Network pharmacology based virtual screening of active constituents of Prunella vulgaris L. and the molecular mechanism against breast cancer.

abstract：:Transition metal oxides (TMOs) exhibit many emergent phenomena ranging from high-temperature superconductivity and giant magnetoresistance to magnetism and ferroelectricity. In addition, when TMOs are interfaced with each other, new functionalities can arise, which are absent in individual components. Here, we report ...

journal_title：Scientific reports

authors： Zhu JX,Wen XD,Haraldsen JT,He M,Panagopoulos C,Chia EE

更新日期：2014-06-20 00:00:00

abstract：:The rational synthesis of alternative materials is highly demanding due to the outbreak of infectious diseases and resistance to antibiotics. Herein, we report a tailored nanoantibiotic synthesis protocol where the antibiotic binding was optimized on the silver-silica core-shell nanoparticles surface to maximize biolo...

journal_title：Scientific reports

authors： de Oliveira JFA,Saito Â,Bido AT,Kobarg J,Stassen HK,Cardoso MB

更新日期：2017-05-02 00:00:00

abstract：:The development of high energy-density lithium-ion secondary batteries as storage batteries in vehicles is attracting increasing attention. In this study, high-voltage bipolar stacked batteries with a quasi-solid-state electrolyte containing a Li-Glyme complex were prepared, and the performance of the device was evalu...

journal_title：Scientific reports

authors： Gambe Y,Sun Y,Honma I

更新日期：2015-03-09 00:00:00

abstract：:Hyperlipidemia, a very common disease throughout the world, usually gives rise to severe liver damages. The current experiment was to investigate the antihyperlipidemic and hepatoprotective properties of alkali- and enzyme-extractable Dictyophora indusiata polysaccharides (Al-DPS and En-DPS) on the hyperlipidemic mice...

journal_title：Scientific reports

authors： Wang W,Liu H,Zhang Y,Feng Y,Yuan F,Song X,Gao Z,Zhang J,Song Z,Jia L

更新日期：2019-10-03 00:00:00

abstract：:Natural Killer cells are innate lymphocytes involved in tumor immunosurveillance. They express activating receptors able to recognize self-molecules poorly expressed on healthy cells but up-regulated upon stress conditions, including transformation. Regulation of ligand expression in tumor cells mainly relays on trans...

journal_title：Scientific reports

authors： Zitti B,Molfetta R,Fionda C,Quatrini L,Stabile H,Lecce M,de Turris V,Ricciardi MR,Petrucci MT,Cippitelli M,Gismondi A,Santoni A,Paolini R

更新日期：2017-09-05 00:00:00

abstract：:In Duchenne muscular dystrophy, progressive loss of muscle tissue is accompanied by fibrosis, chronic inflammation and reduced muscle regenerative capacity. Although much is known about the development of fibrosis and chronic inflammation in muscular dystrophy, less is known about how they are mechanistically linked t...

journal_title：Scientific reports

authors： Arecco N,Clarke CJ,Jones FK,Simpson DM,Mason D,Beynon RJ,Pisconti A

更新日期：2016-05-31 00:00:00

abstract：:Protein kinases are frequently mutated in human cancers, which leads to altered signaling pathways and contributes to tumor growth and progression. ERK3 is an atypical mitogen-activated protein kinase (MAPK) containing an S-E-G activation motif rather than the conserved T-X-Y motif in conventional MAPKs such as ERK1/2...

journal_title：Scientific reports

authors： Alsaran H,Elkhadragy L,Shakya A,Long W

更新日期：2017-11-03 00:00:00

abstract：:Topologically distinct magnetic structures like skyrmions, domain walls, and the uniformly magnetized state have multiple applications in logic devices, sensors, and as bits of information. One of the most promising concepts for applying these bits is the racetrack architecture controlled by electric currents or magne...

journal_title：Scientific reports

authors： Schäffer AF,Siegl P,Stier M,Posske T,Berakdar J,Thorwart M,Wiesendanger R,Vedmedenko EY

更新日期：2020-11-23 00:00:00

abstract：:Interactions and coordination between conspecific individuals have produced a remarkable variety of collective behaviours. This co-operation occurs in vertebrate and invertebrate animals and is well expressed in the group flight of birds, fish shoals and highly organized activities of social insects. How individuals i...

journal_title：Scientific reports

authors： Vannier J,Vidal M,Marchant R,El Hariri K,Kouraiss K,Pittet B,El Albani A,Mazurier A,Martin E

更新日期：2019-10-17 00:00:00

abstract：:Infected dogs are the main reservoir of zoonotic visceral leishmaniasis, a widespread parasitic disease caused by Leishmania infantum. Therefore, the control of canine infections is required to reduce the incidence of human cases. Disease outcome in dogs depends on the fine balance between parasite virulence and effic...

journal_title：Scientific reports

authors： Olías-Molero AI,Corral MJ,Jiménez-Antón MD,Alunda JM

更新日期：2019-12-09 00:00:00

abstract：:This research is emphasized to describe the stability analysis in the form of dual solution of the flow and heat analysis on nanofluid over an exponential stretching cylindrical surface containing microorganisms. The research is also implemented to manifest the dual profiles of velocity, temperature and nanoparticle c...

journal_title：Scientific reports

authors： Ferdows M,Hossan A,Bangalee MZI,Sun S,Alzahrani F

更新日期：2020-10-12 00:00:00

abstract：:It will get entirely unusual derivatives with gratifying chemical bonding schemes for boron clusters by doping with lithium, the lightest alkalis. The geometric structures and electronic properties of the LiBn0/- (n = 10-20) clusters have been studied through Crystal structure AnaLYsis by Particle Swarm Optimization (...

journal_title：Scientific reports

authors： Shi H,Kuang X,Lu C

更新日期：2020-02-03 00:00:00

abstract：:Evaluation of the effect of different parameters for designing a non-viral vector in gene delivery systems has great importance. In this manner, 2D crystals, precisely layered double hydroxides, have attracted the attention of scientists due to their significant adjustability and low-toxicity and low-cost preparation ...

journal_title：Scientific reports

authors： Rabiee N,Bagherzadeh M,Ghadiri AM,Salehi G,Fatahi Y,Dinarvand R

更新日期：2020-11-26 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Alflen A,Prüfer S,Ebner K,Reuter S,Lopez PA,Scharrer I,Banno F,Stassen M,Schild H,Jurk K,Bosmann M,Beckert H,Radsak MP

更新日期：2018-09-26 00:00:00

abstract：:Fatty acid oxidation and subsequent ketogenesis is one of the major mechanisms to maintain hepatic lipid homeostasis under fasting conditions. Fasting hormone glucagon has been shown to stimulate ketone body production through activation of PPARα; however, the signal pathway linking glucagon to PPARα is largely undisc...

journal_title：Scientific reports

authors： Zhang ZN,Gong L,Lv S,Li J,Tai X,Cao W,Peng B,Qu S,Li W,Zhang C,Luan B

更新日期：2016-03-17 00:00:00

abstract：:Since the production of ferromagnetic graphene as an extremely important matter in spintronics has made a revolution in future technology, a great deal of efforts has recently been done to reach a simple and cost-effective method. Up to now, controlling the magnetic properties at extremely low temperature have been in...

journal_title：Scientific reports

authors： Alimohammadian M,Sohrabi B

更新日期：2020-12-07 00:00:00

abstract：:Sugarcane (Saccharum spp.) is a globally important crop for sugar and bioenergy production. Its highly polyploid, complex genome has hindered progress in understanding its molecular structure. Flow cytometric sorting and analysis has been used in other important crops with large genomes to dissect the genome into comp...

journal_title：Scientific reports

authors： Metcalfe CJ,Li J,Giorgi D,Doležel J,Piperidis N,Aitken KS

更新日期：2019-12-18 00:00:00

abstract：:A key pathophysiological process and therapeutic target in the critical early post-injury period of traumatic brain injury (TBI) is cell mitochondrial dysfunction; characterised by elevation of brain lactate/pyruvate (L/P) ratio in the absence of hypoxia. We previously showed that succinate can improve brain extracell...

journal_title：Scientific reports

authors： Stovell MG,Mada MO,Helmy A,Carpenter TA,Thelin EP,Yan JL,Guilfoyle MR,Jalloh I,Howe DJ,Grice P,Mason A,Giorgi-Coll S,Gallagher CN,Murphy MP,Menon DK,Hutchinson PJ,Carpenter KLH

更新日期：2018-07-24 00:00:00

abstract：:PCR inhibitors in clinical specimens negatively affect the sensitivity of diagnostic PCR and RT-PCR or may even cause false-negative results. To overcome PCR inhibition, increase the sensitivity of the assays and simplify the detection protocols, simple methods based on quantitative nested real-time PCR and RT-PCR wer...

journal_title：Scientific reports

authors： Cai D,Behrmann O,Hufert F,Dame G,Urban G

更新日期：2018-02-21 00:00:00

abstract：:Bacterial vaginosis (BV) is associated with HIV acquisition and adverse pregnancy outcomes. Recurrence after metronidazole treatment is high. HIV-negative, non-pregnant Rwandan BV patients were randomized to four groups (n = 17/group) after seven-day oral metronidazole treatment: behavioral counseling only (control), ...

journal_title：Scientific reports

authors： van de Wijgert JHHM,Verwijs MC,Agaba SK,Bronowski C,Mwambarangwe L,Uwineza M,Lievens E,Nivoliez A,Ravel J,Darby AC

更新日期：2020-03-03 00:00:00

abstract：:Oil repellent surface have lots of practical applications in many fields. Current oil repellent coating may suffer from limited liquid repellency to oils or environmental risks. In this work, we report an eco-friendly 'green' processes for preparing oil-repellent surface using a renewable and environmentally benign bi...

journal_title：Scientific reports

authors： Xu LP,Han D,Wu X,Zhang Q,Zhang X,Wang S

更新日期：2016-11-29 00:00:00

abstract：:cAMP responsive element binding protein 3-like 3 (CREB3L3), a transcription factor expressed in the liver and small intestine, governs fasting-response energy homeostasis. Tissue-specific CREB3L3 knockout mice have not been generated till date. To our knowledge, this is the first study using the one-step CRISPR/Cas9 s...

journal_title：Scientific reports

authors： Nakagawa Y,Oikawa F,Mizuno S,Ohno H,Yagishita Y,Satoh A,Osaki Y,Takei K,Kikuchi T,Han SI,Matsuzaka T,Iwasaki H,Kobayashi K,Yatoh S,Yahagi N,Isaka M,Suzuki H,Sone H,Takahashi S,Yamada N,Shimano H

更新日期：2016-06-13 00:00:00

abstract：:Inverse Compton scattering between ultra-relativistic electrons and an intense laser field has been proposed as a major route to generate compact high-brightness and high-energy γ-rays. Attributed to the inherent synchronization mechanism, an all-optical Compton scattering γ-ray source, using one laser to both acceler...

journal_title：Scientific reports

authors： Yu C,Qi R,Wang W,Liu J,Li W,Wang C,Zhang Z,Liu J,Qin Z,Fang M,Feng K,Wu Y,Tian Y,Xu Y,Wu F,Leng Y,Weng X,Wang J,Wei F,Yi Y,Song Z,Li R,Xu Z

更新日期：2016-07-13 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Huang S,Sun C,Hou Y,Tang Y,Zhu Z,Zhang Z,Zhang Y,Wang L,Zhao Q,Chen MG,Guo Z,Wang D,Ju W,Zhou Q,Wu L,He X

更新日期：2019-05-03 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) is a metabolic hormone having anti-oxidative and anti-hypertrophic effects. However, the regulation of FGF21 expression during acute myocardial infarction (AMI) remains unclear. We tested blood samples from 50 patients with AMI and 43 patients with stable angina pectoris (sAP) for F...

journal_title：Scientific reports

authors： Sunaga H,Koitabashi N,Iso T,Matsui H,Obokata M,Kawakami R,Murakami M,Yokoyama T,Kurabayashi M

更新日期：2019-08-14 00:00:00

abstract：:Allelic differential expression (ADE) is common in diploid organisms, and is often the key reason for specific phenotype variations. Thus, ADE detection is important for identification of major genes and causal mutations. To date, sensitive and simple methods to detect ADE are still lacking. In this study, we have dev...

journal_title：Scientific reports

authors： Zhao C,Xie S,Wu H,Luan Y,Hu S,Ni J,Lin R,Zhao S,Zhang D,Li X

更新日期：2019-04-19 00:00:00

abstract：:Cisplatin (CDDP) is potent anticancer agent used for several tumor types. Thymoquinone (TQ) is naturally occurring compound drawing great attention as anticancer and chemomodulator for chemotherapies. Herein, we studied the potential cytotoxicity of thymoquinone, CDDP and their combination against human oral squamous ...

journal_title：Scientific reports

authors： Alaufi OM,Noorwali A,Zahran F,Al-Abd AM,Al-Attas S

更新日期：2017-10-13 00:00:00

abstract：:Neuropathic pain is a complex, chronic pain state that often accompanies tissue damage, inflammation or injury of the nervous system. However the underlying molecular mechanisms still remain unclear. Here, we showed that CXCL12 and CXCR4 were upregulated in the dorsal root ganglion (DRG) after chronic compression of D...

journal_title：Scientific reports

authors： Yu Y,Huang X,Di Y,Qu L,Fan N

更新日期：2017-07-18 00:00:00

abstract：:Methylation of DNA CpG sites is a major mechanism of epigenetic gene silencing and plays important roles in cell division, development and carcinogenesis. One of its regulators is the 64-residue C-terminal Transcriptional Repressor Domain (the TRD) of MBD1, which recruits several repressor proteins such as MCAF1, HDAC...

journal_title：Scientific reports

authors： Hameed UF,Lim J,Zhang Q,Wasik MA,Yang D,Swaminathan K

更新日期：2014-05-09 00:00:00

abstract：:An infinite three dimensional (3D) crystal can be constructed by an infinite number of parallel 2D (hkl) crystal planes (CPs) coupled to each other. Based on lattice model Hamiltonian with the hopping between the nearest neighbor (1NN) CPs and all possible neighbor hoppings within each CP, we analytically prove that a...

journal_title：Scientific reports

authors： Wang H,Gao T,Tao R

更新日期：2015-03-02 00:00:00