Abstract：
:Dyslipidemia and statin use have been associated with colorectal cancer (CRC), but prospective studies have shown mixed results. We aimed to determine whether dyslipidemia is causally linked to CRC risk using a Mendelian randomization approach and to explore the association of statins with CRC. A case-control study was performed including 1336 CRC cases and 2744 controls (MCC-Spain). Subjects were administered an epidemiological questionnaire and were genotyped with an array which included polymorphisms associated with blood lipids levels, selected to avoid pleiotropy. Four genetic lipid scores specific for triglycerides (TG), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), or total cholesterol (TC) were created as the count of risk alleles. The genetic lipid scores were not associated with CRC. The ORs per 10 risk alleles, were for TG 0.91 (95%CI: 0.72-1.16, p = 0.44), for HDL 1.14 (95%CI: 0.95-1.37, p = 0.16), for LDL 0.97 (95%CI: 0.81-1.16, p = 0.73), and for TC 0.98 (95%CI: 0.84-1.17, p = 0.88). The LDL and TC genetic risk scores were associated with statin use, but not the HDL or TG. Statin use, overall, was a non-significant protective factor for CRC (OR 0.84; 95%CI: 0.70-1.01, p = 0.060), but lipophilic statins were associated with a CRC risk reduction (OR 0.78; 95%CI 0.66-0.96, p = 0.018). Using the Mendelian randomization approach, our study does not support the hypothesis that lipid levels are associated with the risk of CRC. This study does not rule out, however, a possible protective effect of statins in CRC by a mechanism unrelated to lipid levels.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ibáñez-Sanz G,Díez-Villanueva A,Riera-Ponsati M,Fernández-Villa T,Fernández Navarro P,Bustamante M,Llorca J,Amiano P,Ascunce N,Fernández-Tardón G,Salcedo Bellido I,Salas D,Capelo Álvarez R,Crous-Bou M,Ortega-Valín L,Pérez-Gdoi
10.1038/s41598-019-49880-wsubject
Has Abstractpub_date
2019-09-16 00:00:00pages
13407issue
1issn
2045-2322pii
10.1038/s41598-019-49880-wjournal_volume
9pub_type
杂志文章abstract：:Nanocrystals of Ln3+ (Ln = Yb, Tm and Ho) doped β-NaLuF4 with average diameter about 200 nm are dispersed in silica-based microtube (MT) by a simple flame heating method. The fabricated microtube has a diameter range from 2 μm to 30 μm and lengths up to hundreds microns. The fluorescence of upconversion nanocrystals (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35941
更新日期：2016-10-25 00:00:00
abstract：:Agrobacterium pathogens of octopine- and nopaline-types force host plants to produce either octopine or nopaline compounds, which they use as nutrients. Two Agrobacterium ABC-transporters and their cognate periplasmic binding proteins (PBPs) OccJ and NocT import octopine and nopaline/octopine, respectively. Here, we s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18243-8
更新日期：2017-12-21 00:00:00
abstract：:The detection of pruritic (itchy) stimuli is mediated by a variety of receptors and channels expressed by primary sensory neurons. The G protein-coupled receptor (GPCR) MRGPRD is selectively expressed by a subset of mouse non-peptidergic nociceptors and functions as the molecular receptor for the itch-inducing chemica...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12770-0
更新日期：2017-10-24 00:00:00
abstract：:To investigate changes in the size of the population of patients who are receiving long-term, active treatment for neovascular age-related macular degeneration (AMD). This retrospective, observational study included 18,165 patients who received anti-vascular endothelial growth factor injections (3,974 eyes). The injec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49749-y
更新日期：2019-09-13 00:00:00
abstract：:The honey bee is threatened by biological agents and pesticides that can act in combination to induce synergistic effects on its physiology and lifespan. The synergistic effects of a parasite/pesticide combination have been demonstrated on workers and queens, but no studies have been performed on drones despite their ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08380-5
更新日期：2017-08-17 00:00:00
abstract：:Sexual segregation in foraging occurs in many animal species, resulting in the partitioning of resources and reduction of competition between males and females, yet the patterns and drivers of such segregation are still poorly understood. We studied the foraging movements (GPS-tracking), habitat use (habitat modelling...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02854-2
更新日期：2017-06-01 00:00:00
abstract：:The secreted frizzled-related protein 5 gene (SFRP5) that antagonize the Wnt/β-catenin signaling is frequently inactivated by promoter methylation and oncogenic activation of the Wnt signaling pathway is common in many cancers. The curcumin-rich Curcuma longa has been reported to potent anti-cancer property involved i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53509-3
更新日期：2019-11-21 00:00:00
abstract：:The nonsynonymous SCN10A single nucleotide polymorphism (SNP) rs6795970 has been reported to associate with PR interval and atrial fibrillation (AF) and in strong linkage disequilibrium (LD) with the AF-associated SNP rs6800541. In this study, we investigated whether rs6795970 polymorphisms are associated with AF recu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44003
更新日期：2017-03-10 00:00:00
abstract：:Although technology has triumphed in facilitating routine genome sequencing, new challenges have been created for the data-analyst. Genome-scale surveys of human variation generate volumes of data that far exceed capabilities for laboratory characterization. By incorporating functional annotations as predictors, stati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13373
更新日期：2015-08-24 00:00:00
abstract：:Phytoplasmas are transmitted by insect vectors in a persistent propagative manner; however, detailed movements and multiplication patterns of phytoplasmas within vectors remain elusive. In this study, spatiotemporal dynamics of onion yellows (OY) phytoplasma in its vector Macrosteles striifrons were investigated by im...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61042-x
更新日期：2020-03-09 00:00:00
abstract：:The bacterial flagellar hook connects the helical flagellar filament to the rotary motor at its base. Bending flexibility of the hook allows the helical filaments to form a bundle behind the cell body to produce thrust for bacterial motility. The hook protein FlgE shows considerable sequence and structural similaritie...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46723
更新日期：2017-04-21 00:00:00
abstract：:Transport of self-propelled particles in a two-dimensional (2D) separate channel is investigated in the presence of the combined forces. By applying an ac force, the particles will be trapped by the separate walls. A dc force produces the asymmetry of the system and induces the longitudinal directed transport. Due to ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24001
更新日期：2016-04-01 00:00:00
abstract：:As fine particle (FP) pollution is harmful to humans, previous studies have focused on the mechanisms of FP removal by forests. The current study aims to compare the FP removal capacities of urban forests and wetlands on the leaf, canopy, and landscape scales. Water washing and scanning electron microscopy are used to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46214
更新日期：2017-04-10 00:00:00
abstract：:In this paper, the effect of binder decay rather than a change in the pigments on the blurring of ancient wall paintings was researched. The simulated wall paintings were prepared by brushing an aqueous solution containing gelatine and ochre grains on the surface of cylindrical compressed soil samples. Then, the dried...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78117-4
更新日期：2020-12-03 00:00:00
abstract：:Our study aimed to investigate the effect of Pap smear screening on stage at diagnosis of cervical cancer in a heterogeneous population of Thai women. Data was merged from the population-based cancer registry and screening registry based on unique identification numbers from 2006 to 2014. Patients being screened had l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52607-6
更新日期：2019-11-15 00:00:00
abstract：:ING2 (inhibitor of growth family member 2) is a component of a chromatin-regulatory complex that represses gene expression and is implicated in cellular processes that promote tumor suppression. However, few direct genomic targets of ING2 have been identified and the mechanism(s) by which ING2 selectively regulates ge...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02137
更新日期：2013-01-01 00:00:00
abstract：:Heat shock protein 90 (HSP90) inhibition is an attractive strategy for cancer treatment. Several HSP90 inhibitors have shown promising effects in clinical oncology trials. However, little is known about HSP90 inhibition-mediated bladder cancer therapy. Here, we report a quantitative proteomic study that evaluates alte...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00143-6
更新日期：2017-03-15 00:00:00
abstract：:Common reference values of arterial stiffness indices could be effective screening tool in detecting vascular phenotypes at risk. However, populations of the same ethnicity may differ in vascular phenotype due to different environmental pressure. We examined applicability of normative equations for central augmentatio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27016
更新日期：2016-05-27 00:00:00
abstract：:Several lines of evidence indicate that Fibronectin Extra Domain A (EDA) promotes metastatic capacity of tumor cells by engaging cell surface α9β1 integrins. This interaction mediated by the C-C loop of EDA activates pro-oncogenic signaling pathways leading to epithelial to mesenchymal transition (EMT) of tumor cells,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37151
更新日期：2016-11-16 00:00:00
abstract：:Post-infectious bronchiolitis obliterans (BO) could be diagnosed via spirometry and chest computed tomography (CT); however, these tests are limited in infants. We aimed to evaluate the utility of lung clearance index (LCI) and air-trapping lung volume from chest CT in infants. This prospective study included 20 infan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15330-8
更新日期：2017-11-09 00:00:00
abstract：:The TREX complex mediates the passage of bulk cellular mRNA export to the nuclear export factor TAP/NXF1 via the export adaptors ALYREF or UIF, which appear to act in a redundant manner. TREX complex recruitment to nascent RNA is coupled with 5' capping, splicing and polyadenylation. Therefore to facilitate expression...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33379-x
更新日期：2018-10-09 00:00:00
abstract：:Glaucoma is a group of progressive optic neuropathies that share common biological and clinical characteristics including irreversible changes to the optic nerve and visual field loss caused by the death of retinal ganglion cells (RGCs). The loss of RGCs manifests as characteristic cupping or optic nerve degeneration,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68811-8
更新日期：2020-07-16 00:00:00
abstract：:The most downstream elements of the Hippo pathway, the TEAD transcription factors, are regulated by several cofactors, such as Vg/VGLL1-3. Earlier findings on human VGLL1 and here on human VGLL3 show that these proteins interact with TEAD via a conserved amino acid motif called the TONDU domain. Surprisingly, our stud...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74584-x
更新日期：2020-10-15 00:00:00
abstract：:Turner syndrome (TS) is characterized by the partial or complete loss of one sex chromosome and results in growth failure, gonadal insufficiency and cardiac anomalies. Treatment with growth hormone (GH) during childhood has indisputable benefits when taking into account the low stature of TS women. Medical records and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52332-0
更新日期：2019-11-04 00:00:00
abstract：:Limbal stem cell deficiency can be treated with transplantation of cultured human limbal epithelial cells (LEC). It can be advantageous to produce LEC in centralized labs and thereafter ship them to eye clinics. The present study used transport simulations of LEC to determine if vigorous shaking during transport alter...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28553-0
更新日期：2018-07-12 00:00:00
abstract：:Predation plays a central role in the lives of most organisms. Predators must find and subdue prey to survive and reproduce, whereas prey must avoid predators to do the same. The resultant antagonistic coevolution often leads to extreme adaptations in both parties. Few examples capture the imagination like a rapid str...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40412
更新日期：2017-01-13 00:00:00
abstract：:We aimed to evaluate the etiologies of constipation in patients with anorectal malformations having a good prognosis for bowel control but a high risk of constipation. We included twenty-five patients from the Odense university hospital in Denmark. Patients were subjected to colon transit time examination and high res...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76841-5
更新日期：2020-11-12 00:00:00
abstract：:Stable isotope labeling is a standard technique for tracing material transfer in molecular, ecological and biogeochemical studies. The main assumption in this approach is that the enrichment with a heavy isotope has no effect on the organism metabolism and growth, which is not consistent with current theoretical and e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44181
更新日期：2017-03-10 00:00:00
abstract：:Iron overload is associated with various pathological changes which contribute to heart failure. Here, we examined mechanisms via which iron alters cardiomyocyte insulin sensitivity. Treatment of primary adult and neonatal cardiomyocytes as well as H9c2 cells with iron decreased insulin sensitivity determined via West...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41111-6
更新日期：2019-03-15 00:00:00
abstract：:Converging evidence supports the involvement of pro-inflammatory pathways and the gut microbiome in major depressive disorder (MDD). Pre-clinical and clinical studies suggest that decreasing pro-inflammatory signaling may provide clinical benefit in MDD. In this study, we used the chronic unpredictable stress (CUS) pa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38055-8
更新日期：2019-04-23 00:00:00
