Abstract:
:YPEL3 that induces cellular senescence in both normal and tumour cells of humans may show altered expression under the influence of incidental mutations. In this study, we proposed the first structure of Native YPEL3 protein and its five possible deleterious mutants-V40M, C61Y, G98R, G108S, and A131T and predicted their deleterious effects to alter stability, flexibility and conformational changes in the protein. The MD simulation (RMSD, RMSF, Rg, h-bond and SASA) analysis revealed that the variants V40M, G98R and G108S increased the flexibility in protein, and variant V40M imparted more compactness to the protein.. In general, variants attributed changes in the native conformation and structure of the YPEL3 protein which might affect the native function of cellular senescence. The study provides opportunities for health professionals and practitioners in formulating précised medicines to effectively cure various cancers. We propose in-vitro or in-vivo studies should consider these reported nsSNPs while examining any malfunction in the YPEL3 protein.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Singh A,Thakur M,Singh SK,Sharma LK,Chandra Kdoi
10.1038/s41598-020-72333-8subject
Has Abstractpub_date
2020-09-17 00:00:00pages
15301issue
1issn
2045-2322pii
10.1038/s41598-020-72333-8journal_volume
10pub_type
杂志文章abstract::Receptor-mediated endocytosis is an essential process in signalling pathways for activation of intracellular signalling cascades. One example is the Wnt signalling pathway that seems to depend on endocytosis of the ligand-receptor complex for initiation of Wnt signal transduction. To date, the roles of different endoc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49082-4
更新日期:2019-09-10 00:00:00
abstract::The commensal microbiome is known to influence a variety of host phenotypes. Microbiome profiling followed by differential abundance analysis has been established as an effective approach to study the mechanisms of host-microbiome interactions. However, it is challenging to interpret the collective functions of the re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78511-y
更新日期:2020-12-08 00:00:00
abstract::Detrimental impacts of extreme heats on the U.S. crop yields have been well-documented by a number of empirical studies. However, less have focused on within-growing season weather variation and the interaction between temperature and precipitation. The objective of this study is to emphasize the importance of disaggr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55037-6
更新日期:2019-12-06 00:00:00
abstract::We propose an internal (on-chip) Wheatstone bridge configuration to evaluate the efficiency of near-field transducers (NFT) as used in heat-assisted magnetic recording (HAMR). The electric field enhancement between the transducer and the image plane is monitored by measuring the resistance of metal electrodes composin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24423
更新日期:2016-04-14 00:00:00
abstract::The repeated measurements of heart rate variability (HRV) is more relevant than a single HRV measurement in predicting patient prognosis but is less addressed previously. This prospective study aimed to investigate the association between repeated measurements of HRV and long-term mortality in chronic hemodialysis pat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57792-3
更新日期:2020-01-21 00:00:00
abstract::For translocated animals, behavioral competence may be key to post-release survival. However, monitoring behavior is typically limited to tracking movements or inferring behavior at a gross scale via collar-mounted sensors. Animal-bourne acoustic monitoring may provide a unique opportunity to monitor behavior at a fin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41455-z
更新日期:2019-03-26 00:00:00
abstract::There is increasing demand for safe and effective sanitizers for irrigation water disinfection to prevent transmission of foodborne pathogens to fresh produce. Here we compared the efficacy of pH-neutral electrolyzed oxidizing water (EOW), sodium hypochlorite (NaClO) and chlorine dioxide (ClO2) against single and mixe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56248-7
更新日期:2019-12-27 00:00:00
abstract::Caloric restriction (CR) is known to promote health and longevity, likely via modification of the gut microbiota (GM). However, functional and metabolic changes induced in the GM during CR are still unidentified. Here, we investigated the short- and long-term effects of CR on the rat GM using a metaproteogenomic appro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33100-y
更新日期:2018-10-03 00:00:00
abstract::In the chemical mechanical polishing process of semiconductor manufacturing, the concentration of 'large' particles ([Formula: see text]0.5 μm) in the slurry, which is considerably larger in size than the main abrasives ([Formula: see text] 0.1 μm), is a critical parameter that strongly influences manufacturing defect...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71768-3
更新日期:2020-09-07 00:00:00
abstract::Introducing artificial pinning centers is a well established strategy to trap quantum vortices and increase the maximal magnetic field and applied electric current that a superconductor can sustain without dissipation. In case of spatially periodic pinning, a clear enhancement of the superconducting critical current a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14604
更新日期:2015-10-01 00:00:00
abstract::Pristine and functionalized multi-walled carbon nanotubes (MWCNTs) were investigated as adsorbent materials inside solid-phase extraction (SPE) cartridges for extraction and preconcentration of 8 EU-relevant organic micropollutants (with different pKa and polarity) before chromatographic analysis of surface water. The...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79244-8
更新日期:2020-12-18 00:00:00
abstract::Once assumed only to be a waste product of anaerobe glycolytic activity, lactate is now recognized as an energy source in skeletal muscles. While lactate metabolism has been extensively studied in vivo, underlying cellular processes are poorly described. This study aimed to examine lactate metabolism in cultured human...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28249-5
更新日期:2018-06-29 00:00:00
abstract::sp-Hybridized carbon atomic wires are appealing systems with large property tunability. In particular, their electronic properties are intimately related to length, structure, and type of functional end-groups as well as to other effects such as the intermolecular charge transfer with metal nanoparticles. Here, by a c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38367-9
更新日期:2019-02-07 00:00:00
abstract::Hydroxyapatite (HA) is the principal inorganic component of bones and teeth and has been widely used as a bone repair material because of its good biocompatibility and bioactivity. Understanding the interactions between proteins and HA is crucial for designing biomaterials for bone regeneration. In this study, we eval...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15219-6
更新日期:2017-11-09 00:00:00
abstract::Resistance of cancer cells to radiotherapy is a major clinical problem in cancer treatment. Therefore, understanding the molecular basis of cellular resistance to radiotherapy and identification of novel targets are essential for improving treatment efficacy for cancer patients. Our previous studies have demonstrated ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14723
更新日期:2015-09-30 00:00:00
abstract::The variation in energy bandgaps of amorphous oxide semiconducting SiZnSnO (a-SZTO) has been investigated by controlling the oxygen partial pressure (Op). The systematic change in Op during deposition has been used to control the electrical characteristics and energy bandgap of a-SZTO. As Op increased, the electrical ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55807-2
更新日期:2019-12-17 00:00:00
abstract::High frequency repetitive transcranial magnetic stimulation (HF-rTMS) over the left dorsolateral prefrontal cortex (L-DLPFC) is a widely applied treatment protocol for chronic smoking and major depressive disorder. However, no previous study has measured the effects of rTMS on both nicotine consumption and anxiety/dep...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80927-5
更新日期:2021-01-15 00:00:00
abstract::Gravity perception plays a key role in how plants develop and adapt to environmental changes. However, more than a century after the pioneering work of Darwin, little is known on the sensing mechanism. Using a centrifugal device combined with growth kinematics imaging, we show that shoot gravitropic responses to stead...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35431
更新日期:2016-10-14 00:00:00
abstract::Bimetallic Pd1-x Pt x solid-solution nanoparticles (NPs) display charging/discharging of hydrogen gas, which has relevance for fuel cell technologies; however, the constituent elements are immiscible in the bulk phase. We examined these material systems using high-energy synchrotron X-ray diffraction, X-ray absorption...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14494-7
更新日期:2017-11-06 00:00:00
abstract::Factor induced reprogramming of fibroblasts is an orchestrated but inefficient process. At the epigenetic level, it results in drastic chromatin changes to erase the existing somatic "memory" and to establish the pluripotent state. Accordingly, alterations of chromatin regulators including Ezh2 influence iPSC generati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08229
更新日期:2015-02-04 00:00:00
abstract::Fertilizer application for rice production has increased significantly in southern China to raise yields, but has led to problems with lodging, quality decline and environmental pollution. Therefore, research on fertilizer-saving cultivation technologies for high-yielding rice is necessary. A two-factor experiment was...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36978-w
更新日期:2019-01-24 00:00:00
abstract::There is growing interest in the conservation and utilization of crop wild relatives (CWR) in international food security policy and research. Legumes play an important role in human health, sustainable food production, global food security, and the resilience of current agricultural systems. Pea belongs to the ancien...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17623-4
更新日期:2017-12-12 00:00:00
abstract::The effect of different contact configurations (semi-infinite extended-channel, normal metal and ferromagnetic metal) on quantum transport through thin Bi2Se3 three-dimensional (3D) topological insulator (TI) slab (channel) has been investigated through Non-Equilibrium Green Function. The issue of contact dependent cu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09479
更新日期:2015-03-30 00:00:00
abstract::Alumina toughened zirconia (ATZ) and zirconia toughened alumina (ZTA) are currently the materials of choice to meet the need for tough, strong, and bioinert ceramics for medical devices. However, the mechanical properties of ZrO2/Al2O3 dispersion ceramics could be considerably increased by reducing the corresponding g...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20589
更新日期:2016-02-05 00:00:00
abstract::At the present study, a one-dimensional model for the flat sheet direct contact membrane distillation (DCMD) for desalination purposes is proposed. Flows and membrane properties have been estimated by appropriate temperature-dependent correlations. Results show that the numerical model is in a very good agreement with...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73964-7
更新日期:2020-10-08 00:00:00
abstract::A fundamental task in cancer research aims at the identification of new pharmacological therapies that can affect tumor growth. Differentiation therapy might exploit this function not only for hematological diseases, such as acute promyelocytic leukemia (APML) but also for epithelial tumors, including lung cancer. Her...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05047-z
更新日期:2017-07-06 00:00:00
abstract::The potential for epigenetic changes in host cells following microbial infection has been widely suggested, but few examples have been reported. We assessed genome-wide patterns of DNA methylation in human macrophage-like U937 cells following infection with Burkholderia pseudomallei, an intracellular bacterial pathoge...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30861
更新日期:2016-08-03 00:00:00
abstract::The room-temperature magnetic properties of ball-milled strontium hexaferrite particles consolidated by spark-plasma sintering are strongly influenced by the milling time. Scanning electron microscopy revealed the ball-milled SrFe12O19 particles to have sizes varying over several hundred nanometers. X-Ray powder-diffr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14112
更新日期:2015-09-15 00:00:00
abstract::The ability to observe chemical reactions at the molecular level convincingly demonstrates the physical and chemical phenomena occurring throughout a reaction mechanism. Videos obtained through in situ transmission electron microscopy (TEM) revealed the oxidation of catalytic soot under practical reaction conditions. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10161
更新日期:2015-07-08 00:00:00
abstract::Sodium taurocholate cotransporting polypeptide (NTCP) is a recently discovered hepatitis B virus (HBV) receptor. In the present study, we used TK-NOG mice with a humanized liver to examine the impact of endogenous NTCP expression on HBV infection. Upon inoculation with HBV, these mice exhibited clear viremia in 2 week...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27782
更新日期:2016-06-09 00:00:00