Abstract：
:Myelination is critical for transduction of neuronal signals, neuron survival and normal function of the nervous system. Myelin disorders account for many debilitating neurological diseases such as multiple sclerosis and leukodystrophies. The lack of experimental models and tools to observe and manipulate this process in vitro has constrained progress in understanding and promoting myelination, and ultimately developing effective remyelination therapies. To address this problem, we developed synthetic mimics of neuronal axons, representing key geometric, mechanical, and surface chemistry components of biological axons. These artificial axons exhibit low mechanical stiffness approaching that of a human axon, over unsupported spans that facilitate engagement and wrapping by glial cells, to enable study of myelination in environments reflecting mechanical cues that neurons present in vivo. Our 3D printing approach provides the capacity to vary independently the complex features of the artificial axons that can reflect specific states of development, disease, or injury. Here, we demonstrate that oligodendrocytes' production and wrapping of myelin depend on artificial axon stiffness, diameter, and ligand coating. This biofidelic platform provides direct visualization and quantification of myelin formation and myelinating cells' response to both physical cues and pharmacological agents.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Espinosa-Hoyos D,Jagielska A,Homan KA,Du H,Busbee T,Anderson DG,Fang NX,Lewis JA,Van Vliet KJdoi
10.1038/s41598-017-18744-6subject
Has Abstractpub_date
2018-01-11 00:00:00pages
478issue
1issn
2045-2322pii
10.1038/s41598-017-18744-6journal_volume
8pub_type
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