Abstract：
:Human papillomavirus (HPV) infection, a primary cause of genital cancer, is also related to the increasing incidence of oropharyngeal cancer among young men. Relatively little is known about the concurrence of oral and genital infection among healthy individuals. Oral and genital swab exfoliated cells were collected simultaneously from 2566 men in rural China. Using general primer-mediated (SPF1/GP6+) PCR and sequencing, HPV testing results were obtained from 2228 men with both valid oral and genital specimens (β-globin-positive). The prevalence of HPV infection was 6.7% in the oral cavity and 16.9% for the external genitalia. Among 43 men (1.9%, 43/2228) with oral-genital coinfection, 60.5% (26/43) harbored an identical HPV type at both sites. The risk of oral HPV infection was higher among men with genital infection than among uninfected men (11.4% vs. 5.7%, Adjusted OR = 2.3, 95% CI: 1.6-3.4). In addition, having multiple lifetime sexual partners was a significant risk for oral-genital HPV coinfection (Adjusted OR = 2.6, 95% CI: 1.0-7.0; 2 partners vs. 1 partner). These findings provide a basis for further understanding the natural history and transmission dynamics of oral HPV infection.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liu F,Hang D,Deng Q,Liu M,Xi L,He Z,Zhang C,Sun M,Liu Y,Li J,Pan Y,Ning T,Guo C,Liang Y,Xu R,Zhang L,Cai H,Ke Ydoi
10.1038/srep15637subject
Has Abstractpub_date
2015-10-27 00:00:00pages
15637issn
2045-2322pii
srep15637journal_volume
5pub_type
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 已发布勘误
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pub_type： 杂志文章
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更新日期：2015-06-30 00:00:00
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-11-25 00:00:00
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-05-31 00:00:00
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journal_title：Scientific reports
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2018-06-13 00:00:00
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pub_type： 杂志文章
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更新日期：2017-03-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-12-21 00:00:00
