Inhibition of PGE2/EP4 receptor signaling enhances oxaliplatin efficacy in resistant colon cancer cells through modulation of oxidative stress.

abstract：:Facial mimicry has been suggested to be a behavioral index for emotional empathy. The present study is the first to investigate the link between facial muscle activity and empathy for pain by facial electromyographic (EMG) recording while observers watched videos depicting real-life painful events. Three types of visu...

journal_title：Scientific reports

authors： Sun YB,Wang YZ,Wang JY,Luo F

更新日期：2015-12-09 00:00:00

abstract：:Familial breast cancer is estimated to account for 15-20% of all cases of breast cancer. Surveillance for familial breast cancer is well-established world-wide. However, this service does not exist in Jordan, due to the scarcity of information with regard to the genetic profiling of these patients, and therefore lack ...

journal_title：Scientific reports

authors： Abu-Helalah M,Azab B,Mubaidin R,Ali D,Jafar H,Alshraideh H,Drou N,Awidi A

更新日期：2020-10-16 00:00:00

abstract：:The expression of aminoglycoside-modifying enzymes represents a survival strategy of antibiotic-resistant bacteria. Aminoglycoside 2'-N-acetyltransferase [AAC(2')] neutralizes aminoglycoside drugs by acetylation of their 2' amino groups in an acetyl coenzyme A (CoA)-dependent manner. To understand the structural featu...

journal_title：Scientific reports

authors： Jeong CS,Hwang J,Do H,Cha SS,Oh TJ,Kim HJ,Park HH,Lee JH

更新日期：2020-12-09 00:00:00

abstract：:Vδ2 γδ (Vδ2) T cells, a major human γδ T cell subset, exhibit broad anti-tumor and anti-infective activity; however, their precise role in chronic hepatitis C virus (HCV) infections remains unclear. In this study, we analyzed the phenotype and function of Vδ2 T cells in 43 HCV-infected patients compared to 39 healthy ...

journal_title：Scientific reports

authors： Yin W,Tong S,Zhang Q,Shao J,Liu Q,Peng H,Hu H,Peng M,Hu P,Ren H,Tian Z,Zhang D

更新日期：2016-05-19 00:00:00

abstract：:Prunella vulgaris L, a perennial herb widely used in Asia in the treatment of various diseases including cancer. In vitro studies have demonstrated the therapeutic effect of Prunella vulgaris L. against breast cancer through multiple pathways. However, the nature of the biological mechanisms remains unclear. In this s...

journal_title：Scientific reports

authors： Zhang X,Shen T,Zhou X,Tang X,Gao R,Xu L,Wang L,Zhou Z,Lin J,Hu Y

更新日期：2020-09-25 00:00:00

abstract：:Parametric analysis of Cerebellar Ataxia (CA) could be of immense value compared to its subjective clinical assessments. This study focuses on a comprehensive scheme for objective assessment of CA through the instrumented versions of 9 commonly used neurological tests in 5 domains- speech, upper limb, lower limb, gait...

journal_title：Scientific reports

authors： Kashyap B,Phan D,Pathirana PN,Horne M,Power L,Szmulewicz D

更新日期：2020-06-11 00:00:00

abstract：:Joubert syndrome (JS) is an inherited ciliopathy characterized by a distinctive cerebellar and brain stem malformation which is known as the "molar tooth sign" on axial brain images, hypotonia, and developmental delay. Approximately 25-30% of patients with JS have kidney disease and many of them progress to end-stage ...

journal_title：Scientific reports

authors： Takagi Y,Miura K,Yabuuchi T,Kaneko N,Ishizuka K,Takei M,Yajima C,Ikeuchi Y,Kobayashi Y,Takizawa T,Hisano M,Tsurusaki Y,Matsumoto N,Hattori M

更新日期：2021-01-11 00:00:00

abstract：:People with normal hearing thresholds can nonetheless have difficulty with understanding speech in noisy backgrounds. The origins of such supra-threshold hearing deficits remain largely unclear. Previously we showed that the auditory brainstem response to running speech is modulated by selective attention, evidencing ...

journal_title：Scientific reports

authors： Saiz-Alía M,Forte AE,Reichenbach T

更新日期：2019-10-01 00:00:00

abstract：:Although Heme Oxygenase-1 (HO-1) induction in various forms of kidney injury is protective, its role in age-related renal pathology is unknown. In the ageing kidney there is nephron loss and lesions of focal glomerulosclerosis, interstitial fibrosis, tubular atrophy and arteriolosclerosis. Underlying mechanisms includ...

journal_title：Scientific reports

authors： Poulaki E,Detsika MG,Fourtziala E,Lianos EA,Gakiopoulou H

更新日期：2020-03-31 00:00:00

abstract：:Secreted Protein Acidic and Rich in Cysteine (SPARC)-related modular calcium-binding protein-2 (SMOC2), a secreted matricellular protein, is reported to be involved in various processes related to cancer progression such as regulating the cell cycle, angiogenesis, and invasion. However, its expression and prognostic s...

journal_title：Scientific reports

authors： Kim HS,Choi JH,Lee JY,Kang J,Myung JK,Kim WH,Jang BG

更新日期：2020-03-17 00:00:00

abstract：:Coral reefs have been subject to mass coral bleaching, potentially causing rapid and widespread degradation of ecosystem services that depend on live coral cover, such as fisheries catch. Fisheries species in tropical waters associate with a wide range of habitats, so assessing the dependency of fisheries on coral ree...

journal_title：Scientific reports

authors： Brown CJ,Taylor W,Wabnitz CCC,Connolly RM

更新日期：2020-10-20 00:00:00

abstract：:Although recent studies have shed insights on some of the potential causes of male infertility, new underlining molecular mechanisms still remain to be elucidated. Makorin-2 (Mkrn2) is an evolutionarily conserved gene whose biological functions are not fully known. We developed an Mrkn2 knockout mouse model to study t...

journal_title：Scientific reports

authors： Qian X,Wang L,Zheng B,Shi ZM,Ge X,Jiang CF,Qian YC,Li DM,Li W,Liu X,Yin Y,Zheng JT,Shen H,Wang M,Guo XJ,He J,Lin M,Liu LZ,Sha JH,Jiang BH

更新日期：2016-12-23 00:00:00

abstract：:Sustainable wastewater treatment has been attracting increasing attentions over the past decades. However, the production of nitrous oxide (N2O), a potent GHG, from the energy-efficient granule-based autotrophic nitrogen removal is largely unknown. This study applied a previously established N2O model, which incorpora...

journal_title：Scientific reports

authors： Peng L,Sun J,Liu Y,Dai X,Ni BJ

更新日期：2017-04-03 00:00:00

abstract：:Sodium taurocholate cotransporting polypeptide (NTCP) is a recently discovered hepatitis B virus (HBV) receptor. In the present study, we used TK-NOG mice with a humanized liver to examine the impact of endogenous NTCP expression on HBV infection. Upon inoculation with HBV, these mice exhibited clear viremia in 2 week...

journal_title：Scientific reports

authors： Nakabori T,Hikita H,Murai K,Nozaki Y,Kai Y,Makino Y,Saito Y,Tanaka S,Wada H,Eguchi H,Takahashi T,Suemizu H,Sakamori R,Hiramatsu N,Tatsumi T,Takehara T

更新日期：2016-06-09 00:00:00

abstract：:Human group-specific component protein (Gc protein) is a multifunctional serum protein which has three common allelic variants, Gc1F, Gc1S and Gc2 in humans. Gc1 contains an O-linked trisaccharide [sialic acid-galactose-N-acetylgalactosamine (GalNAc)] on the threonine420 (Thr420) residue and can be converted to a pote...

journal_title：Scientific reports

authors： Nabeshima Y,Abe C,Kawauchi T,Hiroi T,Uto Y,Nabeshima YI

更新日期：2020-11-05 00:00:00

abstract：:Cisplatin (CDDP) is potent anticancer agent used for several tumor types. Thymoquinone (TQ) is naturally occurring compound drawing great attention as anticancer and chemomodulator for chemotherapies. Herein, we studied the potential cytotoxicity of thymoquinone, CDDP and their combination against human oral squamous ...

journal_title：Scientific reports

authors： Alaufi OM,Noorwali A,Zahran F,Al-Abd AM,Al-Attas S

更新日期：2017-10-13 00:00:00

abstract：:Compared with the commercially available single nucleotide polymorphism (SNP) chip based on the Bead Chip technology, the solution hybrid selection (SHS)-based target enrichment SNP chip is not only design-flexible, but also cost-effective for genotype sequencing. In this study, we propose to design an animal SNP chip...

journal_title：Scientific reports

authors： Qiao X,Su R,Wang Y,Wang R,Yang T,Li X,Chen W,He S,Jiang Y,Xu Q,Wan W,Zhang Y,Zhang W,Chen J,Liu B,Liu X,Fan Y,Chen D,Jiang H,Fang D,Liu Z,Wang X,Zhang Y,Mao D,Wang Z,Di R,Zhao Q,Zhong T,Yang H,Wa

更新日期：2017-08-17 00:00:00

abstract：:Accurate measurements of autonomic nerve regulation in heart failure (HF) were unresolved. The discriminating performance of deceleration and acceleration capacities of heart rate in HF was evaluated in 130 HF patients and 212 controls. Acceleration capacity and deceleration capacity were independent risk factors for ...

journal_title：Scientific reports

authors： Hu W,Jin X,Zhang P,Yu Q,Yin G,Lu Y,Xiao H,Chen Y,Zhang D

更新日期：2016-03-23 00:00:00

abstract：:Accumulating evidence indicates the association between obesity and lung function. However, no previous study has examined whether obesity affects lung function in normal weight participants with high body fat. We hypothesized that subjects with normal weight obesity (NWO) were inversely associated with lung function ...

journal_title：Scientific reports

authors： Chen YY,Kao TW,Fang WH,Wang CC,Chang YW,Yang HF,Wu CJ,Sun YS,Chen WL

更新日期：2019-06-20 00:00:00

abstract：:This corrects the article DOI: 10.1038/srep44640. ...

journal_title：Scientific reports

authors： Dong S,Wen P,Zhang Q,Li X,Tan K,Nieh J

更新日期：2017-06-30 00:00:00

abstract：:Both genetic and environmental factors are suggested to influence overweight and obesity risks. Although individual loci and genes have been frequently shown to be associated with body mass index (BMI), the overall interaction of these genes and their role in BMI remains underexplored. Data were collected in 90 health...

journal_title：Scientific reports

authors： Joseph PV,Jaime-Lara RB,Wang Y,Xiang L,Henderson WA

更新日期：2019-05-15 00:00:00

abstract：:A bound state in the continuum (BIC) is an unusual localized state that is embedded in a continuum of extended states. Here, we present the general condition for BICs to arise from wave equation separability. Then we show that by exploiting perturbations of certain symmetry such BICs can be turned into resonances that...

journal_title：Scientific reports

authors： Rivera N,Hsu CW,Zhen B,Buljan H,Joannopoulos JD,Soljačić M

更新日期：2016-09-19 00:00:00

abstract：:Dramatic functional changes of enzyme usually require scores of alterations in amino acid sequence. However, in the case of guanylate kinase (GK), the functional novelty is induced by a single (S→P) mutation, leading to the functional transition of the enzyme from a phosphoryl transfer kinase into a phosphorprotein in...

journal_title：Scientific reports

authors： Zhang Y,Niu H,Li Y,Chu H,Shen H,Zhang D,Li G

更新日期：2015-02-12 00:00:00

abstract：:Immunosuppression is critical for tumor growth and metastasis as well as obstacle to effective immunotherapy. Here, we demonstrate that host deficiency in caveolin-2, a member of caveolin protein family, increases M1-polarized tumor-associated macrophage (TAM) and CD8 T cell infiltration into subcutaneously implanted ...

journal_title：Scientific reports

authors： Liu Y,Qi X,Li G,Sowa G

更新日期：2019-12-12 00:00:00

abstract：:Heat shock factor-1 (HSF1) protects neurons from death caused by the accumulation of misfolded proteins by stimulating the transcription of genes encoding heat shock proteins (HSPs). This stimulatory action depends on the association of trimeric HSF1 to sequences within HSP gene promoters. However, we recently describ...

journal_title：Scientific reports

authors： Qu Z,Titus ASCLS,Xuan Z,D'Mello SR

更新日期：2018-11-22 00:00:00

abstract：:Vitamin D and parathyroid hormone (PTH) regulate mineral metabolism and are required to maintain calcium levels. Vitamin D deficiency is common, particularly during pregnancy, and has been associated with hypertensive disorders of pregnancy. We sought to determine whether maternal 25(OH)D, PTH and calcium concentratio...

journal_title：Scientific reports

authors： Santorelli G,Whitelaw D,Farrar D,West J,Lawlor DA

更新日期：2019-02-04 00:00:00

abstract：:High temperature inhibits wheat grain filling. Polyamines (PAs) are closely associated with plant resistance caused by abiotic stress. However, little is known about the effect of PAs on the grain filling of wheat under heat stress. Two wheat varieties differing in heat resistance were used, and endogenous PAs levels ...

journal_title：Scientific reports

authors： Jing J,Guo S,Li Y,Li W

更新日期：2020-05-04 00:00:00

abstract：:Peripheral blood indices of systemic inflammation such as the neutrophil-lymphocyte ratio (NLR) have been shown to be prognostic in various cancers. We aim to investigate the clinical significance of these indices in patients with soft tissue sarcoma (STS). Seven hundred and twelve patients with available blood counts...

journal_title：Scientific reports

authors： Chan JY,Zhang Z,Chew W,Tan GF,Lim CL,Zhou L,Goh WL,Poon E,Somasundaram N,Selvarajan S,Sittampalam K,Chin F,Teh J,Tan MH,Soo KC,Teo M,Farid M,Quek R

更新日期：2018-08-10 00:00:00

abstract：:Lipopolysaccharide (LPS) is a major component of the outer wall of gram negative bacteria. In high doses LPS contributes to the inflammation in gram negative sepsis, and in low doses contributes to the low grade inflammation characteristic of the metabolic syndrome. We wanted to assess the role of beta2-glycoprotein I...

journal_title：Scientific reports

authors： Zhou S,Chen G,Qi M,El-Assaad F,Wang Y,Dong S,Chen L,Yu D,Weaver JC,Beretov J,Krilis SA,Giannakopoulos B

更新日期：2016-09-27 00:00:00

abstract：:Antimicrobial peptides (AMP) are highly conserved immune effectors across the tree of life and are employed as combinations. In the beetle Tenebrio molitor, a defensin and a coleoptericin are highly expressed in vivo after inoculation with S. aureus. The defensin displays strong in vitro activity but no survival benef...

journal_title：Scientific reports

authors： Makarova O,Johnston P,Rodriguez-Rojas A,El Shazely B,Morales JM,Rolff J

更新日期：2018-10-18 00:00:00