Abstract:
:Ocimum is one of the most revered medicinally useful plants which have various species. Each of the species is distinct in terms of metabolite composition as well as the medicinal property. Some basil types are used more often as an aromatic and flavoring ingredient. It would be informative to know relatedness among the species which though belong to the same genera while exclusively different in terms of metabolic composition and the operating pathways. In the present investigation the similar effort has been made in order to differentiate three commonly occurring Ocimum species having the high medicinal value, these are Ocimum sanctum, O. gratissimum and O. kilimandscharicum. The parameters for the comparative analysis of these three Ocimum species comprised of temporal changes in number leaf trichomes, essential oil composition, phenylpropanoid pathway genes expression and the activity of important enzymes. O. gratissimum was found to be richest in phenylpropanoid accumulation as well as their gene expression when compared to O. sanctum while O. kilimandscharicum was found to be accumulating terpenoid. In order to get an overview of this qualitative and quantitative regulation of terpenes and phenylpropenes, the expression pattern of some important transcription factors involved in secondary metabolism were also studied.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Rastogi S,Shah S,Kumar R,Kumar A,Shasany AKdoi
10.1038/s41598-020-61957-5subject
Has Abstractpub_date
2020-03-23 00:00:00pages
5234issue
1issn
2045-2322pii
10.1038/s41598-020-61957-5journal_volume
10pub_type
杂志文章abstract::Circulating tumor DNA (ctDNA) has become an attractive biomarker in human oncology, and its use may be informative in canine cancer. Thus, we used droplet digital PCR or PCR for antigen receptor rearrangement, to explore tumor-specific point mutations, copy number alterations, and chromosomal rearrangements in the pla...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80332-y
更新日期:2021-01-13 00:00:00
abstract::The eastern North American migratory population of monarch butterflies (Danaus plexippus) is in serious decline. Habitat restoration, including adding millions of host plants to compensate for loss of milkweed in US cropland, is a key part of the international conservation strategy to return this iconic butterfly to s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30731-z
更新日期:2018-08-14 00:00:00
abstract::Immune checkpoint inhibitors (ICIs) elicit antitumour effects by activating the host immunity and cause immune-related adverse events (irAEs). ICI-related interstitial lung disease (ICI-ILD) is a fatal irAE that is difficult to treat; moreover, its incidence is relatively higher in patients with lung cancer. Therefore...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70743-2
更新日期:2020-08-13 00:00:00
abstract::Changes in land cover have become key components of global environmental change and represent the impact of human activity. To better understand the fundamental processes of land transition characteristics before and after the implementation of ecological programmes, we determined the dominant systematic changes in la...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44496
更新日期:2017-03-21 00:00:00
abstract::Breast cancer (BC) has a higher incidence in young Lebanese woman as compared to the West. We assessed the microRNA (miRNA) microarray profile of tissues derived from Lebanese patients with early BC and performed mRNA-miRNA integration analysis. 173 miRNAs were significantly dysregulated in 45 BC versus 17 normal adja...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16978-y
更新日期:2017-12-04 00:00:00
abstract::Glioblastoma multiforme (GBM) is a highly invasive and chemoradioresistant brain malignancy. Temozolomide (TMZ), a DNA-alkylating agent, is effective against GBM and has become the standard first-line drug. However, the mechanism by which TMZ regulates the progression of GBM remains elusive. Here, we demonstrate that ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01160
更新日期:2013-01-01 00:00:00
abstract::As the world's oceans are currently threatened by anthropogenic pollution and climate change, coral breeding has become an important conservation method, since it can limit marine organisms' exposure to sub-optimal environment conditions. However, the aquarium environment is inherently different from the ocean, and th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33341-x
更新日期:2018-10-11 00:00:00
abstract::A hypereutectic Al-Fe-Cu alloy with a high-volume fraction ferro-aluminum second phase (AlFe phases for short) was reheated in the solid-liquid region and the microstructure evolution was investigated. During semisolid heating, the high-melting AlFe phases in the Al-Fe-Cu alloy were demonstrated to stunt the grain gro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-80983-5
更新日期:2021-01-15 00:00:00
abstract::The understanding of the relationship between topology and behaviour in interconnected networks would allow to charac- terise and predict behaviour in many real complex networks since both are usually not simultaneously known. Most previous studies have focused on the relationship between topology and synchronisation....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22617
更新日期:2016-03-04 00:00:00
abstract::H5N1 highly pathogenic avian influenza virus (HPAIV) poses a huge threat to public health and the global economy. These viruses cause systemic infection in poultry and accidental human infection leads to severe pneumonia, associated with high mortality rates. The hemagglutinin (HA) of H5N1 HPAIV possesses multiple bas...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74604-w
更新日期:2020-10-22 00:00:00
abstract::Histone acetylation has been linked to cardiac hypertrophy and heart failure. However, the pathological implications of changes in histone methylation and the effects of interventions with histone methyltransferase inhibitors for heart failure have not been fully clarified. Here, we focused on H3K9me3 status in the he...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39752
更新日期:2017-01-04 00:00:00
abstract::Little is known on the causes and pathogenesis of the adipose tissue disorder (familial) Multiple Symmetric Lipomatosis (MSL). In a four-generation MSL-family, we performed whole exome sequencing (WES) in 3 affected individuals and 1 obligate carrier and identified Calcyphosine-like (CAPSL) as the most promising candi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44382-1
更新日期:2019-06-11 00:00:00
abstract::The therapeutic potential of nonthermal plasma for cancer treatment has been reported recently. The heterogeneity of cancer cells need to be addressed to design effective anticancer treatments. Here, we show that treatment with nonthermal atmospheric-pressure plasma dissolved in a liquid (liquid plasma) induces oxidat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29020
更新日期:2016-07-01 00:00:00
abstract::Carcinoembryonic antigen (CEA) is the only blood based protein biomarker at present, used for preoperative screening of advanced colorectal cancer (CRC) patients to determine the appropriate curative treatments and post-surveillance screening for tumour recurrence. Current diagnostics for CRC detection have several li...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80354-6
更新日期:2021-01-12 00:00:00
abstract::The present study shows the thorough investigations on optical properties and hydrodynamic diameters of glutathione (GSH) stabilized nanosilver clusters (AgNC) at different stages of synthesis and engineering for the optimized absolute quantum yield to generate fluorescent images of Dalton Lymphoma Ascites (DLA) tumou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34843-4
更新日期:2018-11-07 00:00:00
abstract::Sensory organs are thought to sample the environment rhythmically thereby providing periodic perceptual input. Whisking and sniffing are governed by oscillators which impose rhythms on the motor-control of sensory acquisition and consequently on sensory input. Saccadic eye movements are the main visual sampling mechan...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00881-7
更新日期:2017-04-20 00:00:00
abstract::One of the most challenging issues in HIV-associated neurocognitive disorders (HAND) caused by HIV-1 virotoxins and drug abuse is the lack of understanding the underlying mechanisms that are commonly associated with disorders of the blood-brain barrier (BBB), which mainly consists of brain microvascular endothelial ce...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40467
更新日期:2017-01-11 00:00:00
abstract::Rho GTPases are master regulators of the eukaryotic cytoskeleton. The activation of Rho GTPases is governed by Rho guanine nucleotide exchange factors (GEFs). Three RhoGEF isoforms are produced by the gene ARHGEF25; p63RhoGEF580, GEFT and a recently discovered longer isoform of 619 amino acids (p63RhoGEF619). The subc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36825
更新日期:2016-11-11 00:00:00
abstract::To compare the performance of eight score systems (MELD, uMELD, MELD-Na. iMELD, UKELD, MELD-AS, CTP, and mCTP) in predicting the post-transplant mortality, we analyzed the data of 6,014 adult cirrhotic patients who underwent liver transplantation between January 2003 and December 2010 from the China Liver Transplant R...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42253
更新日期:2017-02-13 00:00:00
abstract::Landscape's spatial structure has vast implications for the dynamics and distribution of species populations and ecological communities. However, the characterization of the structure of spatial networks has not received nearly as much attention as networks of species interactions counterparts. Recent experiments show...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65669-8
更新日期:2020-05-26 00:00:00
abstract::Spin torque oscillator (STO) has been attracting a great deal of attention as a candidate for the next generation microwave signal sources for various modern electronics systems since its advent. However, the phase noise of STOs under free running oscillation is still too large to be used in practical microwave applic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18134
更新日期:2015-12-11 00:00:00
abstract::The etiology of insulin resistance in Type 1 Diabetes (T1D) is unknown, however it affects approximately 20% of T1D patients. Intramyocellular lipids (IMCL) have been identified as a mechanism of insulin resistance. We examined skeletal muscle of T1D rats to determine if alterations in lipid metabolism were evident an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26379
更新日期:2016-05-20 00:00:00
abstract::Accurate alignment of an intraocular lens (IOL) is indispensable for achieving accurate postoperative refractive outcomes. Thus, we evaluated decentration and tilt of single- and three-piece IOLs, as well as anterior chamber depth (ACD), at 3 hours, 24 hours, 2 weeks, and 4 weeks after cataract surgery, using swept-so...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-018-28609-1
更新日期:2018-07-06 00:00:00
abstract::The domain wall-related change in the anisotropic magnetoresistance in L-shaped permalloy nanowires is measured as a function of the magnitude and orientation of the applied magnetic field. The magnetoresistance curves, compiled into so-called domain wall magnetoresistance state space maps, are used to identify highly...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06045
更新日期:2014-08-13 00:00:00
abstract::Sweet sorghum bagasse (SSB) is a promising raw material for silage fermentation due to its high residual nutritive, but the efficient fermentation strategy of SSB has not been reported yet. This study evaluated the effects of microbial inoculant on the fermentation quality, chemical composition and microbial community...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57628-0
更新日期:2020-01-21 00:00:00
abstract::IncX4 plasmids are associated with the dissemination of the mcr-1 genes in Enterobacteriaceae. We screened IncX4 plasmids among 2,470 isolates of Enterobacteriaceae and determined the mcr-1 positive isolates. Forty-three isolates were observed to carry IncX4 type plasmid, among which 13 were identified to carry mcr-1 ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00095-x
更新日期:2017-03-24 00:00:00
abstract::Understanding drought-tolerance mechanisms and identifying genetic dominance are important for crop improvement. Setaria italica, which is extremely drought-tolerant, has been regarded as a model plant for studying stress biology. Moreover, different genotypes of S. italica have evolved various drought-tolerance/avoid...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08854-6
更新日期:2017-08-30 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-43810-6
更新日期:2019-10-30 00:00:00
abstract::Antidiabetic medication may modify the incidence of hepatocellular carcinoma (HCC). We aimed to compare the use of different antidiabetic strategies and the incidence of HCC. PubMed, Embase.com and Cochrane Library databases were searched up to 31 October 2015 and randomized controlled trials (RCTs), cohort studies or...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析,评审
doi:10.1038/srep33743
更新日期:2016-09-19 00:00:00
abstract::Fermented foods play a major role in the diet of people in Africa, where a wide variety of raw materials are fermented. Understanding the microbial populations of these products would help in the design of specific starter cultures to produce standardized and safer foods. In this study, the bacterial diversity of Afri...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50190-4
更新日期:2019-09-25 00:00:00