Abstract：
:Development of novel anti-influenza A virus (IAV) drugs with high efficiency and low toxicity is critical for preparedness against influenza outbreaks. Herein, we investigated the anti-IAV activities and mechanisms of fucoidan in vitro and in vivo. The results showed that a fucoidan KW derived from brown algae Kjellmaniella crassifolia effectively blocked IAV infection in vitro with low toxicity. KW possessed broad anti-IAV spectrum and low tendency of induction of viral resistance, superior to the anti-IAV drug amantadine. KW was capable of inactivating virus particles before infection and blocked some stages after adsorption. KW could bind to viral neuraminidase (NA) and inhibit the activity of NA to block the release of IAV. KW also interfered with the activation of EGFR, PKCα, NF-κB, and Akt, and inhibited both IAV endocytosis and EGFR internalization in IAV-infected cells, suggesting that KW may also inhibit cellular EGFR pathway. Moreover, intranasal administration of KW markedly improved survival and decreased viral titers in IAV-infected mice. Therefore, fucoidan KW has the potential to be developed into a novel nasal drop or spray for prevention and treatment of influenza in the future.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wang W,Wu J,Zhang X,Hao C,Zhao X,Jiao G,Shan X,Tai W,Yu Gdoi
10.1038/srep40760subject
Has Abstractpub_date
2017-01-17 00:00:00pages
40760issn
2045-2322pii
srep40760journal_volume
7pub_type
杂志文章abstract：:Atomoxetine is a norepinephrine reuptake inhibitor indicated in the treatment of attention-deficit/hyperactivity disorder. It is primarily metabolized by CYP2D6 to its equipotent metabolite, 4-hydroxyatomoxetine, which promptly undergoes further glucuronidation to an inactive 4-HAT-O-glucuronide. Clinical trials have ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30841-8
更新日期：2018-08-17 00:00:00
abstract：:Tinnitus (phantom auditory perception associated with hearing loss) can seriously affect wellbeing. Its neural substrate is unknown however it has been linked with abnormal activity in auditory pathways. Though no cure currently exists, repetitive transcranial magnetic stimulation (rTMS) has been shown to reduce tinni...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38234
更新日期：2016-12-01 00:00:00
abstract：:Random lasers consisting of slab waveguides with two-dimensional disordered wrinkling patterns that act as scattering resonators are reported. As active material 2,2',7,7'-tetraphenyl-9,9'-spirobifluorene is used which is sandwiched between an oxidized silicon wafer and a cladding with higher glass transition temperat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59236-4
更新日期：2020-02-12 00:00:00
abstract：:By moving the alkoxy group on the spacer from position 5 to position 4 to add another protocol for the algorithm for intermolecular and intramolecular hydrogen bonding interactions, highly regioselectivity of noncovalent synthesis of the hydrazide-based cyclic hexamers was achieved: one out of thirteen possible isomer...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01059
更新日期：2013-01-01 00:00:00
abstract：:Alternations in the p53 regulatory network may render cancer cells resistant to the radiation-induced apoptosis. In this theoretical study we search for the best protocols combining targeted therapy with radiation to treat cancers with wild-type p53, but having downregulated expression of PTEN or overexpression of Wip...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69380-6
更新日期：2020-07-28 00:00:00
abstract：:Adipose stromal cells (ASC) secrete various trophic factors that assist in the protection of neurons in a variety of neuronal death models. In this study, we tested the effects of human ASC conditional medium (ASC-CM) in human amyotrophic lateral sclerosis (ALS) transgenic mouse model expressing mutant superoxide dism...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16953
更新日期：2015-11-20 00:00:00
abstract：:Cerebral aneurysms are abnormal focal dilatations of arterial vessel walls with pathological vessel structure alterations. Sudden rupture can lead to a subarachnoid hemorrhage, which is associated with a high mortality. Therefore, the origin of cerebral aneurysms as well as the progression to the point of rupture need...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69222-5
更新日期：2020-07-23 00:00:00
abstract：:Carbon coated TiO2 (TiO2@C) is fabricated by a convenient and green one-pot solvothermal method, in which ethylene glycol serve as both the reaction medium and carbon source without the addition of any other carbon additives. During the solvothermal process, ethylene glycol polymerize and coordinate with Ti4+ to form ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43895
更新日期：2017-03-03 00:00:00
abstract：:One of the most exciting areas in lithium ion batteries is engineering structured silicon anodes. These new materials promise to lead the next generation of batteries with significantly higher reversible charge capacity than current technologies. One drawback of these materials is that their production involves costly...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00795
更新日期：2012-01-01 00:00:00
abstract：:Prostate cancer (PCa) is the most common solid neoplasm diagnosed in developed countries. Nerve-sparing radical prostatectomy (NS-RP) has been widely accepted as the best choice treatment for localised PCa. However, erectile dysfunction (ED) and urinary incontinence are commonly observed after NS-RP. Using meta-analys...
journal_title：Scientific reports
pub_type： 杂志文章,评审
doi：10.1038/srep05801
更新日期：2014-07-23 00:00:00
abstract：:Zebrafish (Danio rerio), largely used as a model for studying developmental processes, has also emerged as a valuable system for modelling human inflammatory diseases. However, in a context where even mice have been questioned as a valid model for these analysis, a systematic study evaluating the reproducibility of hu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41905
更新日期：2017-02-03 00:00:00
abstract：:DEMETER-like DNA glycosylases (DMLs) initiate the base excision repair-dependent DNA demethylation to regulate a wide range of biological processes in plants. Six putative SmDML genes, termed SmDML1-SmDML6, were identified from the genome of S. miltiorrhiza, an emerging model plant for Traditional Chinese Medicine (TC...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25315-w
更新日期：2018-05-08 00:00:00
abstract：:The Earth's climate has experienced dramatic changes over the past 22,000 years; however, the total meridional heat transport (MHT) of the climate system remains stable. A 22,000-year-long simulation using an ocean-atmosphere coupled model shows that the changes in atmosphere and ocean MHT are significant but tend to ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16661
更新日期：2015-11-16 00:00:00
abstract：:Monolayer germanene, a novel graphene-like germanium allotrope akin to silicene has been recently grown on metallic substrates. Lying directly on the metal surfaces the reconstructed atom-thin sheets are prone to lose the massless Dirac fermion character and unique associated physical properties of free standing germa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20714
更新日期：2016-02-10 00:00:00
abstract：:We successfully realised plasmon-driven selective reduction reactions of 2-amino-5-nitrobenzenethiol (2A-5-NBT) to 3,3'-dimercapto-4,4'-diaminoazobenzene , an azobenzene derivative, using surface-enhanced Raman scattering (SERS) spectroscopy, and supported by the theoretical calculations. The SERS spectra demonstrated...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10269
更新日期：2015-06-01 00:00:00
abstract：:We describe a novel method to achieve a universal, massive, and fully automated analysis of cell motility behaviours, starting from time-lapse microscopy images. The approach was inspired by the recent successes in application of machine learning for style recognition in paintings and artistic style transfer. The orig...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64246-3
更新日期：2020-05-06 00:00:00
abstract：:Artificial interface anisotropy is demonstrated in alternating Co/Pt and Co/Pd stripe patterns, providing a means of forming magnetic anisotropy using lithography. In-plane hysteresis loops measured along two principal directions are explained in depth by two competing shape and interface anisotropies, thus confirming...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26709
更新日期：2016-05-24 00:00:00
abstract：:Somatic copy number alterations (SCNAs) affecting oncogenic drivers have a firmly established role in promoting cancer. However, no agreed-upon standard exists for calling locus-specific amplifications and deletions in each patient sample. Here, we report the correlative analysis of copy number amplitude and length wi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19649
更新日期：2016-01-20 00:00:00
abstract：:Comet assay is a widely used method, especially in the field of genotoxicity, to quantify and measure DNA damage visually at the level of individual cells with high sensitivity and efficiency. Generally, computer programs are used to analyze comet assay output images following two main steps. First, each comet region ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75592-7
更新日期：2020-11-03 00:00:00
abstract：:Time-series data from multicomponent systems capture the dynamics of the ongoing processes and reflect the interactions between the components. The progression of processes in such systems usually involves check-points and events at which the relationships between the components are altered in response to stimuli. Det...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08937
更新日期：2015-03-11 00:00:00
abstract：:Stylosanthes guianensis (Aubl.) Sw. is an economically important pasture and forage legume in tropical regions of the world. Genetic improvement of the crop can be enhanced through marker-assisted breeding. However, neither single nucleotide polymorphism (SNP) markers nor SNP-based genetic linkage map has been previou...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40489-7
更新日期：2019-03-07 00:00:00
abstract：:Spiral waves anchored to obstacles in cardiac tissues may cause lethal arrhythmia. To unpin these anchored spirals, comparing to high-voltage side-effect traditional therapies, wave emission from heterogeneities (WEH) induced by the uniform electric field (UEF) has provided a low-voltage alternative. Here we provide a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04831
更新日期：2014-04-29 00:00:00
abstract：:Biological computation requires in vivo control of molecular behavior to progress development of autonomous devices. miRNA switches represent excellent, easily engineerable synthetic biology tools to achieve user-defined gene regulation. Here we present the construction of a synthetic network to implement detoxificati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81679-6
更新日期：2021-01-28 00:00:00
abstract：:Tolerance to Dutch elm disease (DED) has been linked to the rapid and/or high induction of disease-responsive genes after infection with the fungus Ophiostoma novo-ulmi. Although the fungal infection by O. novo-ulmi primarily takes places in xylem vessels, it is still unclear how xylem contributes to the defense again...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07779-4
更新日期：2017-08-02 00:00:00
abstract：:Hepatitis B Virus (HBV) replication in hepatocytes is restricted by the host innate immune system and related intracellular signaling pathways. Transforming growth factor β-activated kinase 1 (TAK1) is a key mediator of toll-like receptors and pro-inflammatory cytokine signaling pathways. Here, we report that silencin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39901
更新日期：2017-01-03 00:00:00
abstract：:The flagellum is a rotary motor that enables bacteria to swim in liquids and swarm over surfaces. Numerous global regulators control flagellar assembly in response to cellular and environmental factors. Previous studies have also shown that flagellar assembly is affected by the growth-rate of the cell. However, a syst...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41189
更新日期：2017-01-24 00:00:00
abstract：:The present work focuses on the postseismic deformation observed in the region of L'Aquila (central Italy) following the Mw 6.3 earthquake that occurred on April 6, 2009. A new, 16-month-long dataset of COSMO-SkyMed SAR images was analysed using the Persistent Scatterer Pairs interferometric technique. The analysis re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16558
更新日期：2015-11-10 00:00:00
abstract：:Mechanistic studies of deregulated ERG in prostate cancer and other cancers continue to enhance its role in cancer biology and its utility as a biomarker and therapeutic target. Here, we show that ERG, through its physical interaction with androgen receptor, induces AR aggregation and endoplasmic reticulum stress in t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01187-4
更新日期：2017-04-24 00:00:00
abstract：:Proper determination of agonist efficacy is essential in the assessment of agonist selectivity and signalling bias. Agonist efficacy is a relative term that is dependent on the system in which it is measured, especially being dependent on receptor expression level. The operational model (OM) of functional receptor ago...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40993-w
更新日期：2019-03-15 00:00:00
abstract：:Deep eutectic solvents have been recently reported as an interesting alternative to improve the therapeutic efficacy of conventional drugs, hence called therapeutic deep eutectic solvents (THEDES). The main objective of this work was to evaluate the potential of limonene (LIM) based THEDES as new possible systems for ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51472-7
更新日期：2019-10-17 00:00:00
