Abstract：
:SERS spectra excited at 785 nm of the bacteria Chlamydia trahomatis (elementary bodies, EB) and Neisseria gonorrheoae, the causative pathogens for the two most common sexually transmitted diseases (STD), chlamydia and gonorrhea, respectively, are reported. Although both are Gram-negative bacteria, the SERS signatures of C. trachomatis and N. gonorrheoae are completely different. N. gonorrheoae SERS spectra are due to the starvation induced nucleotide metabolites adenine and guanine, and the surface associated co-enzyme nicotinamide adenine dinucleotide and are very similar on Au and Ag although the spectrum appears more rapidly on Ag. The C. trachomatis SERS spectrum is dominated by the vibrational features of cell surface proteins. While features attributable to specific residues and the amide backbone characterize the C. trachomatis spectrum on Ag, the corresponding SERS spectrum on Au substrates displays vibrational characteristics of aggregated proteins. The prospects for the development of a SERS based platform for rapid ( journal_name journal_title authors doi subject pub_date pages issue issn pii journal_volume pub_type
abstract：:Pachychoroid spectrum diseases have attracted increasing attention, though their pathophysiology has yet to be fully elucidated. In this study, we assessed the vascular diameters of vortex veins in pachychoroid spectrum diseases such as central serous chorioretinopathy (CSC), pachychoroid neovasculopathy without polyp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75789-w
更新日期：2020-11-11 00:00:00
abstract：:Soil components (e.g., clays, bacteria and humic substances) are known to produce mineral-organic composites in natural systems. Herein, batch sorption isotherms, isothermal titration calorimetry (ITC), and Cd K-edge EXAFS spectroscopy were applied to investigate the binding characteristics of Cd on montmorillonite(Mo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19499
更新日期：2016-01-21 00:00:00
abstract：:Diabetes mellitus accelerates vascular calcification (VC) and increases the risk of end-stage renal disease (ESRD). Nevertheless, the impact of VC in renal disease progression in type 2 diabetes mellitus (T2DM) is poorly understood. We addressed the effect of VC and mechanisms involved in renal dysfunction in a murine...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55501-3
更新日期：2020-01-09 00:00:00
abstract：:The discovery of circulating tumour DNA molecules created a paradigm shift in tumour biomarkers as predictors of recurrence. Non-invasive prenatal testing (NIPT) to detect circulating cell-free foetal DNA in maternal plasma is increasingly recognised as a valuable substitute to perceive foetal copy number variation (C...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29381-y
更新日期：2018-07-25 00:00:00
abstract：:Following retinal degeneration, retinal remodeling can cause neuronal microcircuits to undergo structural alterations, which particularly affect the dendrites of bipolar cells. However, the mechanisms and functional consequences of such changes remain unclear. Here, we used Royal College of Surgeon (RCS) rats as a mod...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01261-x
更新日期：2017-04-21 00:00:00
abstract：:CIC-DUX4 sarcoma (CDS) is a group of rare, mesenchymal, small round cell tumours that harbour the unique CIC-DUX4 translocation, which causes aberrant gene expression. CDS exhibits an aggressive course and poor clinical outcome, thus novel therapeutic approaches are needed for CDS treatment. Although patient-derived c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04967-0
更新日期：2017-07-05 00:00:00
abstract：:The bacterial stringent response is a key regulator of bacterial virulence, biofilm formation and antibiotic tolerance, and is a promising target for the development of new antibacterial compounds. The intracellular nucleotide (p)ppGpp acts as a messenger orchestrating the stringent response. A synthetic peptide 1018 ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36549
更新日期：2016-11-07 00:00:00
abstract：:Studies of morphological integration and modularity, and of anatomical complexity in human evolution typically focus on skeletal tissues. Here we provide the first network analysis of the musculoskeletal anatomy of both the fore- and hindlimbs of the two species of chimpanzee and humans. Contra long-accepted ideas, ne...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25262-6
更新日期：2018-05-02 00:00:00
abstract：:Extracorporeal membrane oxygenation (ECMO) is used for rescue in severe respiratory and/or circulatory failure. The patient's blood is pumped over artificial surfaces in the ECMO circuit. A platelet activation model was applied to study the potential thrombogenicity of ECMO circuit components: the centrifugal blood pu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32247-y
更新日期：2018-09-18 00:00:00
abstract：:It has been well established that some Armillaria species are symbionts of Polyporus umbellatus, However, little is known about the evolutionary history of P. umbellatus-Armillaria associations. In this research, we used an analysis based on the strength of the phylogenetic signal to investigate P. umbellatus-Armillar...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04578-9
更新日期：2017-06-26 00:00:00
abstract：:Craniofacial muscles drive critical functions in the head, including speech, feeding and expression. Compared with their counterparts in trunk and limbs, craniofacial muscles are of distinct embryonic origins, which might consequently lead to different growth patterns and regenerative potential. In this study, rat lev...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28917-6
更新日期：2018-07-13 00:00:00
abstract：:Quantitative reverse transcription PCR (RT-qPCR) is one of the most efficient, reliable and widely used techniques to quantify gene expression. In this study, we evaluated the performance of six southern corn rootworm, Diabrotica undecimpunctata howardi (Barber), housekeeping genes (HKG), β-actin (Actin), β-tubulin (T...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47020-y
更新日期：2019-07-24 00:00:00
abstract：:The celebrated Jordan-Wigner transformation provides an efficient mapping between spin chains and fermionic systems in one dimension. Here we extend this spin-fermion mapping to arbitrary tree structures, which enables mapping between fermionic and spin systems with nearest-neighbor coupling. The mapping is achieved w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38128-8
更新日期：2019-02-22 00:00:00
abstract：:We herein present a novel and sustainable technology for mercury recycling, with the maximum observed uptake capacity. Facile synthesis of the most efficient (~1.9 gg-1) nano-trap, made of montmorillonite-Fe-iron oxides, was performed to instantaneously remove mercury(II) ions from water. Elemental Hg was recovered fr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34172-6
更新日期：2018-11-02 00:00:00
abstract：:Archaeological evidence suggests that dogs were introduced to the islands of Oceania via Island Southeast Asia around 3,300 years ago, and reached the eastern islands of Polynesia by the fourteenth century AD. This dispersal is intimately tied to human expansion, but the involvement of dogs in Pacific migrations is no...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27363-8
更新日期：2018-06-14 00:00:00
abstract：:Studies have assessed individual components of a western diet, but no study has assessed the long-term, cumulative effects of a western diet on aging and Alzheimer's disease (AD). Therefore, we have formulated the first western-style diet that mimics the fat, carbohydrate, protein, vitamin and mineral levels of wester...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21568
更新日期：2016-02-18 00:00:00
abstract：:Coral reefs around the world are undergoing severe decline in the past few decades. Mass coral mortalities have predominantly been reported to be caused by coral bleaching or disease outbreaks. Temporary hypoxic conditions caused by algal blooms can trigger mass coral mortalities though are reported rarely. In this st...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79152-x
更新日期：2020-12-17 00:00:00
abstract：:Hepatocyte spheroids are useful models for mimicking liver phenotypes in vitro because of their three-dimensionality. However, the lack of a biomaterial platform which allows the facile manipulation of spheroid cultures on a large scale severely limits their application in automated high-throughput drug safety testing...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61699-4
更新日期：2020-03-16 00:00:00
abstract：:Ordered/disordered phase separation occurring in bio-membranes has piqued researchers' interest because these ordered domains, called lipid rafts, regulate important biological functions. The structure of the ordered domain has been examined with artificial membranes, which undergo macroscopic ordered/disordered phase...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79083-7
更新日期：2020-12-21 00:00:00
abstract：:In-resin CLEM of Epon embedded samples can greatly simplify the correlation of fluorescent images with electron micrographs. The usefulness of this technique is limited at present by the low number of fluorescent proteins that resist CLEM processing. Additionally, no study has reported the possibility of two-color in-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78879-x
更新日期：2020-12-14 00:00:00
abstract：:Nanocarrier systems for the encapsulation of agrochemicals can contribute to sustainable agriculture, but few nanosystems have been developed for plant growth regulators (PGRs). The present study evaluated the effects of seed priming using alginate/chitosan (nanoALG/CS) and chitosan/tripolyphosphate (nanoCS/TPP) conta...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43494-y
更新日期：2019-05-09 00:00:00
abstract：:Antimicrobial resistance seriously threatened human health. Combination therapy is generally an effective strategy to fight resistance, while some data on its effects are conflicting. To explore the reasons, the fractional inhibitory concentration indexes (FICIs) of three designed combinations against methicillin-resi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25714-z
更新日期：2018-05-08 00:00:00
abstract：:Due to their immunosuppressive properties, mesenchymal stem cells (MSC) have been evaluated for the treatment of immunological diseases. However, the animal-derived growth supplements utilized for MSC manufacturing may lead to clinical complications. Characterization of alternative media formulations is imperative for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16570
更新日期：2015-11-13 00:00:00
abstract：:A tool to predict peritonitis-associated treatment failure among peritoneal dialysis (PD) patients has not yet been established. We conducted a multicentre, retrospective cohort study among 1,025 PD patients between 2006 and 2016 in Thailand to develop and internally validate such a tool. Treatment failure was defined...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究
doi：10.1038/s41598-018-33196-2
更新日期：2018-10-04 00:00:00
abstract：:Nilaparvata lugens (Stål) (Hemiptera: Delphacidae) is a major rice pest that harbors an endosymbiont ascomycete fungus, Entomomyces delphacidicola str. NLU (also known as yeast-like symbiont, YLS). Driving by demand of novel population management tactics (e.g. RNAi), the importance of YLS has been studied and revealed...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42206
更新日期：2017-02-13 00:00:00
abstract：:α-Dystroglycanopathy (α-DGP) is a group of muscular dystrophy characterized by abnormal glycosylation of α-dystroglycan (α-DG), including Fukuyama congenital muscular dystrophy (FCMD), muscle-eye-brain disease, Walker-Warburg syndrome, and congenital muscular dystrophy type 1D (MDC1D), etc. LARGE, the causative gene f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08316
更新日期：2015-02-09 00:00:00
abstract：:Plants traditionally used by farmers to manage livestock ailments could reduce reliance on synthetic antibiotics and anthelmintics but in many cases their chemical composition is unknown. As a case study, we analyzed the metabolite profiles of 17 plant species and 45 biomass samples from agricultural grasslands in Eng...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20091-z
更新日期：2018-01-26 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-23329-y
更新日期：2018-03-19 00:00:00
abstract：:Tolerance to Dutch elm disease (DED) has been linked to the rapid and/or high induction of disease-responsive genes after infection with the fungus Ophiostoma novo-ulmi. Although the fungal infection by O. novo-ulmi primarily takes places in xylem vessels, it is still unclear how xylem contributes to the defense again...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07779-4
更新日期：2017-08-02 00:00:00
abstract：:Voice disorder such as vocal fatigue is a common and complex multifaceted clinical problem that presents a significant impact on quality of life. In this study, the functional near-infrared diffuse optical technique (fNIRS-DOT) was proposed as a novel approach for human vocal cords oxidative metabolism detection and a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16807-2
更新日期：2017-12-05 00:00:00
