COMPSRA: a COMprehensive Platform for Small RNA-Seq data Analysis.

abstract：:Resin composites containing reinforcing inert glass fillers combined with bioactive glass (BG) can aid in the prevention of secondary caries, which is a major cause of failure of contemporary composite restorations. A series of previous studies on experimental resin composites filled with BG 45S5 has demonstrated that...

journal_title：Scientific reports

authors： Par M,Spanovic N,Tauböck TT,Attin T,Tarle Z

更新日期：2019-11-21 00:00:00

abstract：:Free-ocean CO2 enrichment (FOCE) experiments have been deployed in marine ecosystems to manipulate carbonate system conditions to those predicted in future oceans. We investigated whether the pH/carbonate chemistry of extremely cold polar waters can be manipulated in an ecologically relevant way, to represent conditio...

journal_title：Scientific reports

authors： Stark JS,Roden NP,Johnstone GJ,Milnes M,Black JG,Whiteside S,Kirkwood W,Newbery K,Stark S,van Ooijen E,Tilbrook B,Peltzer ET,Berry K,Roberts D

更新日期：2018-02-12 00:00:00

abstract：:Crotoxin (CTX) is the primary toxin of South American rattlesnake Crotalus durissus terrificus venom. CTX reduces tumour mass, and tumour cell proliferation and these effects seem to involve the formation of new vessels. Angiogenesis has a key role in tumour growth and progression and is regulated by macrophage secret...

journal_title：Scientific reports

authors： de Araújo Pimenta L,de Almeida MES,Bretones ML,Cirillo MC,Curi R,Sampaio SC

更新日期：2019-03-12 00:00:00

abstract：:The jerantinine family of Aspidosperma indole alkaloids from Tabernaemontana corymbosa are potent microtubule-targeting agents with broad spectrum anticancer activity. The natural supply of these precious metabolites has been significantly disrupted due to the inclusion of T. corymbosa on the endangered list of threat...

journal_title：Scientific reports

authors： Smedley CJ,Stanley PA,Qazzaz ME,Prota AE,Olieric N,Collins H,Eastman H,Barrow AS,Lim KH,Kam TS,Smith BJ,Duivenvoorden HM,Parker BS,Bradshaw TD,Steinmetz MO,Moses JE

更新日期：2018-07-13 00:00:00

abstract：:Biomodels made of poly(vinyl alcohol) (PVA) are demanded because they can represent the geometries and mechanical properties of human tissues realistically. Injecting and molding, commonly used in three-dimensional (3D) modeling, help to represent the blood vessels accurately. However, these techniques sometimes requi...

journal_title：Scientific reports

authors： Shimizu Y,Tanabe T,Yoshida H,Kasuya M,Matsunaga T,Haga Y,Kurihara K,Ohta M

更新日期：2018-11-08 00:00:00

abstract：:Anoectochilus roxburghii and Anoectochilus formasanus are the major species of genus Anoectochilus used in traditional Chinese medicine for their abundant content of flavonoids and some other medicinal constituents. In recent years, their wild resources are gradually exhausted due to over-collection and ecological det...

journal_title：Scientific reports

authors： Yang L,Zhang JC,Qu JT,He G,Yu HQ,Li WC,Fu FL

更新日期：2019-12-27 00:00:00

abstract：:We propose a novel stochastic global optimization algorithm with applications to the refinement stage of protein docking prediction methods. Our approach can process conformations sampled from multiple clusters, each roughly corresponding to a different binding energy funnel. These clusters are obtained using a densit...

journal_title：Scientific reports

authors： Zarbafian S,Moghadasi M,Roshandelpoor A,Nan F,Li K,Vakli P,Vajda S,Kozakov D,Paschalidis IC

更新日期：2018-04-12 00:00:00

abstract：:The value of image cytometry DNA ploidy analysis and dysplasia grading to predict malignant transformation has been determined in oral lesions considered to be at 'high' risk on the basis of clinical information and biopsy result. 10-year follow up data for 259 sequential patients with oral lesions clinically at 'high...

journal_title：Scientific reports

authors： Zaini ZM,McParland H,Møller H,Husband K,Odell EW

更新日期：2018-10-26 00:00:00

abstract：:The chicken egg resists most environmental microbes suggesting that it potentially contains efficient antimicrobial molecules. Considering that some heparin-binding proteins in mammals are antibacterial, we investigated the presence and the antimicrobial activity of heparin-binding proteins from chicken egg white. Mas...

journal_title：Scientific reports

authors： Guyot N,Labas V,Harichaux G,Chessé M,Poirier JC,Nys Y,Réhault-Godbert S

更新日期：2016-06-13 00:00:00

abstract：:We design a novel long-range hybrid wedge plasmonic (LRHWP) waveguide composed of two identical dielectric nanowires symmetrically placed on two opposed wedges of a diamond shaped metal wire. With strong coupling between the dielectric nanowire mode and long-range surface plasmon polariton (SPP) mode, both deep subwav...

journal_title：Scientific reports

authors： Zhang Z,Wang J

更新日期：2014-11-03 00:00:00

abstract：:Homogeneously distributed zinc nanoparticles (NPs) on the glass substrate were investigated for the transmittance, mechanical durability, and antibacterial effect. The buffered Ti NPs between Zn NPs and glass substrate were studied for an enhancement of the transmittance and mechanical endurance. The Ti NPs buffered Z...

journal_title：Scientific reports

authors： Choi HJ,Choi JS,Park BJ,Eom JH,Heo SY,Jung MW,An KS,Yoon SG

更新日期：2014-09-03 00:00:00

abstract：:Surface enhanced Raman scattering (SERS) is generally and widely used to enhance the vibrational fingerprint of molecules located at the vicinity of noble metal nanoparticles. In this work, SERS is originally used to enhance the own vibrational density of states (VDOS) of nude and isolated gold nanoparticles. This off...

journal_title：Scientific reports

authors： Carles R,Benzo P,Pécassou B,Bonafos C

更新日期：2016-12-16 00:00:00

abstract：:Tumor necrosis factor receptor 2 (TNFR2) is known to mediate immune suppression and tissue regeneration. Interestingly, the transmembrane form of tumor necrosis factor (tmTNF) is necessary to robustly activate TNFR2. To characterize the stoichiometry and composition of tmTNF during TNFR2 activation, we constructed dif...

journal_title：Scientific reports

authors： Fischer R,Marsal J,Guttà C,Eisler SA,Peters N,Bethea JR,Pfizenmaier K,Kontermann RE

更新日期：2017-07-26 00:00:00

abstract：:Several mosquito species have been described as vectors for the Zika virus (ZIKV), such as those in the Aedes, Anopheles, Mansonia and Culex genera. Our previous survey studies were found the ZIKV RNA positive in both male, female and larvae of Culex quinquefasciatus Say and Aedes aegypti (L.) mosquitoes collected fro...

journal_title：Scientific reports

authors： Phumee A,Chompoosri J,Intayot P,Boonserm R,Boonyasuppayakorn S,Buathong R,Thavara U,Tawatsin A,Joyjinda Y,Wacharapluesadee S,Siriyasatien P

更新日期：2019-03-27 00:00:00

abstract：:In spite of its prevalence in animals and plants, endogenous nitric oxide (NO) has been rarely reported in fungi. We present here our observations on production of intracellular NO and its possible roles during development of Neurospora crassa, a model filamentous fungus. Intracellular NO was detected in hypha 8-16 ho...

journal_title：Scientific reports

authors： Pengkit A,Jeon SS,Son SJ,Shin JH,Baik KY,Choi EH,Park G

更新日期：2016-07-18 00:00:00

abstract：:The aim of the study was to investigate the effect of 2nd-line pazopanib on the different CTCs subpopulations in SCLC patients and evaluate the clinical relevance of their changes. Different CTCs subpopulations were evaluated before pazopanib initiation (n = 56 patients), after one-cycle (n = 35) and on disease progre...

journal_title：Scientific reports

authors： Messaritakis I,Politaki E,Koinis F,Stoltidis D,Apostolaki S,Plataki M,Dermitzaki EK,Georgoulias V,Kotsakis A

更新日期：2018-02-02 00:00:00

abstract：:Circadian clocks keep time via ~ 24 h transcriptional feedback loops. In Drosophila, CLOCK-CYCLE (CLK-CYC) activators and PERIOD-TIMELESS (PER-TIM) repressors are feedback loop components whose transcriptional status varies over a circadian cycle. Although changes in the state of activators and repressors has been cha...

journal_title：Scientific reports

authors： Mahesh G,Rivas GBS,Caster C,Ost EB,Amunugama R,Jones R,Allen DL,Hardin PE

更新日期：2020-10-21 00:00:00

abstract：:The aim was to investigate the ability of self-assembling Peptide P11-4 Matrix (SAPM) to remineralize artificial initial caries lesions compared to the use of fluoride varnish. Volunteers were recruited for this randomised, cross-over in situ trial. Bovine specimens, half including orthodontic brackets, were recessed ...

journal_title：Scientific reports

authors： Jablonski-Momeni A,Korbmacher-Steiner H,Heinzel-Gutenbrunner M,Jablonski B,Jaquet W,Bottenberg P

更新日期：2019-01-22 00:00:00

abstract：:Helicobacter pylori (H. pylori) is one of the most important factors that affect the development of gastric cancer, and its mechanism remains un-elucidated. Our present study found that, miR-30a is crucial for regulating the growth and migration of H. pylori infected gastric cancer in vitro by targeting COX-2 and BCL9...

journal_title：Scientific reports

authors： Liu X,Ji Q,Zhang C,Liu X,Liu Y,Liu N,Sui H,Zhou L,Wang S,Li Q

更新日期：2017-08-02 00:00:00

abstract：:Single photons are of paramount importance to future quantum technologies, including quantum communication and computation. Nonlinear photonic devices using parametric processes offer a straightforward route to generating photons, however additional nonlinear processes may come into play and interfere with these sourc...

journal_title：Scientific reports

authors： Husko CA,Clark AS,Collins MJ,De Rossi A,Combrié S,Lehoucq G,Rey IH,Krauss TF,Xiong C,Eggleton BJ

更新日期：2013-11-04 00:00:00

abstract：:Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in hum...

journal_title：Scientific reports

authors： Bakke J,Wright WC,Zamora AE,Ong SS,Wang YM,Hoyer JD,Brewer CT,Thomas PG,Chen T

更新日期：2017-08-15 00:00:00

abstract：:Attosecond (asec) X-ray free-electron laser (XFEL) has attracted considerable interest over the past years. Nowadays typical XFEL application experiments demand 1010-1011 photons per pulse, which corresponds to a peak power of terawatts (TW) in case of asec hard X-ray pulse. To the realization of such TW asec-XFEL pul...

journal_title：Scientific reports

authors： Shim CH,Parc YW,Kim DE

更新日期：2020-01-28 00:00:00

abstract：:Cell-free enzymatic reaction cascades combine the advantages of well-established in vitro biocatalysis with the power of multi-step in vivo pathways. The absence of a regulatory cell environment enables direct process control including methods for facile bottleneck identification and process optimization. Within this ...

journal_title：Scientific reports

authors： Gmelch TJ,Sperl JM,Sieber V

更新日期：2019-08-13 00:00:00

abstract：:Although recovery following a stroke is limited, undamaged neurons under the right conditions can establish new connections and take on-board lost functions. Sonic hedgehog (Shh) signaling is integral for developmental axon growth, but its role after injury has not been fully examined. To investigate the effects of Sh...

journal_title：Scientific reports

authors： Berretta A,Gowing EK,Jasoni CL,Clarkson AN

更新日期：2016-02-23 00:00:00

abstract：:Non-Markovianity has recently attracted large interest due to significant advances in its characterization and its exploitation for quantum information processing. However, up to now, only non-Markovian regimes featuring environment to system backflow of information (strong non-Markovianity) have been experimentally s...

journal_title：Scientific reports

authors： Bernardes NK,Cuevas A,Orieux A,Monken CH,Mataloni P,Sciarrino F,Santos MF

更新日期：2015-12-02 00:00:00

abstract：:Gut bacteria influence the development of different pathologies caused by bacteria, fungi and parasitoids in insects. Wax moth larvae became more susceptible to fungal infections after envenomation by the ectoparasitoid Habrobracon hebetor. In addition, spontaneous bacterioses occurred more often in envenomated larvae...

journal_title：Scientific reports

authors： Polenogova OV,Kabilov MR,Tyurin MV,Rotskaya UN,Krivopalov AV,Morozova VV,Mozhaitseva K,Kryukova NA,Alikina T,Kryukov VY,Glupov VV

更新日期：2019-03-08 00:00:00

abstract：:Foliar fungi of silver birch (Betula pendula) in an experimental Finnish forest were investigated across a gradient of tree species richness using molecular high-throughput sequencing and visual macroscopic assessment. We hypothesized that the molecular approach detects more fungal taxa than visual assessment, and tha...

journal_title：Scientific reports

authors： Nguyen D,Boberg J,Cleary M,Bruelheide H,Hönig L,Koricheva J,Stenlid J

更新日期：2017-02-02 00:00:00

abstract：:Impaired immune function contributes to the development of chronic obstructive pulmonary disease (COPD). Disease progression is further exacerbated by pathogen infections due to impaired immune responses. Elimination of infected cells is achieved by cytotoxic CD8(+)  T cells that are activated by MHC I-mediated presen...

journal_title：Scientific reports

authors： Keller IE,Vosyka O,Takenaka S,Kloß A,Dahlmann B,Willems LI,Verdoes M,Overkleeft HS,Marcos E,Adnot S,Hauck SM,Ruppert C,Günther A,Herold S,Ohno S,Adler H,Eickelberg O,Meiners S

更新日期：2015-05-19 00:00:00

abstract：:Myelination is critical for transduction of neuronal signals, neuron survival and normal function of the nervous system. Myelin disorders account for many debilitating neurological diseases such as multiple sclerosis and leukodystrophies. The lack of experimental models and tools to observe and manipulate this process...

journal_title：Scientific reports

authors： Espinosa-Hoyos D,Jagielska A,Homan KA,Du H,Busbee T,Anderson DG,Fang NX,Lewis JA,Van Vliet KJ

更新日期：2018-01-11 00:00:00

abstract：:The mechanisms of pattern formation during embryonic development remain poorly understood. Embryonic stem cells in culture self-organise to form spatial patterns of gene expression upon geometrical confinement indicating that patterning is an emergent phenomenon that results from the many interactions between the cell...

journal_title：Scientific reports

authors： Wang M,Tsanas A,Blin G,Robertson D

更新日期：2020-10-01 00:00:00