Author Correction: Linking drug target and pathway activation for effective therapy using multi-task learning.

abstract：:Double-strand breaks (DSBs) are the most lethal DNA damages induced by ionising radiation (IR) and their efficient repair is crucial to limit genomic instability. The cellular DSB response after low IR doses is of particular interest but its examination requires the analysis of high cell numbers. Here, we present an a...

journal_title：Scientific reports

authors： Lengert N,Mirsch J,Weimer RN,Schumann E,Haub P,Drossel B,Löbrich M

更新日期：2018-11-23 00:00:00

abstract：:It is unknown whether YOD (young onset diabetes) and LOD (late onset diabetes) require similar insulin doses for intensive insulin therapy with a metformin add-on to achieve glycemic control. We analyzed data from our two previously performed randomized, controlled open-label trials. Patients were randomized to receiv...

journal_title：Scientific reports

authors： Li FF,Liu BL,Yin GP,Zhang DF,Zhai XF,Chen MY,Su XF,Wu JD,Ye L,Ma JH

更新日期：2017-11-27 00:00:00

abstract：:Chaetosiphella stipae stipae is a xerothermophilous aphid, associated with Palaearctic temperate steppe zones or dry mountain valleys, where there are grasses from the genus Stipa. Its geographical distribution shows several populations that are spread from Spain, across Europe and Asia Minor, to Mongolia and China. G...

journal_title：Scientific reports

authors： Wieczorek K,Bugaj-Nawrocka A,Kanturski M,Miller GL

更新日期：2017-03-08 00:00:00

abstract：:Leprosy remains persistently endemic in several low- or middle income countries. Transmission is still ongoing as indicated by the unabated rate of leprosy new case detection, illustrating the insufficiency of current prevention methods. Therefore, low-complexity tools suitable for large scale screening efforts to spe...

journal_title：Scientific reports

authors： van Hooij A,Tjon Kon Fat EM,Batista da Silva M,Carvalho Bouth R,Cunha Messias AC,Gobbo AR,Lema T,Bobosha K,Li J,Weng X,Salgado CG,Spencer JS,Corstjens PLAM,Geluk A

更新日期：2018-12-18 00:00:00

abstract：:Two polar vessels, Akademik Shokalskiy and Xuelong, were trapped by thick sea ice in the Antarctic coastal region just to the west of 144°E and between 66.5°S and 67°S in late December 2013. This event demonstrated the rapid establishment of extreme Antarctic sea ice conditions on synoptic time scales. The event was a...

journal_title：Scientific reports

authors： Wang Z,Turner J,Sun B,Li B,Liu C

更新日期：2014-06-17 00:00:00

abstract：:The discovery of circulating tumour DNA molecules created a paradigm shift in tumour biomarkers as predictors of recurrence. Non-invasive prenatal testing (NIPT) to detect circulating cell-free foetal DNA in maternal plasma is increasingly recognised as a valuable substitute to perceive foetal copy number variation (C...

journal_title：Scientific reports

authors： Nakabayashi M,Kawashima A,Yasuhara R,Hayakawa Y,Miyamoto S,Iizuka C,Sekizawa A

更新日期：2018-07-25 00:00:00

abstract：:Parent selection is the core of hybrid breeding. The breeding strategy involving the parental identification of superior open-pollinated progeny of Populous tomentosa germplasm resources can significantly improve the efficiency of parental matching. However, due to some factors such as loose powdering time and pollen ...

journal_title：Scientific reports

authors： Han Z,Han Q,Xia Y,Geng X,Du K,Yang J,Kang X

更新日期：2020-10-29 00:00:00

abstract：:Allergic contact hypersensitivity (CHS) is an inflammatory skin disease mediated by allergen specific T cells. In this study, we investigated the role of transcription factor NFAT1 in the pathogenesis of contact hypersensitivity. NFAT1 knock out (KO) mice spontaneously developed CHS-like skin inflammation in old age. ...

journal_title：Scientific reports

authors： Kwon HK,Kim GC,Hwang JS,Kim Y,Chae CS,Nam JH,Jun CD,Rudra D,Surh CD,Im SH

更新日期：2016-01-18 00:00:00

abstract：:Lead (Pb) toxicity is a major environmental concern affirming the need of proper mitigation strategies. In the present work, potential of combined treatment of 24-Epibrassinolide (24-EBL) and Salicylic acid (SA) against Pb toxicity to Brassica juncea L. seedlings were evaluated. Seedlings pre-imbibed in EBL (0.1 mM) a...

journal_title：Scientific reports

authors： Kohli SK,Bali S,Tejpal R,Bhalla V,Verma V,Bhardwaj R,Alqarawi AA,Abd Allah EF,Ahmad P

更新日期：2019-03-05 00:00:00

abstract：:The stratum corneum plays a crucial role in epidermal barrier function. Various changes occur in granular cells at the uppermost stratum granulosum during cornification. To understand the temporal details of this process, we visualized the cell shape and organelles of cornifying keratinocytes in a living human epiderm...

journal_title：Scientific reports

authors： Ipponjima S,Umino Y,Nagayama M,Denda M

更新日期：2020-03-26 00:00:00

abstract：:The macrophage migration inhibitory factor (MIF) is a cytokine that plays an important role in inhibiting the growth of pathogenic Mycobacterium tuberculosis (M.tb) and regulates immune responses against M.tb pathogen. MIF -173 G > C gene polymorphism may affect immunity in an individual and leads to susceptibility to...

journal_title：Scientific reports

authors： Areeshi MY,Mandal RK,Dar SA,Jawed A,Wahid M,Lohani M,Panda AK,Mishra BN,Akhter N,Haque S

更新日期：2017-12-05 00:00:00

abstract：:It is well known that haem serves as the prosthetic group of various haemoproteins that function in oxygen transport, respiratory chain, and drug metabolism. However, much less is known about the functions of the catabolites of haem in mammalian cells. Haem is enzymatically degraded to iron, carbon monoxide (CO), and ...

journal_title：Scientific reports

authors： Takeda TA,Mu A,Tai TT,Kitajima S,Taketani S

更新日期：2015-05-20 00:00:00

abstract：:Polycrystalline CeGe is investigated by means of DC and AC susceptibility, non-linear DC susceptibility, electrical transport and heat capacity measurements in the low temperature regime. This compound shows two peaks at low magnetic field around TI ~ 10.7 and TII ~ 7.3 K due to antiferromagnetic ordering and subseque...

journal_title：Scientific reports

authors： Singh K,Mukherjee K

更新日期：2019-03-26 00:00:00

abstract：:The impact of obesity on health-related quality of life (HRQoL) in chronic kidney disease (CKD) population has not been elucidated, despite the impairment of HRQoL in the obese among general population. We hypothesized that the impact of obesity on HRQoL might be confounded by impaired renal function in CKD population...

journal_title：Scientific reports

authors： Suh SH,Choi HS,Kim CS,Bae EH,Ma SK,Lee DH,Kim SW

更新日期：2020-02-11 00:00:00

abstract：:The platinum-based chemotherapeutic agent, oxaliplatin, is used to treat advanced colorectal cancer (CRC). Unfortunately, nearly all patients acquire resistance to oxaliplatin after long-term use, limiting its therapeutic efficacy. Since COX-2 and PGE2 signaling can impact colon cancer cell proliferation and survival,...

journal_title：Scientific reports

authors： Huang H,Aladelokun O,Ideta T,Giardina C,Ellis LM,Rosenberg DW

更新日期：2019-03-20 00:00:00

abstract：:The hippocampus has a significant association with memory, cognition and emotions. The dopaminergic projections from both the ventral tegmental area and substantia nigra are thought to be involved in hippocampal activity. To date, however, few studies have investigated dopaminergic innervation in the hippocampus or th...

journal_title：Scientific reports

authors： Castro-Hernández J,Adlard PA,Finkelstein DI

更新日期：2017-03-14 00:00:00

abstract：:During germ cell development, epigenetic modifications undergo extensive remodeling. Abnormal epigenetic modifications usually result in germ cell loss and reproductive defect. Prmt5 (Protein arginine methyltransferase 5) encodes a protein arginine methyltransferase which has been demonstrated to play important roles ...

journal_title：Scientific reports

authors： Wang Y,Zhu T,Li Q,Liu C,Han F,Chen M,Zhang L,Cui X,Qin Y,Bao S,Gao F

更新日期：2015-06-15 00:00:00

abstract：:The housefly (Musca domestica L.) lives in close association with its microbiota and its symbionts are suggested to have pivotal roles in processes such as metabolism and immune response, but it is unclear how the profound physiological changes during ontogeny affect the housefly's associated microbiota and their meta...

journal_title：Scientific reports

authors： de Jonge N,Michaelsen TY,Ejbye-Ernst R,Jensen A,Nielsen ME,Bahrndorff S,Nielsen JL

更新日期：2020-05-12 00:00:00

abstract：:Superresolution microscopy offers the advantage of imaging biological structures within cells at the nano-scale. Here we apply two superresolution microscopy techniques, specifically 3D structured illumination microscopy (3D-SIM) and direct stochastic optical reconstruction microscopy (dSTORM), a type of single molecu...

journal_title：Scientific reports

authors： Sudhaharan T,Hariharan S,Lim JSY,Liu JZ,Koon YL,Wright GD,Chiam KH,Ahmed S

更新日期：2019-02-21 00:00:00

abstract：:Radiomics has shown promise in improving models for predicting patient outcomes. However, to maximize the information gain of the radiomics features, especially in larger patient cohorts, the variability in radiomics features owing to differences between scanners and scanning protocols must be accounted for. To this a...

journal_title：Scientific reports

authors： Ger RB,Zhou S,Chi PM,Lee HJ,Layman RR,Jones AK,Goff DL,Fuller CD,Howell RM,Li H,Stafford RJ,Court LE,Mackin DS

更新日期：2018-08-29 00:00:00

abstract：:Transition metal oxides potentially present higher specific capacities than the current anodes based on carbon, providing an increasing energy density as compared to commercial Li-ion batteries. However, many parameters could influence the performance of the batteries, which depend on the processing of the electrode m...

journal_title：Scientific reports

authors： Prado FD,Andersen HF,Taeño M,Mæhlen JP,Ramírez-Castellanos J,Maestre D,Karazhanov S,Cremades A

更新日期：2020-03-26 00:00:00

abstract：:The frontal lobes are essential for human volition and goal-directed behavior, yet their function remains unclear. While various models have highlighted working memory, reinforcement learning, and cognitive control as key functions, a single framework for interpreting the range of effects observed in prefrontal cortex...

journal_title：Scientific reports

authors： Alexander WH,Brown JW

更新日期：2018-03-01 00:00:00

abstract：:Graphene has shown enormous potential for innovation in various research fields. The current chemical approaches based on exfoliation of graphite via graphite oxide (GO) are potential for large-scale synthesis of graphene but suffer from high cost, great operation difficulties, and serious waste discharge. We report a...

journal_title：Scientific reports

authors： Hong Y,Wang Z,Jin X

更新日期：2013-12-06 00:00:00

abstract：:Acid-base homeostasis is critical for normal growth, development, and hearing function. The sodium-hydrogen exchanger 6 (NHE6), a protein mainly expressed in early and recycling endosomes, plays an important role in regulating organellar pH. Mutations in NHE6 cause complex, slowly progressive neurodegeneration. Little...

journal_title：Scientific reports

authors： Kucharava K,Brand Y,Albano G,Sekulic-Jablanovic M,Glutz A,Xian X,Herz J,Bodmer D,Fuster DG,Petkovic V

更新日期：2020-02-27 00:00:00

abstract：:Despite recent advances in melanoma treatment, metastasis and resistance to therapy remain serious clinical challenges. NME1 is a metastasis suppressor, a class of proteins which inhibits metastatic spread of cancer cells without impact on growth of the primary tumor. We have identified a rare subpopulation of cells w...

journal_title：Scientific reports

authors： Snyder D,Wang Y,Kaetzel DM

更新日期：2020-02-06 00:00:00

abstract：:Tau is a microtubule-associated protein whose C-terminal domain consisting of four repeat regions R1, R2, R3 and R4 binds to microtubules to stabilize them. In several neurodegenerative diseases, tau detaches from microtubules to form insoluble aggregates leading to tauopathy. Microtubules are made up of αβ tubulin su...

journal_title：Scientific reports

authors： Bhandare VV,Kumbhar BV,Kunwar A

更新日期：2019-07-25 00:00:00

abstract：:The growing interest in engineered tumor models prompted us to devise a method for the non-invasive assessment of such models. Here, we report on bioluminescence imaging (BLI) for the assessment of engineered tumor models in the fertilized chicken egg, i.e, chick chorioallantoic membrane (CAM) assay. One prostate canc...

journal_title：Scientific reports

authors： Jefferies B,Lenze F,Sathe A,Truong N,Anton M,von Eisenhart-Rothe R,Nawroth R,Mayer-Kuckuk P

更新日期：2017-07-10 00:00:00

abstract：:Among abundant reconstructions of Holocene climate in Europe, only a handful has addressed winter conditions, and most of these are restricted in length and/or resolution. Here we present a record of late autumn through early winter air temperature and moisture source changes in East-Central Europe for the Holocene, b...

journal_title：Scientific reports

authors： Perșoiu A,Onac BP,Wynn JG,Blaauw M,Ionita M,Hansson M

更新日期：2017-04-26 00:00:00

abstract：:We report that misfolded cytosolic proteins can be cleared from mammalian cells by directing them to endoplasmic reticulum (ER). NAT1 R64W and Parkin R42P are naturally occurring misfolded variants of cytosolic enzymes that acetylate arylamines and ubiquitinate proteins, respectively. We demonstrate that proteasome in...

journal_title：Scientific reports

authors： Liu F,Koepp DM,Walters KJ

更新日期：2015-07-14 00:00:00

abstract：:We explore two small molecules containing arms of dicyano-n-hexylrhodanine and diathiafulvalene wings terminated with benzothiadiazole linker, denoted as BAF-4CN and BAF-2HDT, respectively, as small molecule non-fullerene acceptors (SMNFAs) in organic solar cells. The proposed materials are mixed with a low band gap p...

journal_title：Scientific reports

authors： Datt R,Suman,Bagui A,Siddiqui A,Sharma R,Gupta V,Yoo S,Kumar S,Singh SP

更新日期：2019-06-12 00:00:00