Amiodarone as an autophagy promoter reduces liver injury and enhances liver regeneration and survival in mice after partial hepatectomy.

Abstract:

:The deregulation of autophagy is involved in liver regeneration. Here, we investigated the role of autophagy in the regulation of liver regeneration after partial hepatectomy (PHx) and the development of pharmacological interventions for improved liver regeneration after PHx. We show that autophagy was activated in the early stages of liver regeneration following 70% PHx in vivo. Moreover, amiodarone was associated with a significant enhancement of autophagy, liver growth, and hepatocyte proliferation, along with reduced liver injury and the termination of liver regeneration due to decreased transforming growth factor-β1 expression after 70% PHx. The promotion of autophagy appeared to selectively increase the removal of damaged mitochondria. We also found that Atg7 knockdown or pretreatment with chloroquine aggravated the liver injury associated with 70% PHx and reduced liver growth and hepatocyte proliferation. Finally, amiodarone improved liver regeneration, survival, and liver injury after 90% PHx. In conclusion, our results indicate that autophagy plays an important role in mouse liver regeneration and that modulating autophagy with amiodarone may be an effective method of improving liver regeneration, increasing survival, and ameliorating liver injury following PHx.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Lin CW,Chen YS,Lin CC,Chen YJ,Lo GH,Lee PH,Kuo PL,Dai CY,Huang JF,Chung WL,Yu ML

doi

10.1038/srep15807

subject

Has Abstract

pub_date

2015-10-30 00:00:00

pages

15807

issn

2045-2322

pii

srep15807

journal_volume

5

pub_type

杂志文章
  • Live-cell imaging of subcellular structures for quantitative evaluation of pluripotent stem cells.

    abstract::Pluripotent stem cells (PSCs) have various degrees of pluripotency, which necessitates selection of PSCs with high pluripotency before their application to regenerative medicine. However, the quality control processes for PSCs are costly and time-consuming, and it is essential to develop inexpensive and less laborious...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37779-x

    authors: Nishimura K,Ishiwata H,Sakuragi Y,Hayashi Y,Fukuda A,Hisatake K

    更新日期:2019-02-11 00:00:00

  • Caveolae-mediated albumin transcytosis is enhanced in dengue-infected human endothelial cells: A model of vascular leakage in dengue hemorrhagic fever.

    abstract::Vascular leakage is a life-threatening complication of dengue virus (DENV) infection. Previously, association between "paracellular" endothelial hyperpermeability and plasma leakage had been extensively investigated. However, whether "transcellular" endothelial leakage is involved in dengue hemorrhagic fever (DHF) and...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep31855

    authors: Chanthick C,Kanlaya R,Kiatbumrung R,Pattanakitsakul SN,Thongboonkerd V

    更新日期:2016-08-22 00:00:00

  • Transcription factor ZNF148 is a negative regulator of human muscle differentiation.

    abstract::Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in hum...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08267-5

    authors: Bakke J,Wright WC,Zamora AE,Ong SS,Wang YM,Hoyer JD,Brewer CT,Thomas PG,Chen T

    更新日期:2017-08-15 00:00:00

  • Active neutron and gamma-ray imaging of highly enriched uranium for treaty verification.

    abstract::The detection and characterization of highly enriched uranium (HEU) presents a large challenge in the non-proliferation field. HEU has a low neutron emission rate and most gamma rays are low energy and easily shielded. To address this challenge, an instrument known as the dual-particle imager (DPI) was used with a por...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08253-x

    authors: Hamel MC,Polack JK,Ruch ML,Marcath MJ,Clarke SD,Pozzi SA

    更新日期:2017-08-11 00:00:00

  • Hybrid surgery versus anterior cervical discectomy and fusion for multilevel cervical degenerative disc diseases: a meta-analysis.

    abstract::The objective of this meta-analysis is to compare hybrid surgery (HS) and cervical discectomy and fusion (ACDF) for multilevel cervical degenerative disc diseases (DDD). Systematic searches of all published studies through March 2015 were identified from Cochrane Library, Medline, PubMed, Embase, ScienceDirect, CNKI, ...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析,评审

    doi:10.1038/srep13454

    authors: Tian P,Fu X,Li ZJ,Sun XL,Ma XL

    更新日期:2015-08-26 00:00:00

  • A high-fat diet impairs reproduction by decreasing the IL1β level in mice treated at immature stage.

    abstract::Obesity causes low-grade inflammation that is involved in male infertility. Interleukin 1 beta (IL1β) plays an important role in this process. A high-fat diet (HFD) is the most common cause of obesity. However, the effect of a HFD on IL1β and its consequence in reproduction remain unclear. We established a HFD model i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-00505-0

    authors: Zhang J,Li K,Yuan M,Zhang J,Huang G,Ao J,Tan H,Li Y,Gong D,Li J,Kang L,An N,Li F,Lin P,Huang L

    更新日期:2017-04-03 00:00:00

  • Glider observations of interleaving layers beneath the Kuroshio primary velocity core east of Taiwan and analyses of underlying dynamics.

    abstract::Submesoscale interleaving layers are caused by lateral intrusions of dissimilar water masses in frontal zones, which are significant processes in shaping physical, biogeochemical, and ecological parameters in the ocean. Possible interleaving layers were sometimes observed by ship-based conductivity-temperature-depth (...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47912-z

    authors: Jan S,Wang SH,Yang KC,Yang YJ,Chang MH

    更新日期:2019-08-06 00:00:00

  • The possible role of Dickkopf-1, Golgi protein- 73 and Midkine as predictors of hepatocarcinogenesis: a review and an Egyptian study.

    abstract::Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death worldwide. The use of alpha fetoprotein (AFP) alone was not an accurate biomarker for HCC despite its high specificity. Therefore, we assessed the possible role of serum biomarkers that have been mentioned briefly in previous studie...

    journal_title:Scientific reports

    pub_type: 杂志文章,评审

    doi:10.1038/s41598-020-62051-6

    authors: N Zekri AR,El Kassas M,Salam ESE,Hassan RM,Mohanad M,Gabr RM,M Lotfy M,Abdel-Zaher RAT,Bahnassy AA,Ahmed OS

    更新日期:2020-03-20 00:00:00

  • Combination of the Manifold Dimensionality Reduction Methods with Least Squares Support vector machines for Classifying the Species of Sorghum Seeds.

    abstract::This study was carried out for rapid and noninvasive determination of the class of sorghum species by using the manifold dimensionality reduction (MDR) method and the nonlinear regression method of least squares support vector machines (LS-SVM) combing with the mid-infrared spectroscopy (MIRS) techniques. The methods ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep19917

    authors: Chen YM,Lin P,He JQ,He Y,Li XL

    更新日期:2016-01-28 00:00:00

  • Relationship Between Homodimeric Glucocorticoid Receptor and Transcriptional Regulation Assessed via an In Vitro Fluorescence Correlation Spectroscopy-Microwell System.

    abstract::Glucocorticoid receptor (GR) is a hormone-activated transcription regulatory protein involved in metabolism as well as adrenocortical responses to psychosocial stress. Ligand-activated GR localizes to the nucleus, where GR homodimers regulate gene transcription via direct binding to glucocorticoid response elements (G...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-25393-w

    authors: Oasa S,Mikuni S,Yamamoto J,Kurosaki T,Yamashita D,Kinjo M

    更新日期:2018-05-10 00:00:00

  • Newtonian flow inside carbon nanotube with permeable boundary taking into account van der Waals forces.

    abstract::Here, water flow inside large radii semi-infinite carbon nanotubes is investigated. Permeable wall taking into account the molecular interactions between water and a nanotube, and the slip boundary condition will be considered. Furthermore, interactions among molecules are approximated by the continuum approximation. ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48614-2

    authors: Chan Y,Lee SL,Chen W,Zheng L,Shi Y,Ren Y

    更新日期:2019-08-20 00:00:00

  • Effect of adipose-derived mesenchymal stem cell transplantation on vascular calcification in rats with adenine-induced kidney disease.

    abstract::Previous studies have investigated the use of mesenchymal stem cells (MSCs) to treat damaged kidneys. However, the effect of adipose-derived MSCs (ASCs) on vascular calcification in chronic kidney disease (CKD) is still poorly understood. In the present study, we explored the potential of ASCs for the treatment of CKD...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-14492-9

    authors: Yokote S,Katsuoka Y,Yamada A,Ohkido I,Yokoo T

    更新日期:2017-10-25 00:00:00

  • Prenatal Maternal Stress from a Natural Disaster Alters Urinary Metabolomic Profiles in Project Ice Storm Participants.

    abstract::Prenatal stress is known to epigenetically program offspring physiology and behaviour, and may become a risk factor for adult complex diseases. To gain insight into the underlying environment-gene interactions, we used proton nuclear magnetic resonance spectroscopy to analyze urinary metabolomes of male and female ado...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章

    doi:10.1038/s41598-018-31230-x

    authors: Paxman EJ,Boora NS,Kiss D,Laplante DP,King S,Montina T,Metz GAS

    更新日期:2018-08-28 00:00:00

  • The association between oxidative stress and corneal hysteresis in patients with glaucoma.

    abstract::Systemic antioxidative status has been implicated in glaucoma pathogenesis. Additionally, corneal hysteresis (CH) may contribute to glaucoma progression. Here, we evaluated the relationship between biological antioxidant potential (BAP) and CH. This study included 103 patients with open-angle glaucoma (OAG). We used a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-57520-x

    authors: Uchida K,Himori N,Hashimoto K,Shiga Y,Tsuda S,Omodaka K,Nakazawa T

    更新日期:2020-01-17 00:00:00

  • Heritability estimates of the novel trait 'suppressed in ovo virus infection' in honey bees (Apis mellifera).

    abstract::Honey bees are under pressure due to abnormal high colony death rates, especially during the winter. The infestation by the Varroa destructor mite and the viruses that this ectoparasite transmits are generally considered as the bees' most important biological threats. Almost all efforts to remedy this dual infection h...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-71388-x

    authors: de Graaf DC,Laget D,De Smet L,Claeys Boúúaert D,Brunain M,Veerkamp RF,Brascamp EW

    更新日期:2020-08-31 00:00:00

  • Rifampicin Resistant Tuberculosis in Lesotho: Diagnosis, Treatment Initiation and Outcomes.

    abstract::The Lesotho guidelines for the management of drug-resistant tuberculosis (TB) recommend initiation of patients diagnosed with rifampicin resistant (RR)-TB on a standardized drug resistant regimen while awaiting confirmation of rifampicin resistant TB (RR-TB) and complete drug susceptibility test results. Review of dia...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-58690-4

    authors: Katende B,Esterhuizen TM,Dippenaar A,Warren RM

    更新日期:2020-02-05 00:00:00

  • Noncanonical NF-κB mediates the Suppressive Effect of Neutrophil Elastase on IL-8/CXCL8 by Inducing NKRF in Human Airway Smooth Muscle.

    abstract::Neutrophil elastase (NE) suppresses IL-8/CXCL8 in human airway smooth muscle cells (hASM) while stimulating its production in respiratory epithelial cells. This differential effect is mediated by the selective induction of NKRF and dysregulation in chronic inflammatory diseases. We hypothesized that the differential a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep44930

    authors: Ho SC,Wu SM,Feng PH,Liu WT,Chen KY,Chuang HC,Chan YF,Kuo LW,Lee KY

    更新日期:2017-03-21 00:00:00

  • Biochemical and genetic characterization of a novel metallo-β-lactamase from marine bacterium Erythrobacter litoralis HTCC 2594.

    abstract::Metallo-β-lactamases (MBLs) are a group of enzymes that can inactivate most commonly used β-lactam-based antibiotics. Among MBLs, New Delhi metallo-β-lactamase-1 (NDM-1) constitutes an urgent threat to public health as evidenced by its success in rapidly disseminating worldwide since its first discovery. Here we repor...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-19279-0

    authors: Jiang XW,Cheng H,Huo YY,Xu L,Wu YH,Liu WH,Tao FF,Cui XJ,Zheng BW

    更新日期:2018-01-16 00:00:00

  • Growth factor restriction impedes progression of wound healing following cataract surgery: identification of VEGF as a putative therapeutic target.

    abstract::Secondary visual loss occurs in millions of patients due to a wound-healing response, known as posterior capsule opacification (PCO), following cataract surgery. An intraocular lens (IOL) is implanted into residual lens tissue, known as the capsular bag, following cataract removal. Standard IOLs allow the anterior and...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep24453

    authors: Eldred JA,McDonald M,Wilkes HS,Spalton DJ,Wormstone IM

    更新日期:2016-04-14 00:00:00

  • Improving extracellular vesicles visualization: From static to motion.

    abstract::In the last decade, extracellular vesicles (EVs) have become a hot topic. The findings on EVs content and effects have made them a major field of interest in cancer research. EVs, are able to be internalized through integrins expressed in parental cells, in a tissue specific manner, as a key step of cancer progression...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62920-0

    authors: Reclusa P,Verstraelen P,Taverna S,Gunasekaran M,Pucci M,Pintelon I,Claes N,de Miguel-Pérez D,Alessandro R,Bals S,Kaushal S,Rolfo C

    更新日期:2020-04-16 00:00:00

  • Strong association between vertebral endplate defect and Modic change in the general population.

    abstract::Modic change (MC) is considered an independent risk factor for low back pain (LBP) but its aetiology remains unclear. In this cross-sectional, large-scale population-based study we sought to characterise associations between endplate defect (ED) and MC in a population sample of broad age range. The study population co...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-34933-3

    authors: Määttä JH,Rade M,Freidin MB,Airaksinen O,Karppinen J,Williams FMK

    更新日期:2018-11-09 00:00:00

  • Comparison of oral microbiome profiles in stimulated and unstimulated saliva, tongue, and mouth-rinsed water.

    abstract::Epidemiological studies using saliva have revealed relationships between the oral microbiome and many oral and systemic diseases. However, when collecting from a large number of participants such as a large-scale cohort study, the time it takes to collect saliva can be a problem. Mouth-rinsed water, which is water tha...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52445-6

    authors: Jo R,Nishimoto Y,Umezawa K,Yama K,Aita Y,Ichiba Y,Murakami S,Kakizawa Y,Kumagai T,Yamada T,Fukuda S

    更新日期:2019-11-06 00:00:00

  • Peritumoral and intratumoral radiomic features predict survival outcomes among patients diagnosed in lung cancer screening.

    abstract::The National Lung Screening Trial (NLST) demonstrated that screening with low-dose computed tomography (LDCT) is associated with a 20% reduction in lung cancer mortality. One potential limitation of LDCT screening is overdiagnosis of slow growing and indolent cancers. In this study, peritumoral and intratumoral radiom...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-67378-8

    authors: Pérez-Morales J,Tunali I,Stringfield O,Eschrich SA,Balagurunathan Y,Gillies RJ,Schabath MB

    更新日期:2020-06-29 00:00:00

  • Inactivation efficacy of atmospheric air plasma and airborne acoustic ultrasound against bacterial biofilms.

    abstract::Biofilms are complex microbial communities that present serious contamination risks to our environment and health. In this study, atmospheric air plasma and airborne acoustic ultrasound technology were applied to inactivate Escherichia coli and Listeria innocua biofilms. Both technologies were efficient in controlling...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-81977-z

    authors: Patange AD,Simpson JC,Curtin JF,Burgess CM,Cullen PJ,Tiwari BK

    更新日期:2021-01-27 00:00:00

  • Social rank-associated stress vulnerability predisposes individuals to cocaine attraction.

    abstract::Studies of personality have suggested that dissimilarities in ability to cope with stressful situations results in differing tendency to develop addictive behaviors. The present study used selectively bred stress-resilient, socially-dominant (Dom) and stress-vulnerable, socially-submissive (Sub) mice to investigate th...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-19816-x

    authors: Yanovich C,Kirby ML,Michaelevski I,Yadid G,Pinhasov A

    更新日期:2018-01-29 00:00:00

  • The ion channels and transporters gene expression profile indicates a shift in excitability and metabolisms during malignant progression of Follicular Lymphoma.

    abstract::The definition of the gene expression profile of genes encoding Ion Channels and Transporters (ICT-GEP) represents a novel and attracting aspect in cancer. We determined the ICT-GEP of Follicular Lymphoma (FL), and compared it with that of the more aggressive Diffuse Large B Cell Lymphoma (DLBCL). cDNA microarray data...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-44661-x

    authors: Magi A,Masselli M,Sala C,Guerriero A,Laise P,Puccini B,Rigacci L,Breschi C,Crociani O,Pillozzi S,Arcangeli A

    更新日期:2019-06-13 00:00:00

  • Tosylation of alcohols: an effective strategy for the functional group transformation of organic derivatives of polyoxometalates.

    abstract::Recently, the organic functionalization of polyoxometalates (POMs) has drawn increasing interest, and an easy and effective route to achieve organic derivatives is of great importance. Herein, the first reported synthesis of a tosyl ester derivative of the polyoxometalate (Bu4N)2[V6O13{(OCH2)3CCH2SO3C7H4}2]·2.5CH3CN (...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12633-8

    authors: Jia H,Li Q,Bayaguud A,She S,Huang Y,Chen K,Wei Y

    更新日期:2017-10-02 00:00:00

  • Consequences of in utero exposure to Zika virus in offspring of AG129 mice.

    abstract::Zika virus (ZIKV) can cause various diseases in offspring after congenital infection. The purpose of this study was to identify disease phenotypes in pups exposed to ZIKV in utero. Female interferon-α/β, -γ receptor knockout mice (AG129) were infected intraperitoneally with ZIKV 7.5 days' post coitus (dpc). Viral RNA,...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-27611-x

    authors: Julander JG,Siddharthan V,Park AH,Preston E,Mathur P,Bertolio M,Wang H,Zukor K,Van Wettere AJ,Sinex DG,Morrey JD

    更新日期:2018-06-20 00:00:00

  • Relationships of wild and domesticated rices (Oryza AA genome species) based upon whole chloroplast genome sequences.

    abstract::Rice is the most important crop in the world, acting as the staple food for over half of the world's population. The evolutionary relationships of cultivated rice and its wild relatives have remained contentious and inconclusive. Here we report on the use of whole chloroplast sequences to elucidate the evolutionary an...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep13957

    authors: Wambugu PW,Brozynska M,Furtado A,Waters DL,Henry RJ

    更新日期:2015-09-10 00:00:00

  • Discordancy Partitioning for Validating Potentially Inconsistent Pharmacogenomic Studies.

    abstract::The Genomics of Drug Sensitivity in Cancer (GDSC) and Cancer Cell Line Encyclopedia (CCLE) are two major studies that can be used to mine for therapeutic biomarkers for cancers of a large variety. Model validation using the two datasets however has proved challenging. Both predictions and signatures do not consistentl...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-15590-4

    authors: Rao JS,Liu H

    更新日期:2017-11-09 00:00:00