Abstract：
:Turner syndrome (TS) is characterized by the partial or complete loss of one sex chromosome and results in growth failure, gonadal insufficiency and cardiac anomalies. Treatment with growth hormone (GH) during childhood has indisputable benefits when taking into account the low stature of TS women. Medical records and biochemical findings of 33 TS women treated with GH in childhood (GH+) were compared to those of 124 TS women who did not receive GH (GH-). It seems that the GH-treated group might have had a more severe initial phenotype than the untreated group, as evidenced by higher FSH, more feeding issues in infancy, more lymphedema cases and urinary system malformations. GH+ women were significantly taller and had a better lipid profile and lower prevalence of arterial hypertension than GH- . However, they also had lower thrombocyte counts, a greater prevalence of retrognathism and nail anomalies, especially when the GH treatment was delayed. Long-term GH use was not as effective for growth as GH treatment during the initial period and seemed to have resulted in elevated creatinine levels. GH treatment in childhood has benefits in adulthood; however, adverse effects may occur, especially in individuals with treatment that is delayed or is too long.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Irzyniec T,Jeż W,Lepska K,Maciejewska-Paszek I,Frelich Jdoi
10.1038/s41598-019-52332-0subject
Has Abstractpub_date
2019-11-04 00:00:00pages
15951issue
1issn
2045-2322pii
10.1038/s41598-019-52332-0journal_volume
9pub_type
杂志文章abstract：:In order to obtain a detailed understanding of the modulation of electronic properties in nanoporous Si (np-Si) nanowires with containing ordered, nanometer-sized cylindrical pores, we propose a theoretical method to clarify the band shift and associated with the dielectric modification determined by the geometrical p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14647-8
更新日期：2017-10-31 00:00:00
abstract：:The prevalence of chronic kidney disease (CKD), characterized by progressive renal dysfunction with tubulointerstitial fibrosis, is increasing because of societal aging. Uremic toxins, accumulated during renal dysfunction, cause kidney damage, leading to renal deterioration. A recent metabolomic analysis revealed that...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11049-8
更新日期：2017-09-11 00:00:00
abstract：:Liver chips have been developed to recapitulate in vivo physiological conditions to enhance hepatocyte functions for assessing acute responses to drugs. To develop liver chips that can assess repeated dosing chronic hepatotoxicity, we need to ensure that hepatocyte functions be maintained at constant values over two w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13848-5
更新日期：2017-11-06 00:00:00
abstract：:Two genera of terrestrial slugs (Arion and Geomalacus) display a striking disproportion in species richness in the Iberian Peninsula. While there are 17 Iberian endemic species in Arion, morphological criteria only recognize four species within Geomalacus. Sequence data were used to test whether these differences coul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16417-y
更新日期：2017-11-23 00:00:00
abstract：:Machine learning algorithms have recently shown their precision and potential in many different use cases and fields of medicine. Most of the algorithms used are supervised and need a large quantity of labeled data to achieve high accuracy. Also, most applications of machine learning in medicine are attempts to mimic ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73902-7
更新日期：2020-10-12 00:00:00
abstract：:Multiferroic BiFeO3 exhibits excellent magnetoelectric coupling critical for magnetic information processing with minimal power consumption. However, the degenerate nature of the easy spin axis in the (111) plane presents roadblocks for real world applications. Here, we explore the stabilization and switchability of t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12969
更新日期：2015-08-06 00:00:00
abstract：:Plant litter is an important component in wetland ecosystems, and the role of plant litter decomposition is considered to be important for wetland ecosystem functions and services. However, the consequences of litter inputs have seldom been experimentally tested in real ecosystems such as constructed wetlands (CWs). T...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50161-9
更新日期：2019-09-25 00:00:00
abstract：:Methicillin resistant Staphylococcus aureus (MRSA) is a major human pathogen, which causes superficial to lethal clinical infections. Neutrophils are the most abundant leukocytes in the blood and are the first defense mechanism against S. aureus infections. Here we show Staphylococcal Superantigen-Like protein 11 (SSL...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40817-x
更新日期：2019-03-12 00:00:00
abstract：:In photosynthesis Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) catalyses the often rate limiting CO2-fixation step in the Calvin cycle. This makes Rubisco both the gatekeeper for carbon entry into the biosphere and a target for functional improvement to enhance photosynthesis and plant growth. Encumbering...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22284
更新日期：2016-03-01 00:00:00
abstract：:For accurate micro-scale quantification of a specific protein in biological fluids, immunoaffinity chromatography (IAC) and isoelectric focusing (IEF) were combined in a single fused-silica capillary. The inner wall of the capillary was coated with an anti-E-tag antibody at the inlet side to form an IAC column, and po...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39221
更新日期：2016-12-15 00:00:00
abstract：:The physiologic response to tobacco smoke can be measured by gene-expression profiling of the airway epithelium. Temporal resolution of kinetics of gene-expression alterations upon smoking-cessation might delineate distinct biological processes that are activated during recovery from tobacco smoke exposure. Using whol...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43295-3
更新日期：2019-05-06 00:00:00
abstract：:Cerebellar involvement in cognition, as well as in sensorimotor control, is increasingly recognized and is thought to depend on connections with the cerebral cortex. Anatomical investigations in animals and post-mortem humans have established that cerebro-cerebellar connections are contralateral to each other and incl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13079-8
更新日期：2017-10-09 00:00:00
abstract：:This meta-analysis aims to evaluate whether the extant literature justifies any definitive conclusions about whether and how SITBs may be associated with brain differences. A total of 77 papers (N = 4,903) published through January 1, 2019 that compared individuals with and without SITBs were included, resulting in 88...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-020-59490-6
更新日期：2020-02-12 00:00:00
abstract：:Savant syndrome is a phenomenon whereby individuals with cognitive impairments have one or more outstanding abilities, inconsistent with their general intellectual functioning. Approximately 50% of savant individuals have autism spectrum disorder (ASD), and 10-30% of people with ASD have savant skills. To shed additio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59209-7
更新日期：2020-02-10 00:00:00
abstract：:The ideal strategy for hair cell regeneration is promoting residual supporting cell proliferation followed by induction of hair cell differentiation. In this study, cultured neonatal mouse organs of Corti were treated with neomycin to eliminate hair cells followed by incubation with recombined adenovirus expressing Pa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02996
更新日期：2013-10-21 00:00:00
abstract：:Thaumatin is an intensely sweet-tasting protein that elicits sweet taste at a concentration of 50 nM, a value 100,000 times larger than that of sucrose on a molar basis. Here we attempted to produce a protein with enhanced sweetness by removing negative charges on the interacting side of thaumatin with the taste recep...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20255
更新日期：2016-02-03 00:00:00
abstract：:Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive movement disturbances caused by the selective loss of dopamine (DA) neurons in the substantia nigra. Despite the identification of the causal mechanisms underlying the pathogenesis of PD, effective treatments remain elusive. In this s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49876-6
更新日期：2019-09-20 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-65968-0
更新日期：2020-06-04 00:00:00
abstract：:Extensive research indicates that inter-sexual selection drives the evolution of complex vocal communication in birds, but parallel lines of evidence are almost entirely absent in mammals. This dearth of evidence, particularly among primates, limits our understanding of the link between sociality and vocal complexity....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19680
更新日期：2016-01-21 00:00:00
abstract：:Human pluripotent stem cells (hPSCs) offer tremendous promise in tissue engineering and cell-based therapies due to their unique combination of two properties: pluripotency and unlimited proliferative capacity. However, directed differentiation of hPSCs to clinically relevant cell lineages is needed to achieve the goa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01684-6
更新日期：2017-05-08 00:00:00
abstract：:Contact electrification (CE)-charging of surfaces that are contacted and separated, is a common phenomenon, however it is not completely understood yet. Recent studies using surface imaging techniques and chemical analysis revealed a 'spatial' bipolar distribution of charges at the nano dimension, which made a paradig...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20413-1
更新日期：2018-02-06 00:00:00
abstract：:We have studied an expansion behavior of pressurized bubbles at the orifice of a capillary inserted in gelator-solvent (agarose-water) mixtures as a function of the gelator concentration in which the phase transition points are included. The pressure (P) -dependence of the radius of the curvature (R) of the bubbles mo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58905-8
更新日期：2020-02-14 00:00:00
abstract：:Developmental changes in salamander skulls, before and after metamorphosis, affect the feeding capabilities of these animals. How changes in cranial morphology and tissue properties affect the function of the skull are key to decipher the early evolutionary history of the crown-group of salamanders. Here, 3D cranial b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10553-1
更新日期：2017-08-31 00:00:00
abstract：:The properties of metal matrix composites (MMCs) can be optimized effectively through adjusting the type or the volume fraction of reinforcement. Generally, the coefficient of thermal expansion (CTE) of MMCs can be reduced by increasing the volume fraction of the reinforcement with lower CTE than metal matrix. However...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27118
更新日期：2016-06-03 00:00:00
abstract：:We studied the spin-transfer torque (STT) in graphene based normal-metal/topological-insulator/ferromagnet heterostructures (N/TI/F), which is induced by the helical spin-polarized current in the quantum spin Hall insulator. We found that the STT is comparable in magnitude to the STT in ferromagnetic-normal- ferromagn...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22680-4
更新日期：2018-03-12 00:00:00
abstract：:The newly designed fentanyl derivative [( ±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide] (NFEPP) was recently shown to produce analgesia selectively via peripheral mu-opioid receptors (MOR) at acidic pH in rat inflamed tissues. Here, we examined the pH-dependency of NFEPP binding to brain MOR and it...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75509-4
更新日期：2020-10-29 00:00:00
abstract：:Expression profiling of multiple microRNAs (miRNAs) generally provides valuable information for understanding various biological processes. Thus, it is necessary to develop a sensitive and accurate miRNA assay suitable for multiplexing. Isothermal exponential amplification reaction (EXPAR) has received significant int...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11895-6
更新日期：2017-09-12 00:00:00
abstract：:A major task of episodic memory is to create unique, distinguishable representations of highly overlapping perceptual inputs. Several studies on this basic function have shown that it is based on the intact functioning of certain subregions of the hippocampus and is among the most sensitive behavioral indicators of mi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73374-9
更新日期：2020-10-02 00:00:00
abstract：:In this paper, we demonstrate a novel dual-pump approach to generate robust optical frequency comb with varying free spectral range (FSR) spacing in a CMOS-compatible high-Q micro-ring resonator (MRR). The frequency spacing of the comb can be tuned by an integer number FSR of the MRR freely in our dual-pump scheme. Th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28501
更新日期：2016-06-24 00:00:00
abstract：:The frequency noise of an optical frequency comb is routinely measured through the hetherodyne beat of one comb tooth against a stable continuous-wave laser. After frequency-to-voltage conversion, the beatnote is sent to a spectrum analyzer to retrive the power spectral density of the frequency noise. Because narrow-l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16338
更新日期：2015-11-09 00:00:00
