Cell-penetrating peptide (CPP)-conjugated proteins is an efficient tool for manipulation of human mesenchymal stromal cells.

abstract：:Gamma-aminobutyric acid (GABA) is a widely conserved signaling molecule that in animals has been adapted as a neurotransmitter. GABA is synthesized from the amino acid glutamate by the action of glutamate decarboxylases (GADs). Two vertebrate genes, GAD1 and GAD2, encode distinct GAD proteins: GAD67 and GAD65, respect...

journal_title：Scientific reports

authors： Grone BP,Maruska KP

更新日期：2016-07-27 00:00:00

abstract：:We study the spreading of cell aggregates deposited on adhesive substrates decorated with microparticles (MPs). A cell monolayer expands around the aggregate. The cells on the periphery of the monolayer take up the MPs, clearing the substrate as they progress and forming an aureole of cells filled with MPs. We study t...

journal_title：Scientific reports

authors： Beaune G,Lam AYW,Dufour S,Winnik FM,Brochard-Wyart F

更新日期：2017-11-16 00:00:00

abstract：:Circulating levels of Brain Derived Neurotrophic Factor (BDNF) are lower in coronary heart disease (CHD) than in healthy subjects and are associated with coronary events and mortality. However, the mechanism(s) underling this association is not fully understood. We hypothesize that BDNF may influence fibrin fiber stru...

journal_title：Scientific reports

authors： Amadio P,Porro B,Sandrini L,Fiorelli S,Bonomi A,Cavalca V,Brambilla M,Camera M,Veglia F,Tremoli E,Barbieri SS

更新日期：2019-01-23 00:00:00

abstract：:The Spike protein of the novel coronavirus SARS-CoV2 contains an insertion 680SPRRAR↓SV687 forming a cleavage motif RxxR for furin-like enzymes at the boundary of S1/S2 subunits. Cleavage at S1/S2 is important for efficient viral entry into target cells. The insertion is absent in other CoV-s of the same clade, includ...

journal_title：Scientific reports

authors： Örd M,Faustova I,Loog M

更新日期：2020-10-09 00:00:00

abstract：:Many human introns carry out a function, in the sense that they are critical to maintain normal cellular activity. Their identification is fundamental to understanding cellular processes and disease. However, being noncoding elements, such functional introns are poorly predicted based on traditional approaches of sequ...

journal_title：Scientific reports

authors： Chorev M,Joseph Bekker A,Goldberger J,Carmel L

更新日期：2017-06-23 00:00:00

abstract：:Myelopoiesis involves differentiation of hematopoietic stem cells to cellular populations that are restricted in their self-renewal capacity, beginning with the common myeloid progenitor (CMP) and leading to mature cells including monocytes and granulocytes. This complex process is regulated by various extracellular a...

journal_title：Scientific reports

authors： Rajasekhar M,Schmitz U,Flamant S,Wong JJ,Bailey CG,Ritchie W,Holst J,Rasko JEJ

更新日期：2018-05-08 00:00:00

abstract：:Visual evoked potential-based brain-computer interfaces (BCIs) have been widely investigated because of their easy system configuration and high information transfer rate (ITR). However, the uncomfortable flicker or brightness modulation of existing methods restricts the practical interactivity of BCI applications. In...

journal_title：Scientific reports

authors： Han C,Xu G,Xie J,Chen C,Zhang S

更新日期：2018-04-11 00:00:00

abstract：:Bragg coherent X-ray diffraction imaging (BCDI) has emerged as a powerful technique to image the local displacement field and strain in nanocrystals, in three dimensions with nanometric spatial resolution. However, BCDI relies on both dataset collection and phase retrieval algorithms that can induce artefacts in the r...

journal_title：Scientific reports

authors： Carnis J,Gao L,Labat S,Kim YY,Hofmann JP,Leake SJ,Schülli TU,Hensen EJM,Thomas O,Richard MI

更新日期：2019-11-22 00:00:00

abstract：:There are only few studies that explore the ecological consequences of forest management on several organism groups. We studied the short-term effects of four forestry treatments including preparation cutting, clear-cutting, retention tree group and gap-cutting in a temperate managed forest on the assemblage structure...

journal_title：Scientific reports

authors： Elek Z,Kovács B,Aszalós R,Boros G,Samu F,Tinya F,Ódor P

更新日期：2018-11-19 00:00:00

abstract：:This prospective randomized double-masked study investigated the effects of 20 mg lutein supplementation with two different capsules (beeswax or glycerol fatty acid esters) for 6 months on the fellow eyes of 39 Japanese patients with unilateral age-related macular degeneration, and assessed the factors associated with...

journal_title：Scientific reports

authors： Sawa M,Shunto T,Nishiyama I,Yokoyama A,Shigeta R,Miura S,Kawasaki R

更新日期：2020-04-06 00:00:00

abstract：:8-band k · p Hamiltonian together with envelope function approximation and planewave expansion method are applied to calculate the electronic band structure and material gain for Ge1-wSnw/SiyGe1-x-ySnx/Ge1-wSnw quantum wells (QWs) grown on virtual Ge1-zSnz substrates integrated with Si platform. It is clearly shown ho...

journal_title：Scientific reports

authors： Mączko HS,Kudrawiec R,Gladysiewicz M

更新日期：2019-03-01 00:00:00

abstract：:Cold atmospheric plasma (CAP), a technology based on quasi-neutral ionized gas at low temperatures, is currently being evaluated as a new highly selective alternative addition to existing cancer therapies. Here, we present a first attempt to identify the mechanism of CAP action. CAP induced a robust ~2-fold G2/M incre...

journal_title：Scientific reports

authors： Volotskova O,Hawley TS,Stepp MA,Keidar M

更新日期：2012-01-01 00:00:00

abstract：ABSTARCT:The relationship between chronic kidney disease (CKD), which is defined by declined estimated glomerular filtration rate (eGFR) and/or proteinuria, and asymptomatic intracranial arterial stenosis (ICAS) is largely unknown. We conducted a population-based, cross-sectional study by recruiting 5209 participants f...

journal_title：Scientific reports

authors： Li Z,Li J,Wang A,Pan H,Wu S,Zhao X

更新日期：2017-07-04 00:00:00

abstract：:Diabetes mellitus (DM) during pregnancy can result in fetal overgrowth, likely due to placental dysfunction, which has health consequences for the infant. Here we test our prediction from previous work using a placental cell line that high glucose concentrations affect placental lipid metabolism. Placentas from women ...

journal_title：Scientific reports

authors： Hulme CH,Nicolaou A,Murphy SA,Heazell AEP,Myers JE,Westwood M

更新日期：2019-10-01 00:00:00

abstract：:A tribochemistry-assisted method has been developed for nondestructive surface nanofabrication on GaAs. Without any applied electric field and post etching, hollow nanostructures can be directly fabricated on GaAs surfaces by sliding a SiO2 microsphere under an ultralow contact pressure in humid air. TEM observation o...

journal_title：Scientific reports

authors： Song C,Li X,Dong H,Yu B,Wang Z,Qian L

更新日期：2015-03-12 00:00:00

abstract：:Aldehyde-oxidase-4 (AOX4) is one of the mouse aldehyde oxidase isoenzymes and its physiological function is unknown. The major source of AOX4 is the Harderian-gland, where the enzyme is characterized by daily rhythmic fluctuations. Deletion of the Aox4 gene causes perturbations in the expression of the circadian-rhyth...

journal_title：Scientific reports

authors： Terao M,Barzago MM,Kurosaki M,Fratelli M,Bolis M,Borsotti A,Bigini P,Micotti E,Carli M,Invernizzi RW,Bagnati R,Passoni A,Pastorelli R,Brunelli L,Toschi I,Cesari V,Sanoh S,Garattini E

更新日期：2016-07-26 00:00:00

abstract：:The heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is considered as a human carcinogenic or mutagenic compound that is produced from the co-condensation of creatinine and amino acids as meats cook at high temperatures. The cooking of meats at high temperatures produces fumes, and these fumes...

journal_title：Scientific reports

authors： Poudel BK,Choi J,Park JH,Doh KO,Byeon JH

更新日期：2017-09-07 00:00:00

abstract：:Visible indication based on the aggregation of colloidal nanoparticles (NPs) is highly advantageous for rapid on-site detection of biological entities, which even untrained persons can perform without specialized instrumentation. However, since the extent of aggregation should exceed a certain minimum threshold to pro...

journal_title：Scientific reports

authors： Lim S,Koo OK,You YS,Lee YE,Kim MS,Chang PS,Kang DH,Yu JH,Choi YJ,Gunasekaran S

更新日期：2012-01-01 00:00:00

abstract：:Real-time quantitative polymerase chain reaction (qPCR) data are found to display periodic patterns in the fluorescence intensity as a function of sample number for fixed cycle number. This behavior is seen for technical replicate datasets recorded on several different commercial instruments; it occurs in the baseline...

journal_title：Scientific reports

authors： Spiess AN,Rödiger S,Burdukiewicz M,Volksdorf T,Tellinghuisen J

更新日期：2016-12-13 00:00:00

abstract：:The structure of metallic glasses is a long-standing question because the lack of long-range order makes diffraction based techniques difficult to be applied. Here, we used scanning tunneling microscopy with large tunneling resistance of 6 GΩ at low temperature in order to minimize forces between probe and sample and ...

journal_title：Scientific reports

authors： Pawlak R,Marot L,Sadeghi A,Kawai S,Glatzel T,Reimann P,Goedecker S,Güntherodt HJ,Meyer E

更新日期：2015-08-13 00:00:00

abstract：:Uncertainty in the form of risk or ambiguity can arise from the interaction with nature and other players, while strategic uncertainty arises only in interactions with others. Here, we systematically compare binary decisions between a safe option and a potentially higher paying but uncertain option in four experimenta...

journal_title：Scientific reports

authors： Chierchia G,Nagel R,Coricelli G

更新日期：2018-02-23 00:00:00

abstract：:Antitumor drug development based on the concept of intervening in the antioxidant system of cancer cells has been gaining increased interest. In this study, we propose a promising strategy for cancer treatment using modulation of oxidative stress by suppression of glutathione S-transferases (GSTs), a typical antioxida...

journal_title：Scientific reports

authors： Fujitani N,Yoneda A,Takahashi M,Takasawa A,Aoyama T,Miyazaki T

更新日期：2019-10-14 00:00:00

abstract：:COX-2 inhibition may be of benefit in the treatment of tuberculosis (TB) through a number of pathways including efflux pump inhibition (increasing intracellular TB drug levels) and diverse effects on inflammation and the immune response. We investigated celecoxib (a COX-2 inhibitor) alone and with standard anti-tuberc...

journal_title：Scientific reports

authors： Naftalin CM,Verma R,Gurumurthy M,Hee KH,Lu Q,Yeo BCM,Tan KH,Lin W,Yu B,Seng KY,Lee LS,Paton NI

更新日期：2018-09-10 00:00:00

abstract：:Previous studies showed that better adherence to the Mediterranean diet (MD) is associated with lower risk of chronic diseases, but limited data are available on bone health. We investigated the association of the MD with bone mineral density (BMD) in Chinese adults. We included 2371 participants aged 40-75 years in t...

journal_title：Scientific reports

authors： Chen GD,Dong XW,Zhu YY,Tian HY,He J,Chen YM

更新日期：2016-05-09 00:00:00

abstract：:The Notch signaling network determines stemness in various tissues and targeting signaling activity in malignant brain cancers by gamma-secretase inhibitors (GSI) has shown promising preclinical success. However, the clinical translation remains challenging due to severe toxicity side effects and emergence of therapy ...

journal_title：Scientific reports

authors： Herrera-Rios D,Li G,Khan D,Tsiampali J,Nickel AC,Aretz P,Hewera M,Suwala AK,Jiang T,Steiger HJ,Kamp MA,Muhammad S,Hänggi D,Maciaczyk J,Zhang W,Kahlert UD

更新日期：2020-10-01 00:00:00

abstract：:The dorsal anterior cingulate cortex (dACC) has been identified as a core region affected by many disorders, representing a promising target for neuromodulation. High Definition-transcranial Direct Current Stimulation (HD-tDCS) is a non-invasive neuromodulation technique that has already shown promising outcomes and h...

journal_title：Scientific reports

authors： To WT,Eroh J,Hart J Jr,Vanneste S

更新日期：2018-03-13 00:00:00

abstract：:Adaptive responses to hypoxia regulate hepatic lipid metabolism, but their consequences in nonalcoholic fatty liver disease (NAFLD) are largely unknown. Here, we show that hypoxia inducible factor-1 (HIF-1), a key determinant of hypoxic adaptations, prevents excessive hepatic lipid accumulation in the progression of N...

journal_title：Scientific reports

authors： Arai T,Tanaka M,Goda N

更新日期：2018-09-21 00:00:00

abstract：:Generation and manipulation of quantum entangled electrons is an important concept in quantum mechanics, and necessary for advances in quantum information processing; but not yet established in solid state systems. A promising device is a superconductor-two quantum dots Cooper pair splitter. Early nanowire based devic...

journal_title：Scientific reports

authors： Borzenets IV,Shimazaki Y,Jones GF,Craciun MF,Russo S,Yamamoto M,Tarucha S

更新日期：2016-03-14 00:00:00

abstract：:The heterogeneity of major depressive disorder (MDD) is attributed to the fact that diagnostic criteria (e.g., DSM-5) are only based on clinical symptoms. The discovery of blood biomarkers has the potential to change the diagnosis of MDD. The purpose of this study was to identify blood biomarkers of DNA methylation by...

journal_title：Scientific reports

authors： Yamagata H,Ogihara H,Matsuo K,Uchida S,Kobayashi A,Seki T,Kobayashi M,Harada K,Chen C,Miyata S,Fukuda M,Mikuni M,Hamamoto Y,Watanabe Y,Nakagawa S

更新日期：2021-01-27 00:00:00

abstract：:Directional transport of auxin is essential for plant development, with PIN auxin transport proteins representing an integral part of the machinery that controls hormone distribution. However, unlike the rapidly emerging framework of molecular determinants regulating PIN protein abundance and subcellular localization,...

journal_title：Scientific reports

authors： Benjamins R,Barbez E,Ortbauer M,Terpstra I,Lucyshyn D,Moulinier-Anzola J,Khan MA,Leitner J,Malenica N,Butt H,Korbei B,Scheres B,Kleine-Vehn J,Luschnig C

更新日期：2016-08-24 00:00:00