Mitochondrial toxicity and body shape changes during nucleos(t)ide analogues administration in patients with chronic hepatitis B.

abstract：:Increasing life expectancy and a growing share of older people around the world spotlight the issue of health during additional years of life. Research on trends of proportions of older people with activity limitations for low and middle income countries is sparse. We use data from the World Health Survey and the UN W...

journal_title：Scientific reports

authors： Weber D,Scherbov S

更新日期：2020-06-26 00:00:00

abstract：:Numerous neurological dysfunctions are characterized by undesirable nerve activity. By providing reversible nerve blockage, electric stimulation with an implanted electrode holds promise in the treatment of these conditions. However, there are several limitations to its application, including poor bio-compatibility an...

journal_title：Scientific reports

authors： Skach J,Conway C,Barrett L,Ye H

更新日期：2020-10-22 00:00:00

abstract：:High-voltage electrical defibrillation remains the only reliable method of quickly controlling life-threatening cardiac arrhythmias. This paper is devoted to studying an alternative approach, low-voltage cardioversion (LVC), which is based on ideas from non-linear dynamics and aims to remove sources of cardiac arrhyth...

journal_title：Scientific reports

authors： Pravdin SF,Epanchintsev TI,Panfilov AV

更新日期：2020-11-26 00:00:00

abstract：:Obesity involves alterations in transcriptional programs that can change in response to genetic and environmental signals through chromatin modifications. Since chromatin modifications involve different biochemical, neurological and molecular signaling pathways related to energy homeostasis, we hypothesize that geneti...

journal_title：Scientific reports

authors： Giri AK,Parekatt V,Dwivedi OP,Banerjee P,Bandesh K,Prasad G,Tandon N,Bharadwaj D

更新日期：2018-03-02 00:00:00

abstract：:Cell motility requires the precise coordination of cell polarization, lamellipodia formation, adhesion, and force generation. LKB1 is a multi-functional serine/threonine kinase that associates with actin at the cellular leading edge of motile cells and suppresses FAK. We sought to understand how LKB1 coordinates these...

journal_title：Scientific reports

authors： Wilkinson S,Hou Y,Zoine JT,Saltz J,Zhang C,Chen Z,Cooper LA,Marcus AI

更新日期：2017-01-19 00:00:00

abstract：:Transparent Er3+-doped germanotellurite glass ceramics (GCs) with variable Te/Ge ratio were prepared by controllable heat-treated process. X-ray diffraction (XRD) and transmission electron microscope (TEM) confirmed the formation of nanocrystals in glass matrix. Raman spectra were used to investigate the evolution of ...

journal_title：Scientific reports

authors： Kang S,Xiao X,Pan Q,Chen D,Qiu J,Dong G

更新日期：2017-03-07 00:00:00

abstract：:Porcine epidemic diarrhea virus (PEDV) is a devastating cause of diarrhea in pigs worldwide. Most of studies have focused on molecular and pathogenic characterization of PEDV, whereas there were limited studies in understanding the role of gut microbiota (GM) in viral-associated diarrhea. Here, using the Illumina MiSe...

journal_title：Scientific reports

authors： Song D,Peng Q,Chen Y,Zhou X,Zhang F,Li A,Huang D,Wu Q,Ye Y,He H,Wang L,Tang Y

更新日期：2017-12-12 00:00:00

abstract：:Quantum bits (qubits) are at the heart of quantum information processing schemes. Currently, solid-state qubits, and in particular the superconducting ones, seem to satisfy the requirements for being the building blocks of viable quantum computers, since they exhibit relatively long coherence times, extremely low diss...

journal_title：Scientific reports

authors： Ivić Z,Lazarides N,Tsironis GP

更新日期：2016-07-12 00:00:00

abstract：:Frequent self-monitoring of blood glucose (SMBG) is the only accurate method available for insulin dose titration in patients with T1DM. Professional continuous glucose monitoring (p-CGM) is blinded recording of glucose trends over 5-7 days and helps physicians to guide insulin titration to patient. This study was pla...

journal_title：Scientific reports

authors： Raviteja KV,Kumar R,Dayal D,Sachdeva N

更新日期：2019-04-16 00:00:00

abstract：:To compare the soil water balance, yield and water use efficiency (WUE) of spring maize under different mulching types in the Loess Plateau, a 7-year field experiment was conducted in the Changwu region of the Loess Plateau. Three treatments were used in this experiment: straw mulch (SM), plastic film mulch (PM) and c...

journal_title：Scientific reports

authors： Lin W,Liu W,Xue Q

更新日期：2016-12-15 00:00:00

abstract：:In order to make full use of the impact of internal and external factors on the performance of title catalyst for ethyl benzene oxidation, the key internal influencing factors on the catalytic performance were modulated by coordinating and grafting manganese porphyrin to mesoporous and macroporous chitosan, and the im...

journal_title：Scientific reports

authors： Mo LQ,Huang XF,Wang GC,Huang G,Liu P

更新日期：2020-08-24 00:00:00

abstract：:Rising global temperatures are proving to be detrimental for the agriculture. Hence, strategies are needed to induce thermotolerance in food crops to sustain the food production. GABA (γ-aminobutyric acid), a non-protein amino acid, can partially protect plants from high-temperature stress. This study hypothesises tha...

journal_title：Scientific reports

authors： Priya M,Sharma L,Kaur R,Bindumadhava H,Nair RM,Siddique KHM,Nayyar H

更新日期：2019-05-24 00:00:00

abstract：:On-chip integration of optical detection units into the microfluidic systems for online monitoring is highly desirable for many applications and is also well in line with the spirit of optofluidics technology-fusion of optics and microfluidics for advanced functionalities. This paper reports the construction of a UV-V...

journal_title：Scientific reports

authors： Wang N,Tan F,Zhao Y,Tsoi CC,Fan X,Yu W,Zhang X

更新日期：2016-06-29 00:00:00

abstract：:Parkinson's disease is a neurodegenerative disorder, and no treatment has been yet established to prevent disease progression. Coenzyme Q10, an antioxidant, has been considered a promising neuroprotective agent; however, conventional oral administration provides limited efficacy due to its very low bioavailability. In...

journal_title：Scientific reports

authors： Park HW,Park CG,Park M,Lee SH,Park HR,Lim J,Paek SH,Choy YB

更新日期：2020-06-12 00:00:00

abstract：:Pinellia (Pinellia ternata (Thunb.) Breit.), as important medicinal plant, has been used to treat various ailments for a long time. The sixteen ploid plant (2n = 16 * 13 = 208) Pinellia T2Plus line was obtained from an octoploid (2n = 8 * 13 = 104) T2 line by chromosome-doubling technique. Compared with T2 line, the c...

journal_title：Scientific reports

authors： Lu J,Liu JN,Sarsaiya S,Duns GJ,Han J,Jin L,Chen J

更新日期：2020-03-12 00:00:00

abstract：:Cell penetrating peptides (CPPs) are peptides that can be translocated into cells and used as a carrier platform for the intracellular uptake of cargo molecules. Subject to the source of CPP sequences and their positively charged nature, the cytotoxicity and immunogenicity of conventional CPPs needs to be optimized to...

journal_title：Scientific reports

authors： Young Kim H,Young Yum S,Jang G,Ahn DR

更新日期：2015-06-26 00:00:00

abstract：:Gold nanoparticles have particular properties distinct from those of bulk gold crystals, and such nanoparticles are used in various applications in optics, catalysis, and drug delivery. Many reports on microbial synthesis of gold nanoparticles have appeared. However, the molecular details (reduction and dispersion) of...

journal_title：Scientific reports

authors： Kikuchi F,Kato Y,Furihata K,Kogure T,Imura Y,Yoshimura E,Suzuki M

更新日期：2016-10-11 00:00:00

abstract：:We investigate instability mechanisms in amorphous In-Ga-Zn-O transistors based on bias and illumination stress-recovery experiments coupled with analysis using stretched exponentials and inverse Laplace transform to retrieve the distribution of activation energies associated with metastable oxygen defects. Results sh...

journal_title：Scientific reports

authors： Lee S,Nathan A,Jeon S,Robertson J

更新日期：2015-10-08 00:00:00

abstract：:Daphnia are important to understanding the biogeochemistry of aquatic ecosystems, mainly because of their ability to filter bacteria, algae and inorganic particles as well. Although there are many studies on the general effects that biotic and abiotic stressors, increased temperature and hypoxia, salinity, metals, pha...

journal_title：Scientific reports

authors： Serra T,Müller MF,Colomer J

更新日期：2019-03-07 00:00:00

abstract：:We combine matter-wave interferometry and cavity optomechanics to propose a coherent matter-light interface based on mechanical motion at the quantum level. We demonstrate a mechanism that is able to transfer non-classical features imprinted on the state of a matter-wave system to an optomechanical device, transducing...

journal_title：Scientific reports

authors： Xuereb A,Ulbricht H,Paternostro M

更新日期：2013-11-29 00:00:00

abstract：:At present, it remains poorly understood how the olfactory neuron migrates through the thick neuroepithelium during its maturation from a stem cell and how it develops a specific sensitivity to environmental odorants after maturation. We investigated the cytochemical features associated with the development of olfacto...

journal_title：Scientific reports

authors： Klimenkov IV,Sudakov NP,Pastukhov MV,Svinov MM,Kositsyn NS

更新日期：2018-02-27 00:00:00

abstract：:Rabies is still a public health threat in China. Evaluating the exposure history, clinical characteristics, and post-exposure prophylaxis (PEP) of the cases could help in identifying approaches to reducing the number of these preventable deaths. We analysed data collected from 10,971 case-investigations conducted in C...

journal_title：Scientific reports

authors： Guo C,Li Y,Huai Y,Rao CY,Lai S,Mu D,Yin W,Yu H,Nie S

更新日期：2018-11-21 00:00:00

abstract：:In this paper, we analyze the synchronization problem of master-slave probabilistic Boolean networks (PBNs). The master Boolean network (BN) is a deterministic BN, while the slave BN is determined by a series of possible logical functions with certain probability at each discrete time point. In this paper, we firstly ...

journal_title：Scientific reports

authors： Lu J,Zhong J,Li L,Ho DW,Cao J

更新日期：2015-08-28 00:00:00

abstract：:Infection diagnosis and antibiotic susceptibility testing (AST) are time-consuming and often laborious clinical practices. This paper presents a microwave-microfluidic biosensor for rapid, contactless and non-invasive device for testing the concentration and growth of Escherichia Coli (E. Coli) in medium solutions of ...

journal_title：Scientific reports

authors： Narang R,Mohammadi S,Ashani MM,Sadabadi H,Hejazi H,Zarifi MH,Sanati-Nezhad A

更新日期：2018-10-25 00:00:00

abstract：:By means of extensive ab initio calculations, a new two-dimensional (2D) atomic material tin selenide monolayer (coined as tinselenidene) is predicted to be a semiconductor with an indirect gap (~1.45 eV) and a high hole mobility (of order 10000 cm(2)V(-1)S(-1)), and will bear an indirect-direct gap transition under a...

journal_title：Scientific reports

authors： Zhang LC,Qin G,Fang WZ,Cui HJ,Zheng QR,Yan QB,Su G

更新日期：2016-02-01 00:00:00

abstract：:The impacts of flooding are expected to rise due to population increases, economic growth and climate change. Hence, understanding the physical and spatiotemporal characteristics of risk drivers (hazard, exposure and vulnerability) is required to develop effective flood mitigation measures. Here, the long-term trend i...

journal_title：Scientific reports

authors： Tanoue M,Hirabayashi Y,Ikeuchi H

更新日期：2016-10-26 00:00:00

abstract：:Despite the initiative by WHO and other international organizations to eliminate HCV in the medium term, hepatitis C infection is still a major public health problem. Even non-injecting drugs users who engage in harmful or addictive drug use are at greater risk of acquiring the infection, when compared to the general ...

journal_title：Scientific reports

authors： Coutinho C,Bastos LS,da Mota JC,Toledo L,Costa K,Bertoni N,Bastos FI

更新日期：2019-01-24 00:00:00

abstract：:How chromosomes fold into 3D structures and how genome functions are affected or even controlled by their spatial organization remain challenging questions. Hi-C experiment has provided important structural insights for chromosome, and Hi-C data are used here to construct the 3D chromatin structure which are character...

journal_title：Scientific reports

authors： Xie WJ,Meng L,Liu S,Zhang L,Cai X,Gao YQ

更新日期：2017-06-06 00:00:00

abstract：:Sensory representations are typically endowed with intrinsic noise, leading to variability and inaccuracies in perceptual responses. The Bayesian framework accounts for an optimal strategy to deal with sensory-motor uncertainty, by combining the noisy sensory input with prior information regarding the distribution of ...

journal_title：Scientific reports

authors： Ege R,Opstal AJV,Van Wanrooij MM

更新日期：2018-11-06 00:00:00

abstract：:Traditional methods employed to discover new antibiotics are both a time-consuming and financially-taxing venture. This has led researchers to mine existing libraries of clinical molecules in order to repurpose old drugs for new applications (as antimicrobials). Such an effort led to the discovery of auranofin, a drug...

journal_title：Scientific reports

authors： Thangamani S,Mohammad H,Abushahba MF,Sobreira TJ,Hedrick VE,Paul LN,Seleem MN

更新日期：2016-03-03 00:00:00