Abstract:
:Shewanella species are facultative anaerobic bacteria that colonize redox-stratified habitats where O2 and nutrient concentrations fluctuate. The model species Shewanella oneidensis MR-1 possesses genes coding for three terminal oxidases that can perform O2 respiration: a bd-type quinol oxidase and cytochrome c oxidases of the cbb3-type and the A-type. Whereas the bd- and cbb3-type oxidases are routinely detected, evidence for the expression of the A-type enzyme has so far been lacking. Here, we investigated the effect of nutrient starvation on the expression of these terminal oxidases under different O2 tensions. Our results reveal that the bd-type oxidase plays a significant role under nutrient starvation in aerobic conditions. The expression of the cbb3-type oxidase is also modulated by the nutrient composition of the medium and increases especially under iron-deficiency in exponentially growing cells. Most importantly, under conditions of carbon depletion, high O2 and stationary-growth, we report for the first time the expression of the A-type oxidase in S. oneidensis, indicating that this terminal oxidase is not functionally lost. The physiological role of the A-type oxidase in energy conservation and in the adaptation of S. oneidensis to redox-stratified environments is discussed.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Le Laz S,Kpebe A,Bauzan M,Lignon S,Rousset M,Brugna Mdoi
10.1038/srep19726subject
Has Abstractpub_date
2016-01-27 00:00:00pages
19726issn
2045-2322pii
srep19726journal_volume
6pub_type
杂志文章abstract::In the study, 15 K. pneumoniae strains were isolated from the mink experiencing respiratory distress in mideastern Shandong province, China, and the prevalence of K. pneumoniae in the sampled mink was 11.9% (15/126). Fourteen (93.33%) of the 15 K. pneumoniae isolates were identified as serotype K2 and hypermucoviscosi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17681-8
更新日期:2017-12-11 00:00:00
abstract::p53 and aldehyde dehydrogenase (ALDH) have been implicated in key tumorigenesis processes including cancer initiating cell (CIC) maintenance; however, the relationship between these two mediators remains poorly defined. In this study, ALDH isoform expression diversity was revealed in CICs with disparate p53 functional...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57758-5
更新日期:2020-01-23 00:00:00
abstract::New strategies are needed to develop better tools to control TB, including identification of novel antigens for vaccination. Such Mtb antigens must be expressed during Mtb infection in the major target organ, the lung, and must be capable of eliciting human immune responses. Using genome-wide transcriptomics of Mtb in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37793
更新日期:2016-11-28 00:00:00
abstract::Epilepsy is a widespread neurological disease characterized by abnormal neuronal activity resulting in recurrent seizures. There is mounting evidence that a circadian system disruption, involving clock genes and their downstream transcriptional regulators, is associated with epilepsy. In this study, we characterized t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60638-7
更新日期:2020-02-28 00:00:00
abstract::The role of isochrony in speech-the hypothetical division of speech units into equal duration intervals-has been the subject of a long-standing debate. Current approaches in neurosciences have brought new perspectives in that debate through the theoretical framework of predictive coding and cortical oscillations. Here...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76594-1
更新日期:2020-11-11 00:00:00
abstract::To determine the incidence of acute cardiac injury (ACI), the factors associated with ACI and the in-hospital mortality in patients with COVID-19, especially in severe patients. All consecutive in-patients with laboratory-confirmed COVID-19 from Tongji Hospital in Wuhan during February 1 and March 29, 2020 were includ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77172-1
更新日期:2020-11-24 00:00:00
abstract::RNA virus-based episomal vector (REVec) is an emerging viral vector system that mediates long-term stable gene expression in variety of cell types in vitro. However, little is known about its tissue tropism and persistence of gene expression in vivo. Here, to evaluate the feasibility of REVec for in vivo gene delivery...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62630-7
更新日期:2020-04-03 00:00:00
abstract::The brain is organized into large scale spatial networks that can be detected during periods of rest using fMRI. The brain is also a dynamic organ with activity that changes over time. We developed a method and investigated properties where the connections as a function of time are derived and quantified. The point ba...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39156
更新日期:2016-12-19 00:00:00
abstract::It is shown that in the ergodic regime, the temperature dependence of Young's modulus is solely determined by the magnetic properties of a material. For the large class of materials with paramagnetic or diamagnetic response, simple functional forms of the temperature derivative of Young's modulus are derived and compa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05238-8
更新日期:2017-07-07 00:00:00
abstract::The synthetic Angiotensin Converting Enzyme (ACE) inhibitors have side effects and hence demands for natural ACE inhibitors have been rising. The aim of this study is to purify and introduce natural ACE inhibitors extracted from Zizyphus jujuba fruits. Proteins from Zizyphus jujuba were lysed by trypsin, papain and th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60972-w
更新日期:2020-03-04 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-61223-8
更新日期:2020-03-03 00:00:00
abstract::In this work, an enzymatic biofuel cell (EBC) based on a membraneless and mediatorless glucose enzymatic fuel cell system was constructed for operation in physiological conditions (pH 7.0 and temperature 37 °C). The new platform EBC made of nanocomposite, including magnetic nanoparticles (Fe3O4 NPs) and reduced graphe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12417-0
更新日期:2017-10-10 00:00:00
abstract::The chemokine CCL3 is frequently overexpressed in malignancies and overexpression leads to microenvironmental dysfunction. In murine models of chronic myelogenous leukemia (CML), CCL3 is critical for the maintenance of a leukemia stem cell population, and leukemia progression. With CCL3 implicated as a potentially via...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32978-y
更新日期:2018-10-02 00:00:00
abstract::Cardiac tissue engineering using biomaterials with or without combination of stem cell therapy offers a new option for repairing infarcted heart. However, the bioactivity of biomaterials remains to be optimized because currently available biomaterials do not mimic the biochemical components as well as the structural p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39988
更新日期:2017-01-04 00:00:00
abstract::Considering the significance of mast cells (MCs) in the course of various physiological and pathological processes, and the pivotal role of endogenous molecules, i.e., cathelicidins and defensins as multifunctional modulators, the study examines the constitutive and cathelicidin LL-37/defensin hBD-2-induced expression...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30289-w
更新日期:2018-08-06 00:00:00
abstract::Rubber dams are widely used for landscaping in urban rivers and they retain large amounts of sediments. The sediments are rich in phosphorus (P) which can cause river eutrophication. Little is known about P release in rubber dams. We investigated the potential of sediment P release by isotherm experiment in an urban r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59493-3
更新日期:2020-02-17 00:00:00
abstract::Ultrasound-enhanced drug delivery has shown great promise in providing targeted burst release of drug at the site of the disease. Yet current solid ultrasound-responsive particles are non-degradable with limited potential for drug-loading. Here, we report on an ultrasound-responsive multi-cavity poly(lactic-co-glycoli...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46022-0
更新日期:2019-07-03 00:00:00
abstract::Recently, magnetic nanoparticles (MNPs), which can be manipulated in the magnetic field, have received much attention in tumor therapy. Extremely low frequency magnetic field (ELMF) system can initiate MNPs vibrating and the movement of MNPs inside of cells can be controlled by adjusting the frequency and intensity of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46287
更新日期:2017-04-11 00:00:00
abstract::Modulating the tumor microenvironment to promote an effective immune response is critical in managing any type of tumor. Melanoma is an aggressive skin cancer and the incidence rate is increasing worldwide. Potent protease inhibitors have recently been extensively researched as potential therapeutic agents against var...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52609-4
更新日期:2019-11-07 00:00:00
abstract::To realize power efficient solution-processed phosphorescent organic light-emitting diodes (s-PhOLEDs), the corresponding high driving voltage issue should be well solved. To solve it, efforts have been devoted to the exploitation of novel host or interfacial materials. However, the issues of charge trapping of phosph...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12487
更新日期:2015-07-24 00:00:00
abstract::Environmental stimuli have the ability to generate specific representations of the rewards they predict and in so doing alter the selection and performance of reward-seeking actions. The basolateral amygdala participates in this process, but precisely how is unknown. To rectify this, we monitored, in near-real time, b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12511
更新日期:2015-07-27 00:00:00
abstract::China has one of the highest rates of cesarean sections in the world. However, limited epidemiological studies have evaluated the risk factors for cesarean section among Chinese women. Thus, the aim of this cohort study was to investigate the associations between pre-pregnancy BMI, gestational weight gain (GWG) and th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37168
更新日期:2016-11-22 00:00:00
abstract::Detection dogs, specially trained domestic dogs (Canis familiaris), have become a valuable, noninvasive, conservation tool because they remove the dependence of attracting species to a particular location. Further, detection dogs locate samples independent of appearance, composition, or visibility allowing researchers...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32244-1
更新日期:2018-09-14 00:00:00
abstract::Selenium and selenium nanoparticles (SeNPs) are extensively used in biomedicine, electronics and some other industrial applications. The bioproduction of SeNPs is gaining interest as a green method to manufacture these biotechnologically relevant products. Several microorganisms have been used for the production of Se...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16252-1
更新日期:2017-11-22 00:00:00
abstract::Fire ants are widely studied, invasive and venomous arthropod pests. There is significant biomedical interest in immunotherapy against fire ant stings. However, mainly due to practical reasons, the physiological effects of envenomation has remained poorly characterized. The present study takes advantage of a recently-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32327-z
更新日期:2018-09-26 00:00:00
abstract::Airway smooth muscle (ASM) cells exhibit plastic phenotypic behavior marked by reversible modulation and maturation between contractile and proliferative phenotypic states. Integrins are a class of transmembrane proteins that have been implicated as novel therapeutic targets for asthma treatment. We previously showed ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46260-2
更新日期:2019-07-09 00:00:00
abstract::A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41598-017-17100-y
更新日期:2017-12-05 00:00:00
abstract::The current molecular docking study provided the Free Energy of Binding (FEB) for the interaction (nanotoxicity) between VDAC mitochondrial channels of three species (VDAC1-Mus musculus, VDAC1-Homo sapiens, VDAC2-Danio rerio) with SWCNT-H, SWCNT-OH, SWCNT-COOH carbon nanotubes. The general results showed that the FEB ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13691-8
更新日期:2017-10-16 00:00:00
abstract::There is a growing interest concerning the relevance of salivary cortisone levels in stress-related research. However, studies investigating morning patterns and day-to-day variability of cortisone versus cortisol levels are lacking. Cortisol and cortisone analysis by liquid chromatography-tandem mass spectroscopy (LC...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55571-3
更新日期:2019-12-17 00:00:00
abstract::The aetiology of septic acute kidney injury (AKI) is not completely elucidated. Early identification of AKI in septic patients is considered to improve survival rate since it allows rapid treatment onset. We evaluated clinical, haematological, urinary, B-mode, spectral Doppler, and contrast-enhanced ultrasound variabl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65902-4
更新日期:2020-06-02 00:00:00