Abstract：
:Maintaining balance while walking on a narrow beam is a challenging motor task. One important factor is that the foot's ability to exert torque on the support surface is limited by the beam width. Still, the feet serve as a critical interface between the body and the external environment, and it is unclear how the mechanical properties of the feet affect balance. This study examined how constraining the motion of the foot joints with rigid soles influenced balance performance when walking on a beam. We recorded whole-body kinematics of subjects with varying skill levels as they walked on a narrow beam with and without wearing flat, rigid soles on their feet. We computed changes in whole-body motion and angular momentum across the two conditions. Results showed that walking with rigid soles improved balance performance in both expert and novice subjects, but that improvements in balance performance with rigid soles did not affect or transfer to subsequent task performance with bare feet. The absence of any aftereffects suggested that the improved balance performance resulting from constraining the foot joints by a rigid sole was the result of a mechanical effect rather than a change in neural control. Although wearing rigid soles can be used to assist balance, there appears to be limited benefit for training or rehabilitation of balance ability.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Huber ME,Chiovetto E,Giese M,Sternad Ddoi
10.1038/s41598-020-64035-ysubject
Has Abstractpub_date
2020-05-06 00:00:00pages
7629issue
1issn
2045-2322pii
10.1038/s41598-020-64035-yjournal_volume
10pub_type
杂志文章abstract：:Currently, there is no appropriate treatment option for patients with sorafenib-resistant hepatocellular carcinoma (HCC). Meanwhile, pronounced anticancer activities of newly-developed mitochondria-accumulating self-assembly peptides (Mito-FF) have been demonstrated. This study intended to determine the anticancer eff...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79536-z
更新日期：2021-01-13 00:00:00
abstract：:Many stroke survivors with aphasia in the acute period experience spontaneous recovery within the first six months after the stroke. However, approximately 30-40% sustain permanent aphasia and the factors determining incomplete recovery are unclear. Suboptimal recovery may be influenced by disruption of areas seemingl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07607-9
更新日期：2017-08-15 00:00:00
abstract：:Micronutrients are essential for survival and growth for all the organisms including pathogens. In this manuscript, we report that zinc (Zn) chelator N,N,N',N'-tetrakis(2-pyridinylmethyl)-1,2-ethylenediamine (TPEN) affects growth and viability of intracellular pathogen Leishmania donovani (LD) by a concentration and t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10041-6
更新日期：2017-09-05 00:00:00
abstract：:Histone acetylation has been linked to cardiac hypertrophy and heart failure. However, the pathological implications of changes in histone methylation and the effects of interventions with histone methyltransferase inhibitors for heart failure have not been fully clarified. Here, we focused on H3K9me3 status in the he...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39752
更新日期：2017-01-04 00:00:00
abstract：:The iron binding capacities (IBC) of fulvic acid (FA) and humic acid (HA) were determined in the salinity range from 5 to 40. The results indicated that IBC decreased while salinity increased. In addition, dissolved iron (dFe), FA and HA were also determined along the Yangtze River estuary's increasing salinity gradie...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01533-6
更新日期：2017-05-03 00:00:00
abstract：:CRISPR-Cas9/gRNA exhibits therapeutic efficacy against latent human immunodeficiency virus (HIV) genome but the delivery of this therapeutic cargo to the brain remains as a challenge. In this research, for the first time, we demonstrated magnetically guided non-invasive delivery of a nano-formulation (NF), composed of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40222-4
更新日期：2019-03-08 00:00:00
abstract：:The preparation of mesoporous iron oxides with controllable physiochemical properties for effective therapeutic drug delivery remains a formidable challenge. Herein, iron oxide mesoporous magnetic microparticles (IO-MMMs) were prepared by a modified reverse hard-templating approach using, for the first time, acid-prep...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46007-z
更新日期：2019-07-01 00:00:00
abstract：:Gyroviruses (GyVs) are small, single-stranded, circular DNA viruses in the genus Gyrovirus, which consists of the chicken anemia virus (CAV) prototype and nine other viral species. These different GyV species have been reported in chickens, humans, mice, and companion animals. To date, CAV has been identified in the f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49955-8
更新日期：2019-09-16 00:00:00
abstract：:PC4 is an abundant single-strand DNA binding protein that has been implicated in transcription and DNA repair. Here, we show that PC4 is involved in the cellular DNA damage response. To elucidate the role, we used the DT40 chicken B cell model, which produces clustered DNA lesions at Ig loci via the action of activati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28890
更新日期：2016-07-04 00:00:00
abstract：:Chlorpyrifos is one of the most widely used pesticides that acts on the nervous system by inhibiting acetylcholinesterase. Prolonged use of chlorpyrifos causes severe neurological, autoimmune, and persistent developmental disorders in humans. Therefore, in this study, a highly sensitive and robust biosensor platform w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36746-w
更新日期：2019-01-22 00:00:00
abstract：:No licensed human vaccines are currently available against leishmaniasis. Several anti-leishmanial vaccines are currently undergoing testing, including genetically modified live-attenuated parasite vaccines. Studies with live attenuated Leishmania vaccines such as centrin deleted Leishmania donovani parasites (LdCen -...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05088-4
更新日期：2017-07-05 00:00:00
abstract：:Cystic fibrosis (CF) patients experience heightened levels of anxiety and depression. Stress from dealing with chronic disease and rigorous treatment regimens certainly are primary contributors to these outcomes. We previously have demonstrated that microtubule alterations in CF are linked to a number of CF phenotypes...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73298-4
更新日期：2020-10-01 00:00:00
abstract：:The aesthetic value of landscapes contributes to human well-being. However, studies which have investigated the link between biodiversity and ecosystem services have not taken aesthetic value into account. In this study we evaluated how the aesthetics of coralligenous reefs, a key marine ecosystem in the Mediterranean...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34229
更新日期：2016-09-28 00:00:00
abstract：:During pregnancy several maternal adaptations occur in order to support the growing fetus which are further exacerbated by gestational diabetes mellitus (GDM). Previously we developed a mouse model of GDM, however we did not evaluate alterations to energy and fat metabolism. We have also shown that alterations in lipi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77529-6
更新日期：2020-11-30 00:00:00
abstract：:Toxin-antitoxin (TA) systems were initially discovered as plasmid addiction systems on low-copy-number plasmids. Thousands of TA loci have since been identified on chromosomes, plasmids and mobile elements in bacteria and archaea with diverse roles in bacterial physiology and in maintenance of genetic elements. Here, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46318-1
更新日期：2019-07-08 00:00:00
abstract：:Agrosilvopastoral and silvopastoral systems can increase carbon sequestration, offset greenhouse gas (GHG) emissions and reduce the carbon footprint generated by animal production. The objective of this study was to estimate GHG emissions, the tree and grass aboveground biomass production and carbon storage in differe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16821-4
更新日期：2017-12-01 00:00:00
abstract：:The digit ratio has been used as a retrospective noninvasive biomarker to investigate the putative effects of prenatal exposure to androgens. In recent years, many scholars have paid attention to the association between 2D:4D (the second and fourth digits) and prostatic cancer. This study explored the prognostic signi...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究
doi：10.1038/s41598-017-05638-w
更新日期：2017-07-12 00:00:00
abstract：:The rivers originating in the southern Andes (18°-55°S) support numerous ecosystems and a large number of human populations and socio-economic activities in the adjacent lowlands of Chile, Argentina and Bolivia. Here we show that ca. 75% of the total variance in the streamflow records from this extensive region can be...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53981-x
更新日期：2019-11-29 00:00:00
abstract：:To understand the mechanisms of male sterility in cotton (Gossypium spp.), combined histological, biochemical and transcription analysis using RNA-Seq was carried out in the anther of the single-gene recessive genic male sterility system of male sterile line 1355A and male fertile line 1355B, which are near-isogenic l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09608
更新日期：2015-06-05 00:00:00
abstract：:The renin-angiotensin system is known to regulate blood pressure as well as water- and electrolyte balance. An activated RAS is involved in the development of hypertension and hypertension-related organ damage. Thus, inhibitors of the RAS are protective and markedly increasing the life span of patients. In contrast, r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76712-z
更新日期：2020-11-12 00:00:00
abstract：:We demonstrate fluorescent Fe embedded magnetic nanodiamonds by ion implantation and two-step annealing. The diamond characteristics with a highly ordered core and a graphite surface layer are maintained after the implantation process. After the two-step annealing process, a bright red fluorescence associated with nit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37820-z
更新日期：2019-02-04 00:00:00
abstract：:Climate change significantly impacts the vegetation growth and terrestrial ecosystems. Using satellite remote sensing observations, here we focus on investigating vegetation dynamics and the likelihood of vegetation-related drought under varying climate conditions across China. We first compare temporal trends of Norm...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35105
更新日期：2016-10-07 00:00:00
abstract：:Studies on dsDNA bacteriophages have revealed that a DNA packaging complex assembles at a special vertex called the 'portal vertex' and consists of a portal, a DNA packaging ATPase and other components. AdV protein IVa2 is presumed to function as a DNA packaging ATPase. However, a protein that functions as a portal is...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07997-w
更新日期：2017-08-08 00:00:00
abstract：:Despite the efficacy of synthetic fungicides in controlling postharvest diseases, public concerns regarding chemical residues in food and an increase in drug-resistant strains of pathogens have led to a need for new agents to control postharvest diseases. The current study was performed to find control agents of micro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49779-6
更新日期：2019-09-19 00:00:00
abstract：:We report the detection of genomic signatures of giant viruses (GVs) in the metagenomes of three environment samples from Mumbai, India, namely, a pre-filter of a household water purifier, a sludge sample from wastewater treatment plant (WWTP), and a drying bed sample of the same WWTP. The de novo assembled contigs of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40171-y
更新日期：2019-03-06 00:00:00
abstract：:SERS spectra excited at 785 nm of the bacteria Chlamydia trahomatis (elementary bodies, EB) and Neisseria gonorrheoae, the causative pathogens for the two most common sexually transmitted diseases (STD), chlamydia and gonorrhea, respectively, are reported. Although both are Gram-negative bacteria, the SERS signatures ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23562-5
更新日期：2018-03-26 00:00:00
abstract：:The Salicornia europaea L. (SE) plant is a halophyte that has been widely consumed as a seasoned vegetable, and it has been recently reported to counteract chronic diseases related to oxidative and inflammatory stress. In this study, we performed an initial phytochemical analysis with in vitro biochemical tests and ch...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25381-0
更新日期：2018-05-08 00:00:00
abstract：:Protandric species switch sex during their lifetime. According to theory, the time (body size) at which sex change occurs is determined by the reproductive success of individuals affected by social interactions as well as by post-copulatory factors. Experimental evidence is biased to few social systems making the expl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29439
更新日期：2016-07-07 00:00:00
abstract：:In this paper, α-Fe2O3 nanoparticles (NPs)-reduced graphene oxide (RGO), α-FeOOH nanorods (NRs)-RGO and porous α-Fe2O3 NRs-RGO could be selectively synthesized by hydrothermal method. The investigations indicated that the obtained α-Fe2O3 NPs, α-FeOOH NRs and porous α-Fe2O3 NRs were either attached on the surface of R...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11131-1
更新日期：2017-09-11 00:00:00
abstract：:We previously identified novel bioactive polysaccharides from Bactrocera cucurbitae and Antheraea yamamai that activate innate immunity in RAW264 murine macrophages. However, in terms of potential applications in the cultivation of prawns, there were problems with the availability of these insects. However, we have no...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27241-3
更新日期：2018-06-11 00:00:00
