当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Comparison of Two Protocols of Carbon Tetrachloride-Induced Cirrhosis in Rats - Improving Yield and Reproducibility.

Comparison of Two Protocols of Carbon Tetrachloride-Induced Cirrhosis in Rats - Improving Yield and Reproducibility.

Abstract：

:Despite being a cardinal experimental model, the induction of cirrhosis in rats by repeated exposure to carbon tetrachloride (CCl4) has low reproducibility. Here, we compared two models of cirrhosis induced by orogastric administration of CCl4 once (CCl4-1xWk) or twice a week (CCl4-2xWk) for 12 weeks in male Sprague-Dawley rats. Control rats received water instead of CCl4. Both CCl4 protocols similarly attenuated body weight gain (p < 0.01 vs. Control). Although both CCl4 protocols increased hepatic fibrosis, portal hypertension and splenomegaly, the magnitude of these alterations was higher and more consistent in CCl4-2xWk rats. Importantly, two CCl4-1xWk rats did not develop cirrhosis versus a 100% yield of cirrhosis in CCl4-2xWk rats. The CCl4-2xWk protocol consistently induced liver atrophy together with hematological, biochemical and coagulation abnormalities characteristic of advanced cirrhosis that were absent in CCl4-1xWk rats. Ascites occurred in 20% and 80% of rats in theCCl4-1xWk and CCl4-2xWk groups (p < 0.01). All rats showed normal renal function, arterial blood gases and stable systemic hemodynamics. The total dose of CCl4 and mortality rate were similar in both protocols. The CCl4-2xWk protocol, therefore, was highly reproducible and effective for the induction of experimental cirrhosis within a confined time, representing a valuable advance for liver research.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Fortea JI,Fernández-Mena C,Puerto M,Ripoll C,Almagro J,Bañares J,Bellón JM,Bañares R,Vaquero J

doi

10.1038/s41598-018-27427-9

subject

Has Abstract

pub_date

2018-06-15 00:00:00

pages

9163

issue

1

issn

2045-2322

pii

10.1038/s41598-018-27427-9

journal_volume

8

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Local decomposition induced by dislocation motions inside precipitates in an Al-alloy.

    abstract：:Dislocations in crystals are linear crystallographic defects, which move in lattice when crystals are plastically deformed. Motion of a partial dislocation may remove or create stacking fault characterized with a partial of a lattice translation vector. Here we report that motion of partial dislocations inside an inte...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep01039

    authors： Yang B,Zhou YT,Chen D,Ma XL

    更新日期：2013-01-01 00:00:00

  • The complexity of clinically-normal sinus-rhythm ECGs is decreased in equine athletes with a diagnosis of paroxysmal atrial fibrillation.

    abstract：:Equine athletes have a pattern of exercise which is analogous to human athletes and the cardiovascular risks in both species are similar. Both species have a propensity for atrial fibrillation (AF), which is challenging to detect by ECG analysis when in paroxysmal form. We hypothesised that the proarrhythmic backgroun...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-63343-7

    authors： Alexeenko V,Fraser JA,Bowen M,Huang CL,Marr CM,Jeevaratnam K

    更新日期：2020-04-22 00:00:00

  • Paradoxical Role of Glypican-1 in Prostate Cancer Cell and Tumor Growth.

    abstract：:Recent studies suggest that glypican-1 (GPC-1) is a biomarker for prostate cancer, but there are few studies elucidating the role of GPC-1 in prostate cancer progression. We observed high expression of GPC-1 in more aggressive prostate cancer cell lines such as PC-3 and DU-145. While inhibition of GPC-1 expression in ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-47874-2

    authors： Quach ND,Kaur SP,Eggert MW,Ingram L,Ghosh D,Sheth S,Nagy T,Dawson MR,Arnold RD,Cummings BS

    更新日期：2019-08-07 00:00:00

  • Resistin Induces Hypertension and Insulin Resistance in Mice via a TLR4-Dependent Pathway.

    abstract：:Resistin, an adipokine involved in insulin resistance (IR) and diabetes, has recently been reported to play a role in cardiovascular events. However, its effect on blood pressure (BP) and the underlying mechanisms remain unclear. In the present study, we showed that resistin induces hypertension and IR in wild type (W...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep22193

    authors： Jiang Y,Lu L,Hu Y,Li Q,An C,Yu X,Shu L,Chen A,Niu C,Zhou L,Yang Z

    更新日期：2016-02-26 00:00:00

  • Study of Structural stability and formation mechanisms in DSPC and DPSM liposomes: A coarse-grained molecular dynamics simulation.

    abstract：:Liposomes or biological vesicles can be created from cholesterol, phospholipid, and water. Their stability is affected by their phospholipid composition which can influence disease treatment and drug delivery efficacy. In this study, the effect of phospholipid type on the formation and stability of liposomes using coa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-58730-z

    authors： Hashemzadeh H,Javadi H,Darvishi MH

    更新日期：2020-02-04 00:00:00

  • A perfectly stoichiometric and flat CeO2(111) surface on a bulk-like ceria film.

    abstract：:In surface science and model catalysis, cerium oxide (ceria) is mostly grown as an ultra-thin film on a metal substrate in the ultra-high vacuum to understand fundamental mechanisms involved in diverse surface chemistry processes. However, such ultra-thin films do not have the contribution of a bulk ceria underneath, ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep21165

    authors： Barth C,Laffon C,Olbrich R,Ranguis A,Parent P,Reichling M

    更新日期：2016-02-16 00:00:00

  • Manganese superoxide dismutase is required to maintain osteoclast differentiation and function under static force.

    abstract：:Bone homeostasis is maintained by the balance of osteoblasts (OBs) and osteoclasts (OCs). Increased activity of OCs not only contributes to pathological bone resorption, such as osteoporosis and periodontitis, but also is responsible for physiological conditions like orthodontic tooth movement (OTM). However, the deta...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep08016

    authors： Guo T,Zhang L,Konermann A,Zhou H,Jin F,Liu W

    更新日期：2015-01-26 00:00:00

  • Factors associated with acute cardiac injury and their effects on mortality in patients with COVID-19.

    abstract：:To determine the incidence of acute cardiac injury (ACI), the factors associated with ACI and the in-hospital mortality in patients with COVID-19, especially in severe patients. All consecutive in-patients with laboratory-confirmed COVID-19 from Tongji Hospital in Wuhan during February 1 and March 29, 2020 were includ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-77172-1

    authors： He X,Wang L,Wang H,Xie Y,Yu Y,Sun J,Yan J,Du Y,Shen Y,Zeng H

    更新日期：2020-11-24 00:00:00

  • Publisher Correction: Fast, sensitive method for trisaccharide biomarker detection in mucopolysaccharidosis type 1.

    abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-018-23332-3

    authors： Makino E,Klodnitsky H,Leonard J,Lillie J,Lund TC,Marshall J,Nietupski J,Orchard PJ,Miller WP,Phaneuf C,Tietz D,Varban ML,Donovan M,Belenki A

    更新日期：2018-03-19 00:00:00

  • Improved antitumor activity of TRAIL fusion protein via formation of self-assembling nanoparticle.

    abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been known as a promising agent for cancer therapy due to its specific apoptosis-inducing effect on tumor cells rather than most normal cells. However, systemically delivered TRAIL suffers from a rapid clearance from the body with an extremely short h...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep41904

    authors： Huang K,Duan N,Zhang C,Mo R,Hua Z

    更新日期：2017-02-22 00:00:00

  • Low-flux scanning electron diffraction reveals substructures inside the ordered membrane domain.

    abstract：:Ordered/disordered phase separation occurring in bio-membranes has piqued researchers' interest because these ordered domains, called lipid rafts, regulate important biological functions. The structure of the ordered domain has been examined with artificial membranes, which undergo macroscopic ordered/disordered phase...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-79083-7

    authors： Kinoshita M,Yamaguchi S,Matsumori N

    更新日期：2020-12-21 00:00:00

  • Angiotensin type 1a receptor deficiency decreases amyloid β-protein generation and ameliorates brain amyloid pathology.

    abstract：:Alzheimer's disease is characterized by neuronal loss and cerebral accumulation of amyloid-β protein (Aβ) and lowering the generation of Aβ is a pivotal approach in the strategy of Alzheimer's disease treatment. Midlife hypertension is a major risk factor for the future onset of sporadic Alzheimer's disease and the us...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep12059

    authors： Liu J,Liu S,Matsumoto Y,Murakami S,Sugakawa Y,Kami A,Tanabe C,Maeda T,Michikawa M,Komano H,Zou K

    更新日期：2015-07-08 00:00:00

  • High corrosion resistance and weak corrosion anisotropy of an as-rolled Mg-3Al-1Zn (in wt.%) alloy with strong crystallographic texture.

    abstract：:Combining with electrochemical corrosion measurements, immersion and hydrogen evolution testing performed in 0.9 wt.% NaCl solution at 37 °C, the corrosion resistance of an as-rolled Mg-3%Al-1%Zn alloy before and after a 3% compressive strain along the rolling direction was investigated. Results revealed that the corr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-16351-z

    authors： Wang BJ,Xu DK,Xin YC,Sheng LY,Han EH

    更新日期：2017-11-22 00:00:00

  • Predicting episodic memory formation for movie events.

    abstract：:Episodic memories are long lasting and full of detail, yet imperfect and malleable. We quantitatively evaluated recollection of short audiovisual segments from movies as a proxy to real-life memory formation in 161 subjects at 15 minutes up to a year after encoding. Memories were reproducible within and across individ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep30175

    authors： Tang H,Singer J,Ison MJ,Pivazyan G,Romaine M,Frias R,Meller E,Boulin A,Carroll J,Perron V,Dowcett S,Arellano M,Kreiman G

    更新日期：2016-09-30 00:00:00

  • Microscale Temperature Shaping Using Spatial Light Modulation on Gold Nanoparticles.

    abstract：:Heating on the microscale using focused lasers gave rise to recent applications, e.g., in biomedicine, biology and microfluidics, especially using gold nanoparticles as efficient nanoabsorbers of light. However, such an approach naturally leads to nonuniform, Gaussian-like temperature distributions due to the diffusiv...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-40382-3

    authors： Durdevic L,Robert HML,Wattellier B,Monneret S,Baffou G

    更新日期：2019-03-15 00:00:00

  • Molecularly imprinted polymer decorated nanoporous gold for highly selective and sensitive electrochemical sensors.

    abstract：:Electrochemical nanosensors based on nanoporous gold leaf (NPGL) and molecularly imprinted polymer (MIP) are developed for pharmaceutical analysis by using metronidazole (MNZ) as a model analyte. NPGL, serving as the loading platform for MIP immobilization, possesses large accessible surface area with superb electric ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep07699

    authors： Li Y,Liu Y,Liu J,Liu J,Tang H,Cao C,Zhao D,Ding Y

    更新日期：2015-01-09 00:00:00

  • Author Correction: Isolation and identification of two pairs of cytotoxic diterpene tautomers and their tautomerization mechanisms.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-61343-1

    authors： Dai LP,Li XF,Feng QM,Zhang LX,Liu QY,Xu EP,Wu H,Wang ZM

    更新日期：2020-03-04 00:00:00

  • Identification of a new cannabidiol n-hexyl homolog in a medicinal cannabis variety with an antinociceptive activity in mice: cannabidihexol.

    abstract：:The two most important and studied phytocannabinoids present in Cannabis sativa L. are undoubtedly cannabidiol (CBD), a non-psychotropic compound, but with other pharmacological properties, and Δ9-tetrahydrocannabinol (Δ9-THC), which instead possesses psychotropic activity and is responsible for the recreative use of ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-79042-2

    authors： Linciano P,Citti C,Russo F,Tolomeo F,Laganà A,Capriotti AL,Luongo L,Iannotta M,Belardo C,Maione S,Forni F,Vandelli MA,Gigli G,Cannazza G

    更新日期：2020-12-16 00:00:00

  • CF-PA2Vtech: a cell-free human protein array technology for antibody validation against human proteins.

    abstract：:Antibodies are widely used for the detection of specific molecules such as peptides, proteins, and chemical compounds. The specificity of an antibody is therefore its most important feature. However, it is very difficult to confirm antibody specificity. Recently, we made a human protein array consisting of 19,712 kind...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-55785-5

    authors： Morishita R,Sugiyama S,Denda M,Tokunaga S,Kido K,Shioya R,Ozawa S,Sawasaki T

    更新日期：2019-12-18 00:00:00

  • Host Directed Therapy for Chronic Tuberculosis via Intrapulmonary Delivery of Aerosolized Peptide Inhibitors Targeting the IL-10-STAT3 Pathway.

    abstract：:Here we demonstrate that aerosols of host directed therapies [HDT] administered during a chronic Mycobacterium tuberculosis (Mtb) infection have bactericidal effect. The pulmonary bacterial load of C57BL/6 mice chronically infected with Mtb was reduced by 1.7 and 0.6 log10CFU after two weeks of treatment via aerosol d...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35023-0

    authors： Upadhyay R,Sanchez-Hidalgo A,Wilusz CJ,Lenaerts AJ,Arab J,Yeh J,Stefanisko K,Tarasova NI,Gonzalez-Juarrero M

    更新日期：2018-11-09 00:00:00

  • Peritoneal Dialysis Catheter Emplacement by Advanced Laparoscopy: 8-year Experience from a Medical Center of China.

    abstract：:Laparoscopic experience and relevant reports about PD catheter emplacement in Chinese patients are seldom. In this study, we described our experience with advanced laparoscopy for PD catheter implantation in Chinese patients. There were one hundred and thirty Chinese patients accepted advanced laparoscopic approach fo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09596-1

    authors： Mo M,Ju Y,Hu H,Zhang W,Pan J,Zheng Q,Chen J,Su L,Dou X

    更新日期：2017-08-22 00:00:00

  • Elucidation of crystal and electronic structures within highly strained BiFeO3 by transmission electron microscopy and first-principles simulation.

    abstract：:Crystal and electronic structures of ~380 nm BiFeO3 film grown on LaAlO3 substrate are comprehensively studied using advanced transmission electron microscopy (TEM) technique combined with first-principles theory. Cross-sectional TEM images reveal the BiFeO3 film consists of two zones with different crystal structures...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep46498

    authors： Bae IT,Kovács A,Zhao HJ,Íñiguez J,Yasui S,Ichinose T,Naganuma H

    更新日期：2017-04-19 00:00:00

  • Long-term in vivo imaging reveals tumor-specific dissemination and captures host tumor interaction in zebrafish xenografts.

    abstract：:Understanding mechanisms mediating tumor metastasis is crucial for diagnostic and therapeutic targeting. Here, we take advantage of a transparent embryonic zebrafish xenograft model (eZXM) to visualize and track metastatic cells in real time using selective plane illumination microscopy (SPIM) for up to 30 h. Injected...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-69956-2

    authors： Asokan N,Daetwyler S,Bernas SN,Schmied C,Vogler S,Lambert K,Wobus M,Wermke M,Kempermann G,Huisken J,Brand M,Bornhäuser M

    更新日期：2020-08-06 00:00:00

  • Design and Fabrication of 3D printed Scaffolds with a Mechanical Strength Comparable to Cortical Bone to Repair Large Bone Defects.

    abstract：:A challenge in regenerating large bone defects under load is to create scaffolds with large and interconnected pores while providing a compressive strength comparable to cortical bone (100-150 MPa). Here we design a novel hexagonal architecture for a glass-ceramic scaffold to fabricate an anisotropic, highly porous th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep19468

    authors： Roohani-Esfahani SI,Newman P,Zreiqat H

    更新日期：2016-01-19 00:00:00

  • The freezing Rènyi quantum discord.

    abstract：:As a universal quantum character of quantum correlation, the freezing phenomenon is researched by geometry and quantum discord methods, respectively. In this paper, the properties of Rènyi discord is studied for two independent Dimer System coupled to two correlated Fermi-spin environments under the non-Markovian cond...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-51206-9

    authors： Li XY,Zhu QS,Zhu MZ,Wu H,Wu SY,Zhu MC

    更新日期：2019-10-14 00:00:00

  • Mechanisms on the morphology variation of hematite crystals by Al substitution: The modification of Fe and O reticular densities.

    abstract：:Al substitution in hematite is ubiquitous in soils. With the increase of Al amount, the hematite morphology changes from rhombohedral crystals to disk-shaped ones, but the underlying mechanism is poorly understood. Herein, a series of Al-substituted hematite were synthesized and characterized by synchrotron X-ray diff...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep35960

    authors： Li W,Liang X,An P,Feng X,Tan W,Qiu G,Yin H,Liu F

    更新日期：2016-10-27 00:00:00

  • A clinical investigation treating different types of fibroids identified by MRI-T2WI imaging with ultrasound guided high intensity focused ultrasound.

    abstract：:Clinical data from 172 cases of uterine fibroids with different appearances on MRI-T2WI and accepted ultrasound guided high intensity focused ultrasound (USgHIFU) treatment were retrospectively analyzed. This study aimed to evaluate the clinical safety and efficacy of ablating different types of fibroids, classified b...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-11486-5

    authors： Zhao WP,Zhang J,Han ZY,Yao JP,Zhou X,Liang P

    更新日期：2017-09-07 00:00:00

  • Skin Carotenoid Index in a large Japanese population sample.

    abstract：:Carotenoids are anti-oxidative agents. Human skin and eyes contain specific carotenoid species known to prevent various pathologies caused by oxidative stress. We quantified skin and eye carotenoid levels and investigated their potential correlation in a population including 985 Japanese patients and staff members of ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45751-6

    authors： Obana A,Gohto Y,Gellermann W,Ermakov IV,Sasano H,Seto T,Bernstein PS

    更新日期：2019-06-27 00:00:00

  • Ideal memcapacitors and meminductors are overunity devices.

    abstract：:It is rigorously proved that ideal memcapacitors and meminductors are not passive or cyclo-passive devices. Equivalently, this implies that there exist excitation profiles that allow to extract more energy from the device than it is supplied with; so that their energy conversion efficiency exceeds 100%. This means tha...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73833-3

    authors： Jeltsema D,van der Schaft A

    更新日期：2020-10-07 00:00:00

  • Association of residual feed intake with growth and slaughtering performance, blood metabolism, and body composition in growing lambs.

    abstract：:The aim of this study was to determine the association of residual feed intake (RFI) with growth performance, blood metabolic parameters, and body composition factors in growing lambs. Individual body weight (BW) and dry matter intake (DMI) were determined in 137 male Hu lambs that were given a pellet feed four times ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-13042-7

    authors： Zhang X,Wang W,Mo F,La Y,Li C,Li F

    更新日期：2017-10-04 00:00:00