Trimethylamine-N-Oxide (TMAO) Predicts Cardiovascular Mortality in Peripheral Artery Disease.

abstract：:Low haemocompatibility of left ventricular assist devices (LVAD) surfaces necessitates anticoagulative therapy. Endothelial cell (EC) seeding can support haemocompatibility, however, the availability of autologous ECs is limited. In contrast, allogeneic ECs are readily available in sufficient quantity, but HLA dispari...

journal_title：Scientific reports

authors： Figueiredo C,Eicke D,Yuzefovych Y,Avsar M,Hanke JS,Pflaum M,Schmitto JD,Blasczyk R,Haverich A,Wiegmann B

更新日期：2019-08-05 00:00:00

abstract：:The protection of tropical forests is one of the most urgent issues in conservation biology because of the rapid deforestation that has occurred over the last 50 years. Even in protected forests, the anthropogenic effects from newly expanding villages such as harvesting of medicinal plants, pasturing cattle and forest...

journal_title：Scientific reports

authors： Popradit A,Srisatit T,Kiratiprayoon S,Yoshimura J,Ishida A,Shiyomi M,Murayama T,Chantaranothai P,Outtaranakorn S,Phromma I

更新日期：2015-10-05 00:00:00

abstract：:The prediction of drug-target interactions is a key step in the drug discovery process, which serves to identify new drugs or novel targets for existing drugs. However, experimental methods for predicting drug-target interactions are expensive and time-consuming. Therefore, the in silico prediction of drug-target inte...

journal_title：Scientific reports

authors： Kuang Q,Xu X,Li R,Dong Y,Li Y,Huang Z,Li Y,Li M

更新日期：2015-09-09 00:00:00

abstract：:CIC-DUX4 sarcoma (CDS) is a group of rare, mesenchymal, small round cell tumours that harbour the unique CIC-DUX4 translocation, which causes aberrant gene expression. CDS exhibits an aggressive course and poor clinical outcome, thus novel therapeutic approaches are needed for CDS treatment. Although patient-derived c...

journal_title：Scientific reports

authors： Oyama R,Takahashi M,Yoshida A,Sakumoto M,Takai Y,Kito F,Shiozawa K,Qiao Z,Arai Y,Shibata T,Araki Y,Endo M,Kawai A,Kondo T

更新日期：2017-07-05 00:00:00

abstract：:Molecular behaviour of liquid water under proton irradiation is of great importance to a number of technological and medical applications. The highly energetic proton generates a time-varying field that is highly localized and heterogeneous at the molecular scale, and massive electronic excitations are produced as a r...

journal_title：Scientific reports

authors： Reeves KG,Kanai Y

更新日期：2017-01-13 00:00:00

abstract：:Breast cancer is the most frequently diagnosed malignancy among women, and triple-negative breast cancer (TNBC) is a highly aggressive subtype. Increasing evidence has shown that lncRNAs are involved in tumor growth, cell-cycle, and apoptosis through interactions with miRNAs or mRNAs. However, there is still limited d...

journal_title：Scientific reports

authors： Le K,Guo H,Zhang Q,Huang X,Xu M,Huang Z,Yi P

更新日期：2019-10-22 00:00:00

abstract：:Global lake systems have undergone rapid degradation over the past century. Scientists and managers are struggling to manage the highly degraded lake systems to cope with escalating anthropogenic pressures. Improved knowledge of how lakes and social systems co-evolved up to the present is vital for understanding, mode...

journal_title：Scientific reports

authors： Zhang K,Yang X,Kattel G,Lin Q,Shen J

更新日期：2018-11-21 00:00:00

abstract：:Guidelines endorse targeted temperature management to reduce neurological sequelae and mortality after cardiac arrest (CA). Additional therapeutic approaches are lacking. Inhaled nitric oxide (iNO) given post systemic ischemia/reperfusion injury improves outcomes. Attenuated inflammation by iNO might be crucial in bra...

journal_title：Scientific reports

authors： Brücken A,Bleilevens C,Berger P,Nolte K,Gaisa NT,Rossaint R,Marx G,Derwall M,Fries M

更新日期：2018-04-30 00:00:00

abstract：:A novel and facile two-step strategy has been designed to prepare high performance bi-transition-metals (Fe- and Mo-) carbide supported on nitrogen-doped graphene (FeMo-NG) as electrocatalysts for oxygen reduction reactions (ORR). The as-synthesized FeMo carbide -NG catalysts exhibit excellent electrocatalytic activit...

journal_title：Scientific reports

authors： Chen M,Liu J,Zhou W,Lin J,Shen Z

更新日期：2015-05-22 00:00:00

abstract：:Members of the TGF-β superfamily are important regulators of chondrocyte function. Sox9, a key transcriptional regulator of chondrogenesis, is required for TGF-β-mediated regulation of specific cartilage genes. TGF-β can signal through a canonical, Smad-mediated pathway or non-conical pathways, including p38. Here we ...

journal_title：Scientific reports

authors： Coricor G,Serra R

更新日期：2016-12-08 00:00:00

abstract：:The significant risk of disease transmission has selected for effective immune-defense strategies in insect societies. Division of labour, with individuals specialized in immunity-related tasks, strongly contributes to prevent the spread of diseases. A trade-off, however, may exist between phenotypic specialization to...

journal_title：Scientific reports

authors： Cini A,Bordoni A,Cappa F,Petrocelli I,Pitzalis M,Iovinella I,Dani FR,Turillazzi S,Cervo R

更新日期：2020-06-02 00:00:00

abstract：:Small RNA-Seq is a common means to interrogate the small RNA'ome or the full spectrum of small RNAs (<200 nucleotide length) of a biological system. A pivotal problem in NGS based small RNA analysis is identifying and quantifying the small RNA'ome constituent components. For example, small RNAs in the circulatory syst...

journal_title：Scientific reports

authors： Li J,Kho AT,Chase RP,Pantano L,Farnam L,Amr SS,Tantisira KG

更新日期：2020-03-12 00:00:00

abstract：:Spinocerebellar ataxia type-3 (SCA3) is a neurodegenerative disorder caused by a polyglutamine repeat expansion in the ataxin-3 protein. Cleavage of mutant ataxin-3 by proteolytic enzymes yields ataxin-3 fragments containing the polyglutamine stretch. These shorter ataxin-3 fragments are thought to be involved in SCA3...

journal_title：Scientific reports

authors： Toonen LJ,Schmidt I,Luijsterburg MS,van Attikum H,van Roon-Mom WM

更新日期：2016-10-12 00:00:00

abstract：:The hitherto difficult task of reliably estimating populations of wide-ranging megafauna has been enabled by advances in capture-recapture methodology. Here we combine photographic sampling with a Bayesian spatially-explicit capture-recapture (SCR) model to estimate population parameters for the endangered Asian eleph...

journal_title：Scientific reports

authors： Goswami VR,Yadava MK,Vasudev D,Prasad PK,Sharma P,Jathanna D

更新日期：2019-06-12 00:00:00

abstract：:GABA is a key regulator of adult-born dentate granule cell (abDGC) maturation so mapping the functional connectivity between abDGCs and local interneurons is required to understand their development and integration into the hippocampal circuit. We recorded from birthdated abDGCs in mice and photoactivated parvalbumin ...

journal_title：Scientific reports

authors： Remmers CL,Castillon CCM,Armstrong JN,Contractor A

更新日期：2020-10-16 00:00:00

abstract：:Tyrosine hydroxylase (TH), the initial enzyme in the melanin pathway, catalyzes tyrosine conversion into Dopa. Although expression and regulation of TH have been shown to affect cuticle pigmentation in insects, no direct functional studies to date have focused on the specific physiological processes involving the enzy...

journal_title：Scientific reports

authors： Qiao L,Du M,Liang X,Hao Y,He X,Si F,Mei T,Chen B

更新日期：2016-07-15 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) regulate hard tissue formation, including bone and tooth. Growth differentiation factor 5 (GDF5), a known BMP, is expressed in cartilage and regulates chondrogenesis, and mutations have been shown to cause osteoarthritis. Notably, GDF5 is also expressed in periodontal ligament tissue...

journal_title：Scientific reports

authors： Liu J,Saito K,Maruya Y,Nakamura T,Yamada A,Fukumoto E,Ishikawa M,Iwamoto T,Miyazaki K,Yoshizaki K,Ge L,Fukumoto S

更新日期：2016-03-31 00:00:00

abstract：:Based on the polarization-sensitive absorption of graphene under conditions of total internal reflection, a novel optical sensor combining graphene and a microfluidic structure was constructed to achieve the sensitive real-time monitoring of refractive indexes. The atomic thickness and strong broadband absorption of g...

journal_title：Scientific reports

authors： Xing F,Liu ZB,Deng ZC,Kong XT,Yan XQ,Chen XD,Ye Q,Zhang CP,Chen YS,Tian JG

更新日期：2012-01-01 00:00:00

abstract：:This study evaluated the prognostic value of a panel of 29 oncogenes derived from the analysis of The Cancer Genome Atlas (TCGA data) or from the recent literature on bladder tumors on a well-characterized series of muscle-invasive bladder cancer (MIBC) and non-MIBC (NMIBC) samples and tried to identify molecular prog...

journal_title：Scientific reports

authors： Le Goux C,Vacher S,Schnitzler A,Barry Delongchamps N,Zerbib M,Peyromaure M,Sibony M,Allory Y,Bieche I,Damotte D,Pignot G

更新日期：2020-10-06 00:00:00

abstract：:Luteinizing hormone (LH) is one of the main pituitary hormones that regulate ovulation, however its role has not been studied in giant panda. In this study, we developed an ELISA method for the detection of panda urinary LH. We analyzed urinary hormones of 24 female pandas during 36 breeding periods, we found females ...

journal_title：Scientific reports

authors： Cai K,Yie S,Zhang Z,Wang J,Cai Z,Luo L,Liu Y,Wang H,Huang H,Wang C,Huang X,Lan J,Hou R

更新日期：2017-01-16 00:00:00

abstract：:Causal Structure Discovery (CSD) is the problem of identifying causal relationships from large quantities of data through computational methods. With the limited ability of traditional association-based computational methods to discover causal relationships, CSD methodologies are gaining popularity. The goal of the st...

journal_title：Scientific reports

authors： Shen X,Ma S,Vemuri P,Simon G,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2020-02-19 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) infection promotes a generalized activation of host responses that involves not only CD4 T cells, but also cells of the microenvironment, which are not directly infected, such as endothelial cells. The mechanisms triggering HIV-1-associated vascular alterations remain poorly...

journal_title：Scientific reports

authors： Balducci E,Leroyer AS,Lacroix R,Robert S,Todorova D,Simoncini S,Lyonnet L,Chareyre C,Zaegel-Faucher O,Micallef J,Poizot-Martin I,Roll P,Dignat-George F

更新日期：2019-07-16 00:00:00

abstract：:Molecular imaging is a powerful tool for investigating intracellular signalling, but it is difficult to acquire conventional fluorescence imaging from photoreceptive cells. Here we demonstrated that human opsin5 (OPN5) photoreceptor mediates light-induced Ca(2+) response in human embryonic kidney (HEK293) and mouse ne...

journal_title：Scientific reports

authors： Sugiyama T,Suzuki H,Takahashi T

更新日期：2014-06-19 00:00:00

abstract：:Maternal obesity and overnutrition during pregnancy and lactation can program an increased risk of obesity in offspring. In this context, improving maternal metabolism may help reduce the intergenerational transmission of obesity. Here we show that, in Sprague-Dawley rats, selectively altering obese maternal gut micro...

journal_title：Scientific reports

authors： Paul HA,Bomhof MR,Vogel HJ,Reimer RA

更新日期：2016-02-12 00:00:00

abstract：:This study aimed to design and functionally characterize peptide mimetics of the nanobody (Nb) related to the β2-adrenergic receptor (β2-AR) (nanobody-derived peptide, NDP). We postulated that the computationally derived and optimized complementarity-determining region 3 (CDR3) of Nb is sufficient for its interaction ...

journal_title：Scientific reports

authors： Sencanski M,Glisic S,Šnajder M,Veljkovic N,Poklar Ulrih N,Mavri J,Vrecl M

更新日期：2019-11-12 00:00:00

abstract：:Delivery of proteins has been regarded as the safest and most useful application in therapeutic application of stem cells, because proteins can regulate gene expression transiently without any genomic alteration. However, it is difficult to accurately measure efficiency or quantity of intracellular protein uptake. Her...

journal_title：Scientific reports

authors： Jo J,Hong S,Choi WY,Lee DR

更新日期：2014-03-14 00:00:00

abstract：:The ability to respond appropriately to challenges is an important contributor to fitness. Variation in the regulation of glucocorticoid hormones, which mediate the phenotypic response to challenges, can therefore influence the ability to persist in a given environment. We compared stress responsiveness in four popula...

journal_title：Scientific reports

authors： Zimmer C,Taff CC,Ardia DR,Rose AP,Aborn DA,Johnson LS,Vitousek MN

更新日期：2020-08-13 00:00:00

abstract：:In this study, we demonstrate that the lysine methyltransferase G9a inhibits sarcomere organization through regulation of the MEF2C-HDAC5 regulatory axis. Sarcomeres are essential for muscle contractile function. Presently, skeletal muscle disease and dysfunction at the sarcomere level has been associated with mutatio...

journal_title：Scientific reports

authors： Ow JR,Palanichamy Kala M,Rao VK,Choi MH,Bharathy N,Taneja R

更新日期：2016-09-26 00:00:00

abstract：:Interactions between human cytomegalovirus (HCMV) infection and environmental factors can increase susceptibility to essential hypertension (EH). Although endothelial dysfunction is the initial factor of EH, the epigenetic mechanisms through which HCMV infection induces endothelial cell dysfunction are poorly understo...

journal_title：Scientific reports

authors： Zhang X,Tang N,Xi D,Feng Q,Liu Y,Wang L,Tang Y,Zhong H,He F

更新日期：2020-02-10 00:00:00

abstract：:There are more than 2300 genes that are predominantly expressed in mouse testes. The role of hundreds of these genes has been studied in mouse spermatogenesis but still there are many genes whose function is unknown. Gene knockout (KO) strategy in mice is widely used for in vivo study of gene function. The present stu...

journal_title：Scientific reports

authors： Khan M,Jabeen N,Khan T,Hussain HMJ,Ali A,Khan R,Jiang L,Li T,Tao Q,Zhang X,Yin H,Yu C,Jiang X,Shi Q

更新日期：2018-03-21 00:00:00