当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Deficiency of Mkrn2 causes abnormal spermiogenesis and spermiation, and impairs male fertility.

Deficiency of Mkrn2 causes abnormal spermiogenesis and spermiation, and impairs male fertility.

Abstract：

:Although recent studies have shed insights on some of the potential causes of male infertility, new underlining molecular mechanisms still remain to be elucidated. Makorin-2 (Mkrn2) is an evolutionarily conserved gene whose biological functions are not fully known. We developed an Mrkn2 knockout mouse model to study the role of this gene, and found that deletion of Mkrn2 in mice led to male infertility. Mkrn2 knockout mice produced abnormal sperms characterized by low number, poor motility, and aberrant morphology. Disruption of Mkrn2 also caused failure of sperm release (spermiation failure) and misarrangement of ectoplasmic specialization (ES) in testes, thus impairing spermiogenesis and spermiation. To understand the molecular mechanism, we found that expression of Odf2, a vital protein in spermatogenesis, was significantly decreased. In addition, we found that expression levels of Odf2 were decreased in Mkrn2 knockout mice. We also found that MKRN2 was prominently expressed in the sperm of normal men, but was significantly reduced in infertile men. This result indicates that our finding is clinically relevant. The results of our study provided insights into a new mechanism of male infertility caused by the MKRN2 downregulation.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Qian X,Wang L,Zheng B,Shi ZM,Ge X,Jiang CF,Qian YC,Li DM,Li W,Liu X,Yin Y,Zheng JT,Shen H,Wang M,Guo XJ,He J,Lin M,Liu LZ,Sha JH,Jiang BH

doi

10.1038/srep39318

subject

Has Abstract

pub_date

2016-12-23 00:00:00

pages

39318

issn

2045-2322

pii

srep39318

journal_volume

6

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Temporal variation in nutrient requirements of tea (Camellia sinensis) in China based on QUEFTS analysis.

    abstract：:Fertilisation datasets collected from field experiments (n = 21) in tea-producing areas from 2016 to 2018 were used to build a quantitative evaluation of the fertility of tropical soils (QUEFTS) model to estimate nutrient uptake of tea plants, and to investigate relationships between tea yield and nutrient accumulatio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-57809-x

    authors： Tang S,Liu Y,Zheng N,Li Y,Ma Q,Xiao H,Zhou X,Xu X,Jiang T,He P,Wu L

    更新日期：2020-02-04 00:00:00

  • Analysis of Optic Chiasmal Compression Caused by Brain Tumors Using Optical Coherence Tomography Angiography.

    abstract：:We have quantitatively evaluated the macular and peripapillary microvascular changes in eyes with chiasmal compression caused by brain tumors compared with healthy control eyes using optical coherence tomography angiography (OCT-A) and correlated them with other ocular parameters. This cross-sectional study involved t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-59158-1

    authors： Lee GI,Park KA,Oh SY,Kong DS

    更新日期：2020-02-07 00:00:00

  • The allergic response mediated by fire ant venom proteins.

    abstract：:Fire ants are widely studied, invasive and venomous arthropod pests. There is significant biomedical interest in immunotherapy against fire ant stings. However, mainly due to practical reasons, the physiological effects of envenomation has remained poorly characterized. The present study takes advantage of a recently-...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-32327-z

    authors： Zamith-Miranda D,Fox EGP,Monteiro AP,Gama D,Poublan LE,de Araujo AF,Araujo MFC,Atella GC,Machado EA,Diaz BL

    更新日期：2018-09-26 00:00:00

  • MicroRNA-155 is upregulated in ascites in patients with spontaneous bacterial peritonitis.

    abstract：:MircoRNA's (miR) have been recognised as important modulators of gene expression and potential biomarkers. However, they have been rarely investigated in bio fluids apart from blood. We investigated the association of miR-125b and miR-155 with complications of cirrhosis. Ascites was prospectively collected from patien...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40556

    authors： Lutz P,M Haimid M,Pohlmann A,Lehmann J,Jansen C,Schierwagen R,Klein S,Strassburg CP,Spengler U,Trebicka J

    更新日期：2017-01-11 00:00:00

  • Nucleic acid-based polymers effective against hepatitis B Virus infection in patients don't harbor immunostimulatory properties in primary isolated liver cells.

    abstract：:Nucleic acid polymers (NAPs) block the release of subviral particles from hepatocytes, a mechanism consistent with their antiviral activity against hepatitis B virus (HBV) in patients. Analysis of immunostimulatory properties of NAPs were conducted with several NAP species: REP 2006, the prototypic degenerate NAP [dN]...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep43838

    authors： Real CI,Werner M,Paul A,Gerken G,Schlaak JF,Vaillant A,Broering R

    更新日期：2017-03-08 00:00:00

  • Genetic diversity, seasonality and transmission network of human metapneumovirus: identification of a unique sub-lineage of the fusion and attachment genes.

    abstract：:Human metapneumovirus (HMPV) is an important viral respiratory pathogen worldwide. Current knowledge regarding the genetic diversity, seasonality and transmission dynamics of HMPV among adults and children living in tropical climate remains limited. HMPV prevailed at 2.2% (n = 86/3,935) among individuals presented wit...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27730

    authors： Chow WZ,Chan YF,Oong XY,Ng LJ,Nor'E SS,Ng KT,Chan KG,Hanafi NS,Pang YK,Kamarulzaman A,Tee KK

    更新日期：2016-06-09 00:00:00

  • Closing the sea surface mixed layer temperature budget from in situ observations alone: Operation Advection during BoBBLE.

    abstract：:Sea surface temperature (SST) is a fundamental driver of tropical weather systems such as monsoon rainfall and tropical cyclones. However, understanding of the factors that control SST variability is lacking, especially during the monsoons when in situ observations are sparse. Here we use a ground-breaking observation...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-63320-0

    authors： Vijith V,Vinayachandran PN,Webber BGM,Matthews AJ,George JV,Kannaujia VK,Lotliker AA,Amol P

    更新日期：2020-04-27 00:00:00

  • Increasing New Delhi metallo-β-lactamase-positive Escherichia coli among carbapenem non-susceptible Enterobacteriaceae in Taiwan during 2016 to 2018.

    abstract：:New Delhi metallo-β-lactamase (NDM) had been reported to be the predominant carbapenemase among Escherichia coli in Taiwan. However, studies focusing on the clonal background and epidemiology of plasmids carrying NDM genes were limited. Between 2016 and 2018, all clinical E. coli and Klebsiella pneumoniae isolates tha...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-82166-8

    authors： Huang YS,Tsai WC,Li JJ,Chen PY,Wang JT,Chen YT,Chen FJ,Lauderdale TL,Chang SC

    更新日期：2021-01-28 00:00:00

  • Efficient Generation of Transgenic Buffalos (Bubalus bubalis) by Nuclear Transfer of Fetal Fibroblasts Expressing Enhanced Green Fluorescent Protein.

    abstract：:The possibility of producing transgenic cloned buffalos by nuclear transfer of fetal fibroblasts expressing enhanced green fluorescent protein (EGFP) was explored in this study. When buffalo fetal fibroblasts (BFFs) isolated from a male buffalo fetus were transfected with pEGFP-N1 (EGFP is driven by CMV and Neo is dri...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-25120-5

    authors： Lu F,Luo C,Li N,Liu Q,Wei Y,Deng H,Wang X,Li X,Jiang J,Deng Y,Shi D

    更新日期：2018-05-03 00:00:00

  • Prediction models and risk assessment for silicosis using a retrospective cohort study among workers exposed to silica in China.

    abstract：:This study aims to develop a prognostic risk prediction model for the development of silicosis among workers exposed to silica dust in China. The prediction model was performed by using retrospective cohort of 3,492 workers exposed to silica in an iron ore, with 33 years of follow-up. We developed a risk score system ...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/srep11059

    authors： Tse LA,Dai J,Chen M,Liu Y,Zhang H,Wong TW,Leung CC,Kromhout H,Meijer E,Liu S,Wang F,Yu IT,Shen H,Chen W

    更新日期：2015-06-19 00:00:00

  • Novel common variants and susceptible haplotype for exfoliation glaucoma specific to Asian population.

    abstract：:The common variants in lysyl oxidase-like 1 gene (LOXL1) are associated with exfoliation glaucoma (XFG) patients developed through exfoliation syndrome (XFS). However, the risk allele of a variant in LOXL1 has been found to be inverted between Asian and Caucasian populations. Therefore, we newly performed a genome-wid...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05340

    authors： Nakano M,Ikeda Y,Tokuda Y,Fuwa M,Ueno M,Imai K,Sato R,Omi N,Adachi H,Kageyama M,Mori K,Kinoshita S,Tashiro K

    更新日期：2014-06-18 00:00:00

  • US Power Production at Risk from Water Stress in a Changing Climate.

    abstract：:Thermoelectric power production in the United States primarily relies on wet-cooled plants, which in turn require water below prescribed design temperatures, both for cooling and operational efficiency. Thus, power production in US remains particularly vulnerable to water scarcity and rising stream temperatures under ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-12133-9

    authors： Ganguli P,Kumar D,Ganguly AR

    更新日期：2017-09-20 00:00:00

  • High-speed and Large-scale Privacy Amplification Scheme for Quantum Key Distribution.

    abstract：:State-of-art quantum key distribution (QKD) systems are performed with several GHz pulse rates, meanwhile privacy amplification (PA) with large scale inputs has to be performed to generate the final secure keys with quantified security. In this paper, we propose a fast Fourier transform (FFT) enhanced high-speed and l...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-50290-1

    authors： Tang BY,Liu B,Zhai YP,Wu CQ,Yu WR

    更新日期：2019-10-31 00:00:00

  • Alterations of the volatile metabolome in mouse models of Alzheimer's disease.

    abstract：:In the present study, we tested whether the volatile metabolome was altered by mutations of the Alzheimer's disease (AD)-implicated amyloid precursor protein gene (APP) and comprehensively examined urinary volatiles that may potentially serve as candidate biomarkers of AD. Establishing additional biomarkers in screeni...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep19495

    authors： Kimball BA,Wilson DA,Wesson DW

    更新日期：2016-01-14 00:00:00

  • Non-enzymatic-browning-reaction: a versatile route for production of nitrogen-doped carbon dots with tunable multicolor luminescent display.

    abstract：:The non-enzymatic browning, namely Maillard reaction is commonly invoked to account for abiotic chemical transformations of organic matter. Here we report a new reaction pathway via the Maillard reaction to systematically synthesize a series of nitrogen-doped carbon dots (C-dots) with superhigh quantum yield (QY) and ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep03564

    authors： Wei W,Xu C,Wu L,Wang J,Ren J,Qu X

    更新日期：2014-01-06 00:00:00

  • Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing.

    abstract：:ABX464 is a first-in-class, clinical-stage, small molecule for oral administration that has shown strong anti-inflammatory effects in the DSS-model for inflammatory bowel disease (IBD) and also prevents replication of the HIV virus. ABX464 which binds to cap binding complex (CBC) has demonstrated safety and efficacy i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-37813-y

    authors： Vautrin A,Manchon L,Garcel A,Campos N,Lapasset L,Laaref AM,Bruno R,Gislard M,Dubois E,Scherrer D,Ehrlich JH,Tazi J

    更新日期：2019-01-28 00:00:00

  • Mendelian randomization analysis rules out disylipidaemia as colorectal cancer cause.

    abstract：:Dyslipidemia and statin use have been associated with colorectal cancer (CRC), but prospective studies have shown mixed results. We aimed to determine whether dyslipidemia is causally linked to CRC risk using a Mendelian randomization approach and to explore the association of statins with CRC. A case-control study wa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49880-w

    authors： Ibáñez-Sanz G,Díez-Villanueva A,Riera-Ponsati M,Fernández-Villa T,Fernández Navarro P,Bustamante M,Llorca J,Amiano P,Ascunce N,Fernández-Tardón G,Salcedo Bellido I,Salas D,Capelo Álvarez R,Crous-Bou M,Ortega-Valín L,Pérez-G

    更新日期：2019-09-16 00:00:00

  • Author Correction: The thiazide sensitive sodium chloride co-transporter NCC is modulated by site-specific ubiquitylation.

    abstract：:A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-018-22153-8

    authors： Rosenbaek LL,Rizzo F,Wu Q,Rojas-Vega L,Gamba G,MacAulay N,Staub O,Fenton RA

    更新日期：2018-03-06 00:00:00

  • Endothelial dysfunction in systemic lupus erythematosus - a case-control study and an updated meta-analysis and meta-regression.

    abstract：:Endothelium-dependent flow-mediated dilation (ED-FMD), a biophysical marker of endothelial dysfunction, is apparently impaired in patients with systemic lupus erythematosus (SLE) but such observation is inconsistent. Here, we assessed and compared the brachial artery ED-FMD (baED-FMD) using ultrasonography between SLE...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/s41598-017-07574-1

    authors： Mak A,Kow NY,Schwarz H,Gong L,Tay SH,Ling LH

    更新日期：2017-08-04 00:00:00

  • Maternal obesity and severe pre-eclampsia among immigrant women: a mediation analysis.

    abstract：:We investigated the extent to which pre-pregnancy obesity mediates the association between maternal place of birth and severe pre-eclampsia in the PreCARE cohort of pregnant women in Paris (n = 9,579). Adjusted path analysis logistic regression models were used to assess the role of pre-pregnancy obesity as a mediator...

    journal_title：Scientific reports

    pub_type： 杂志文章,多中心研究

    doi：10.1038/s41598-020-62032-9

    authors： Siddiqui A,Deneux-Tharaux C,Luton D,Schmitz T,Mandelbrot L,Estellat C,Howell EA,Khoshnood B,Bertille N,Azria E

    更新日期：2020-03-23 00:00:00

  • Biomechanical investigation of extragraft bone formation influences on the operated motion segment after anterior cervical spinal discectomy and fusion.

    abstract：:Although the clinical importance of extragraft bone formation (ExGBF) and bridging (ExGBB) has been reported, few studies have investigated the biomechanical influences of ExGBF on the motion segment. In this study, ExGBF was simulated at the C5-C6 motion segment after anterior cervical discectomy and fusion using a d...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54785-9

    authors： Park WM,Jin YJ

    更新日期：2019-12-11 00:00:00

  • Dysregulated Neurotransmission induces Trans-synaptic degeneration in reconstructed Neuronal Networks.

    abstract：:Increasing evidence suggests that pathological hallmarks of chronic degenerative syndromes progressively spread among interconnected brain areas in a disease-specific stereotyped pattern. Functional brain imaging from patients affected by various neurological syndromes such as traumatic brain injury and stroke indicat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29918-1

    authors： Deleglise B,Lassus B,Soubeyre V,Doulazmi M,Brugg B,Vanhoutte P,Peyrin JM

    更新日期：2018-08-02 00:00:00

  • Ternary phase behaviour and vesicle formation of a sodium N-lauroylsarcosinate hydrate/1-decanol/water system.

    abstract：:The phase behaviour of a system composed of amino acid-based surfactant (sodium N-lauroylsarcosinate hydrate), 1-decanol and deionised water was investigated for vesicle formation. Changing the molar ratio of the amphiphiles, two important aggregate structures were observed in the aqueous corner of the phase diagram. ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00071

    authors： Akter N,Radiman S,Mohamed F,Rahman IA,Reza MI

    更新日期：2011-01-01 00:00:00

  • Particle size effect on sorting with optical lattice.

    abstract：:Transport of mesoscale particles due to driving flow fields or external forces on a periodic surface appears in many areas. Geometrical and physical characteristics of particles affect the velocities of the particles in these periodic landscapes. In this paper, we present a numerical simulation based on solving the La...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-75187-2

    authors： Madadi E,Biagooi M,Mohammadjafari F,Nedaaee Oskoee S

    更新日期：2020-10-26 00:00:00

  • Inhibiting P. fluorescens biofilms with fluoropolymer-embedded silver nanoparticles: an in-situ spectroscopic study.

    abstract：:Surface colonization by microorganisms leads to the formation of biofilms, i.e. aggregates of bacteria embedded within a matrix of extracellular polymeric substance. This promotes adhesion to the surface and protects bacterial community, providing an antimicrobial-resistant environment. The inhibition of biofilm growt...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-12088-x

    authors： Sportelli MC,Tütüncü E,Picca RA,Valentini M,Valentini A,Kranz C,Mizaikoff B,Barth H,Cioffi N

    更新日期：2017-09-19 00:00:00

  • JDP2 overexpression provokes cardiac dysfunction in mice.

    abstract：:The transcriptional regulator JDP2 (Jun dimerization protein 2) has been identified as a prognostic marker for patients to develop heart failure after myocardial infarction. We now performed in vivo studies on JDP2-overexpressing mice, to clarify the impact of JDP2 on heart failure progression. Therefore, during birth...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-26052-w

    authors： Heger J,Bornbaum J,Würfel A,Hill C,Brockmann N,Gáspár R,Pálóczi J,Varga ZV,Sárközy M,Bencsik P,Csont T,Török S,Kojonazarov B,Schermuly RT,Böngler K,Parahuleva M,Ferdinandy P,Schulz R,Euler G

    更新日期：2018-05-16 00:00:00

  • Publisher Correction: Vascular Supply of the Human Spiral Ganglion: Novel Three-Dimensional Analysis Using Synchrotron Phase-Contrast Imaging and Histology.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-64611-2

    authors： Mei X,Glueckert R,Schrott-Fischer A,Li H,Ladak HM,Agrawal SK,Rask-Andersen H

    更新日期：2020-05-01 00:00:00

  • Shape Tailored Magnetic Nanorings for Intracellular Hyperthermia Cancer Therapy.

    abstract：ABSTARCT:This work explores a new class of vortex/magnetite/iron oxide nanoparticles designed for magnetic hyperthermia applications. These nanoparticles, named Vortex Iron oxide Particles (VIPs), are an alternative to the traditional Superparamagnetic Iron Oxide Nanoparticles (SPIONs), since VIPs present superior heat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-14633-0

    authors： Dias CSB,Hanchuk TDM,Wender H,Shigeyosi WT,Kobarg J,Rossi AL,Tanaka MN,Cardoso MB,Garcia F

    更新日期：2017-11-01 00:00:00

  • Cisplatin Enhances Hepatitis B Virus Replication and PGC-1α Expression through Endoplasmic Reticulum Stress.

    abstract：:Chronic hepatitis B infection remains a serious public health issue worldwide. Hepatitis B virus (HBV) reactivation is commonly reported in patients receiving anticancer therapy, immunosuppressive therapy, or organ and tissue transplantation. However, the precise mechanisms underlying chemotherapeutic agent-related HB...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-21847-3

    authors： Li X,Pan E,Zhu J,Xu L,Chen X,Li J,Liang L,Hu Y,Xia J,Chen J,Chen W,Hu J,Wang K,Tang N,Huang A

    更新日期：2018-02-22 00:00:00

  • The Matrikine Acetylated Proline-Glycine-Proline Couples Vascular Inflammation and Acute Cardiac Rejection.

    abstract：:The extracellular matrix (ECM) is a dynamic, bioactive structure critical to organ development, structure and function. Excessive remodeling of the ECM is a hallmark of a variety of inflammatory conditions including vascular disease. Endothelin-1 (ET1) synthesis is understood to promote cardiovascular diseases includi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07610-0

    authors： Payne GA,Li J,Xu X,Jackson P,Qin H,Pollock DM,Wells JM,Oparil S,Leesar M,Patel RP,Blalock JE,Gaggar A

    更新日期：2017-08-08 00:00:00