Abstract:
:Metabolic syndrome, including obesity and insulin resistance, has been reported to lower lung function in elderly subjects with asthma or chronic obstructive lung disease. This study aimed to find the association between lung function and insulin resistance in Korean young adults. This study used data from the Korean National Health and Nutrition Examination Survey 2011-2013, which is a representative sample of the Korean population. A total of 1,922 young adults aged 19 to 40 were included in the analysis. The association between lung function test and insulin resistance was evaluated. Weighted logistic regression analyses showed a significant negative correlation of insulin resistance with FVC% predicted (correlation coefficient γ = -0.130, P < 0.0001), FEV1% predicted (γ = -0.074, P = 0.004) and FEV1/FVC ratio (γ = -0.059, P = 0.019) in young adults, especially in subjects without asthma (γ for FVC% predicted, FEV1% predicted and FEV1/FVC ratio = -0.138, -0.092, and -0.061, respectively). This study demonstrates an inverse correlation between insulin resistance and lung function in Korean young adults. Young adults with preclinical insulin resistance have a higher risk of impaired lung function.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lee YB,Kim YS,Lee DH,Kim HY,Lee JI,Ahn HS,Sohn TS,Lee TK,Song JY,Yeo CD,Hong M,Han K,Jeong SC,Chae HSdoi
10.1038/s41598-017-11337-3subject
Has Abstractpub_date
2017-09-15 00:00:00pages
11726issue
1issn
2045-2322pii
10.1038/s41598-017-11337-3journal_volume
7pub_type
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