Molecular Analysis of BRCA1 in Human Breast Cancer Cells Under Oxidative Stress.

abstract：:The aim of the study was to determine damage severity of wood-destroying insects on logs stored in forest depots. The Bevan damage classification (BDC) system, developed in 1987, was utilized to determine damage severity in log depots in 21 locations throughout seven provinces in Turkey. Pheromone traps were placed in...

journal_title：Scientific reports

authors： Yalcin M,Akcay C,Tascioglu C,Yuksel B,Ozbayram AK

更新日期：2020-08-13 00:00:00

abstract：:Histamine is an important neurotransmitter that contributes to various processes, including the sleep-wake cycle, learning, memory, and stress responses. Its actions are mediated through histamine H1-H4 receptors. Gene knockout and pharmacological studies have revealed the importance of H1 receptors in learning and me...

journal_title：Scientific reports

authors： Kárpáti A,Yoshikawa T,Naganuma F,Matsuzawa T,Kitano H,Yamada Y,Yokoyama M,Futatsugi A,Mikoshiba K,Yanai K

更新日期：2019-11-11 00:00:00

abstract：:We study the spreading of cell aggregates deposited on adhesive substrates decorated with microparticles (MPs). A cell monolayer expands around the aggregate. The cells on the periphery of the monolayer take up the MPs, clearing the substrate as they progress and forming an aureole of cells filled with MPs. We study t...

journal_title：Scientific reports

authors： Beaune G,Lam AYW,Dufour S,Winnik FM,Brochard-Wyart F

更新日期：2017-11-16 00:00:00

abstract：:Human learners can generalize a new concept from a small number of samples. In contrast, conventional machine learning methods require large amounts of data to address the same types of problems. Humans have cognitive biases that promote fast learning. Here, we developed a method to reduce the gap between human beings...

journal_title：Scientific reports

authors： Taniguchi H,Sato H,Shirakawa T

更新日期：2018-05-09 00:00:00

abstract：:Upper mantle viscosity plays a key role in understanding plate tectonics and is usually extrapolated from laboratory-based creep measurements of upper mantle conditions or constrained by modeling geodetic and post-seismic observations. At present, an effective method to obtain a high-resolution viscosity structure is ...

journal_title：Scientific reports

authors： Xu Y,Zhang A,Yang B,Bao X,Wang Q,Xia J,Yang W

更新日期：2018-01-29 00:00:00

abstract：:Recent studies have indicated that different post-translational modifications (PTMs) synergistically orchestrate specific biological processes by crosstalks. However, the preference of the crosstalk among different PTMs and the evolutionary constraint on the PTM crosstalk need further dissections. In this study, the i...

journal_title：Scientific reports

authors： Pan Z,Liu Z,Cheng H,Wang Y,Gao T,Ullah S,Ren J,Xue Y

更新日期：2014-12-05 00:00:00

abstract：:Indoleamine 2,3 dioxygenase-1 (IDO-1) is an enzyme in the kynurenine pathway which augments tumor-induced immune tolerance. Previous studies in childhood acute myeloid leukemia (AML) have shown a negative correlation of IDO-1 mRNA expression with outcomes. The aim of our study was to develop a practical and objective ...

journal_title：Scientific reports

authors： Mangaonkar A,Mondal AK,Fulzule S,Pundkar C,Park EJ,Jillella A,Kota V,Xu H,Savage NM,Shi H,Munn D,Kolhe R

更新日期：2017-10-16 00:00:00

abstract：:Classical swine fever (CSF) is a notifiable, highly contagious viral disease of swine which results in severe welfare and economic consequences in affected countries. To improve preparedness, it is critical to have some understanding of how CSF would spread should it be introduced. Based on the data recorded during th...

journal_title：Scientific reports

authors： Porphyre T,Correia-Gomes C,Chase-Topping ME,Gamado K,Auty HK,Hutchinson I,Reeves A,Gunn GJ,Woolhouse ME

更新日期：2017-02-22 00:00:00

abstract：:It is well known that the Gobi Desert is the dominant source area of the Badain Jaran Desert (BJD) and the Chinese Loess Plateau (CLP). However, due to the absence of quantitative analyses, there are nearly no exact assessments of its actual contribution. Combinations of field investigations, wind tunnel experiments, ...

journal_title：Scientific reports

authors： Wang X,Cai D,Sun J,Lu H,Liu W,Qiang M,Cheng H,Che H,Hua T,Zhang C

更新日期：2019-01-30 00:00:00

abstract：:Plants experience a highly variable light environment over the course of the day. To reveal the molecular mechanisms of their photosynthetic response to fluctuating light, we examined the role of two cyclic electron flows around photosystem I (CEF-PSI)--one depending on PROTON GRADIENT REGULATION 5 (PGR5) and one on N...

journal_title：Scientific reports

authors： Yamori W,Makino A,Shikanai T

更新日期：2016-02-02 00:00:00

abstract：:Whereas epidemiologic studies consistently identify different rates and types of problematic behavior in boys and girls, there has been little research examining the ecocultural context in which these gender differences in child behavior problems develop, especially in non-Western settings. This qualitative study in r...

journal_title：Scientific reports

authors： Langer JA,Ramos JV,Ghimire L,Rai S,Kohrt BA,Burkey MD

更新日期：2019-05-21 00:00:00

abstract：:Misfolding of translated proteins occurs in all domains of life. In most cells, misfolded proteins coalesce in discrete aggregates at distinct cellular locations. In many bacteria, including mycobacteria, protein aggregates are located at the cellular pole. Yet the mechanism by which aggregates are sorted to the mycob...

journal_title：Scientific reports

authors： Zhang YW,Zhu JH,Wang ZQ,Wu Y,Meng X,Zheng X,Javid B

更新日期：2019-10-10 00:00:00

abstract：:Identifying the occurrence mechanism of drug-induced side effects (SEs) is critical for design of drug target and new drug development. The expression of genes in biological processes is regulated by transcription factors(TFs) and/or microRNAs. Most of previous studies were focused on a single level of gene or gene se...

journal_title：Scientific reports

authors： Jia X,Jin Q,Liu X,Bian X,Wang Y,Liu L,Ma H,Tan F,Gu M,Chen X

更新日期：2017-07-20 00:00:00

abstract：:ADP-ribosyltransferases (ARTs) modify proteins with single units or polymers of ADP-ribose to regulate DNA repair. However, the substrates for these enzymes are ill-defined. For example, although histones are modified by ARTs, the sites on these proteins ADP-ribosylated following DNA damage and the ARTs that catalyse ...

journal_title：Scientific reports

authors： Rakhimova A,Ura S,Hsu DW,Wang HY,Pears CJ,Lakin ND

更新日期：2017-03-02 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Markowitz J,Wang J,Vangundy Z,You J,Yildiz V,Yu L,Foote IP,Branson OE,Stiff AR,Brooks TR,Biesiadecki B,Olencki T,Tridandapani S,Freitas MA,Papenfuss T,Phelps MA,Carson WE

更新日期：2018-03-06 00:00:00

abstract：:Editor's Note: this Article has been retracted; the Retraction Note is available at https://www.nature.com/articles/s41598-020-76500-9. ...

journal_title：Scientific reports

authors： Sudhakar YA,Verma RK,Pawar SC

更新日期：2020-11-26 00:00:00

abstract：:Orofacial pain impairs a patient's speech, swallowing, eating and interpersonal relations. Thirty-seven patients with a premalignant oral lesion, 124 patients with oral squamous cell carcinoma (OSSC), and 21 patients with a recurrence of OSSC were evaluated for their orofacial pain. The University of California San Fr...

journal_title：Scientific reports

authors： Yang Y,Zhang P,Li W

更新日期：2017-03-16 00:00:00

abstract：:Cancer stem cells play an important role on tumor progression. Biomarkers of stem cell property and their relationship to extranodal involvement of malignant lymphocytes are undefined in diffuse large B-cell lymphoma (DLBCL). Here we showed that junctional adhesion molecule-A (JAM-A) was highly expressed in DLBCL pati...

journal_title：Scientific reports

authors： Xu PP,Sun YF,Fang Y,Song Q,Yan ZX,Chen Y,Jiang XF,Fei XC,Zhao Y,Leboeuf C,Li B,Wang CF,Janin A,Wang L,Zhao WL

更新日期：2017-08-07 00:00:00

abstract：:Biomodels made of poly(vinyl alcohol) (PVA) are demanded because they can represent the geometries and mechanical properties of human tissues realistically. Injecting and molding, commonly used in three-dimensional (3D) modeling, help to represent the blood vessels accurately. However, these techniques sometimes requi...

journal_title：Scientific reports

authors： Shimizu Y,Tanabe T,Yoshida H,Kasuya M,Matsunaga T,Haga Y,Kurihara K,Ohta M

更新日期：2018-11-08 00:00:00

abstract：:Species abundance distributions (SAD) are central to the description of diversity and have played a major role in the development of theories of biodiversity and biogeography. However, most work on species abundance distributions has focused on one single spatial scale. Here we used data on arthropods to test predicti...

journal_title：Scientific reports

authors： Borda-de-Água L,Whittaker RJ,Cardoso P,Rigal F,Santos AMC,Amorim IR,Parmakelis A,Triantis KA,Pereira HM,Borges PAV

更新日期：2017-06-20 00:00:00

abstract：:The jerantinine family of Aspidosperma indole alkaloids from Tabernaemontana corymbosa are potent microtubule-targeting agents with broad spectrum anticancer activity. The natural supply of these precious metabolites has been significantly disrupted due to the inclusion of T. corymbosa on the endangered list of threat...

journal_title：Scientific reports

authors： Smedley CJ,Stanley PA,Qazzaz ME,Prota AE,Olieric N,Collins H,Eastman H,Barrow AS,Lim KH,Kam TS,Smith BJ,Duivenvoorden HM,Parker BS,Bradshaw TD,Steinmetz MO,Moses JE

更新日期：2018-07-13 00:00:00

abstract：:Intestinal-type sinonasal adenocarcinoma (ITAC) is a rare tumor carrying poor prognosis and needing new treatment options. The aim of this study was to identify actionable gene mutations that can guide new personalized target-specific therapies in ITAC patients. A series of 48 tumor and 27 corresponding germline DNA s...

journal_title：Scientific reports

authors： Sánchez-Fernández P,Riobello C,Costales M,Vivanco B,Cabal VN,García-Marín R,Suárez-Fernández L,López F,Cabanillas R,Hermsen MA,Llorente JL

更新日期：2021-01-26 00:00:00

abstract：:Viral oncoproteins E6/E7 play key oncogenic role in human papillomavirus (HPV)-mediated cervical carcinogenesis in conjunction with aberrant activation of cellular signaling events. GLI-signaling has been implicated in metastasis and tumor recurrence of cervical cancer. However, the interaction of GLI-signaling with H...

journal_title：Scientific reports

authors： Vishnoi K,Mahata S,Tyagi A,Pandey A,Verma G,Jadli M,Singh T,Singh SM,Bharti AC

更新日期：2016-09-28 00:00:00

abstract：:Cas13 endonuclease activity depends on the RNA local secondary structure with strong preference for single-stranded (SS) regions. Hence, it becomes indispensable to identify the SS regions for effective Cas13 mediated RNA knockdown. We herein present rational gRNA design by integrating experimental structure-seq data ...

journal_title：Scientific reports

authors： Bandaru S,Tsuji MH,Shimizu Y,Usami K,Lee S,Takei NK,Yoshitome K,Nishimura Y,Otsuki T,Ito T

更新日期：2020-07-14 00:00:00

abstract：:Glial cells actively maintain the homeostasis of brain parenchyma, regulating neuronal excitability and preserving the physiological composition of the extracellular milieu. Under pathological conditions, some functions of glial cells could be compromised, exacerbating the neurotoxic processes. We investigated if the ...

journal_title：Scientific reports

authors： Grimaldi A,D'Alessandro G,Di Castro MA,Lauro C,Singh V,Pagani F,Sforna L,Grassi F,Di Angelantonio S,Catacuzzeno L,Wulff H,Limatola C,Catalano M

更新日期：2018-05-16 00:00:00

abstract：:Mucositis is the limiting toxicity of radio(chemo)therapy of head and neck cancer. Diagnostics, prophylaxis and correction of this condition demand new accurate and objective approaches. Here we report on an in vivo longitudinal monitoring of the oral mucosa dynamics in 25 patients during the course of radiotherapy of...

journal_title：Scientific reports

authors： Maslennikova AV,Sirotkina MA,Moiseev AA,Finagina ES,Ksenofontov SY,Gelikonov GV,Matveev LA,Kiseleva EB,Zaitsev VY,Zagaynova EV,Feldchtein FI,Gladkova ND,Vitkin A

更新日期：2017-11-28 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Tätte K,Pagani L,Pathak AK,Kõks S,Ho Duy B,Ho XD,Sultana GNN,Sharif MI,Asaduzzaman M,Behar DM,Hadid Y,Villems R,Chaubey G,Kivisild T,Metspalu M

更新日期：2019-04-10 00:00:00

abstract：:This study investigates physicochemical impact of ultrasonic irradiations on surface topography of woven fabrics. In a simultaneous in-situ sonochemical method, the synthesis and coating of zinc oxide nanoparticles (ZnO NPs) on woven textiles were successfully achieved. Different instruments i.e. Alambeta, moisture ma...

journal_title：Scientific reports

authors： Noman MT,Petru M,Amor N,Louda P

更新日期：2020-12-03 00:00:00

abstract：:2-hydroxy-1,4 naphthoquinone (lawsone) is widely used and induces environmental pollutions during its production and application. In the present study, a lawsone-degrading bacterium strain, LH-3 was successfully isolated from the activated sludge. Based on the 16S rRNA gene analysis, the strain LH-3 phylogenetically b...

journal_title：Scientific reports

authors： Yang L,Cai T,Ding D,Cai T,Jiang C,Li H,Yang Q,Chen L

更新日期：2017-07-28 00:00:00

abstract：:CD4+Foxp3+ regulatory T cells (Tregs) are the main immune suppressors with subpopulation of inflamed-tissue related memory Tregs (mTregs) and non-related resting Treg (rTregs). Previously, Treg was proposed to be the cause of chronicity of hepatitis B virus (HBV) infection but with controversies. We then investigated ...

journal_title：Scientific reports

authors： Hu CC,Jeng WJ,Chen YC,Fang JH,Huang CH,Teng W,Hsieh YC,Lin YC,Chien RN,Sheen IS,Lin CY

更新日期：2017-11-10 00:00:00