Abstract:
:The objective of this study was to investigate the associations between selenium exposure and cancer risk. We identified 69 studies and applied meta-analysis, meta-regression and dose-response analysis to obtain available evidence. The results indicated that high selenium exposure had a protective effect on cancer risk (pooled OR = 0.78; 95%CI: 0.73-0.83). The results of linear and nonlinear dose-response analysis indicated that high serum/plasma selenium and toenail selenium had the efficacy on cancer prevention. However, we did not find a protective efficacy of selenium supplement. High selenium exposure may have different effects on specific types of cancer. It decreased the risk of breast cancer, lung cancer, esophageal cancer, gastric cancer, and prostate cancer, but it was not associated with colorectal cancer, bladder cancer, and skin cancer.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Cai X,Wang C,Yu W,Fan W,Wang S,Shen N,Wu P,Li X,Wang Fdoi
10.1038/srep19213subject
Has Abstractpub_date
2016-01-20 00:00:00pages
19213issn
2045-2322pii
srep19213journal_volume
6pub_type
杂志文章,meta分析abstract::Jasmonates (JAs) play important roles in plant growth, development and defense. Comprehensive metabolomics profiling of plants under JA treatment provides insights into the interaction and regulation network of plant hormones. Here we applied high resolution mass spectrometry based metabolomics approach on Arabidopsis...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37674
更新日期:2016-11-24 00:00:00
abstract::As a universal quantum character of quantum correlation, the freezing phenomenon is researched by geometry and quantum discord methods, respectively. In this paper, the properties of Rènyi discord is studied for two independent Dimer System coupled to two correlated Fermi-spin environments under the non-Markovian cond...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51206-9
更新日期:2019-10-14 00:00:00
abstract::An important safety concern on cell-based gene therapy is that few methods have been available to control the proliferation and functioning of therapeutic protein-expressing cells after transplantation. We previously reported that the proliferation and functioning of the cells transfected with herpes simplex virus thy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55269-6
更新日期:2019-12-11 00:00:00
abstract::This study investigates the relationship between objective cognitive impairment (OCI), subjective cognitive complaints and depressive symptoms in men and women with classical and non-classical Fabry disease (FD). Cognitive functioning was assessed using a neuropsychological test battery, subjective cognitive complaint...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37320-0
更新日期:2019-01-17 00:00:00
abstract::It is well recognized that osteocytes communicate with each other via gap junctions and that connxin43 (Cx43) shows its great potential in gap junction for the contribution enabling transmission of small molecules and operating in an autocrine/a paracrine manner. Fibroblast growth factors (FGFs) play significant roles...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33247-8
更新日期:2018-10-04 00:00:00
abstract::The GntR family transcription regulator HpaR1 identified from Xanthomonas campestris pv. campestris has been previously shown to positively regulate the genes responsible for hypersensitive reaction and pathogenicity and to autorepress its own expression. Here, we demonstrated that HpaR1 is a global regulator that pos...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19862
更新日期:2016-01-28 00:00:00
abstract::The prefrontal cortex (PF) is involved in outcome-based flexible adaptation in a dynamically changing environment. The outcome signal dissipates gradually over time, but the temporal dynamics of this dissipation remains unknown. To examine this issue, we analyzed the outcome-related activity of PF neurons in 2 monkeys...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25622
更新日期:2016-05-10 00:00:00
abstract::Prosthesis embodiment, the perception of a prosthesis as part of one's body, may be an important component of functional recovery for individuals with upper limb absence. This work determined whether embodiment differs between body-powered and myoelectric prosthesis users. In a sample of nine individuals with transrad...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72470-0
更新日期:2020-09-22 00:00:00
abstract::Awe, a complex emotion composed by the appraisal components of vastness and need for accommodation, is a profound and often meaningful experience. Despite its importance, psychologists have only recently begun empirical study of awe. At the experimental level, a main issue concerns how to elicit high intensity awe exp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01242-0
更新日期:2017-04-27 00:00:00
abstract::A better understanding of the mechanisms underlying cell tropisms and the efficiency of viral infection is critical for the development of vaccines and antiviral drugs for viral diseases. In this study, we worked on the entry mechanisms of guinea pig cytomegalovirus and found that endogenous expression of a combinatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65545-5
更新日期:2020-05-22 00:00:00
abstract::Peach (Prunus persica, Rosaceae) is an extremely popular tree fruit worldwide, with an annual production near 20 million tons. Peach is widely thought to have origins in China, but its evolutionary history is largely unknown. The oldest evidence for the peach has been Chinese archaeological records dating to 8000-7000...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16794
更新日期:2015-11-26 00:00:00
abstract::Studies on the transcriptional control of gene expression play an important role in many areas of biology. Reference genes, which are often referred to as housekeeping genes, such as GAPDH, G3PDH, EF2, RpL7A, RpL10, TUBα and Actin, have traditionally been assumed to be stably expressed in all conditions, and they are ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08630-6
更新日期:2017-08-21 00:00:00
abstract::To compare the performance of eight score systems (MELD, uMELD, MELD-Na. iMELD, UKELD, MELD-AS, CTP, and mCTP) in predicting the post-transplant mortality, we analyzed the data of 6,014 adult cirrhotic patients who underwent liver transplantation between January 2003 and December 2010 from the China Liver Transplant R...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42253
更新日期:2017-02-13 00:00:00
abstract::Non-fibrillar protein aggregates that appear in the earlier stages of amyloid fibril formation are sometimes considered to play a key role in amyloid nucleation; however, the structural features of these aggregates currently remain unclear. We herein identified a characteristic pathway of fibril formation by human ins...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18390-y
更新日期:2018-01-08 00:00:00
abstract::Soybean seeds are an important source of vegetable oil and biomaterials. The content of individual triacylglycerol species (TAG) in soybean seeds is difficult to quantify in an accurate and rapid way. The present study establishes an approach to quantify TAG species in soybean seeds utilizing an electrospray ionizatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06581
更新日期:2014-10-10 00:00:00
abstract::Open algal cultivation platforms often suffer crop losses to herbivorous grazers that have potential to devastate biomass production within a few days. While a number of studies suggest synthetic chemicals as control agents for voracious algal grazers, environmental and safety concerns associated with the use of these...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23535-8
更新日期:2018-03-29 00:00:00
abstract::Lipomas are benign fatty tumors with a high prevalence rate, mostly found in adults but have a good prognosis. Until now, reason for lipoma occurrence not been identified. We performed whole exome sequencing to define the mutational spectrum in ten lipoma patients along with their matching control samples. We presente...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50805-w
更新日期:2019-10-07 00:00:00
abstract::The rainbow trout, a carnivorous fish, displays a 'glucose-intolerant' phenotype revealed by persistent hyperglycaemia when fed a high carbohydrate diet (HighCHO). Epigenetics refers to heritable changes in gene activity and is closely related to environmental changes and thus to metabolism adjustments governed by nut...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32187
更新日期:2016-08-26 00:00:00
abstract::During locomotion, the human ankle-foot system dynamically alters its gearing, or leverage of the ankle joint on the ground. Shifting ankle-foot gearing regulates speed of plantarflexor (i.e., calf muscle) contraction, which influences economy of force production. Here, we tested the hypothesis that manipulating ankle...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65626-5
更新日期:2020-05-29 00:00:00
abstract::The selective arterial calcium injection (SACI) test is useful for patients with functional pancreatic neuroendocrine tumors (F-PNETs). This study evaluated which patients with F-PNETs would benefit from the SACI test. We retrospectively analyzed the preoperative findings of patients on computed tomography (CT), magne...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80538-0
更新日期:2021-01-08 00:00:00
abstract::Since domestication, a large number of livestock breeds adapted to local conditions have been created by natural and artificial selection, representing one of the most powerful ways in which human groups have constructed niches to meet their need. Although many authors have described local breeds as the result of cult...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24641-3
更新日期:2018-04-24 00:00:00
abstract::Bacteria show sophisticated control of their cellular organization, and many bacteria deploy different polar landmark proteins to organize the cell pole. Super-resolution microscopy, such as Photo-Activated Localization Microscopy (PALM), provides the nanoscale localization of molecules and is crucial for better under...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43051-7
更新日期:2019-04-30 00:00:00
abstract::Green reduction of graphene oxide (GO) by phytochemicals was explored using the aqueous extract of kaffir lime peels. The research methods included preparation of extracts, preparation of GO, preparation and characterization of reduced-GO (RGO) using Fourier Transform Infrared (FTIR), X-ray diffraction (XRD), and UV-V...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57433-9
更新日期:2020-01-20 00:00:00
abstract::The Y chromosome has high genetic variability with low rates of parallel and back mutations, which make up the most informative haplotyping system. To examine whether Y chromosome haplogroups (Y-hgs) could modify the effects of autosomal variants on non-obstructive azoospermia (NOA), based on our previous genome-wide ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33363
更新日期:2016-09-15 00:00:00
abstract::We investigated the effect of the crude herbal extract from Uncaria tomentosa (UT) on non-alcoholic fatty liver disease (NAFLD) in two models of obesity: high fat diet (HFD) and genetically obese (ob/ob) mice. Both obese mouse models were insulin resistant and exhibited an abundance of lipid droplets in the hepatocyte...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29044-y
更新日期:2018-07-20 00:00:00
abstract::To date, only two pigments have been identified in avian eggshells: rusty-brown protoporphyrin IX and blue-green biliverdin IXα. Most avian eggshell colours can be produced by a mixture of these two tetrapyrrolic pigments. However, tinamou (Tinamidae) eggshells display colours not easily rationalised by combination of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68070-7
更新日期:2020-07-09 00:00:00
abstract::Enamel proteins form a scaffold for growing hydroxyapatite crystals during enamel formation. They are then almost completely degraded during enamel maturation, resulting in a protein content of only 1% (w/v) in mature enamel. Nevertheless, this small amount of remaining proteins has important effects on the mechanical...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15194
更新日期:2015-10-15 00:00:00
abstract::The clinical application of dihydroartemisinin (DHA) has been hampered due to its poor water-solubility. To overcome this hurdle, we devised a novel polymer-drug conjugate, multiarm polyethylene glycol-dihydroartemisinin (PEG-DHA), made by linking DHA with multiarm polyethylene glycol. Herein, we investigated PEG-DHA ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05871
更新日期:2014-07-29 00:00:00
abstract::In this study, nanowires/nanowalls were generated on a silicon wafer through a chemical etching method. Octadecyltrichlorosilane (OTS) was deposited onto the nanowire/nanowall surfaces to alter their hydrophobicity. The hydrophobic characteristics of the surfaces were further modified via a 1.5-μm-thick layer of n-oct...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38678
更新日期:2016-12-09 00:00:00
abstract::Osteosarcoma pulmonary metastases are typically treated with resection and/or chemotherapy. We hypothesize that stereotactic radiosurgery (SRS) can be an alternative to surgery that can achieve high rates of local control with limited toxicity. From January 2005 to December 2013, 73 patients who developed pulmonary me...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14521-7
更新日期:2017-12-12 00:00:00