Abstract:
:Following retinal degeneration, retinal remodeling can cause neuronal microcircuits to undergo structural alterations, which particularly affect the dendrites of bipolar cells. However, the mechanisms and functional consequences of such changes remain unclear. Here, we used Royal College of Surgeon (RCS) rats as a model of retinal degeneration, to study structural changes in rod bipolar cells (RBCs) and the underlying mechanisms of these changes. We found that, with retinal degeneration, RBC dendrites extended into the outer nuclear layer (ONL) of the retina, and the ectopic dendrites formed synapses with the remaining photoreceptors. This ectopic neuritogenesis was associated with brain-derived neurotrophic factor (BDNF) - expression of which was negatively regulated by miR-125b-5p. Overexpression of miR-125b-5p in the retinae of RCS rats diminished RBC ectopic dendrites, and compromised the b-wave of the flash electroretinogram (ERG). In contrast, down-regulation of miR-125b-5p (or exogenous BDNF treatment) increased RBC ectopic dendrites, and improved b-wave. Furthermore, we showed that the regulation of ectopic neuritogenesis by BDNF occurred via the downstream modulation of the TrkB-CREB signaling pathway. Based on these findings, we conclude that ectopic dendrites are likely to be providing functional benefits and that, in RCS rats, miR-125b-5p regulates ectopic neuritogenesis by RBCs through modulation of the BDNF-TrkB-CREB pathway. This suggests that therapies that reduce miR-125b-5p expression could be beneficial in human retinal degenerative disease.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Fu Y,Hou B,Weng C,Liu W,Dai J,Zhao C,Yin ZQdoi
10.1038/s41598-017-01261-xsubject
Has Abstractpub_date
2017-04-21 00:00:00pages
1011issue
1issn
2045-2322pii
10.1038/s41598-017-01261-xjournal_volume
7pub_type
杂志文章abstract::ING2 (inhibitor of growth family member 2) is a component of a chromatin-regulatory complex that represses gene expression and is implicated in cellular processes that promote tumor suppression. However, few direct genomic targets of ING2 have been identified and the mechanism(s) by which ING2 selectively regulates ge...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02137
更新日期:2013-01-01 00:00:00
abstract::Glutamate (Glu), the key excitatory neurotransmitter in the central nervous system, is considered essential for brain functioning and has a vital role in learning and memory formation. Earlier it was considered as a harmful agent but later found to be useful for many body functions. However, studies regarding the effe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68041-y
更新日期:2020-07-08 00:00:00
abstract::Uterus transplantation (UTx) is a potential option for women with uterine factor infertility to have a child. The clinical features indicating irreversible rejection of the uterus are unknown. In our experimental series of allogeneic UTx in cynomolgus macaques, six female macaques were retrospectively examined, which ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70914-1
更新日期:2020-08-17 00:00:00
abstract::A robust method is presented for the segmentation of the full cerebral vasculature in 4-dimensional (4D) computed tomography (CT). The method consists of candidate vessel selection, feature extraction, random forest classification and postprocessing. Image features include among others the weighted temporal variance i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15617-w
更新日期:2017-11-15 00:00:00
abstract::Two types of periodic and transient motions of large woodpeckers are considered. A drumming woodpecker may be modeled as a harmonic oscillator with a periodic forcing function. The transient behavior that occurs after the forcing is turned off suggests that the double knocks of Campephilus woodpeckers may be modeled i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13035-6
更新日期:2017-10-02 00:00:00
abstract::Healthy neonates exhibit a well-functioning haemostatic system despite peculiarities regarding composition of clotting factors and inhibitors as well as impaired platelet aggregation. Thrombocytopenia and severe bleeding events are feared in sick infants. Recombinant factor VIIa (rFVIIa) is a haemostatic agent used as...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44199-y
更新日期:2019-05-29 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-66186-4
更新日期:2020-06-16 00:00:00
abstract::This study was to evaluate the effect of Epigallocatechin-3-gallate (EGCG) on the bond strength of two adhesive systems to the Sodium hypochlorite (NaOCl) treated intraradicular dentin. The roots were accepted regular root canal treatments and post space preparations, and further divided into eight groups according to...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04107-8
更新日期:2017-06-26 00:00:00
abstract::Hydrogen is known to be present as an impurity in amorphous oxide semiconductors at the 0.1% level. Using amorphous ZnO as a simplified model system, we show that the hydrogens pair up at oxygen vacancies in the amorphous network, where they form metal-H-metal bridge bonds. These bonds are shown to create filled defec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17290-5
更新日期:2017-12-04 00:00:00
abstract::Hybridization between heterospecific individuals has been documented as playing a direct role in promoting paternal leakage and mitochondrial heteroplasmy in both natural populations and laboratory conditions, by relaxing the egg-sperm recognition mechanisms. Here, we tested the hypothesis that hybridization can lead ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55764-w
更新日期:2019-12-16 00:00:00
abstract::Memristors, memcapacitors, and meminductors represent an innovative generation of circuit elements whose properties depend on the state and history of the system. The hysteretic behavior of one of their constituent variables, is their distinctive fingerprint. This feature endows them with the ability to store and proc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46736
更新日期:2017-04-24 00:00:00
abstract::Ocimum is one of the most revered medicinally useful plants which have various species. Each of the species is distinct in terms of metabolite composition as well as the medicinal property. Some basil types are used more often as an aromatic and flavoring ingredient. It would be informative to know relatedness among t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61957-5
更新日期:2020-03-23 00:00:00
abstract::Various important topological properties of healthy brain connectome have recently been identified. However, the manner in which brain lesion changes the functional network topology is unknown. We examined how critical specific brain areas are in the maintenance of network topology using multivariate support vector re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17886-x
更新日期:2017-12-20 00:00:00
abstract::Constrained layer dampers (CLD) are in widespread use for passive vibration damping, in applications including aerospace structures. However, the introducing of the damping layer can reduce the stiffness of the sandwich structures. A viscoelastic material filling (VMF) is chosen to balance structural and vibrational p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27963-4
更新日期:2018-06-25 00:00:00
abstract::The incidence of myopia is increasing worldwide, and the investigation on pathophysiology of myopia is becoming more important. This retrospective study aimed to compare the thicknesses of individual retinal layers between high-myopic and control eyes, and to evaluate the effects of age and sex on each retinal layer t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50306-w
更新日期:2019-09-30 00:00:00
abstract::Parathyroid Hormone-Like Hormone (PTHLH) is an autocrine/paracrine ligand that is up-regulated in head and neck squamous cell carcinoma (HNSCC). However, the cellular function and regulatory mechanism in HNSCC remains obscure. We investigated the clinical significance of PTHLH in HNSCC patients, and verified the role ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41131
更新日期:2017-01-25 00:00:00
abstract::In situ reduction of selenite to elemental selenium (Se(0)), by microorganisms in sediments and soils is an important process and greatly affects the environmental distribution and the biological effects of selenium. However, the mechanism behind such a biological process remains unrevealed yet. Here we use Shewanella...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03735
更新日期:2014-01-17 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-28390-1
更新日期:2018-07-03 00:00:00
abstract::Microwave absorbers have important applications in various areas including stealth, camouflage, and antenna. Here, we have designed an ultra-broadband light absorber by integrating two different-sized tapered hyperbolic metamaterial (HMM) waveguides, each of which has wide but different absorption bands due to broadba...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15367
更新日期:2015-10-19 00:00:00
abstract::Necrotizing enterocolitis (NEC) is a devastating gastrointestinal emergency of neonates. Epithelial tight junction (TJ) proteins, such as claudins, are essential for regulation and function of the intestinal barrier. Rho kinase (ROCK) affects cellular permeability and TJ regulation. We hypothesized that TJ protein cha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41442-4
更新日期:2019-03-21 00:00:00
abstract::Quantitative measurement and analysis of tumor metabolic activities could provide a more optimal solution to personalized accurate dose painting. We collected PET images of 58 lung cancer patients, in which the tumor exhibits heterogeneous FDG uptake. We design an automated delineation and quantitative heterogeneity m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28818-8
更新日期:2018-07-13 00:00:00
abstract::Considering the significance of mast cells (MCs) in the course of various physiological and pathological processes, and the pivotal role of endogenous molecules, i.e., cathelicidins and defensins as multifunctional modulators, the study examines the constitutive and cathelicidin LL-37/defensin hBD-2-induced expression...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30289-w
更新日期:2018-08-06 00:00:00
abstract::Childhood obesity and early rapid growth increase the risk for type 2 diabetes. Such early overnutrition can be modeled in mice by reducing litter size. We investigated the effects of early overnutrition and increased dietary fat intake on β cell function in Swiss Webster mice. On a moderate-fat diet, early overnutrit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39177-3
更新日期:2019-03-06 00:00:00
abstract::Artificial grasslands play a role in carbon storage on the Qinghai-Tibetan Plateau. The artificial grasslands exhibit decreased proportions of graminate and increased species richness with age. However, the effect of the graminate proportions and species richness on ecosystem C stocks in artificial grasslands have not...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40307
更新日期:2017-01-09 00:00:00
abstract::Myopia is the commonest eye disorder in the world. High myopes are predisposed to ocular pathologies. The vasoactive intestinal peptide receptor 2 (VIPR2) gene was identified as a myopia susceptibility locus by our group and another group. We continued to fine-map this locus. A case-control study was performed in 4 se...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54619-8
更新日期:2019-12-03 00:00:00
abstract::YPEL3 that induces cellular senescence in both normal and tumour cells of humans may show altered expression under the influence of incidental mutations. In this study, we proposed the first structure of Native YPEL3 protein and its five possible deleterious mutants-V40M, C61Y, G98R, G108S, and A131T and predicted the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72333-8
更新日期:2020-09-17 00:00:00
abstract::Complex regulatory networks control epithelial-to-mesenchymal transition (EMT) but the underlying epigenetic control is poorly understood. Lysine-specific demethylase 1 (LSD1) is a key histone demethylase that alters the epigenetic landscape. Here we explored the role of LSD1 in global epigenetic regulation of EMT, ca...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17913-x
更新日期:2018-01-08 00:00:00
abstract::Communication between vascular plants through volatile organic compounds (VOCs) impacts on ecosystem functioning. However, nothing is known about that between non-vascular plants. To investigate plant-plant VOCs interaction in bryophytes we exposed rare peatland moss Hamatocaulis vernicosus to VOCs of its common compe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64108-y
更新日期:2020-05-04 00:00:00
abstract::Although lizards are often described as having robust neurogenic abilities, only a handful of the more than 6300 species have been explored. Here, we provide the first evidence of homeostatic neurogenesis in the leopard gecko (Eublepharis macularius). We focused our study on the medial cortex, homologue of the mammali...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27880-6
更新日期:2018-06-25 00:00:00
abstract::Quantifying multi-molecular complex assembly in specific cytoplasmic compartments is crucial to understand how cells use assembly/disassembly of these complexes to control function. Currently, biophysical methods like Fluorescence Resonance Energy Transfer and Fluorescence Correlation Spectroscopy provide quantitative...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28822
更新日期:2016-06-30 00:00:00