Abstract：
:A challenge in regenerating large bone defects under load is to create scaffolds with large and interconnected pores while providing a compressive strength comparable to cortical bone (100-150 MPa). Here we design a novel hexagonal architecture for a glass-ceramic scaffold to fabricate an anisotropic, highly porous three dimensional scaffolds with a compressive strength of 110 MPa. Scaffolds with hexagonal design demonstrated a high fatigue resistance (1,000,000 cycles at 1-10 MPa compressive cyclic load), failure reliability and flexural strength (30 MPa) compared with those for conventional architecture. The obtained strength is 150 times greater than values reported for polymeric and composite scaffolds and 5 times greater than reported values for ceramic and glass scaffolds at similar porosity. These scaffolds open avenues for treatment of load bearing bone defects in orthopaedic, dental and maxillofacial applications.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Roohani-Esfahani SI,Newman P,Zreiqat Hdoi
10.1038/srep19468subject
Has Abstractpub_date
2016-01-19 00:00:00pages
19468issn
2045-2322pii
srep19468journal_volume
6pub_type
杂志文章abstract：:In this paper, we used a facile ball milling, microwave radiation and heating treatment method to achieve the surface modification of TiO2 with low g-C3N4 concentration, and a multilayer heterojunction composite with TiO2 as the main part and g-C3N4 as the modification agent was obtained. The obtained materials were a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42438-w
更新日期：2019-04-11 00:00:00
abstract：:HIV-infected subjects under virological control still exhibit a persistent proinflammatory state. Thus, chronic HIV infection changes the host homeostasis towards an adapted immune response that may affect the outcome of coinfections. However, little is known about the impact of HIV infection on inflammatory amplifica...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43275-7
更新日期：2019-05-08 00:00:00
abstract：:One of the causal genes for holoprosencephaly (HPE) is ZIC2 (HPE5). It belongs to the zinc finger protein of the cerebellum (Zic) family of genes that share a C2H2-type zinc finger domain, similar to the GLI family of genes. In order to clarify the role of Zic2 in gene regulation, we searched for its direct target gen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20242-2
更新日期：2018-02-01 00:00:00
abstract：:Outer membrane vesicles (OMVs) produced by Gram-negative bacteria have roles in cell-to-cell signaling, biofilm formation, and stress responses. Here, the effects of abiotic stressors on OMV contents and composition from biofilm cells of the plant health-promoting bacterium Pseudomonas chlororaphis O6 (PcO6) are exami...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78357-4
更新日期：2020-12-04 00:00:00
abstract：:Biomimetic scales provide a convenient template to tailor the bending stiffness of the underlying slender substrate due to their mutual sliding after engagement. Scale stiffness can therefore directly impact the substrate behavior, opening a potential avenue for substrate stiffness tunability. Here, we have developed ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74147-0
更新日期：2020-10-13 00:00:00
abstract：:Priming improves an organism's performance upon a future stress. To test whether cold priming supports protection in spring and how it is affected by cold acclimation, we compared seven Arabidopsis accessions with different cold acclimation potentials in the field and in the greenhouse for growth, photosynthetic perfo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44055
更新日期：2017-03-09 00:00:00
abstract：:Accurate placement of a coordinate system on the radius is important to quantitatively report 3D surgical planning parameters or joint kinematics using 4D imaging techniques. In clinical practice, the scanned length of the radial shaft varies among scanning protocols and scientific studies. The error in positioning a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65060-7
更新日期：2020-05-15 00:00:00
abstract：:Habitat degradation is among the top drivers of the loss of global biodiversity. This problem is particularly acute in coral reef system. Here we investigated whether coral degradation influences predator risk assessment and learning for damselfish. When in a live coral environment, Ambon damselfish were able to learn...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32542
更新日期：2016-09-09 00:00:00
abstract：:Present study is designed for the synthesis, characterization and corrosion inhibition behavior of two diamine aromatic epoxy pre-polymers (DAEPs) namely, N1,N1,N2,N2-tetrakis (oxiran-2-ylmethyl) benzene-1,2-diamine (DAEP1) and 4-methyl-N1,N1,N2,N2-tetrakis (oxiran-2-ylmethyl) benzene-1,2-diamine (DAEP2) for carbon st...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48284-0
更新日期：2019-08-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19282-5
更新日期：2018-01-19 00:00:00
abstract：:Noise stress is a common environmental pollutant whose adverse effect on offspring performance has been less studied. This study was novel in terms of using "noise" as a prenatal stress compared with physical stress to explore the effect of stress during gestation on HPA axis activation, cognitive performance, and mot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09799-6
更新日期：2017-09-05 00:00:00
abstract：:Successful recruitment of new individuals is essential for recovery of degraded coral reefs. Enhancing supply of coral larvae increases initial settlement, however post-settlement survival can be influenced by density-dependent processes. We investigated the influence of larval density on settlement, colony abundance ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62366-4
更新日期：2020-03-26 00:00:00
abstract：:Cyanobacteria harbor unique photoreceptors, designated as cyanobacteriochromes (CBCRs). In this study, we attempted to engineer the chromatic acclimation sensor CcaS, a CBCR derived from the cyanobacterium Synechocystis sp. PCC 6803. The wild-type CcaS induces gene expression under green light illumination and repress...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37595
更新日期：2016-11-24 00:00:00
abstract：:Although the clinical importance of extragraft bone formation (ExGBF) and bridging (ExGBB) has been reported, few studies have investigated the biomechanical influences of ExGBF on the motion segment. In this study, ExGBF was simulated at the C5-C6 motion segment after anterior cervical discectomy and fusion using a d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54785-9
更新日期：2019-12-11 00:00:00
abstract：:The Farnesoid X receptor (FXR) regulates bile salt, glucose and cholesterol homeostasis by binding to DNA response elements, thereby activating gene expression (direct transactivation). FXR also inhibits the immune response via tethering to NF-κB (tethering transrepression). FXR activation therefore has therapeutic po...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14086
更新日期：2015-09-15 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22193
更新日期：2016-02-26 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18055-w
更新日期：2018-02-19 00:00:00
abstract：:Intensive research has been focused on the synthesis of long-lasting SrAl2O4:EuDy in luminescent materials field. Traditionally, SrAl2O4:EuDy is synthesized in bulk form by solid state. However, their development remains restrained due to this technique is not compatible with large-scale production, sustainability and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00541-w
更新日期：2017-03-28 00:00:00
abstract：:Pulsed electromagnetic fields (PEMFs) have been considered a potential treatment modality for fracture healing, however, the mechanism of their action remains unclear. Mammalian target of rapamycin (mTOR) signaling may affect osteoblast proliferation and differentiation. This study aimed to assess the osteogenic diffe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23499-9
更新日期：2018-03-23 00:00:00
abstract：:The synthesis of highly biocompatible polymers is important for modern biotechnologies and medicine. Here, we report a unique process based on a two-step high-pressure ramp (HPR) for the ultrafast and efficient bulk polymerization of 2-(hydroxyethyl)methacrylate (HEMA) at room temperature without photo- and thermal ac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18244
更新日期：2015-12-16 00:00:00
abstract：:Laser radiation pressure is a basis of numerous applications in science and technology such as atom cooling, particle manipulation, material processing, etc. This light force for the case of scalar beams is proportional to the intensity-weighted wavevector known as optical current. The ability to design the optical cu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35341
更新日期：2016-10-13 00:00:00
abstract：:Application of alginate-microencapsulated therapeutic cells is a promising approach for diseases that require a local and constant supply of therapeutic molecules. However most conventional alginate microencapsulation systems are associated with low mechanical stability and protrusion of cells which is associated with...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06856
更新日期：2014-10-31 00:00:00
abstract：:Herbs may contain pesticide residues which are an important discriminator of food security and food quality. The challenge of the research was to assess the fate of the herbicide clethodim (CLE) and the insecticide spirotetramat (SPI) applied in herbs (BBCH 11-21) during herb growth and processing under controlled gre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58130-3
更新日期：2020-01-28 00:00:00
abstract：:In a globalized world, plant invasions are common challenges for native ecosystems. Although a considerable number of invasive plants form arbuscular mycorrhizae, interactions between arbuscular mycorrhizal (AM) fungi and invasive and native plants are not well understood. In this study, we conducted a greenhouse expe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77030-0
更新日期：2020-11-20 00:00:00
abstract：:The artificial earthquake of mb 6.1 related to the North Korea's sixth nuclear test occured at Mt. Mantap, North Korea on September 3, 2017. It was reported that a large and complex surface deformation was caused by the event. The surface deformation was composed of expansion of explosions, collapse, compaction and la...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74957-2
更新日期：2020-10-20 00:00:00
abstract：:Herbal medicines usually contain a large group of chemical components, which may be transformed into more complex metabolites in vivo. In this study, we proposed a knowledge-transmitting strategy for metabolites identification of compound formulas. Gegen-Qinlian Decoction (GQD) is a classical formula in traditional Ch...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39534
更新日期：2016-12-20 00:00:00
abstract：:Twenty-six imprinted genes were quantified in bovine in vivo produced oocytes and embryos using RNA-seq. Eighteen were detectable and their transcriptional patterns were: largely decreased (MEST and PLAGL1); first decreased and then increased (CDKN1C and IGF2R); peaked at a specific stage (PHLDA2, SGCE, PEG10, PEG3, G...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17898
更新日期：2015-12-07 00:00:00
abstract：:Two-dimensional nanostructures with controllable magnetic and electronic properties are desirable for their versatile applications in quantum devices. Here, we present a first-principles design on their magnetic and electronic switching controlled by tension. We find that hydrogenated VTe2 monolayer experiences a tran...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07524
更新日期：2014-12-17 00:00:00
abstract：:Geographical origin determination of white rice has become the major issue of food industry. However, there is still lack of a high-throughput method for rapidly and reproducibly differentiating the geographical origins of commercial white rice. In this study, we developed a method that employed lipidomics and deep le...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08892-0
更新日期：2017-08-17 00:00:00
abstract：:We consider synchronization properties of arrays of spin-torque nano-oscillators coupled via an RC load. We show that while the fully synchronized state of identical oscillators may be locally stable in some parameter range, this synchrony is not globally attracting. Instead, regimes of different levels of composition...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04918-9
更新日期：2017-07-05 00:00:00
