Abstract:
:People with normal hearing thresholds can nonetheless have difficulty with understanding speech in noisy backgrounds. The origins of such supra-threshold hearing deficits remain largely unclear. Previously we showed that the auditory brainstem response to running speech is modulated by selective attention, evidencing a subcortical mechanism that contributes to speech-in-noise comprehension. We observed, however, significant variation in the magnitude of the brainstem's attentional modulation between the different volunteers. Here we show that this variability relates to the ability of the subjects to understand speech in background noise. In particular, we assessed 43 young human volunteers with normal hearing thresholds for their speech-in-noise comprehension. We also recorded their auditory brainstem responses to running speech when selectively attending to one of two competing voices. To control for potential peripheral hearing deficits, and in particular for cochlear synaptopathy, we further assessed noise exposure, the temporal sensitivity threshold, the middle-ear muscle reflex, and the auditory-brainstem response to clicks in various levels of background noise. These tests did not show evidence for cochlear synaptopathy amongst the volunteers. Furthermore, we found that only the attentional modulation of the brainstem response to speech was significantly related to speech-in-noise comprehension. Our results therefore evidence an impact of top-down modulation of brainstem activity on the variability in speech-in-noise comprehension amongst the subjects.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Saiz-Alía M,Forte AE,Reichenbach Tdoi
10.1038/s41598-019-50773-1subject
Has Abstractpub_date
2019-10-01 00:00:00pages
14131issue
1issn
2045-2322pii
10.1038/s41598-019-50773-1journal_volume
9pub_type
杂志文章abstract::Visceral adiposity is a risk factor for cardiovascular disorders, type 2 diabetes mellitus (T2D) and associated metabolic diseases. Sub-cutaneous fat is believed to be intrinsically different from visceral fat. To understand molecular mechanisms involved in metabolic advantages of fat transplantation, we studied a rat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00081
更新日期:2011-01-01 00:00:00
abstract::In order to obtain a detailed understanding of the modulation of electronic properties in nanoporous Si (np-Si) nanowires with containing ordered, nanometer-sized cylindrical pores, we propose a theoretical method to clarify the band shift and associated with the dielectric modification determined by the geometrical p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14647-8
更新日期:2017-10-31 00:00:00
abstract::Combining with electrochemical corrosion measurements, immersion and hydrogen evolution testing performed in 0.9 wt.% NaCl solution at 37 °C, the corrosion resistance of an as-rolled Mg-3%Al-1%Zn alloy before and after a 3% compressive strain along the rolling direction was investigated. Results revealed that the corr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16351-z
更新日期:2017-11-22 00:00:00
abstract::Automated vehicles (AVs) will change the role of the driver, from actively controlling the vehicle to primarily monitoring it. Removing the driver from the control loop could fundamentally change the way that drivers sample visual information from the scene, and in particular, alter the gaze patterns generated when un...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80126-2
更新日期:2021-01-08 00:00:00
abstract::In this article, the interaction between bovine serum albumin (BSA) and the cationic 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) at the air-buffer interface was investigated at different subphase's pH values (pH = 3, 5 and 10). Surface pressure measurements (π - A) and penetration kinetics process (π - t) were ca...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18689-w
更新日期:2018-01-10 00:00:00
abstract::Hand size perceptual distortions characterize adult human cognition. Notwithstanding the importance of uncovering how hand size representation develops in humans, studies in this field are still at a preliminary stage. Indeed, it is yet to be understood whether hand size distortions are present and reliable in early c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62206-5
更新日期:2020-03-25 00:00:00
abstract::The environmental fate of the herbicide fenoxaprop-ethyl (FE) in water, sediment and water-sediment microcosm was studied and degradation products fenoxaprop (FA), ethyl-2-(4-hydroxyphenoxy)propanoate (EHPP), 2-(4-hydroxyphenoxy)propanoic acid (HPPA) and 6-chloro-2,3-dihydrobenzoxazol-2-one (CDHB) were monitored. FE, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26797
更新日期:2016-05-26 00:00:00
abstract::When lightning strikes soil, it may generate a cylindrical tube of glass known as a fulgurite. The morphology of a fulgurite is ultimately a consequence of the energy of the lightning strike that formed it, and hence fulgurites may be useful in elucidating the energy distribution frequency of cloud-to-ground lightning...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30586
更新日期:2016-07-28 00:00:00
abstract::Bleaching, the loss of algal symbionts, occurs in marine photosymbiotic organisms at water temperatures minimally exceeding average summer SST (sea surface temperatures). Pre-adaptation allows organisms to persist under warmer conditions, providing the tolerance can be carried to new habitats. Here we provide evidence...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30930
更新日期:2016-08-09 00:00:00
abstract::Myopia is the commonest eye disorder in the world. High myopes are predisposed to ocular pathologies. The vasoactive intestinal peptide receptor 2 (VIPR2) gene was identified as a myopia susceptibility locus by our group and another group. We continued to fine-map this locus. A case-control study was performed in 4 se...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54619-8
更新日期:2019-12-03 00:00:00
abstract::Plastic degradation rates in the marine environment are essential to understand. This study demonstrates that in plastic-microbial interaction experiments, residual monomeric and oligomeric content of PA6 significantly influences the development of dissolved organic carbon. While it is well recognized that additives i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38685-6
更新日期:2019-02-14 00:00:00
abstract::The non-enzymatic browning, namely Maillard reaction is commonly invoked to account for abiotic chemical transformations of organic matter. Here we report a new reaction pathway via the Maillard reaction to systematically synthesize a series of nitrogen-doped carbon dots (C-dots) with superhigh quantum yield (QY) and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03564
更新日期:2014-01-06 00:00:00
abstract::MRI of hyperpolarized media, such as (129)Xe and (3)He, shows great potential for clinical applications. The optimal use of the available spin polarization requires accurate flip angle calibrations and T1 measurements. Traditional flip angle calibration methods are time-consuming and suffer from polarization losses du...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25854
更新日期:2016-05-12 00:00:00
abstract::In cloud water, microorganisms are exposed to very strong stresses especially related to the presence of reactive oxygen species including H2O2 and radicals, which are the driving force of cloud chemistry. In order to understand how the bacterium Pseudomonas graminis isolated from cloud water respond to this oxidative...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49319-2
更新日期:2019-09-05 00:00:00
abstract::Parasitism is a successful survival strategy across all kingdoms and has evolved repeatedly in angiosperms. Parasitic plants obtain nutrients from other plants and some are agricultural pests. Obligate parasites, which cannot complete their lifecycle without a host, may lack functional photosystems (holoparasites), or...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17588
更新日期:2015-12-02 00:00:00
abstract::Globally, lung cancer accounts for approximately 20% of all cancer related deaths. Five-year survival is poor and rates have remained unchanged for the past four decades. There is an urgent need to identify markers of lung carcinogenesis and new targets for therapy. Given the recent successes of immune modulators in c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18907
更新日期:2016-01-13 00:00:00
abstract::China has one of the highest rates of cesarean sections in the world. However, limited epidemiological studies have evaluated the risk factors for cesarean section among Chinese women. Thus, the aim of this cohort study was to investigate the associations between pre-pregnancy BMI, gestational weight gain (GWG) and th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37168
更新日期:2016-11-22 00:00:00
abstract::Asian Longhorned Beetle (ALB) Anoplophora glabripennis is a serious invasive forest pest in several countries including the United States, Canada, and Europe. RNA interference (RNAi) technology is being developed as a novel method for pest management. Here, we identified the ALB core RNAi genes including those coding ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08813-1
更新日期:2017-08-21 00:00:00
abstract::From biomarkers to drug carriers, Extracellular Vesicles (EVs) are being used successfully in numerous applications. However, while the subject has been steadily rising in popularity, current methods of isolating EVs are lagging behind, incapable of isolating EVs at a high enough quantity or quality while also requiri...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55477-0
更新日期:2019-12-16 00:00:00
abstract::Alzheimer's disease (AD), an irreversible progressive neurodegenerative disease, causes characteristic cognitive impairment, and no curative treatments are currently available. Stem cell transplantation offers a powerful tool for the treatment of AD. We conducted a systematic review and meta-analysis of data from cont...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析,评审
doi:10.1038/srep12134
更新日期:2015-07-10 00:00:00
abstract::Maternal overnutrition increases the risk of long-term metabolic dysfunction in offspring. Exercise improves metabolism partly by upregulating mitochondrial biogenesis or function, via increased levels of nicotinamide adenine dinucleotide (NAD+). We have shown that the NAD+ precursor, nicotinamide mononucleotide (NMN)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14866-z
更新日期:2017-11-08 00:00:00
abstract::Lepus yarkandensis is a desert hare of the Tarim Basin in western China, and it has strong adaptability to arid environments. Aquaporins (AQPs) are a family of water channel proteins that facilitate transmembrane water transport. Gastrointestinal tract AQPs are involved in fluid absorption in the small intestine and c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53291-2
更新日期:2019-11-12 00:00:00
abstract::Our motor system can generate representations which carry information about the goals of another agent's actions. However, it is not known whether motor representations play a deeper role in social understanding, and, in particular, whether they enable tracking others' beliefs. Here we show that, for adult observers, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68240-7
更新日期:2020-07-09 00:00:00
abstract::Light-inducible gene regulation has great potential for remote and noninvasive control of the fate and function of target cells. One method to achieve such control is delivery of heat shock protein (HSP) promoter-driven protein expression vectors and photothermal heaters into the cells, followed by activation by illum...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04912-1
更新日期:2017-07-05 00:00:00
abstract::The elastic modulus of ZnO nanowires was measured using a resonance method based on laser Doppler effect and their fracture strains were determined via two-point bending with the aid of optical nanomanipulation. The elastic moduli of ZnO nanowires with diameters of 78 to 310 nm vary from 123 to 154 GPa, which are clos...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09843-5
更新日期:2017-08-25 00:00:00
abstract::Indoleamine 2,3 dioxygenase-1 (IDO-1) is an enzyme in the kynurenine pathway which augments tumor-induced immune tolerance. Previous studies in childhood acute myeloid leukemia (AML) have shown a negative correlation of IDO-1 mRNA expression with outcomes. The aim of our study was to develop a practical and objective ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12940-0
更新日期:2017-10-16 00:00:00
abstract::Nowadays, one of the main challenges is moving towards an eco-sustainable agriculture, able to preserve the food production through a reduced use of pesticides. Current global food sustenance by intensive agriculture is mainly based on economic crop monocultures and drastically reduces the biodiversity, increasing the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76247-3
更新日期:2020-11-05 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-24799-w
更新日期:2018-04-19 00:00:00
abstract::Some styrene/maleic acid (SMA) copolymers solubilise membrane lipids and proteins to form polymer-bounded nanodiscs termed SMA/lipid particles (SMALPs). Although SMALPs preserve a lipid-bilayer core, they appear to be more dynamic than other membrane mimics. We used time-resolved Förster resonance energy transfer and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45875
更新日期:2017-04-05 00:00:00
abstract::Articular cartilage (AC) lacks the ability to self-repair and cell-based approaches, primarily based on using chondrocytes and mesenchymal stem cells (MSCs), are emerging as effective technology to restore cartilage functionality, because cells synergic functionality may support the maintenance of chondrogenic phenoty...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51070-7
更新日期:2019-10-10 00:00:00