Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression.

Abstract:

:The objective of this study was to investigate the associations between selenium exposure and cancer risk. We identified 69 studies and applied meta-analysis, meta-regression and dose-response analysis to obtain available evidence. The results indicated that high selenium exposure had a protective effect on cancer risk (pooled OR = 0.78; 95%CI: 0.73-0.83). The results of linear and nonlinear dose-response analysis indicated that high serum/plasma selenium and toenail selenium had the efficacy on cancer prevention. However, we did not find a protective efficacy of selenium supplement. High selenium exposure may have different effects on specific types of cancer. It decreased the risk of breast cancer, lung cancer, esophageal cancer, gastric cancer, and prostate cancer, but it was not associated with colorectal cancer, bladder cancer, and skin cancer.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Cai X,Wang C,Yu W,Fan W,Wang S,Shen N,Wu P,Li X,Wang F

doi

10.1038/srep19213

subject

Has Abstract

pub_date

2016-01-20 00:00:00

pages

19213

issn

2045-2322

pii

srep19213

journal_volume

6

pub_type

杂志文章,meta分析
  • Effects of MeJA on Arabidopsis metabolome under endogenous JA deficiency.

    abstract::Jasmonates (JAs) play important roles in plant growth, development and defense. Comprehensive metabolomics profiling of plants under JA treatment provides insights into the interaction and regulation network of plant hormones. Here we applied high resolution mass spectrometry based metabolomics approach on Arabidopsis...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep37674

    authors: Cao J,Li M,Chen J,Liu P,Li Z

    更新日期:2016-11-24 00:00:00

  • The freezing Rènyi quantum discord.

    abstract::As a universal quantum character of quantum correlation, the freezing phenomenon is researched by geometry and quantum discord methods, respectively. In this paper, the properties of Rènyi discord is studied for two independent Dimer System coupled to two correlated Fermi-spin environments under the non-Markovian cond...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51206-9

    authors: Li XY,Zhu QS,Zhu MZ,Wu H,Wu SY,Zhu MC

    更新日期:2019-10-14 00:00:00

  • Cell-based interferon gene therapy using proliferation-controllable, interferon-releasing mesenchymal stem cells.

    abstract::An important safety concern on cell-based gene therapy is that few methods have been available to control the proliferation and functioning of therapeutic protein-expressing cells after transplantation. We previously reported that the proliferation and functioning of the cells transfected with herpes simplex virus thy...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55269-6

    authors: Tsujimura M,Kusamori K,Katsumi H,Sakane T,Yamamoto A,Nishikawa M

    更新日期:2019-12-11 00:00:00

  • Predictors of objective cognitive impairment and subjective cognitive complaints in patients with Fabry disease.

    abstract::This study investigates the relationship between objective cognitive impairment (OCI), subjective cognitive complaints and depressive symptoms in men and women with classical and non-classical Fabry disease (FD). Cognitive functioning was assessed using a neuropsychological test battery, subjective cognitive complaint...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37320-0

    authors: Körver S,Geurtsen GJ,Hollak CEM,van Schaik IN,Longo MGF,Lima MR,Vedolin L,Dijkgraaf MGW,Langeveld M

    更新日期:2019-01-17 00:00:00

  • FGF-7 Dictates Osteocyte Cell Processes Through Beta-Catenin Transduction.

    abstract::It is well recognized that osteocytes communicate with each other via gap junctions and that connxin43 (Cx43) shows its great potential in gap junction for the contribution enabling transmission of small molecules and operating in an autocrine/a paracrine manner. Fibroblast growth factors (FGFs) play significant roles...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-33247-8

    authors: Liu XY,Li X,Bai MR,Chen X,Wang CL,Xie J,Ye L

    更新日期:2018-10-04 00:00:00

  • Characterization of the GntR family regulator HpaR1 of the crucifer black rot pathogen Xanthomonas campestris pathovar campestris.

    abstract::The GntR family transcription regulator HpaR1 identified from Xanthomonas campestris pv. campestris has been previously shown to positively regulate the genes responsible for hypersensitive reaction and pathogenicity and to autorepress its own expression. Here, we demonstrated that HpaR1 is a global regulator that pos...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep19862

    authors: Su HZ,Wu L,Qi YH,Liu GF,Lu GT,Tang JL

    更新日期:2016-01-28 00:00:00

  • Event- and time-dependent decline of outcome information in the primate prefrontal cortex.

    abstract::The prefrontal cortex (PF) is involved in outcome-based flexible adaptation in a dynamically changing environment. The outcome signal dissipates gradually over time, but the temporal dynamics of this dissipation remains unknown. To examine this issue, we analyzed the outcome-related activity of PF neurons in 2 monkeys...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25622

    authors: Marcos E,Tsujimoto S,Genovesio A

    更新日期:2016-05-10 00:00:00

  • Differential experiences of embodiment between body-powered and myoelectric prosthesis users.

    abstract::Prosthesis embodiment, the perception of a prosthesis as part of one's body, may be an important component of functional recovery for individuals with upper limb absence. This work determined whether embodiment differs between body-powered and myoelectric prosthesis users. In a sample of nine individuals with transrad...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-72470-0

    authors: Engdahl SM,Meehan SK,Gates DH

    更新日期:2020-09-22 00:00:00

  • Effectiveness of Immersive Videos in Inducing Awe: An Experimental Study.

    abstract::Awe, a complex emotion composed by the appraisal components of vastness and need for accommodation, is a profound and often meaningful experience. Despite its importance, psychologists have only recently begun empirical study of awe. At the experimental level, a main issue concerns how to elicit high intensity awe exp...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01242-0

    authors: Chirico A,Cipresso P,Yaden DB,Biassoni F,Riva G,Gaggioli A

    更新日期:2017-04-27 00:00:00

  • Enhancement of guinea pig cytomegalovirus infection by two endogenously expressed components of the pentameric glycoprotein complex in epithelial cells.

    abstract::A better understanding of the mechanisms underlying cell tropisms and the efficiency of viral infection is critical for the development of vaccines and antiviral drugs for viral diseases. In this study, we worked on the entry mechanisms of guinea pig cytomegalovirus and found that endogenous expression of a combinatio...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65545-5

    authors: Okumura M,Matsuura-Miura M,Makino R,Miura T,Noguchi K,Majima R,Koshizuka T,Inoue N

    更新日期:2020-05-22 00:00:00

  • Peaches Preceded Humans: Fossil Evidence from SW China.

    abstract::Peach (Prunus persica, Rosaceae) is an extremely popular tree fruit worldwide, with an annual production near 20 million tons. Peach is widely thought to have origins in China, but its evolutionary history is largely unknown. The oldest evidence for the peach has been Chinese archaeological records dating to 8000-7000...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16794

    authors: Su T,Wilf P,Huang Y,Zhang S,Zhou Z

    更新日期:2015-11-26 00:00:00

  • Evaluation of Candidate Reference Genes for Quantitative Gene Expression Analysis in Spodoptera exigu a after Long-time Exposure to Cadmium.

    abstract::Studies on the transcriptional control of gene expression play an important role in many areas of biology. Reference genes, which are often referred to as housekeeping genes, such as GAPDH, G3PDH, EF2, RpL7A, RpL10, TUBα and Actin, have traditionally been assumed to be stably expressed in all conditions, and they are ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08630-6

    authors: Płachetka-Bożek A,Augustyniak M

    更新日期:2017-08-21 00:00:00

  • Predicting short-term survival after liver transplantation on eight score systems: a national report from China Liver Transplant Registry.

    abstract::To compare the performance of eight score systems (MELD, uMELD, MELD-Na. iMELD, UKELD, MELD-AS, CTP, and mCTP) in predicting the post-transplant mortality, we analyzed the data of 6,014 adult cirrhotic patients who underwent liver transplantation between January 2003 and December 2010 from the China Liver Transplant R...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep42253

    authors: Ling Q,Dai H,Zhuang R,Shen T,Wang W,Xu X,Zheng S

    更新日期:2017-02-13 00:00:00

  • A specific form of prefibrillar aggregates that functions as a precursor of amyloid nucleation.

    abstract::Non-fibrillar protein aggregates that appear in the earlier stages of amyloid fibril formation are sometimes considered to play a key role in amyloid nucleation; however, the structural features of these aggregates currently remain unclear. We herein identified a characteristic pathway of fibril formation by human ins...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18390-y

    authors: Yamamoto N,Tsuhara S,Tamura A,Chatani E

    更新日期:2018-01-08 00:00:00

  • Comprehensive quantification of triacylglycerols in soybean seeds by electrospray ionization mass spectrometry with multiple neutral loss scans.

    abstract::Soybean seeds are an important source of vegetable oil and biomaterials. The content of individual triacylglycerol species (TAG) in soybean seeds is difficult to quantify in an accurate and rapid way. The present study establishes an approach to quantify TAG species in soybean seeds utilizing an electrospray ionizatio...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep06581

    authors: Li M,Butka E,Wang X

    更新日期:2014-10-10 00:00:00

  • Application of biosurfactant from Bacillus subtilis C9 for controlling cladoceran grazers in algal cultivation systems.

    abstract::Open algal cultivation platforms often suffer crop losses to herbivorous grazers that have potential to devastate biomass production within a few days. While a number of studies suggest synthetic chemicals as control agents for voracious algal grazers, environmental and safety concerns associated with the use of these...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-23535-8

    authors: Yun JH,Cho DH,Lee B,Kim HS,Chang YK

    更新日期:2018-03-29 00:00:00

  • Identification of somatic alterations in lipoma using whole exome sequencing.

    abstract::Lipomas are benign fatty tumors with a high prevalence rate, mostly found in adults but have a good prognosis. Until now, reason for lipoma occurrence not been identified. We performed whole exome sequencing to define the mutational spectrum in ten lipoma patients along with their matching control samples. We presente...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50805-w

    authors: Kanojia D,Dakle P,Mayakonda A,Parameswaran R,Puhaindran ME,Min VLK,Madan V,Koeffler P

    更新日期:2019-10-07 00:00:00

  • Remodelling of the hepatic epigenetic landscape of glucose-intolerant rainbow trout (Oncorhynchus mykiss) by nutritional status and dietary carbohydrates.

    abstract::The rainbow trout, a carnivorous fish, displays a 'glucose-intolerant' phenotype revealed by persistent hyperglycaemia when fed a high carbohydrate diet (HighCHO). Epigenetics refers to heritable changes in gene activity and is closely related to environmental changes and thus to metabolism adjustments governed by nut...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep32187

    authors: Marandel L,Lepais O,Arbenoits E,Véron V,Dias K,Zion M,Panserat S

    更新日期:2016-08-26 00:00:00

  • Gearing Up the Human Ankle-Foot System to Reduce Energy Cost of Fast Walking.

    abstract::During locomotion, the human ankle-foot system dynamically alters its gearing, or leverage of the ankle joint on the ground. Shifting ankle-foot gearing regulates speed of plantarflexor (i.e., calf muscle) contraction, which influences economy of force production. Here, we tested the hypothesis that manipulating ankle...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65626-5

    authors: Ray SF,Takahashi KZ

    更新日期:2020-05-29 00:00:00

  • Usefulness of selective arterial calcium injection tests for functional pancreatic neuroendocrine tumors.

    abstract::The selective arterial calcium injection (SACI) test is useful for patients with functional pancreatic neuroendocrine tumors (F-PNETs). This study evaluated which patients with F-PNETs would benefit from the SACI test. We retrospectively analyzed the preoperative findings of patients on computed tomography (CT), magne...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-80538-0

    authors: Nakano Y,Kitago M,Shinoda M,Nakatsuka S,Kurihara I,Yagi H,Abe Y,Oshima G,Hori S,Yokose T,Kitagawa Y

    更新日期:2021-01-08 00:00:00

  • Human and ecological determinants of the spatial structure of local breed diversity.

    abstract::Since domestication, a large number of livestock breeds adapted to local conditions have been created by natural and artificial selection, representing one of the most powerful ways in which human groups have constructed niches to meet their need. Although many authors have described local breeds as the result of cult...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-24641-3

    authors: Colino-Rabanal VJ,Rodríguez-Díaz R,Blanco-Villegas MJ,Peris SJ,Lizana M

    更新日期:2018-04-24 00:00:00

  • Single molecule super-resolution imaging of bacterial cell pole proteins with high-throughput quantitative analysis pipeline.

    abstract::Bacteria show sophisticated control of their cellular organization, and many bacteria deploy different polar landmark proteins to organize the cell pole. Super-resolution microscopy, such as Photo-Activated Localization Microscopy (PALM), provides the nanoscale localization of molecules and is crucial for better under...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43051-7

    authors: Altinoglu I,Merrifield CJ,Yamaichi Y

    更新日期:2019-04-30 00:00:00

  • Green Reduction of Graphene Oxide using Kaffir Lime Peel Extract (Citrus hystrix) and Its Application as Adsorbent for Methylene Blue.

    abstract::Green reduction of graphene oxide (GO) by phytochemicals was explored using the aqueous extract of kaffir lime peels. The research methods included preparation of extracts, preparation of GO, preparation and characterization of reduced-GO (RGO) using Fourier Transform Infrared (FTIR), X-ray diffraction (XRD), and UV-V...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-57433-9

    authors: Wijaya R,Andersan G,Permatasari Santoso S,Irawaty W

    更新日期:2020-01-20 00:00:00

  • Y chromosome haplogroups based genome-wide association study pinpoints revelation for interactions on non-obstructive azoospermia.

    abstract::The Y chromosome has high genetic variability with low rates of parallel and back mutations, which make up the most informative haplotyping system. To examine whether Y chromosome haplogroups (Y-hgs) could modify the effects of autosomal variants on non-obstructive azoospermia (NOA), based on our previous genome-wide ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep33363

    authors: Lu C,Wen Y,Hu W,Lu F,Qin Y,Wang Y,Li S,Yang S,Lin Y,Wang C,Jin L,Shen H,Sha J,Wang X,Hu Z,Xia Y

    更新日期:2016-09-15 00:00:00

  • Uncaria tomentosa improves insulin sensitivity and inflammation in experimental NAFLD.

    abstract::We investigated the effect of the crude herbal extract from Uncaria tomentosa (UT) on non-alcoholic fatty liver disease (NAFLD) in two models of obesity: high fat diet (HFD) and genetically obese (ob/ob) mice. Both obese mouse models were insulin resistant and exhibited an abundance of lipid droplets in the hepatocyte...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-29044-y

    authors: Araujo LCC,Feitosa KB,Murata GM,Furigo IC,Teixeira SA,Lucena CF,Ribeiro LM,Muscará MN,Costa SKP,Donato J Jr,Bordin S,Curi R,Carvalho CRO

    更新日期:2018-07-20 00:00:00

  • Expanding the eggshell colour gamut: uroerythrin and bilirubin from tinamou (Tinamidae) eggshells.

    abstract::To date, only two pigments have been identified in avian eggshells: rusty-brown protoporphyrin IX and blue-green biliverdin IXα. Most avian eggshell colours can be produced by a mixture of these two tetrapyrrolic pigments. However, tinamou (Tinamidae) eggshells display colours not easily rationalised by combination of...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68070-7

    authors: Hamchand R,Hanley D,Prum RO,Brückner C

    更新日期:2020-07-09 00:00:00

  • The effect of enamel proteins on erosion.

    abstract::Enamel proteins form a scaffold for growing hydroxyapatite crystals during enamel formation. They are then almost completely degraded during enamel maturation, resulting in a protein content of only 1% (w/v) in mature enamel. Nevertheless, this small amount of remaining proteins has important effects on the mechanical...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15194

    authors: Baumann T,Carvalho TS,Lussi A

    更新日期:2015-10-15 00:00:00

  • Novel multiarm polyethylene glycol-dihydroartemisinin conjugates enhancing therapeutic efficacy in non-small-cell lung cancer.

    abstract::The clinical application of dihydroartemisinin (DHA) has been hampered due to its poor water-solubility. To overcome this hurdle, we devised a novel polymer-drug conjugate, multiarm polyethylene glycol-dihydroartemisinin (PEG-DHA), made by linking DHA with multiarm polyethylene glycol. Herein, we investigated PEG-DHA ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep05871

    authors: Dai L,Wang L,Deng L,Liu J,Lei J,Li D,He J

    更新日期:2014-07-29 00:00:00

  • Surface Characteristics of Silicon Nanowires/Nanowalls Subjected to Octadecyltrichlorosilane Deposition and n-octadecane Coating.

    abstract::In this study, nanowires/nanowalls were generated on a silicon wafer through a chemical etching method. Octadecyltrichlorosilane (OTS) was deposited onto the nanowire/nanowall surfaces to alter their hydrophobicity. The hydrophobic characteristics of the surfaces were further modified via a 1.5-μm-thick layer of n-oct...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep38678

    authors: Yilbas BS,Salhi B,Yousaf MR,Al-Sulaiman F,Ali H,Al-Aqeeli N

    更新日期:2016-12-09 00:00:00

  • Efficacy and safety of stereotactic radiosurgery for pulmonary metastases from osteosarcoma: Experience in 73 patients.

    abstract::Osteosarcoma pulmonary metastases are typically treated with resection and/or chemotherapy. We hypothesize that stereotactic radiosurgery (SRS) can be an alternative to surgery that can achieve high rates of local control with limited toxicity. From January 2005 to December 2013, 73 patients who developed pulmonary me...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-14521-7

    authors: Yu W,Liu Z,Tang L,Lin F,Yao Y,Shen Z

    更新日期:2017-12-12 00:00:00