Abstract:
:The anatomic and functional combinations of cusps and lophs (ridges) define the tooth shape of rodent molars, which distinguishes species. The species-specific cusp patterns result from the spatiotemporal induction of enamel knots (EKs), which require precisely controlled cellular behavior to control the epithelial invagination. Despite the well-defined roles of EK in cusp patterning, the determinants of the ultimate cuspal shapes and involvement of epithelial cellular geometry are unknown. Using two typical tooth patterns, the lophodont in gerbils and the bunodont in mice, we showed that the cuspal shape is determined by the dental epithelium at the cap stage, whereas the cellular geometry in the inner dental epithelium (IDE) is correlated with the cuspal shape. Intriguingly, fine tuning Rac1 and RhoA interconvert cuspal shapes between two species by remolding the cellular geometry. Either inhibition of Rac1 or ectopic expression of RhoA could region-distinctively change the columnar shape of IDE cells in gerbils to drive invagination to produce cusps. Conversely, RhoA reduction in mice inhibited invagination and developed lophs. Furthermore, we found that Rac1 and RhoA modulate the choices of cuspal shape by coordinating adhesion junctions, actin distribution, and fibronectin localization to drive IDE invagination.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Li L,Tang Q,Nakamura T,Suh JG,Ohshima H,Jung HSdoi
10.1038/srep37828subject
Has Abstractpub_date
2016-11-28 00:00:00pages
37828issn
2045-2322pii
srep37828journal_volume
6pub_type
杂志文章abstract::Globally, a small percentage of oil is recovered from reservoirs using primary and secondary recovery mechanisms, and thus a major focus of the oil industry is toward developing new technologies to increase recovery. Many new technologies utilize surfactants, macromolecules, and even nanoparticles, which are difficult...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11816-7
更新日期:2017-09-14 00:00:00
abstract::Due to chromatic aberration, blue images are defocused when the eye is focused to the middle of the visible spectrum, yet we normally are not aware of chromatic blur. The eye suffers from monochromatic aberrations which degrade the optical quality of all images projected on the retina. The combination of monochromatic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79911-w
更新日期:2021-01-11 00:00:00
abstract::A light reflection device combined with visible light spectrophotometer was used to measure the reflectance-wavelength curves of colored stainless steel after coloring, hardening and sealing. After these processes, the coordinate in CIE 1931 color coordinate system and brightness of samples were confirmed by chromatom...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70359-6
更新日期:2020-08-11 00:00:00
abstract::The objective of this study was to investigate the associations between selenium exposure and cancer risk. We identified 69 studies and applied meta-analysis, meta-regression and dose-response analysis to obtain available evidence. The results indicated that high selenium exposure had a protective effect on cancer ris...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/srep19213
更新日期:2016-01-20 00:00:00
abstract::Dislocations in crystals are linear crystallographic defects, which move in lattice when crystals are plastically deformed. Motion of a partial dislocation may remove or create stacking fault characterized with a partial of a lattice translation vector. Here we report that motion of partial dislocations inside an inte...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01039
更新日期:2013-01-01 00:00:00
abstract::The inward rectifier Kir2.1 current (IKir2.1) was reported to be facilitated by fluid flow. However, the mechanism underlying this facilitation remains uncertain. We hypothesized that during K+ influx or efflux, [K+] adjacent to the outer mouth of the Kir2.1 channel might decrease or increase, respectively, compared w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39585
更新日期:2016-12-22 00:00:00
abstract::Programmed cell death 5 (PDCD5) is believed to play a crucial role in p53 activation; however, the underlying mechanism of how PDCD5 function is regulated during apoptosis remains obscure. Here, we report that the serine/threonine phosphatase PPEF-1 interacts with and dephosphorylates PDCD5 at Ser-119, which leads to ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39222
更新日期:2017-01-04 00:00:00
abstract::A tribochemistry-assisted method has been developed for nondestructive surface nanofabrication on GaAs. Without any applied electric field and post etching, hollow nanostructures can be directly fabricated on GaAs surfaces by sliding a SiO2 microsphere under an ultralow contact pressure in humid air. TEM observation o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09020
更新日期:2015-03-12 00:00:00
abstract::Clinical trials have recently demonstrated the effectiveness of Pre-Exposure Prophylaxis (PrEP) in preventing HIV infection. Consequently, PrEP may soon be used for epidemic control. We model the dynamic interactions that will occur between treatment programs and potential PrEP interventions in resource-constrained co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00185
更新日期:2011-01-01 00:00:00
abstract::Arterial/venous thrombosis is the major cardiovascular disorder accountable for substantial mortality; and the current demand for antithrombotic agents is extensive. Heparinases depolymerize unfractionated heparin (UFH) for the production of low molecular-weight heparins (LMWHs; used as anticoagulants against thrombos...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42740-7
更新日期:2019-04-24 00:00:00
abstract::Endoconidiophora resinifera (=Ceratocystis resinifera) is a blue-stain fungus that occurs on conifers. The data showed that the Endoconidiophora resinifera mitochondrial genome is one of the largest mitochondrial genomes (>220 kb) so far reported among members of the Ascomycota. An exceptional large number of introns ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35926-y
更新日期:2018-12-04 00:00:00
abstract::Development of conformal n-channel organic phototransistor (OPT) array is urgent for future applications of organic complementary circuits in portable and wearable electronics and optoelectronics. In this work, the ultrathin conformal OPT array based on air-stable n-type PTCDI-C13H27 was fabricated. The OPT array show...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35062-7
更新日期:2018-11-09 00:00:00
abstract::We quantitatively evaluated breast tumor movement and volume changes between magnetic resonance imaging (MRI) scans in prone and supine positions. Twenty-seven breast tumor patients who received neoadjuvant systemic therapy (NST) for breast-conserving surgery were studied. Before and after NST, MRI scans in prone and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61802-9
更新日期:2020-03-17 00:00:00
abstract::Recent evidence suggests that some seizures are preceded by preictal changes that start from minutes to hours before an ictal event. Nevertheless an adequate statistical evaluation in a large database of continuous multiday recordings is still missing. Here, we investigated the existence of preictal changes in long-te...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04545
更新日期:2014-04-01 00:00:00
abstract::The adaptation of herbivorous insects to various host plants facilitates the spread and outbreak of many important invasive pests, however, the molecular mechanisms that underneath this process are poorly understood. In the past three decades, two species of the whitefly Bemisia tabaci complex, Middle East-Asia Minor ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12387-3
更新日期:2017-09-21 00:00:00
abstract::Anticarsia gemmatalis (velvetbean caterpillar) and Chrysodeixis includens (soybean looper) are two important defoliation pests of soybeans. In the present study, we have investigated the susceptibility and brush border membrane-binding properties of both species to Bacillus thuringiensis Cry1Ea toxin. Bioassays perfor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54850-3
更新日期:2019-12-03 00:00:00
abstract::This study investigated how changes in reservoir water level affect mosquito abundance and malaria transmission in Ethiopia. Digital elevation models of three Ethiopian dams at lowland, midland and highland elevations were used to quantify water surface area and wetted shoreline at different reservoir water levels (70...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54536-w
更新日期:2019-12-02 00:00:00
abstract::Studies have demonstrated that inflammatory bowel disease (IBD) patients are at an increased risk of developing anxiety and/or depression. IBD patients with depression/anxiety have higher rates of hospitalization and increased disease severity than those without. So far, there is a paucity of data concerning the impac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81213-8
更新日期:2021-01-14 00:00:00
abstract::Dibutyl phthalate (DBP) is recognized as an environmental endocrine disruptor that has been detected in fetal and postnatal samples. Recent evidence found that in utero DBP exposure was associated with an increase of adipose tissue weight and serum lipids in offspring, but the precise mechanism is unknown. Here we aim...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73477-3
更新日期:2020-10-01 00:00:00
abstract::In this study, we assessed the role of different reactive oxygen species (ROS) generated by soft jet plasma and chemical-induced ROS systems with regard to cell death in T98G, A549, HEK293 and MRC5 cell lines. For a comparison with plasma, we generated superoxide anion (O2(-)), hydroxyl radical (HO·), and hydrogen per...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08587
更新日期:2015-02-26 00:00:00
abstract::Oxidative stress due to hypobaric hypoxia at extreme altitudes causes severe neuronal damage and irreversible cognitive loss. Owing to contraindications of current drug therapies, the aim of the study was to investigate memory enhancing potential of aqueous extract of Ganoderma lucidum (GLAQ) and underlying neuroprote...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65812-5
更新日期:2020-06-02 00:00:00
abstract::The innovation of iconic gestures is essential to establishing the vocabularies of signed languages, but might iconicity also play a role in the origin of spoken words? Can people create novel vocalizations that are comprehensible to naïve listeners without prior convention? We launched a contest in which participants...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20961-6
更新日期:2018-02-08 00:00:00
abstract::Patients with chronic kidney disease have a greater risk of cognitive impairment. Cerebral uremic solute accumulation causes uremic encephalopathy; however, the association of protein-bound uremic toxins on cognitive function remains unclear. The present study aimed to investigate the association of two protein-bound ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57004-7
更新日期:2019-12-31 00:00:00
abstract::Given the complex nature of the interaction between gas and solid atoms, the development of nanoscale science and technology has engendered a need for further understanding of gas transport behavior through nanopores and more tractable models for large-scale simulations. In the present paper, we utilize molecular dyna...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23629
更新日期:2016-03-29 00:00:00
abstract::Knowledge of the structure-property-function relationship of humic substances (HSs) is key for understanding their role in soil. Despite progress, studies on this topic are still under discussion. We analyzed 37 humic fractions with respect to their isotopic composition, structural characteristics, and properties resp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20798
更新日期:2016-02-10 00:00:00
abstract::The symmetrically stable craniofacial bony structure supports the complex functions and delicate contour of the face. Congenital craniofacial deformities are often accompanied by bony defects and have been repetitively correlated with compromised dento-maxillary stability, but neither the extent nor the pattern of cle...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40478-w
更新日期:2019-03-12 00:00:00
abstract::Malaria-associated acute lung injury (ALI) is a frequent complication of severe malaria that is often caused by "excessive" immune responses. To better understand the mechanism of ALI in malaria infection, here we investigated the roles of galectin (Gal)-1, 3, 8, 9 and the receptors of Gal-9 (Tim-3, CD44, CD137, and P...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32024
更新日期:2016-08-24 00:00:00
abstract::Vitamin D may reduce mortality from prostate cancer (PC). We examined the associations of post-treatment plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D concentrations with PC mortality. Participants were PC cases from the New South Wales Prostate Cancer Care. All contactable and consenting participants, at 4.9...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62182-w
更新日期:2020-05-08 00:00:00
abstract::Various important topological properties of healthy brain connectome have recently been identified. However, the manner in which brain lesion changes the functional network topology is unknown. We examined how critical specific brain areas are in the maintenance of network topology using multivariate support vector re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17886-x
更新日期:2017-12-20 00:00:00
abstract::Cattleyak are interspecific hybrids between cattle and yak, exhibiting the same prominent adaptability as yak and much higher performances than yak. However, male infertility of cattleyak resulted from spermatogenic arrest has greatly restricted their effective utilization in yak breeding. In past decades, much work h...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18607-0
更新日期:2018-01-12 00:00:00