Abstract：
:The current theories of antimalarial mechanism of artemisinin are inadequate to fully explain the observed effects. In our study, "organism-like" formation of Schistosoma hemozoin granules by attaching to and utilizing erythrocytes to form new ones was observed. This indicates that heme iron is transferred from erythrocytes to hemozoin granules during their formation. However, as a disposal product of heme detoxification, these granules are not completely expelled from the Schistosoma gut, but decomposed again between microvilli in the posterior portion of the gut to transfer iron to eggs. Based on the function of iron transport supported by our observation of the unique process of Schistosoma hemozoin formation, here we propose a new viewpoint of antimalarial mechanism of artemisinin, which emphasizes the final outcome, i.e., interference of iron utilization in parasites by artemisinin, instead of focusing on the mode of interaction between artemisinin and heme or hemozoin. This suggests that artemisinin and its endoperoxides derivatives likely hit the Achilles' heel of hemozoin-producing and iron-dependent organisms.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sun J,Li C,Wang Sdoi
10.1038/srep34463subject
Has Abstractpub_date
2016-10-03 00:00:00pages
34463issn
2045-2322pii
srep34463journal_volume
6pub_type
杂志文章abstract：:Plants adapted to extreme conditions can be at high risk from climate change; arctic-alpine plants, in particular, could "run out of space" as they are out-competed by expansion of woody vegetation. Mountain regions could potentially provide safe sites for arctic-alpine plants in a warmer climate, but empirical eviden...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55989-9
更新日期：2019-12-23 00:00:00
abstract：:Electroporation (EP), the increase of cell membrane permeability due to the application of electric pulses, is a universal phenomenon with a broad range of applications. In medicine, some of the foremost EP-based tumor treatments are electrochemotherapy (ECT), irreversible electroporation, and gene electrotransfer (GE...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79858-y
更新日期：2021-01-14 00:00:00
abstract：:HAUSP (herpes virus-associated ubiquitin specific protease, known as ubiquitin specific protease 7), one of DUBs, regulates the dynamics of the p53 and Mdm2 network in response to DNA damage by deubiquitinating both p53 and its E3 ubiquitin ligase, Mdm2. Its concerted action increases the level of functional p53 by pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12793
更新日期：2015-08-04 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-75277-1
更新日期：2020-10-20 00:00:00
abstract：:The microwave properties of nano-scale structures are important in a wide variety of applications in quantum technology. Here we describe a low-power cryogenic near-field scanning microwave microscope (NSMM) which maintains nano-scale dielectric contrast down to the single microwave photon regime, up to 109 times lowe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48780-3
更新日期：2019-08-29 00:00:00
abstract：:Homologous recombination (HR) events are key drivers of cancer-promoting mutations, and the ability to visualize these events in situ provides important information regarding mutant cell type, location, and clonal expansion. We have previously created the Rosa26 Direct Repeat (RaDR) mouse model wherein HR at an integr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30557-9
更新日期：2018-08-14 00:00:00
abstract：:Malaria remains a major public health problem in the Peruvian Amazon where the persistence of high-risk transmission areas (hotspots) challenges the current malaria control strategies. This study aimed at identifying significant space-time clusters of malaria incidence in Loreto region 2002-2013 and to determine signi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40350
更新日期：2017-01-16 00:00:00
abstract：:We presented the unusual result of photobleaching (PB) in Ge-deficient Ge16.8Se83.2 thin films with continuous irradiation with 560 nm laser for 12000 s, which is contradicted with the previous reports that the PB only occurs in GexSe100-x films with x > 30. Observation of the dynamics variations of the photo-induced ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14796-w
更新日期：2017-11-06 00:00:00
abstract：:Maize (corn) is the dominant grain grown in the world. Total maize production in 2018 equaled 1.12 billion tons. Maize is used primarily as an animal feed in the production of eggs, dairy, pork and chicken. The US produces 32% of the world's maize followed by China at 22% and Brazil at 9% ( https://apps.fas.usda.gov/p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71898-8
更新日期：2020-09-11 00:00:00
abstract：:Dendritic spines are small, bulbous protrusions along dendrites in neurons and play a critical role in synaptic transmission. Dendritic spines come in a variety of shapes that depend on their developmental state. Additionally, roughly 14-19% of mature spines have a specialized endoplasmic reticulum called the spine ap...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48028-0
更新日期：2019-08-12 00:00:00
abstract：:Fruit firmness is an important market driven trait in sweet cherry (Prunus avium L.) where the desirable increase in fruit firmness is associated with landrace and bred cultivars. The aim of this work was to investigate the genetic basis of fruit firmness using plant materials that include wild cherry (syn. mazzard), ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41484-8
更新日期：2019-03-21 00:00:00
abstract：:Editor's Note: this Article has been retracted; the Retraction Note is available at https://www.nature.com/articles/s41598-020-76500-9. ...
journal_title：Scientific reports
pub_type： 已发布勘误,撤回出版物
doi：10.1038/s41598-020-76500-9
更新日期：2020-11-26 00:00:00
abstract：:Bradysia odoriphaga and Bradysia difformis are devastating pests of vegetable, ornamental crops and edible mushrooms causing significant losses. Temperature may be an important factor restricting their population abundance in the summer. To determine the effects of short-term heat shock on adults, their survival, long...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13560-4
更新日期：2017-10-17 00:00:00
abstract：:In music, the perception of pitch is governed largely by its tonal function given the preceding harmonic structure of the music. While behavioral research has advanced our understanding of the perceptual representation of musical pitch, relatively little is known about its representational structure in the brain. Usin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19222-3
更新日期：2018-01-16 00:00:00
abstract：:Nα-acetylation is a naturally occurring irreversible modification of N-termini of proteins catalyzed by Nα-acetyltransferases (NATs). Although present in all three domains of life, it is little understood in bacteria. The functional grouping of NATs into six types NatA - NatF, in eukaryotes is based on subunit require...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28892
更新日期：2016-06-29 00:00:00
abstract：:The kynurenine pathway (KP) is dysregulated in neuroinflammatory diseases including Alzheimer's disease (AD), however has not been investigated in preclinical AD characterized by high neocortical amyloid-β load (NAL), prior to cognitive impairment. Serum KP metabolites were measured in the cognitively normal KARVIAH c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25968-7
更新日期：2018-05-22 00:00:00
abstract：:A top-down scalable method to produce flexible water and blood repellent tubes is introduced. The method is based on replication of overhanging nanostructures from an aluminum tube template to polydimethylsiloxane (PDMS) via atomic layer deposition (ALD) assisted sacrificial etching. The nanostructured PDMS/titania tu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16369-3
更新日期：2017-11-22 00:00:00
abstract：:In actively deforming regions, crustal deformation is accommodated by earthquakes and through a variety of transient aseismic phenomena. Here, we study the 2010-2014 Pollino (Southern Italy) swarm sequence (main shock M W 5.1) located within the Pollino seismic gap, by analysing the surface deformation derived from Gl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00649-z
更新日期：2017-04-12 00:00:00
abstract：:Effective treatment of osteomyelitis remains a formidable clinical challenge. The rapid emergence of multidrug-resistant bacteria has renewed interest in developing antimicrobial biomaterials using antiseptic silver ions to treat osteomyelitis. However, inadequate local retention and severe cytotoxic effects have limi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39174
更新日期：2016-12-16 00:00:00
abstract：:Groundwater systems affected by various factors can exhibit complex fractal behaviors, whose reliable characterization however is not straightforward. This study explores the fractal scaling behavior of the groundwater systems affected by plant water use and river stage fluctuations in the riparian zone, using multifr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51657-0
更新日期：2019-10-28 00:00:00
abstract：:The effect on the reproductive system and fertility of living in a space environment remains unclear. Here, we caged 12 male mice under artificial gravity (≈1 gravity) (AG) or microgravity (MG) in the International Space Station (ISS) for 35 days, and characterized the male reproductive organs (testes, epididymides, a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50128-w
更新日期：2019-09-24 00:00:00
abstract：:Naturally occurring metals and metalloids [metal(loid)s] are essential for the physiological functioning of wildlife; however, environmental contamination by metal(loid) and plastic pollutants is a health hazard. Metal(loid)s may interact with plastic in the environment and there is mixed evidence about whether plasti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75024-6
更新日期：2020-10-22 00:00:00
abstract：:The systematics of Oriental freshwater mussels (Bivalvia: Unionidae) is poorly known. Here, we present an integrative revision of the genus Trapezoideus Simpson, 1900 to further understanding of freshwater mussel diversity in the region. We demonstrate that Trapezoideus as currently circumscribed is non-monophyletic, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39365-1
更新日期：2019-03-11 00:00:00
abstract：:Malachite green is a common environmental pollutant that poses a great threat to non-target organisms, including humans. This study reports the characterization of a bacterial strain, Pseudomonas veronii JW3-6, which was isolated from a malachite green enrichment culture. This strain degraded malachite green efficient...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61442-z
更新日期：2020-03-11 00:00:00
abstract：:Periodontal (gum) disease is a highly prevalent infection and inflammation accounting for the majority of tooth loss in adult population worldwide. Porphyromonas gingivalis is a keystone periodontal pathogen and its lipopolysaccharide (PgLPS) acts as a major virulence attribute to the disease. Herein, we deciphered th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29829
更新日期：2016-08-19 00:00:00
abstract：:There has been much interest recently in the discovery of thermally induced magnetisation switching using femtosecond laser excitation, where a ferrimagnetic system can be switched deterministically without an applied magnetic field. Experimental results suggest that the reversal occurs due to intrinsic material prope...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03262
更新日期：2013-11-20 00:00:00
abstract：:A single closed-form analytical solution of the driven nonlinear Schrödinger equation is developed, reproducing a large class of the behaviors in Kerr-comb systems, including bright-solitons, dark-solitons, and a large class of periodic wavetrains. From this analytical framework, a Kerr-comb area theorem and a pump-de...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24742
更新日期：2016-04-25 00:00:00
abstract：:Because of inadequate nutrient and water supply, soils are often unproductive in Northwest China. We studied the effects of manure application at low (LM 7.5 t ha(-1)), medium (MM 15 t ha(-1)), and high (HM 22.5 t ha(-1)) rates combined with fixed levels of chemical fertilizers on maize growth and rainfall use effici...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20994
更新日期：2016-02-12 00:00:00
abstract：:The Cancer/Testes (CT) Antigen HORMAD1 is germ cell-restricted and plays developmental roles in generation and processing of meiotic DNA Double Strand Breaks (DSB). Many tumors aberrantly overexpress HORMAD1 yet the potential impact of this CT antigen on cancer biology is unclear. We tested a potential role of HORMAD1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33601-w
更新日期：2018-10-17 00:00:00
abstract：:Increasing levels of human activity threaten wildlife populations through direct mortality, habitat degradation, and habitat fragmentation. Area closures can improve habitat quality for wildlife, but may be difficult to achieve where tourism or other economic drivers are a priority. Temporal closures that limit human ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40581-y
更新日期：2019-03-07 00:00:00
