Alterations in serum kynurenine pathway metabolites in individuals with high neocortical amyloid-β load: A pilot study.

abstract：:SHH Medulloblastoma (SHH-MB) is a pediatric brain tumor characterized by an inappropriate activation of the developmental Hedgehog (Hh) signaling. SHH-MB patients treated with the FDA-approved vismodegib, an Hh inhibitor that targets the transmembrane activator Smoothened (Smo), have shown the rapid development of dru...

journal_title：Scientific reports

authors： Coni S,Mancuso AB,Di Magno L,Sdruscia G,Manni S,Serrao SM,Rotili D,Spiombi E,Bufalieri F,Petroni M,Kusio-Kobialka M,De Smaele E,Ferretti E,Capalbo C,Mai A,Niewiadomski P,Screpanti I,Di Marcotullio L,Canettieri G

更新日期：2017-03-09 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： An T,Fan T,Zhang XQ,Liu YF,Huang J,Liang C,Lv BH,Wang YQ,Zhao XG,Liu JX,Fu YH,Jiang GJ

更新日期：2020-04-22 00:00:00

abstract：:An in vitro-transcribed RNA aptamer (trans-RA16) that targets non-small cell lung cancer (NSCLC) was previously identified through in vivo SELEX. Trans-RA16 can specifically target and inhibit human NCI-H460 cells in vitro and xenograft tumors in vivo. Here, in a follow-up study, we obtained a chemically-synthesized v...

journal_title：Scientific reports

authors： Wang H,Qin M,Liu R,Ding X,Chen ISY,Jiang Y

更新日期：2019-12-11 00:00:00

abstract：:Current approaches to predicting a cardiovascular disease (CVD) event rely on conventional risk factors and cross-sectional data. In this study, we applied machine learning and deep learning models to 10-year CVD event prediction by using longitudinal electronic health record (EHR) and genetic data. Our study cohort i...

journal_title：Scientific reports

authors： Zhao J,Feng Q,Wu P,Lupu RA,Wilke RA,Wells QS,Denny JC,Wei WQ

更新日期：2019-01-24 00:00:00

abstract：:Food and beverage consumption has a great impact on the environment, although there is a lack of information concerning the whole diet. The environmental impact of 153 Italian adults (51 omnivores, 51 ovo-lacto-vegetarians, 51 vegans) and the inter-individual variability within dietary groups were assessed in a real-l...

journal_title：Scientific reports

authors： Rosi A,Mena P,Pellegrini N,Turroni S,Neviani E,Ferrocino I,Di Cagno R,Ruini L,Ciati R,Angelino D,Maddock J,Gobbetti M,Brighenti F,Del Rio D,Scazzina F

更新日期：2017-07-21 00:00:00

abstract：:Aging-associated decrease in internal anal sphincter (IAS) tone (AADI) is a major contributor in the rectoanal incontinence (RI). To determine the pathogenesis of AADI, we investigated the effect of aging on GPCR activation and related downstream signaling. We particularly investigated two GPCRs that characterize IAS ...

journal_title：Scientific reports

authors： Mohanty I,Singh J,Rattan S

更新日期：2019-05-01 00:00:00

abstract：:In the developing central nervous system (CNS), oligodendrocyte precursor cells (OPCs) migrate along blood vessels and are widely distributed in the CNS. Meanwhile, OPCs require survival factors from the extracellular microenvironment. In other tissues, laminins, heterotrimetric (αβγ) extracellular matrix proteins, pr...

journal_title：Scientific reports

authors： Suzuki N,Hyodo M,Hayashi C,Mabuchi Y,Sekimoto K,Onchi C,Sekiguchi K,Akazawa C

更新日期：2019-12-27 00:00:00

abstract：:Online gambling sites offer many different gambling games. In this work we analyse the gambling logs of numerous solely probability-based gambling games and extract the wager and odds distributions. We find that the log-normal distribution describes the wager distribution at the aggregate level. Viewing the gamblers' ...

journal_title：Scientific reports

authors： Wang X,Pleimling M

更新日期：2019-10-11 00:00:00

abstract：:Multi-junction (MJ) solar cells are one of the most promising technologies achieving high sunlight to electricity conversion efficiency. Resistive losses constitute one of the main underlying mechanisms limiting their efficiency under high illumination. In this paper, we study, by numerical modeling, the extent to whi...

journal_title：Scientific reports

authors： Zeitouny J,Katz EA,Dollet A,Vossier A

更新日期：2017-05-11 00:00:00

abstract：:Conventional myeloablative conditioning (MAC) regimens often cause severe regimen-related toxicity (RRT). Furthermore, many patients suffer from poor quality of life in accordance with the increase in long-term survivors. We therefore devised a reduced-toxicity myeloablative conditioning (RTMAC) regimen consisting of ...

journal_title：Scientific reports

authors： Hirabayashi K,Nakazawa Y,Sakashita K,Kurata T,Saito S,Yoshikawa K,Tanaka M,Yanagisawa R,Koike K

更新日期：2014-11-06 00:00:00

abstract：:Telomerase is expressed in adult mouse, but not in most human, tissues and mouse telomeres are much longer than those in humans. This interspecies difference of telomere homeostasis poses a challenge in modeling human diseases using laboratory mice. Using chromatinized bacterial artificial chromosome reporters, we dis...

journal_title：Scientific reports

authors： Cheng,Zhao Y,Zhang F,Zhang J,Wang S,Zhu J

更新日期：2019-07-04 00:00:00

abstract：:Multi-drug resistant Pseudomonas aeruginosa has increased progressively and impedes further regression in mortality in burn patients. Such wound infections serve as bacterial reservoir for nosocomial infections and are associated with significant morbidity and costs. Anti-microbial polycationic dendrimers G3KL and G3R...

journal_title：Scientific reports

authors： Abdel-Sayed P,Kaeppeli A,Siriwardena T,Darbre T,Perron K,Jafari P,Reymond JL,Pioletti DP,Applegate LA

更新日期：2016-02-25 00:00:00

abstract：:Th17 and regulatory T cells, involved in the pathogenesis of several autoimmune diseases, are new lineages of CD4+ T helper cells. However, the role of their imbalance in human leukocyte antigen B27-associated acute anterior uveitis has not been elucidated. In our study, the percentages of Th17 and Treg cells, their m...

journal_title：Scientific reports

authors： Zhuang Z,Wang Y,Zhu G,Gu Y,Mao L,Hong M,Li Y,Zheng M

更新日期：2017-01-16 00:00:00

abstract：:Once activated, the intracellular receptor NLRP3 assembles an inflammasome protein complex that facilitates the caspase-1-mediated maturation of IL-1β and IL-18. Inactive NLRP3 is guarded by a protein complex containing Hsp90. In response to stress stimuli, Hsp90 is released, and NLRP3 can be activated to promote infl...

journal_title：Scientific reports

authors： Piippo N,Korhonen E,Hytti M,Skottman H,Kinnunen K,Josifovska N,Petrovski G,Kaarniranta K,Kauppinen A

更新日期：2018-04-30 00:00:00

abstract：:Our goals was to evaluate how sentinel lymph node biopsy (SLNB) benefit neck management in patients with parotid cancer. Patients diagnosed with cN0 parotid cancer by preoperative fine needle puncture were prospectively enrolled. The neck status was evaluated by SLNB. If node metastasis was proved by SLNB, a neck diss...

journal_title：Scientific reports

authors： Pan W,Ba K,Niu X,Liu F,Fang Q

更新日期：2019-06-06 00:00:00

abstract：:Fluorescence visualization devices (FVs) are useful for detecting malignant lesions because of their simple and noninvasive application. However, their quantitative application has been challenging. This study aimed to quantitatively and statistically evaluate the change in fluorescence intensity (FI) during the progr...

journal_title：Scientific reports

authors： Kosugi A,Kasahara M,Yang L,Nakamura-Takahashi A,Shibahara T,Mori T

更新日期：2019-05-24 00:00:00

abstract：:In the northeastern United States, chronic wasting disease has recently been detected in white-tailed deer (Odocoileus virginianus) populations, and understanding the relationship between landscape configuration and home range may improve disease surveillance and containment efforts. The objectives of our study were t...

journal_title：Scientific reports

authors： Walter WD,Evans TS,Stainbrook D,Wallingford BD,Rosenberry CS,Diefenbach DR

更新日期：2018-10-02 00:00:00

abstract：:Although accumulating evidence indicates that both β-catenin and osterix (Osx) are essential for bone and tooth development, few studies have investigated the interaction of these two key proteins in the context of cementogenesis. In this study, we used transgenic mice with constitutively active β-catenin and inactive...

journal_title：Scientific reports

authors： Choi H,Kim TH,Yang S,Lee JC,You HK,Cho ES

更新日期：2017-08-15 00:00:00

abstract：:Acetylcholine binding proteins (AChBPs) are unique spatial homologs of the ligand-binding domains of nicotinic acetylcholine receptors (nAChRs), and they reproduce some pharmacological properties of nAChRs. X-ray crystal structures of AСhBP in complex with α-conotoxins provide important insights into the interactions ...

journal_title：Scientific reports

authors： Lin B,Xu M,Zhu X,Wu Y,Liu X,Zhangsun D,Hu Y,Xiang SH,Kasheverov IE,Tsetlin VI,Wang X,Luo S

更新日期：2016-03-01 00:00:00

abstract：:Many insects possess the ability to detect fine fluctuations in the environmental CO2 concentration. In herbivorous species, plant-emitted CO2, in combination with other sensory cues, affect many behaviors including foraging and oviposition. In contrast to the comprehensive knowledge obtained on the insect olfactory p...

journal_title：Scientific reports

authors： Chu X,Kc P,Ian E,Kvello P,Liu Y,Wang GR,Berg BG

更新日期：2020-11-16 00:00:00

abstract：:Information concerning the pathogenic role of honey bee viruses in invasive species are still scarce. The aim of this investigation was to assess the presence of several honey bee viruses, such as Black Queen Cell Virus (BQCV), Kashmir Bee Virus (KBV), Slow Paralysis Virus (SPV), Sac Brood Virus (SBV), Israeli Acute P...

journal_title：Scientific reports

authors： Mazzei M,Cilia G,Forzan M,Lavazza A,Mutinelli F,Felicioli A

更新日期：2019-07-12 00:00:00

abstract：:Spin-polarized triangular graphene nanoflakes (t-GNFs) serve as ideal building blocks for the long-desired ferromagnetic graphene superlattices, but they are always assembled to planar structures which reduce its mechanical properties. Here, by joining t-GNFs in a spiral way, we propose one-dimensional graphene spiral...

journal_title：Scientific reports

authors： Zhang X,Zhao M

更新日期：2014-07-16 00:00:00

abstract：:The anatomic and functional combinations of cusps and lophs (ridges) define the tooth shape of rodent molars, which distinguishes species. The species-specific cusp patterns result from the spatiotemporal induction of enamel knots (EKs), which require precisely controlled cellular behavior to control the epithelial in...

journal_title：Scientific reports

authors： Li L,Tang Q,Nakamura T,Suh JG,Ohshima H,Jung HS

更新日期：2016-11-28 00:00:00

abstract：:The gradient relationship between mean corpuscular volume (MCV) and mortality due to ischemic vascular disease has not been researched using a large-scale population-based study. This study evaluated the association between MCV and death attributable to cerebrovascular disease (CVD) and cardiovascular disease (CAD) in...

journal_title：Scientific reports

authors： Wu TH,Fann JC,Chen SL,Yen AM,Wen CJ,Lu YR,Chen HH,Chiu SY,Liou HH

更新日期：2018-11-08 00:00:00

abstract：:Millions of people are blind worldwide. Sensory substitution (SS) devices (e.g., vOICe) can assist the blind by encoding a video stream into a sound pattern, recruiting visual brain areas for auditory analysis via crossmodal interactions and plasticity. SS devices often require extensive training to attain limited fun...

journal_title：Scientific reports

authors： Stiles NR,Shimojo S

更新日期：2015-10-22 00:00:00

abstract：:The protective effects of statins against stenosis for permanent hemodialysis access have been repeatedly demonstrated in animal studies, but remain controversial in human studies. This study aims to evaluate the association between statin use and permanent hemodialysis access patency using a nationwide hemodialysis c...

journal_title：Scientific reports

authors： Chang HH,Chang YK,Lu CW,Huang CT,Chien CT,Hung KY,Huang KC,Hsu CC

更新日期：2016-02-23 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Lee SH,Ryu S,Lee JY,Seo DC,Kim BJ,Sung KC

更新日期：2019-06-05 00:00:00

abstract：:Heterocyclic amines (HCAs) are formed by cooking protein-rich foods, for instance, meat and fish, and are listed as possible human carcinogens. In the present study, the presence of five potential HCAs (IQ, MeIQ, MeIQx, 4,8-DiMeIQx, and PhIP) in cooked camel meat burgers was analyzed for the first time. The analysis w...

journal_title：Scientific reports

authors： Rizwan Khan M,Naushad M,Abdullah Alothman Z

更新日期：2017-05-10 00:00:00

abstract：:Vaginal microbiota is an important early source of bacterial colonization for newborns. However, only a few small studies have investigated the composition of vaginal microbiota during labor. In this work, we analyzed vaginal swabs collected at 36 weeks gestation and at the onset of labor from 256 women participating ...

journal_title：Scientific reports

authors： Avershina E,Slangsvold S,Simpson MR,Storrø O,Johnsen R,Øien T,Rudi K

更新日期：2017-12-14 00:00:00

abstract：:mRNAs lacking 5' untranslated regions (leaderless mRNAs) are molecular relics of an ancient translation initiation pathway. Nevertheless, they still represent a significant portion of transcriptome in some taxons, including a number of eukaryotic species. In bacteria and archaea, the leaderless mRNAs can bind non-diss...

journal_title：Scientific reports

authors： Akulich KA,Andreev DE,Terenin IM,Smirnova VV,Anisimova AS,Makeeva DS,Arkhipova VI,Stolboushkina EA,Garber MB,Prokofjeva MM,Spirin PV,Prassolov VS,Shatsky IN,Dmitriev SE

更新日期：2016-11-28 00:00:00