Abstract：
:A better understanding of the mechanisms underlying cell tropisms and the efficiency of viral infection is critical for the development of vaccines and antiviral drugs for viral diseases. In this study, we worked on the entry mechanisms of guinea pig cytomegalovirus and found that endogenous expression of a combination of two components (GP131 and GP133) of the pentameric glycoprotein complex, which is required for non-fibroblast cell tropisms, enhanced viral infection more than 10-fold. In addition, D138A alteration in GP131 increased this enhancement by an additional 10-fold. Although differences in the efficiency of viral infection among various cell types are usually explained by differences in viral entry or traffic processes, our experimental evidences dismissed such possibilities. Instead, our findings that i) endogenous expression of GP131 and GP133 after nuclear delivery of viral DNA still enhanced infection and ii) an HDAC inhibitor overcame the need of the endogenous expression led us to hypothesize a novel mechanism that controls the efficiency of viral infection through the activation of gene expression from viral DNA delivered to the nuclei. Further studies of this unexpected phenomena warrant to understand novel but also general mechanisms for cell tropisms of viral infection and determinants that control infection efficiency.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Okumura M,Matsuura-Miura M,Makino R,Miura T,Noguchi K,Majima R,Koshizuka T,Inoue Ndoi
10.1038/s41598-020-65545-5subject
Has Abstractpub_date
2020-05-22 00:00:00pages
8530issue
1issn
2045-2322pii
10.1038/s41598-020-65545-5journal_volume
10pub_type
杂志文章abstract：:We report evidence of the transition from n- to p-type conduction of InN with increasing Mg dopant concentration by using photoconductivity (PC) measurement at room temperature. This transition is depicted as a conversion from negative to positive PC under above-bandgap optical excitation. The n- to p-type transition ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04371
更新日期：2014-03-13 00:00:00
abstract：:The alveolar echinococcosis of human is a severe helminthic disease caused by the larva of Echinococcus multilocularis tapeworms. Novel compounds or therapy strategies for the treatment of alveolar echinococcosis are urgently needed due to the limitation of the widely used albendazole. Magnetic microspheres as drug ca...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69484-z
更新日期：2020-07-28 00:00:00
abstract：:Adenosine receptors (ARs) are potential therapeutic targets for Parkinson's disease, diabetes, pain, stroke and cancers. Prediction of subtype selectivity is therefore important from both therapeutic and mechanistic perspectives. In this paper, we introduced a shape similarity profile as molecular descriptor, namely t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36595
更新日期：2016-11-04 00:00:00
abstract：:Electric double-layer capacitors (EDLCs) or supercapacitors (SCs) are fast energy storage devices with high pulse efficiency and superior cyclability, which makes them useful in various applications including electronics, vehicles and grids. Aqueous SCs are considered to be more environmentally friendly than those bas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39836
更新日期：2017-01-05 00:00:00
abstract：:Functionalization of monoclonal antibodies (mAbs) requires chemical derivatization and/or genetic manipulation. Inherent in these methods are challenges with protein heterogeneity, stability and solubility. Such perturbations could potentially be avoided by using a high affinity, non-covalent intermediate to bridge th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07817
更新日期：2015-01-15 00:00:00
abstract：:Our recent studies, using (SWRxNZB)F1 (SNF1) mice, showed a potential contribution of the gut microbiota and pro-inflammatory immune responses of the gut mucosa to systemic autoimmunity in lupus. Here, using this mouse model, we determined the abundance and the nAg reactivity of IgA antibody produced in the intestine ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71272-8
更新日期：2020-08-31 00:00:00
abstract：:We analyse theoretically the spatiotemporal dynamics of two incoherent counterpropagating Airy beams interacting in a photorefractive crystal under focusing conditions. For a large enough nonlinearity strength the interaction between the two Airy beams leads to light-induced waveguiding. The stability of the waveguide...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13463
更新日期：2015-08-28 00:00:00
abstract：:Colloidal based films have been widely developed for a wide range of applications including chemical and electrical barrier coatings, photonic materials, biomaterials, and pharmaceutical oral drug delivery. Many previous studies investigate methods to generate uniformity or desired stratification of the final componen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66875-0
更新日期：2020-06-24 00:00:00
abstract：:Two polar vessels, Akademik Shokalskiy and Xuelong, were trapped by thick sea ice in the Antarctic coastal region just to the west of 144°E and between 66.5°S and 67°S in late December 2013. This event demonstrated the rapid establishment of extreme Antarctic sea ice conditions on synoptic time scales. The event was a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05317
更新日期：2014-06-17 00:00:00
abstract：:Human papillomavirus (HPV) infection, a primary cause of genital cancer, is also related to the increasing incidence of oropharyngeal cancer among young men. Relatively little is known about the concurrence of oral and genital infection among healthy individuals. Oral and genital swab exfoliated cells were collected s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15637
更新日期：2015-10-27 00:00:00
abstract：:In this study, the effects of different feeding frequencies on the growth and the expression of genes in the GH/IGF axis were assessed in juvenile Chinese sturgeon. The newly hatched Chinese sturgeons were bred for 38 days at three different feeding frequencies groups (feeding frequency of two times a day, TWD; three ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74120-x
更新日期：2020-10-15 00:00:00
abstract：:A novel type of sub-lattice of the Jahn-Teller (JT) centers was arranged in Ti-doped barium hexaferrite BaFe12O19. In the un-doped crystal all iron ions, sitting in five different crystallographic positions, are Fe3+ in the high-spin configuration (S = 5/2) and have a non-degenerate ground state. We show that the elec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63915-7
更新日期：2020-04-27 00:00:00
abstract：:We propose a novel scheme to realize an optical waveguide induced by an active Raman gain (ARG) process in a four-level N-type atomic system. Because of the nature of the ARG, there are two distinct features related to the waveguide: i) It is not absorptive, on the contrary, weak gain is presented; ii) It can be impro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14456-z
更新日期：2017-10-27 00:00:00
abstract：:Si holds great promise as an alloying anode material for Li-ion batteries with improved energy density because of its high theoretical specific capacity and favorable operation voltage range. However, the large volume expansion of Si during electrochemical reaction with Li and the associated adverse effects strongly l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13261-y
更新日期：2017-10-12 00:00:00
abstract：:Hypoxia is a recognized characteristic of tumors that influences efficacy of radiotherapy (RT). Photoacoustic imaging (PAI) is a relatively new imaging technique that exploits the optical characteristics of hemoglobin to provide information on tissue oxygenation. In the present study, PAI based measures of tumor oxyge...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21237
更新日期：2016-02-17 00:00:00
abstract：:Although habitat transformation is one of the main causes of biodiversity loss, there are many examples of species successfully occupying and even proliferating in highly human-modified habitats such are the cities. Thus, there is an increasing interest in understanding the drivers favoring urban life for some species...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03853-z
更新日期：2017-06-14 00:00:00
abstract：:Tau is a microtubule-associated protein whose C-terminal domain consisting of four repeat regions R1, R2, R3 and R4 binds to microtubules to stabilize them. In several neurodegenerative diseases, tau detaches from microtubules to form insoluble aggregates leading to tauopathy. Microtubules are made up of αβ tubulin su...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47249-7
更新日期：2019-07-25 00:00:00
abstract：:We have observed that one in three patients admitted to the Neurological Rehabilitation Ward for Children and Adolescents due to a syndrome or disease associated with neurodysfunction is short of stature for their age. In order to identify the relationship between growth defects (short stature) and syndromes or diseas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52918-8
更新日期：2019-11-11 00:00:00
abstract：:Our study aimed to compare the ability of anthropometric obesity indices to predict MetS and to determine the sex-specific optimal cut-off values for MetS among Malaysian vegetarians. Body weight, height, waist circumference (WC), blood pressure (BP), fasting venous blood sample were collected from 273 vegetarians in ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78035-5
更新日期：2020-11-30 00:00:00
abstract：:The immune responses of males and females to bacterial infections display differences. The mechanisms that underlie this sexual dimorphism are multifactorial. Lipopolysaccharide (LPS) contributes to the pathogenesis of endotoxaemia. We have previously demonstrated that the plasma protein beta-2 glycoprotein-1 (β2GPI) ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07945-8
更新日期：2017-08-15 00:00:00
abstract：:Plant diversity has been shown to determine the composition and functioning of soil biota. Although root-derived organic inputs are discussed as the main drivers of soil communities, experimental evidence is scarce. While there is some evidence that higher root biomass at high plant diversity increases substrate avail...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44641
更新日期：2017-04-04 00:00:00
abstract：:O antigen (O-Ag) in many bacteria is synthesized via the Wzx/Wzy-dependent pathway in which Wzy polymerizes lipid-linked O-Ag subunits to modal lengths regulated by Wzz. Characterization of 83 site-directed mutants of Wzy from Pseudomonas aeruginosa PAO1 (WzyPa) in topologically-mapped periplasmic (PL) and cytoplasmic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03441
更新日期：2013-12-06 00:00:00
abstract：:Lactic acidosis is common in critical care; by contrast, a subtype called alcohol-associated lactic acidosis (AALA) is rarely encountered. The primary purpose of this study was to determine the prognosis of AALA in critically ill patients and the second aim was to determine whether the survival was associated to the p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35368
更新日期：2016-10-17 00:00:00
abstract：:Muscular dystrophy-dystroglycanopathies comprise a heterogeneous and complex group of disorders caused by loss-of-function mutations in a multitude of genes that disrupt the glycobiology of α-dystroglycan, thereby affecting its ability to function as a receptor for extracellular matrix proteins. Of the various genes i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46431-1
更新日期：2019-07-11 00:00:00
abstract：:The Edinburgh Postnatal Depression Scale (EPDS) is frequently used to screen for postpartum depression. However, its factor structure exhibits noticeable inconsistencies between studies. We examined the EPDS at two postpartum time points using a large dataset from outside Western countries. Participants were 91,063 mo...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/s41598-020-67321-x
更新日期：2020-07-15 00:00:00
abstract：:The colour of oyster shells is a very diverse characteristic morphotype, forming intriguing vivid patterns both on the inside and outside of the shell. In the present study, we have identified for the first time, the presence of several porphyrins as constituents of the shell pigmentation of the Crassostrea gigas oyst...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69133-5
更新日期：2020-07-22 00:00:00
abstract：:Tumor-associated macrophages (TAMs) play critical roles in promoting tumor progression and invasion. However, the molecular mechanisms underlying TAM regulation remain to be further investigated and may make significant contributions to cancer treatment. Mammalian microRNAs (miRNAs) have recently been identified as im...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18648
更新日期：2015-12-22 00:00:00
abstract：:Present study aimed to estimate the incidence of recurrent SARS-CoV-2 RNA positivity after recovery from COVID-19 and to determine the factors associated with recurrent positivity. We searched the PubMed, MedRxiv, BioRxiv, the Cochrane Library, ClinicalTrials.gov, and the World Health Organization International Clinic...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-020-77739-y
更新日期：2020-11-26 00:00:00
abstract：:Surface plasmon polaritons (SPPs) and standing wave modes provide interesting and exotic properties for infrared metamaterial absorbers. Coupling of these modes promises further development in this field but restricted by the complexity of modes analysis. In this work, we investigate the general phenomenon of modes co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46093
更新日期：2017-04-11 00:00:00
abstract：:Studies suggest that chromium deficiency is associated with elevated levels of fasting blood glucose, circulating insulin, cholesterol and triglycerides, and decreased proportion of lean body mass. However, data directly relating chromium levels to metabolic syndrome (MetS) risk are lacking. A total of 3,648 American ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15606
更新日期：2015-10-22 00:00:00
