A New Route for High-Purity Organic Materials: High-Pressure-Ramp-Induced Ultrafast Polymerization of 2-(Hydroxyethyl)Methacrylate.

Abstract:

:The synthesis of highly biocompatible polymers is important for modern biotechnologies and medicine. Here, we report a unique process based on a two-step high-pressure ramp (HPR) for the ultrafast and efficient bulk polymerization of 2-(hydroxyethyl)methacrylate (HEMA) at room temperature without photo- and thermal activation or addition of initiator. The HEMA monomers are first activated during the compression step but their reactivity is hindered by the dense glass-like environment. The rapid polymerization occurs in only the second step upon decompression to the liquid state. The conversion yield was found to exceed 90% in the recovered samples. The gel permeation chromatography evidences the overriding role of HEMA2(••) biradicals in the polymerization mechanism. The HPR process extends the application field of HP-induced polymerization, beyond the family of crystallized monomers considered up today. It is also an appealing alternative to typical photo- or thermal activation, allowing the efficient synthesis of highly pure organic materials.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Evlyukhin E,Museur L,Traore M,Perruchot C,Zerr A,Kanaev A

doi

10.1038/srep18244

subject

Has Abstract

pub_date

2015-12-16 00:00:00

pages

18244

issn

2045-2322

pii

srep18244

journal_volume

5

pub_type

杂志文章
  • Antigenic cross-reactivity between Schistosoma mansoni and allergenic invertebrates putatively due to shared glycanic epitopes.

    abstract::Previous studies have shown that rabbit IgG antibodies against Schistosoma mansoni egg antigens (SmSEA) cross-react with allergens in natural rubber latex, peanuts and grass and tree pollens. Here we describe antigenic molecules that cross-react with rabbit anti-S. mansoni IgG antibodies in extracts of the house dust ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-59892-6

    authors: El-Faham MH,Gai F,Igetei JE,Richter S,Falcone FH,Schramm G,Doenhoff MJ

    更新日期:2020-02-25 00:00:00

  • Evaluation of Radiation dosimetry of 99mTc-HYNIC-PSMA and imaging in prostate cancer.

    abstract::This study aims to evaluate the radiation dosimetry of a new technetium-99m‒labelled small-molecule inhibitor of prostate-specific membrane antigen (HYNIC-Glu-Urea-A, 99mTc-HYNIC-PSMA) and its feasibility as a tumor-imaging agent in prostate cancer (PCa) patients. A total of 15 PCa patients were enrolled in this study...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-61129-5

    authors: Zhang J,Zhang J,Xu X,Lu L,Hu S,Liu C,Cheng J,Song S,Zhang Y,Shi LQ

    更新日期:2020-03-06 00:00:00

  • Unique IL-13Rα2/STAT3 mediated IL-13 regulation detected in lung conventional dendritic cells, 24 h post viral vector vaccination.

    abstract::This study demonstrates that 24 h following viral vector-based vaccination IL-13Rα2 functions as a master sensor on conventional dendritic cells (cDCs), abetted by high protein stability coupled with minimal mRNA expression, to rapidly regulate DC mediated IL-13 responses at the lung mucosae, unlike IL-13Rα1. Under lo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-57815-z

    authors: Roy S,Liu HY,Jaeson MI,Deimel LP,Ranasinghe C

    更新日期:2020-01-23 00:00:00

  • Habitat fragmentation is associated to gut microbiota diversity of an endangered primate: implications for conservation.

    abstract::The expansion of agriculture is shrinking pristine forest areas worldwide, jeopardizing the persistence of their wild inhabitants. The Udzungwa red colobus monkey (Procolobus gordonorum) is among the most threatened primate species in Africa. Primarily arboreal and highly sensitive to hunting and habitat destruction, ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep14862

    authors: Barelli C,Albanese D,Donati C,Pindo M,Dallago C,Rovero F,Cavalieri D,Tuohy KM,Hauffe HC,De Filippo C

    更新日期:2015-10-07 00:00:00

  • Magma injection beneath the urban area of Naples: a new mechanism for the 2012-2013 volcanic unrest at Campi Flegrei caldera.

    abstract::We found the first evidence, in the last 30 years, of a renewed magmatic activity at Campi Flegrei caldera from January 2012 to June 2013. The ground deformation, observed through satellite interferometry and GPS measurements, have been interpreted as the effect of the intrusion at shallow depth (3090 ± 138 m) of 0.00...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep13100

    authors: D'Auria L,Pepe S,Castaldo R,Giudicepietro F,Macedonio G,Ricciolino P,Tizzani P,Casu F,Lanari R,Manzo M,Martini M,Sansosti E,Zinno I

    更新日期:2015-08-17 00:00:00

  • Ethanol extract of Lophatheri Herba exhibits anti-cancer activity in human cancer cells by suppression of metastatic and angiogenic potential.

    abstract::Lophatheri Herba (LH), dried leaf of Lophatherum gracile Brongn, has long been used to reduce thirst and treat fever and inflammation in Chinese medicine. Recent studies have shown that LH has anti-viral, anti-bacterial, anti-cancer, anti-oxidant, diuretic, and hyperglycemic properties. However, the effects of an etha...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep36277

    authors: Kim A,Im M,Gu MJ,Ma JY

    更新日期:2016-11-03 00:00:00

  • Nutrient stoichiometry in winter wheat: Element concentration pattern reflects developmental stage and weather.

    abstract::At least 16 nutrient elements are required by plants for growth and survival, but the factors affecting element concentration and their temporal evolution are poorly understood. The objective was to investigate i) element concentration pattern in winter wheat as affected by crop developmental stage and weather, and ii...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep35958

    authors: Weih M,Pourazari F,Vico G

    更新日期:2016-10-24 00:00:00

  • Magnetic Properties Improvement of Die-upset Nd-Fe-B Magnets by Dy-Cu Press Injection and Subsequent Heat Treatment.

    abstract::Ultrafine-grained die-upset Nd-Fe-B magnets are of importance because they provide a wide researching space to redesign the textured structures. Here is presented a route to obtain a new die-upset magnet with substantially improved magnetic properties. After experiencing the optimized heat treatment, both the coercivi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep38335

    authors: Wang Z,Ju J,Wang J,Yin W,Chen R,Li M,Jin C,Tang X,Lee D,Yan A

    更新日期:2016-12-06 00:00:00

  • miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer.

    abstract::Elevated prostaglandin E2 (PGE2) levels are observed in colorectal cancer (CRC) patients, and this increase is associated with poor prognosis. Increased synthesis of PGE2 in CRC has been shown to occur through COX-2-dependent mechanisms; however, loss of the PGE2-catabolizing enzyme, 15-hydroxyprostaglandin dehydrogen...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-41862-2

    authors: Monteleone NJ,Moore AE,Iacona JR,Lutz CS,Dixon DA

    更新日期:2019-04-01 00:00:00

  • Deposition of calcium in an in vitro model of human breast tumour calcification reveals functional role for ALP activity, altered expression of osteogenic genes and dysregulation of the TRPM7 ion channel.

    abstract::Microcalcifications are vital mammographic indicators contributing to the early detection of up to 50% of non-palpable tumours and may also be valuable as prognostic markers. However, the precise mechanism by which they form remains incompletely understood. Following development of an in vitro model using human breast...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-36496-9

    authors: O'Grady S,Morgan MP

    更新日期:2019-01-24 00:00:00

  • A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK.

    abstract::Mycobacterium tuberculosis, the etiological agent of the infectious disease tuberculosis, kills approximately 1.5 million people annually, while the spread of multidrug-resistant strains is of great global concern. Thus, continuous efforts to identify new antitubercular drugs as well as novel targets are crucial. Rece...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-21614-4

    authors: Chiarelli LR,Mori G,Orena BS,Esposito M,Lane T,de Jesus Lopes Ribeiro AL,Degiacomi G,Zemanová J,Szádocka S,Huszár S,Palčeková Z,Manfredi M,Gosetti F,Lelièvre J,Ballell L,Kazakova E,Makarov V,Marengo E,Mikusova K,Col

    更新日期:2018-02-16 00:00:00

  • Horizontally-acquired genetic elements in the mitochondrial genome of a centrohelid Marophrys sp. SRT127.

    abstract::Mitochondrial genomes exhibit diverse features among eukaryotes in the aspect of gene content, genome structure, and the mobile genetic elements such as introns and plasmids. Although the number of published mitochondrial genomes is increasing at tremendous speed, those of several lineages remain unexplored. Here, we ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-41238-6

    authors: Nishimura Y,Shiratori T,Ishida KI,Hashimoto T,Ohkuma M,Inagaki Y

    更新日期:2019-03-19 00:00:00

  • Associating cryptogenic ischemic stroke in the young with cardiovascular risk factor phenotypes.

    abstract::Acute Ischemic Stroke (AIS) in the young is increasing in prevalence and the largest subtype within this cohort is cryptogenic. To curb this trend, new ways of defining cryptogenic stroke and associated risk factors are needed. We aimed to gain insights into the presence or absence of cardiovascular risk factors in ca...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-79499-1

    authors: Dardick JM,Flomenbaum D,Labovitz DL,Cheng N,Liberman AL,Esenwa C

    更新日期:2021-01-11 00:00:00

  • Long-latency interhemispheric interactions between motor-related areas and the primary motor cortex: a dual site TMS study.

    abstract::The primary motor cortex (M1) is highly influenced by premotor/motor areas both within and across hemispheres. Dual site transcranial magnetic stimulation (dsTMS) has revealed interhemispheric interactions mainly at early latencies. Here, we used dsTMS to systematically investigate long-latency causal interactions bet...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13708-2

    authors: Fiori F,Chiappini E,Candidi M,Romei V,Borgomaneri S,Avenanti A

    更新日期:2017-11-02 00:00:00

  • Giant exchange interaction in mixed lanthanides.

    abstract::Combining strong magnetic anisotropy with strong exchange interaction is a long standing goal in the design of quantum magnets. The lanthanide complexes, while exhibiting a very strong ionic anisotropy, usually display a weak exchange coupling, amounting to only a few wavenumbers. Recently, an isostructural series of ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep24046

    authors: Vieru V,Iwahara N,Ungur L,Chibotaru LF

    更新日期:2016-04-18 00:00:00

  • Chronic Rhinosinusitis Associated with Erectile Dysfunction: A Population-Based Study.

    abstract::Few studies have investigated the relationship between chronic rhinosinusitis (CRS) and erectile dysfunction (ED). This case-control study aimed to investigate the association between CRS and the risk of ED in a large national sample. Tapping Taiwan's National Health Insurance Research Database, we identified people 3...

    journal_title:Scientific reports

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/srep32195

    authors: Tai SY,Wang LF,Tai CF,Huang YT,Chien CY

    更新日期:2016-08-31 00:00:00

  • In vitro Studies on The Inhibition of Replication of Zika and Chikungunya Viruses by Dolastane Isolated from Seaweed Canistrocarpus cervicornis.

    abstract::The lack of vaccines and antiviral treatment, along with the increasing number of cases of Zika virus (ZIKV) and Chikungunya virus (CHIKV) infections, emphasize the need for searching for new therapeutic strategies. In this context, the marine brown seaweed Canistrocarpus cervicornis has been proved to hold great anti...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65357-7

    authors: Cirne-Santos CC,de Souza Barros C,de Oliveira MC,Rabelo VW,Azevedo RC,Teixeira VL,Ferreira DF,de Palmer Paixão ICN

    更新日期:2020-05-19 00:00:00

  • Erratum: Boolean Models of Biological Processes Explain Cascade-Like Behavior.

    abstract::This corrects the article DOI: 10.1038/srep20067. ...

    journal_title:Scientific reports

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/srep46387

    authors: Chen H,Wang G,Simha R,Du C,Zeng C

    更新日期:2017-06-30 00:00:00

  • Risk of stroke in patients with rheumatism: a nationwide longitudinal population-based study.

    abstract::The aim of this study was to investigate rheumatoid arthritis (RA), and systemic lupus erythematous (SLE) as risk factors for stroke. The study was analyzed by Using the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005), this cohort study investigated patients with a recorded diagnosis of RA (N = 6114), an...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep05110

    authors: Liou TH,Huang SW,Lin JW,Chang YS,Wu CW,Lin HW

    更新日期:2014-06-05 00:00:00

  • Correlation analysis of sagittal alignment and skeletal muscle mass in patients with spinal degenerative disease.

    abstract::We investigated how skeletal muscle mass (SMM) affects spinal sagittal balance (radiographic parameters) in symptomatic spinal patients. The first purpose of this study was to evaluate the body composition and the spinal sagittal alignment in symptomatic spinal patients. The second purpose of this study was to compare...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-33867-0

    authors: Hiyama A,Katoh H,Sakai D,Sato M,Tanaka M,Nukaga T,Watanabe M

    更新日期:2018-10-19 00:00:00

  • Upregulation of the chromatin remodeler HELLS is mediated by YAP1 in Sonic Hedgehog Medulloblastoma.

    abstract::Medulloblastoma is a malignant pediatric tumor that arises from neural progenitors in the cerebellum. Despite a five-year survival rate of ~70%, nearly all patients incur adverse side effects from current treatment strategies that drastically impact quality of life. Roughly one-third of medulloblastoma are driven by a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50088-1

    authors: Robinson MH,Maximov V,Lallani S,Farooq H,Taylor MD,Read RD,Kenney AM

    更新日期:2019-09-20 00:00:00

  • High-resolution dynamic inversion imaging with motion-aberrations-free using optical flow learning networks.

    abstract::Dynamic optical imaging (e.g. time delay integration imaging) is troubled by the motion blur fundamentally arising from mismatching between photo-induced charge transfer and optical image movements. Motion aberrations from the forward dynamic imaging link impede the acquiring of high-quality images. Here, we propose a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47564-z

    authors: Li J,Liu Z

    更新日期:2019-08-05 00:00:00

  • Mitochondrial toxicity and body shape changes during nucleos(t)ide analogues administration in patients with chronic hepatitis B.

    abstract::Our study purpose was to evaluate mitochondrial (mt)DNA and RNA in peripheral blood mononuclear cells (PBMCs) and body shape changes (BSC) in HBV-infected patients. mtDNA and mtRNA were measured in PBMCs. The presence of BSC was evaluated through a questionnaire and clinical evaluation. A total of 157 subjects were en...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章

    doi:10.1038/s41598-020-58837-3

    authors: Madeddu G,Fiore V,Melis M,Ortu S,Mannu F,Muredda AA,Garrucciu G,Bandiera F,Zaru S,Bagella P,Calvisi DF,Babudieri S

    更新日期:2020-02-06 00:00:00

  • Rigid soles improve balance in beam walking, but improvements do not persist with bare feet.

    abstract::Maintaining balance while walking on a narrow beam is a challenging motor task. One important factor is that the foot's ability to exert torque on the support surface is limited by the beam width. Still, the feet serve as a critical interface between the body and the external environment, and it is unclear how the mec...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-64035-y

    authors: Huber ME,Chiovetto E,Giese M,Sternad D

    更新日期:2020-05-06 00:00:00

  • Map3k8 controls granulocyte colony-stimulating factor production and neutrophil precursor proliferation in lipopolysaccharide-induced emergency granulopoiesis.

    abstract::Map3k8 has been proposed as a useful target for the treatment of inflammatory diseases. We show here that during lipopolysaccharide-induced emergency granulopoiesis, Map3k8 deficiency strongly impairs the increase in circulating mature (Ly6GhighCD11b+) and immature (Ly6GlowCD11b+) neutrophils. After chimaeric bone mar...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-04538-3

    authors: Sánchez Á,Relaño C,Carrasco A,Contreras-Jurado C,Martín-Duce A,Aranda A,Alemany S

    更新日期:2017-07-10 00:00:00

  • Addition of a histone deacetylase inhibitor increases recombinant protein expression in Medicago truncatula cell cultures.

    abstract::Plant cell cultures are an attractive platform for the production of recombinant proteins. A major drawback, hindering the establishment of plant cell suspensions as an industrial platform, is the low product yield obtained thus far. Histone acetylation is associated with increased transcription levels, therefore it i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17006-9

    authors: Santos RB,Pires AS,Abranches R

    更新日期:2017-12-01 00:00:00

  • Sofosbuvir protects Zika virus-infected mice from mortality, preventing short- and long-term sequelae.

    abstract::Zika virus (ZIKV) causes significant public health concerns because of its association with congenital malformations, neurological disorders in adults, and, more recently, death. Considering the necessity to mitigate ZIKV-associated diseases, antiviral interventions are an urgent necessity. Sofosbuvir, a drug in clini...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-09797-8

    authors: Ferreira AC,Zaverucha-do-Valle C,Reis PA,Barbosa-Lima G,Vieira YR,Mattos M,Silva PP,Sacramento C,de Castro Faria Neto HC,Campanati L,Tanuri A,Brüning K,Bozza FA,Bozza PT,Souza TML

    更新日期:2017-08-25 00:00:00

  • Molecular Analysis of BRCA1 in Human Breast Cancer Cells Under Oxidative Stress.

    abstract::The precise manner in which physical changes to the breast cancer susceptibility protein (BRCA1) affect its role in DNA repair events remain unclear. Indeed, cancer cells harboring mutations in BRCA1 suffer from genomic instability and increased DNA lesions. Here, we used a combination of molecular imaging and biochem...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep43435

    authors: Gilmore BL,Liang Y,Winton CE,Patel K,Karageorge V,Varano AC,Dearnaley W,Sheng Z,Kelly DF

    更新日期:2017-03-06 00:00:00

  • Cortical Classification with Rhythm Entropy for Error Processing in Cocktail Party Environment Based on Scalp EEG Recording.

    abstract::Using single-trial cortical signals calculated by weighted minimum norm solution estimation (WMNE), the present study explored a feature extraction method based on rhythm entropy to classify the scalp electroencephalography (EEG) signals of error response from that of correct response during performing auditory-track ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-24535-4

    authors: Tian Y,Xu W,Yang L

    更新日期:2018-04-17 00:00:00

  • Effects of a microbial restoration substrate on plant growth and rhizosphere bacterial community in a continuous tomato cropping greenhouse.

    abstract::Continuous cropping of tomato is increasingly practiced in greenhouse cultivation, leading to several soil-related obstacles. In this study, a type of microbial restoration substrate (MRS) was used to amend soils from the re-cropping of tomato for 8 years under greenhouse-cultivated conditions. Two treatments were est...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70737-0

    authors: Zheng X,Wang Z,Zhu Y,Wang J,Liu B

    更新日期:2020-08-13 00:00:00