Abstract:
:The aetiology of septic acute kidney injury (AKI) is not completely elucidated. Early identification of AKI in septic patients is considered to improve survival rate since it allows rapid treatment onset. We evaluated clinical, haematological, urinary, B-mode, spectral Doppler, and contrast-enhanced ultrasound variables in 20 bitches with pyometra as sepsis models and 12 healthy controls. All animals with pyometra presented some degree of renal damage on histological examination; however, sequential organ failure assessment (SOFA) classified only 40% cases with sepsis. AKI derived from systemic infection was identified in 57% of cases with hypoperfusion and in 22% with inflammation, being an affection of multifactorial origin. Among the evaluated parameters, urinary protein/creatinine ratio >0.15, serum albumin <2.94 mg/dL, time-averaged minimum velocity <21.5 cm/s, renal length/aorta diameter ratio >5.93, pulsatility index >1.53, haematocrit <45%, time-averaged maximum velocity <45.7 cm/s, haemoglobin <16 g/dL, leukocytes >12.53 × 103/uL, and cortical contrast peak intensity <69%, in the order of accuracy, are significant indicators of septic AKI with an accuracy >80%. Thus, AKI is a very prevalent condition in septic patients, derived mainly from changes in renal perfusion and inflammation. Additionally, reviewing the SOFA score parameters is suggested to identify renal failure.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Gasser B,Uscategui RAR,Maronezi MC,Pavan L,Simões APR,Martinato F,Silva P,Crivellenti LZ,Feliciano MARdoi
10.1038/s41598-020-65902-4subject
Has Abstractpub_date
2020-06-02 00:00:00pages
8994issue
1issn
2045-2322pii
10.1038/s41598-020-65902-4journal_volume
10pub_type
杂志文章abstract::Extraction of mouse spinal motor neurons from transgenic mouse embryos recapitulating some aspects of neurodegenerative diseases like amyotrophic lateral sclerosis has met with limited success. Furthermore, extraction and long-term culture of adult mouse spinal motor neurons and glia remain also challenging. We presen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16763
更新日期:2015-11-18 00:00:00
abstract::As an important method for building blocks synthesis, whole cell biocatalysis is hindered by some shortcomings such as unpredictability of reactions, utilization of opportunistic pathogen, and side reactions. Due to its biological and extensively studied genetic background, Pseudomonas putida KT2440 is viewed as a pro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06939
更新日期:2014-11-06 00:00:00
abstract::Changes in land cover have become key components of global environmental change and represent the impact of human activity. To better understand the fundamental processes of land transition characteristics before and after the implementation of ecological programmes, we determined the dominant systematic changes in la...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44496
更新日期:2017-03-21 00:00:00
abstract::Evidence suggest that overexpression of hypoxia-inducible factor-1α (HIF-1α) is linked to multidrug resistance of epilepsy. Here we explored whether aberrant expression of HIF-1α is regulated by miRNAs. Genome-wide microRNA expression profiling was performed on temporal cortex resected from mesial temporal lobe epilep...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32091
更新日期:2016-08-24 00:00:00
abstract::We report low-temperature solution-processed p-CuO nanorods (NRs)/n-ZnO NRs heterojunction light emitting diode (LED), exploiting the native point defects of ZnO NRs. ZnO NRs were synthesized at 90 °C by using hydrothermal method while CuO NRs were synthesized at 100 °C by using microwave reaction system. The electric...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17961
更新日期:2015-12-09 00:00:00
abstract::Hearing loss resulting from hair cell degeneration is a common disease that affects millions of people worldwide. Strategies to overcome the apparent irreversible hair cell loss in mammals become paramount for hearing protection. Here we reported that, by using a well-established gentamicin-induced hair cell loss mode...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08181
更新日期:2015-02-02 00:00:00
abstract::Alzheimer's disease is a debilitating neurodegenerative condition that progressively causes synaptic loss and major neuronal damage. Immunotherapy utilising Aβ as an active immunogen or via passive treatment utilising antibodies raised to amyloid have shown therapeutic promise. The migratory properties of peripheral b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20845-9
更新日期:2018-02-05 00:00:00
abstract::Highly omnidirectional and frequency controllable carbon/polyaniline (C/PANI)-based, two- (2D) and three-dimensional (3D) monopole antennas were fabricated using screen-printing and a one-step, dimensionally confined hydrothermal strategy, respectively. Solvated C/PANI was synthesized by low-temperature interfacial po...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13615
更新日期:2015-09-04 00:00:00
abstract::The present study evaluated the effects of exposing liquid-stored boar semen to different red light LED regimens on sperm quality and reproductive performance. Of all of the tested photo-stimulation procedures, the best pattern consisted of 10 min light, 10 min rest and 10 min of further light (10-10-10 pattern). This...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22569
更新日期:2016-03-02 00:00:00
abstract::Amplicon based metabarcoding promises rapid and cost-efficient analyses of species composition. However, it is disputed whether abundance estimates can be derived from metabarcoding due to taxon specific PCR amplification biases. PCR-free approaches have been suggested to mitigate this problem, but come with considera...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17333-x
更新日期:2017-12-15 00:00:00
abstract::A multi-agent Parrondo's model based on complex networks is used in the current study. For Parrondo's game A, the individual interaction can be categorized into five types of behavioral patterns: the Matthew effect, harmony, cooperation, poor-competition-rich-cooperation and a random mode. The parameter space of Parro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37028
更新日期:2016-11-15 00:00:00
abstract::Present-day terrestrial analogue sites are crucial ground truth proxies for studying life in geochemical conditions close to those assumed to be present on early Earth or inferred to exist on other celestial bodies (e.g. Mars, Europa). Although hypersaline sapropels are border-of-life habitats with moderate occurrence...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06232-w
更新日期:2017-07-21 00:00:00
abstract::A binary metallic superoscillatory lens assisted with annular subwavelength slits is proposed, which generates a longitudinally-polarized super-resolution focal point. The annular slits are designed to selectively transmit radially-polarized light. Simulations using the finite element method show a 0.24 λ focal spot w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56810-3
更新日期:2020-01-28 00:00:00
abstract::Neutrophil extracellular traps (NETs) extruded from neutrophils upon activation are composed of chromatin associated with cytosolic and granular proteins, which ensnare and kill microorganisms. This microbicidal mechanism named classical netosis has been shown to dependent on reactive oxygen species (ROS) generation b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18302
更新日期:2015-12-17 00:00:00
abstract::The early diverged Magnoliaceae shows a historical temperate-tropical distribution among lineages indicating divergent evolution, yet which ecophysiological traits are phylogenetically conserved, and whether these traits are involved in correlated evolution remain unclear. Integrating phylogeny and 20 ecophysiological...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12246
更新日期:2015-07-16 00:00:00
abstract::The expanding distribution of African swine fever (ASF) is threatening the pig industry worldwide. Most outbreaks occur in backyard and small-scale herds, where poor farmers often attempt to limit the disease's economic consequences by the emergency sale of their pigs. The risk of African swine fever virus (ASFV) rele...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17074
更新日期:2015-11-27 00:00:00
abstract::Despite being a cardinal experimental model, the induction of cirrhosis in rats by repeated exposure to carbon tetrachloride (CCl4) has low reproducibility. Here, we compared two models of cirrhosis induced by orogastric administration of CCl4 once (CCl4-1xWk) or twice a week (CCl4-2xWk) for 12 weeks in male Sprague-D...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27427-9
更新日期:2018-06-15 00:00:00
abstract::In this paper, we propose a real time, ultrahigh accuracy and full-field-of-view (RUF) algorithm for full field of view (FOV) imaging system. The proposed algorithm combines rough matching and precise matching method to stitch multiple images with the whole FOV in short time and high imaging quality. In order to verif...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69353-9
更新日期:2020-07-24 00:00:00
abstract::To investigate the safety and efficiency of using robotic staplers for intracorporeal gastroduodenostomy in reduced-port robotic gastrectomy for gastric adenocarcinoma. We retrospectively reviewed patients who underwent totally robotic and laparoscopic gastrectomy with intracorporeal gastroduodenostomy. Gastroduodenos...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71807-z
更新日期:2020-09-07 00:00:00
abstract::Climate change is the greatest threat to coral reef ecosystems. In particular, increasing ocean temperatures are causing severe and widespread coral bleaching, contributing to extensive coral loss and degradation of coral reef habitats globally. Effects of coral bleaching are not however, equally apportioned among dif...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44809-9
更新日期:2019-06-10 00:00:00
abstract::Studies indicate that the gut microbiota (GM) can significantly influence both local and systemic host physiologic processes. With rising concern for optimization of experimental reproducibility and translatability, it is essential to consider the GM in study design. However, GM profiles can vary between rodent produc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28448-0
更新日期:2018-07-04 00:00:00
abstract::Transparent heaters have attracted increasing attention for their usefulness in vehicle windows, outdoor displays, and periscopes. We present high performance transparent heaters based on Ag nanowires with electron beam irradiation. We obtained an Ag-nanowire thin film with 48 ohm/sq of sheet resistance and 88.8% (sub...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17716
更新日期:2015-12-07 00:00:00
abstract::Topical anesthetics are widely applied in order to relieve the discomfort and anxiety caused by needle insertion and other painful superficial interventions at the oral cavity. So far, there are no commercially available effective topical anesthetic formulations for that purpose, and the most of developments are relat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68247-0
更新日期:2020-07-09 00:00:00
abstract::Tuneable pressure effects associated with changing interlayer distances in two-dimensional graphene oxide (GO)/reduced GO (rGO) layers are demonstrated through monitoring the changes in the spin-crossover (SCO) temperature (T 1/2) of [Fe(Htrz)2(trz)](BF4) nanoparticles (NPs) incorporated in the interlayer spaces of th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12444-x
更新日期:2017-09-22 00:00:00
abstract::Aedes aegypti is the primary vector for transmission of Dengue, Zika and chikungunya viruses. Previously it was shown that Dengue virus infection of the mosquito led to an in increased expression of the odorant binding protein 22 (AeOBP22) within the mosquito salivary gland and that siRNA mediated knockdown of AeOBP22...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60242-9
更新日期:2020-02-24 00:00:00
abstract::Advanced age is associated with a decline in cognitive function, likely caused by a combination of modifiable and non-modifiable factors such as genetics and lifestyle choices. Mounting evidence suggests that humanin and other mitochondrial derived peptides play a role in several age-related conditions including neuro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32616-7
更新日期:2018-09-21 00:00:00
abstract::In spite of extensive efforts over decades an experimentally-derived structure of full-length eukaryotic pentameric ligand-gated ion channels (pLGICs) is still lacking. These pharmaceutically highly-relevant channels contain structurally well-conserved and characterized extracellular and transmembrane domains. The int...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23921
更新日期:2016-04-05 00:00:00
abstract::The search for green and sustainable modification method to produce durable bamboo materials remains a challenge in industry. Here, heat treatment in tung oil at 100-200 °C was employed to modify bamboo materials. Oil permeation and distribution in the structure of bamboo samples during heat treatment were explored. T...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49240-8
更新日期:2019-09-06 00:00:00
abstract::ANO1 is a calcium-activated chloride channel that is frequently overexpressed in head and neck squamous cell carcinoma (HNSCC) and other cancers. While ANO1 expression negatively correlates with survival in several cancers, its epigenetic regulation is poorly understood. We analyzed HNSCC samples from TCGA and a separ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15634-9
更新日期:2017-11-09 00:00:00
abstract::The estrogen signaling pathway has been reported to modulate prostate cancer (PCa) progression through the activity of estrogen receptors α and β (ERα and ERβ). Given that selective estrogen receptor modulators (SERMs) are used to treat breast cancer, ERs have been proposed as attractive therapeutic targets in PCa. Ho...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60844-3
更新日期:2020-03-04 00:00:00