Abstract：
:In the present study, channelrhodopsin 2 (ChR2) was specifically introduced into murine cells expressing the Phenylethanolamine n-methyltransferase (Pnmt) gene, which encodes for the enzyme responsible for conversion of noradrenaline to adrenaline. The new murine model enabled the identification of a distinctive class of Pnmt-expressing neuroendocrine cells and their descendants (i.e. Pnmt+ cell derived cells) within the heart. Here, we show that Pnmt+ cells predominantly localized to the left side of the adult heart. Remarkably, many of the Pnmt+ cells in the left atrium and ventricle appeared to be working cardiomyocytes based on their morphological appearance and functional properties. These Pnmt+ cell derived cardiomyocytes (PdCMs) are similar to conventional myocytes in morphological, electrical and contractile properties. By stimulating PdCMs selectively with blue light, we were able to control cardiac rhythm in the whole heart, isolated tissue preparations and single cardiomyocytes. Our new murine model effectively demonstrates functional dissection of cardiomyocyte subpopulations using optogenetics, and opens new frontiers of exploration into their physiological roles in normal heart function as well as their potential application for selective cardiac repair and regeneration strategies.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wang Y,Lin WK,Crawford W,Ni H,Bolton EL,Khan H,Shanks J,Bub G,Wang X,Paterson DJ,Zhang H,Galione A,Ebert SN,Terrar DA,Lei Mdoi
10.1038/srep40687subject
Has Abstractpub_date
2017-01-13 00:00:00pages
40687issn
2045-2322pii
srep40687journal_volume
7pub_type
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pub_type： 临床试验,杂志文章
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