concurrent peripheral artery disease (PAD) on the health-related quality of life (QOL) of people diagnosed with a small abdominal aortic aneurysm (AAA); and secondly, to test whether the peroxisome proliferator-activated receptor α agonist fenofibrate impro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71454-4
更新日期：2020-09-03 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-28601-9
更新日期：2018-07-04 00:00:00
abstract：:Our data about pathogenesis of hepatic steatosis after liver transplantation is scarce. This study aimed to investigate the association between serum adipokines and insulin resistance with hepatic steatosis in liver transplant recipients. We investigated the association between insulin resistance, serum adiponectin, i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69571-1
更新日期：2020-07-29 00:00:00
abstract：:The largest tsunamis are generated by seafloor uplift resulting from rupture of offshore subduction-zone megathrusts. The rupture of the shallowest part of a megathrust often produces unexpected outsize tsunami relative to their seismic magnitude. These are so called 'tsunami earthquakes', which are difficult to ident...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68097-w
更新日期：2020-07-06 00:00:00
