当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Contralateral cortico-ponto-cerebellar pathways reconstruction in humans in vivo: implications for reciprocal cerebro-cerebellar structural connectivity in motor and non-motor areas.

Contralateral cortico-ponto-cerebellar pathways reconstruction in humans in vivo: implications for reciprocal cerebro-cerebellar structural connectivity in motor and non-motor areas.

Abstract：

:Cerebellar involvement in cognition, as well as in sensorimotor control, is increasingly recognized and is thought to depend on connections with the cerebral cortex. Anatomical investigations in animals and post-mortem humans have established that cerebro-cerebellar connections are contralateral to each other and include the cerebello-thalamo-cortical (CTC) and cortico-ponto-cerebellar (CPC) pathways. CTC and CPC characterization in humans in vivo is still challenging. Here advanced tractography was combined with quantitative indices to compare CPC to CTC pathways in healthy subjects. Differently to previous studies, our findings reveal that cerebellar cognitive areas are reached by the largest proportion of the reconstructed CPC, supporting the hypothesis that a CTC-CPC loop provides a substrate for cerebro-cerebellar communication during cognitive processing. Amongst the cerebral areas identified using in vivo tractography, in addition to the cerebral motor cortex, major portions of CPC streamlines leave the prefrontal and temporal cortices. These findings are useful since provide MRI-based indications of possible subtending connectivity and, if confirmed, they are going to be a milestone for instructing computational models of brain function. These results, together with further multi-modal investigations, are warranted to provide important cues on how the cerebro-cerebellar loops operate and on how pathologies involving cerebro-cerebellar connectivity are generated.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Palesi F,De Rinaldis A,Castellazzi G,Calamante F,Muhlert N,Chard D,Tournier JD,Magenes G,D'Angelo E,Gandini Wheeler-Kingshott CAM

doi

10.1038/s41598-017-13079-8

subject

Has Abstract

pub_date

2017-10-09 00:00:00

pages

12841

issue

1

issn

2045-2322

pii

10.1038/s41598-017-13079-8

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Structural and functional role of disulphide bonds and substrate binding residues of the human beta-galactoside alpha-2,3-sialyltransferase 1 (hST3Gal1).

    abstract：:Overexpression of hST3Gal1 leads to hypersialylation of cell-surface glycoconjugates, a cancer-associated condition that promotes cell growth, migration and invasion. Upregulation of this enzyme in ovarian cancer is linked to cancer progression and metastasis, contributing also to chemotherapy resistance. Strategies f...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54384-8

    authors： Ortiz-Soto ME,Reising S,Schlosser A,Seibel J

    更新日期：2019-11-29 00:00:00

  • Virtual Screening, pharmacophore development and structure based similarity search to identify inhibitors against IdeR, a transcription factor of Mycobacterium tuberculosis.

    abstract：:ideR, an essential gene of Mycobacterium tuberculosis, is an attractive drug target as its conditional knockout displayed attenuated growth phenotype in vitro and in vivo. To the best of our knowledge, no inhibitors of IdeR are identified. We carried out virtual screening of NCI database against the IdeR DNA binding d...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04748-9

    authors： Rohilla A,Khare G,Tyagi AK

    更新日期：2017-07-05 00:00:00

  • Inhibition of Influenza A Virus Infection by Fucoidan Targeting Viral Neuraminidase and Cellular EGFR Pathway.

    abstract：:Development of novel anti-influenza A virus (IAV) drugs with high efficiency and low toxicity is critical for preparedness against influenza outbreaks. Herein, we investigated the anti-IAV activities and mechanisms of fucoidan in vitro and in vivo. The results showed that a fucoidan KW derived from brown algae Kjellma...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40760

    authors： Wang W,Wu J,Zhang X,Hao C,Zhao X,Jiao G,Shan X,Tai W,Yu G

    更新日期：2017-01-17 00:00:00

  • Superconductivity in two-dimensional ferromagnetic MnB.

    abstract：:Using the universal structure predictor algorithm, we proposed that two-dimensional MnB structures with p4mmm (α-MnB) and pmma (β-MnB) symmetries could be synthesized. This finding was verified by calculating the dynamical stability, molecular dynamics, and mechanical properties. The α-MnB had an in-plane stiffness Y ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-17235-y

    authors： Farooq MU,Hashmi A,Khan I,Hong J

    更新日期：2017-12-06 00:00:00

  • Accelerated age-related olfactory decline among type 1 Usher patients.

    abstract：:Usher Syndrome (USH) is a rare disease with hearing loss, retinitis pigmentosa and, sometimes, vestibular dysfunction. A phenotype heterogeneity is reported. Recent evidence indicates that USH is likely to belong to an emerging class of sensory ciliopathies. Olfaction has recently been implicated in ciliopathies, but ...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/srep28309

    authors： Ribeiro JC,Oliveiros B,Pereira P,António N,Hummel T,Paiva A,Silva ED

    更新日期：2016-06-22 00:00:00

  • Amiodarone as an autophagy promoter reduces liver injury and enhances liver regeneration and survival in mice after partial hepatectomy.

    abstract：:The deregulation of autophagy is involved in liver regeneration. Here, we investigated the role of autophagy in the regulation of liver regeneration after partial hepatectomy (PHx) and the development of pharmacological interventions for improved liver regeneration after PHx. We show that autophagy was activated in th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep15807

    authors： Lin CW,Chen YS,Lin CC,Chen YJ,Lo GH,Lee PH,Kuo PL,Dai CY,Huang JF,Chung WL,Yu ML

    更新日期：2015-10-30 00:00:00

  • Experimental filtering effect on the daylight operation of a free-space quantum key distribution.

    abstract：:One of the challenges of implementing free-space quantum key distribution (QKD) systems working in daylight is to remove unwanted background noise photons from sunlight. Elaborate elimination of background photons in the spectral, temporal, and spatial domains is an indispensable requirement to decrease the quantum bi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-33699-y

    authors： Ko H,Kim KJ,Choe JS,Choi BS,Kim JH,Baek Y,Youn CJ

    更新日期：2018-10-17 00:00:00

  • Genetic variations in olfactory receptor gene OR2AG2 in a large multigenerational family with asthma.

    abstract：:It is estimated from twin studies that heritable factors account for at-least half of asthma-risk, of which genetic variants identified through population studies explain only a small fraction. Multi-generation large families with high asthma prevalence can serve as a model to identify highly penetrant genetic variant...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54718-6

    authors： Chakraborty S,Dakle P,Sinha A,Vishweswaraiah S,Nagori A,Salimath S,Prakash YS,Lodha R,Kabra SK,Ghosh B,Faruq M,Mahesh PA,Agrawal A

    更新日期：2019-12-13 00:00:00

  • Mutual association of Broad bean wilt virus 2 VP37-derived tubules and plasmodesmata obtained from cytological observation.

    abstract：:The movement protein VP37 of broad bean wilt virus 2 (BBWV 2) forms tubules in the plasmodesmata (PD) for the transport of virions between cells. This paper reports a mutual association between the BBWV 2 VP37-tubule complex and PD at the cytological level as determined by transmission electron microscopy. The generat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep21552

    authors： Xie L,Shang W,Liu C,Zhang Q,Sunter G,Hong J,Zhou X

    更新日期：2016-02-23 00:00:00

  • Ordering Ag nanowire arrays by a glass capillary: a portable, reusable and durable SERS substrate.

    abstract：:Assembly of nanowires into ordered macroscopic structures with new functionalities has been a recent focus. In this Letter, we report a new route for ordering hydrophilic Ag nanowires with high aspect ratio by flowing through a glass capillary. The present glass capillary with well-defined silver nanowire films inside...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00987

    authors： Liu JW,Wang JL,Huang WR,Yu L,Ren XF,Wen WC,Yu SH

    更新日期：2012-01-01 00:00:00

  • Urinary metabolomics reveals the therapeutic effect of HuangQi Injections in cisplatin-induced nephrotoxic rats.

    abstract：:The side effects of cisplatin (CDDP), notably nephrotoxicity, greatly limited its use in clinical chemotherapy. HuangQi Injections (HI), a commonly used preparation of the well-known Chinese herbal medicine Astragali radix, appeared to be promising treatment for nephrotoxicity without compromising the anti-tumor activ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03249-z

    authors： Li CY,Song HT,Wang XX,Wan YY,Ding XS,Liu SJ,Dai GL,Liu YH,Ju WZ

    更新日期：2017-06-15 00:00:00

  • Oriented immobilization of basic fibroblast growth factor: Bioengineered surface design for the expansion of human mesenchymal stromal cells.

    abstract：:E. coli expressed recombinant basic fibroblast growth factor (bFGF) with histidine-tag (bFGF-His) was immobilized onto the surface of a glass plate modified with a Ni(II)-chelated alkanethiol monolayer. The immobilization is expected to take place through the coordination between Ni(II) and His-tag. The bFGF-immobiliz...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-65572-2

    authors： Shakya A,Imado E,Nguyen PK,Matsuyama T,Horimoto K,Hirata I,Kato K

    更新日期：2020-05-29 00:00:00

  • Revisiting the Al/Al₂O₃ interface: coherent interfaces and misfit accommodation.

    abstract：:We study the coherent and semi-coherent Al/α-Al2O3 interfaces using molecular dynamics simulations with a mixed, metallic-ionic atomistic model. For the coherent interfaces, both Al-terminated and O-terminated nonstoichiometric interfaces have been studied and their relative stability has been established. To understa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep04485

    authors： Pilania G,Thijsse BJ,Hoagland RG,Lazić I,Valone SM,Liu XY

    更新日期：2014-03-27 00:00:00

  • Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration.

    abstract：:Alpha synuclein (α-syn) is a central player in neurodegeneration, but the mechanisms triggering its pathology are not fully understood. Here we found that α-syn is a highly efficient substrate for arginyltransferase ATE1 and is arginylated in vivo by a novel mid-chain mechanism that targets the acidic side chains of E...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-11713-z

    authors： Wang J,Han X,Leu NA,Sterling S,Kurosaka S,Fina M,Lee VM,Dong DW,Yates JR 3rd,Kashina A

    更新日期：2017-09-12 00:00:00

  • PANDA: Protein function prediction using domain architecture and affinity propagation.

    abstract：:We developed PANDA (Propagation of Affinity and Domain Architecture) to predict protein functions in the format of Gene Ontology (GO) terms. PANDA at first executes profile-profile alignment algorithm to search against PfamA, KOG, COG, and SwissProt databases, and then launches PSI-BLAST against UniProt for homologue ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-21849-1

    authors： Wang Z,Zhao C,Wang Y,Sun Z,Wang N

    更新日期：2018-02-22 00:00:00

  • Karrikins delay soybean seed germination by mediating abscisic acid and gibberellin biogenesis under shaded conditions.

    abstract：:Karrikins (KAR) are a class of signal compounds, discovered in wildfire smoke, which affect seed germination. Currently, numerous studies have focused on the model plant Arabidopsis in the KAR research field, rather than on crops. Thus the regulatory mechanisms underlying KAR regulation of crop seed germination are la...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep22073

    authors： Meng Y,Chen F,Shuai H,Luo X,Ding J,Tang S,Xu S,Liu J,Liu W,Du J,Liu J,Yang F,Sun X,Yong T,Wang X,Feng Y,Shu K,Yang W

    更新日期：2016-02-23 00:00:00

  • Temperature-dependent changes in neuronal dynamics in a patient with an SCN1A mutation and hyperthermia induced seizures.

    abstract：:Dravet syndrome is the prototype of SCN1A-mutation associated epilepsies. It is characterised by prolonged seizures, typically provoked by fever. We describe the evaluation of an SCN1A mutation in a child with early-onset temperature-sensitive seizures. The patient carries a heterozygous missense variant (c3818C > T; ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep31879

    authors： Peters C,Rosch RE,Hughes E,Ruben PC

    更新日期：2016-09-01 00:00:00

  • On the first evidence of exchange-bias feature in magnetically contrasted consolidates made from CoFe2O4-CoO core-shell nanoparticles.

    abstract：:Hetero-nanostructures based on magnetic contrast oxides have been prepared as highly dense nanoconsolidates. Cobalt ferrite-cobalt oxide core-shell type nanoparticles (NPs) were synthesized by seed mediated growth in polyol and subsequently consolidated by Spark Plasma Sintering (SPS) at 500 °C for a few minutes while...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-55649-y

    authors： Flores-Martinez N,Franceschin G,Gaudisson T,Haj-Khlifa S,Derouich SG,Yaacoub N,Grenèche JM,Menguy N,Valenzuela R,Ammar S

    更新日期：2019-12-19 00:00:00

  • Association between HOMA-IR and Lung Function in Korean Young Adults based on the Korea National Health and Nutrition Examination Survey.

    abstract：:Metabolic syndrome, including obesity and insulin resistance, has been reported to lower lung function in elderly subjects with asthma or chronic obstructive lung disease. This study aimed to find the association between lung function and insulin resistance in Korean young adults. This study used data from the Korean ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-11337-3

    authors： Lee YB,Kim YS,Lee DH,Kim HY,Lee JI,Ahn HS,Sohn TS,Lee TK,Song JY,Yeo CD,Hong M,Han K,Jeong SC,Chae HS

    更新日期：2017-09-15 00:00:00

  • Establishment of a guided, in vivo, multi-channel, abdominal, tissue imaging approach.

    abstract：:Novel tools in humane animal research should benefit the animal as well as the experimentally obtained data. Imaging technologies have proven to be versatile and also in accordance with the demands of the 3 R principle. However, most imaging technologies are either limited by the target organs, number of repetitive im...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-65950-w

    authors： Bahlmann J,Madrahimov N,Daniel F,Theidel D,DeTemple DE,Buettner M,Bleich A,Haverich A,Heisterkamp A,Kalies S

    更新日期：2020-06-08 00:00:00

  • Development of a 3D seed morphological tool for grapevine variety identification, and its comparison with SSR analysis.

    abstract：:Grapevine (Vitis vinifera L.) is one of the classical fruits of the Old World. Among the thousands of domesticated grapevine varieties and variable wild sylvestris populations, the range of variation in pip morphology is very wide. In this study we scanned representative samples of grape pip populations, in an attempt...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-24738-9

    authors： Karasik A,Rahimi O,David M,Weiss E,Drori E

    更新日期：2018-04-25 00:00:00

  • Stable isotopes of carbon and nitrogen help to predict the belowground communities at a regional scale.

    abstract：:At the regional scale, although environmental factors are known to shape the distributions of belowground communities in terrestrial ecosystems, these environmental factors account for relatively low percentages of the variation in belowground communities. More of this variation might be explained by considering ecosy...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07517-w

    authors： Wang B,Wu Y,Chen D

    更新日期：2017-08-04 00:00:00

  • Imitation in Angelman syndrome: the role of social engagement.

    abstract：:Individuals with Angelman syndrome (AS) are characterized by severe cognitive impairments alongside an enhanced drive for social engagement. As knowledge on imitation skills in this population is limited, we conducted the first controlled study of imitation in AS. We examined how 23 individuals with AS and 21 typicall...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-72079-3

    authors： Micheletti S,Vivanti G,Renzetti S,Martelli P,Calza S,“Imitation in Angelman” Study Group.,Fazzi E

    更新日期：2020-10-02 00:00:00

  • Experimental design approach for deposition optimization of RF sputtered chalcogenide thin films devoted to environmental optical sensors.

    abstract：:The development of the optical bio-chemical sensing technology is an extremely important scientific and technological issue for diagnosis and monitoring of diseases, control of industrial processes, environmental detection of air and water pollutants. Owing to their distinctive features, chalcogenide amorphous thin fi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03678-w

    authors： Baudet E,Sergent M,Němec P,Cardinaud C,Rinnert E,Michel K,Jouany L,Bureau B,Nazabal V

    更新日期：2017-06-14 00:00:00

  • Skipping breakfast is associated with adiposity markers especially when sleep time is adequate in adolescents.

    abstract：:Adolescence is a critical stage of development and has an important influence on energy balance-related behaviours (EBRBs). When adolescents are associated with obesity it can lead to increased cardiometabolic risk. Here we assess if EBRBs adopted by adolescents included in a subsample are associated with markers of t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-42859-7

    authors： Forkert ECO,Moraes ACF,Carvalho HB,Manios Y,Widhalm K,González-Gross M,Gutierrez A,Kafatos A,Censi L,De Henauw S,Moreno LA

    更新日期：2019-04-23 00:00:00

  • Beatquency domain and machine learning improve prediction of cardiovascular death after acute coronary syndrome.

    abstract：:Frequency domain measures of heart rate variability (HRV) are associated with adverse events after a myocardial infarction. However, patterns in the traditional frequency domain (measured in Hz, or cycles per second) may capture different cardiac phenomena at different heart rates. An alternative is to consider freque...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep34540

    authors： Liu Y,Scirica BM,Stultz CM,Guttag JV

    更新日期：2016-10-06 00:00:00

  • Undiluted Serum Eye Drops for the Treatment of Persistent Corneal Epitheilal Defects.

    abstract：:Several studies found that 50-100% serum eye drops provided greater benefits without inducing detrimental effects on the corneal epithelial healing. This study assessed the efficacy of undiluted serum eye drops for the treatment of persistent corneal epithelial defects (PED). A total of 109 eyes received 100% serum ey...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep38143

    authors： Lekhanont K,Jongkhajornpong P,Anothaisintawee T,Chuckpaiwong V

    更新日期：2016-12-02 00:00:00

  • Optogenetic Control of Heart Rhythm by Selective Stimulation of Cardiomyocytes Derived from Pnmt+ Cells in Murine Heart.

    abstract：:In the present study, channelrhodopsin 2 (ChR2) was specifically introduced into murine cells expressing the Phenylethanolamine n-methyltransferase (Pnmt) gene, which encodes for the enzyme responsible for conversion of noradrenaline to adrenaline. The new murine model enabled the identification of a distinctive class...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40687

    authors： Wang Y,Lin WK,Crawford W,Ni H,Bolton EL,Khan H,Shanks J,Bub G,Wang X,Paterson DJ,Zhang H,Galione A,Ebert SN,Terrar DA,Lei M

    更新日期：2017-01-13 00:00:00

  • 3D characterization of morphological changes in the intervertebral disc and endplate during aging: A propagation phase contrast synchrotron micro-tomography study.

    abstract：:A better understanding of functional changes in the intervertebral disc (IVD) and interaction with endplate is essential to elucidate the pathogenesis of IVD degeneration disease (IDDD). To date, the simultaneous depiction of 3D micro-architectural changes of endplate with aging and interaction with IVD remains a tech...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep43094

    authors： Cao Y,Liao S,Zeng H,Ni S,Tintani F,Hao Y,Wang L,Wu T,Lu H,Duan C,Hu J

    更新日期：2017-03-07 00:00:00

  • Novel European free-living, non-diazotrophic Bradyrhizobium isolates from contrasting soils that lack nodulation and nitrogen fixation genes - a genome comparison.

    abstract：:The slow-growing genus Bradyrhizobium is biologically important in soils, with different representatives found to perform a range of biochemical functions including photosynthesis, induction of root nodules and symbiotic nitrogen fixation and denitrification. Consequently, the role of the genus in soil ecology and bio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep25858

    authors： Jones FP,Clark IM,King R,Shaw LJ,Woodward MJ,Hirsch PR

    更新日期：2016-05-10 00:00:00