Abstract:
:Parathyroid Hormone-Like Hormone (PTHLH) is an autocrine/paracrine ligand that is up-regulated in head and neck squamous cell carcinoma (HNSCC). However, the cellular function and regulatory mechanism in HNSCC remains obscure. We investigated the clinical significance of PTHLH in HNSCC patients, and verified the role of RUNX2/PTHLH axis, which is stimulated HNSCC cell growth. In patients, PTHLH is a poor prognosis marker. PTHLH expression lead to increasing the cell proliferation potential through an autocrine/paracrine role and elevating blood calcium level in Nod-SCID mice. In public HNSCC microarray cohorts, PTHLH is found to be co-expressed with RUNX2. Physiologically, PTHLH is regulated by RUNX2 and also acting as key calcium regulator. However, elevations of calcium concentration also increased the RUNX2 expression. PTHLH, calcium, and RUNX2 form a positive feedback loop in HNSCC. Furthermore, ectopic RUNX2 expression also increased PTHLH expression and promoted proliferation potential through PTHLH expression. Using cDNA microarray analysis, we found PTHLH also stimulated expression of cell cycle regulators, namely CCNA2, CCNE2, and CDC25A in HNSCC cells, and these genes are also up-regulated in HNSCC patients. In summary, our results reveal that PTHLH expression is a poor prognosis marker in HNSCC patients, and RUNX2-PTHLH axis contributes to HNSCC tumor growth.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Chang WM,Lin YF,Su CY,Peng HY,Chang YC,Hsiao JR,Chen CL,Chang JY,Shieh YS,Hsiao M,Shiah SGdoi
10.1038/srep41131subject
Has Abstractpub_date
2017-01-25 00:00:00pages
41131issn
2045-2322pii
srep41131journal_volume
7pub_type
杂志文章abstract::Cell wall disruption is necessary to maximize lipid extraction yields in conventional species of mass-cultivated microalgae. This study investigated the effect of sonication, solvent choice and number of extractions on the lipid yield, lipid class composition and fatty acid composition of the diatom Porosira glacialis...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79269-z
更新日期:2020-12-17 00:00:00
abstract::In the attempt of implementing iron garnets with perpendicular magnetic anisotropy (PMA) in spintronics, the attention turned towards strain-grown iron garnets. One candidate is Tm3Fe5O12 (TmIG) which possesses an out-of-plane magnetic easy axis when grown under tensile strain. In this study, the effect of film thickn...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53255-6
更新日期:2019-11-25 00:00:00
abstract::Emerging evidence suggests substantial health benefits from using meditation. While there are some indications that the popularity of meditation is increasing, little is known about the prevalence, patterns, and predictors of meditation use in the general population. In this secondary analysis of data from the 2012 US...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36760
更新日期:2016-11-10 00:00:00
abstract::Telomere length (TL) is linked to various age-related diseases, but little is known about telomeres in gestational diabetes mellitus (GDM). We surveyed 509 subjects (113 GDM patients and 396 frequency matched controls) in Nanjing Drum Tower Hospital, Jiangsu province of eastern China. Relative telomere length (RTL) of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44968-9
更新日期:2019-06-11 00:00:00
abstract::Scleroderma is a refractory autoimmune skin fibrotic disorder. Alterations of microRNAs in lesional skin could be a new approach to treating the disease. Here, we found that expression of miR-155 was up regulated in lesional skin tissue from patients with either systemic or localized scleroderma, and correlated with f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20314
更新日期:2016-02-01 00:00:00
abstract::Nitric oxide (NO) signaling has been studied in the eye, including in the pathophysiology of some eye diseases. While NO production by nitric oxide synthase (NOS) enzymes in the eye has been characterized, the more recently described pathways of NO generation by nitrate (NO3-) and nitrite (NO2-) ions reduction has rec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69272-9
更新日期:2020-08-05 00:00:00
abstract::Autism spectrum disorder (ASD) is a continuum of neurodevelopmental disorders and needs new therapeutic approaches. Recently, oxytocin (OXT) showed potential as the first anti-ASD drug. Many reports have described the efficacy of intranasal OXT therapy to improve the core symptoms of patients with ASD; however, the un...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79109-0
更新日期:2020-12-17 00:00:00
abstract::This study aimed to explore the development of mental rotation ability throughout life by comparing different kinds of stimuli. Thirty-six children (6-9 years-old), 30 young (20-28 years-old) and 30 elderly people (60-82 years-old) performed mental rotation tasks with abstract (i.e. two-dimensional lines) and concrete...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37729-7
更新日期:2019-02-04 00:00:00
abstract::The villous cytotrophoblastic cells have the ability to fuse and differentiate, forming the syncytiotrophoblast (STB). The syncytialisation process is essential for placentation. Nevertheless, the mechanisms involved in cell fusion and differentiation are yet to be fully elucidated. It has been suggested that cell sur...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66554-0
更新日期:2020-06-15 00:00:00
abstract::The ratio between the length of second and fourth digits (2D:4D) is a putative biomarker for prenatal testosterone and estrogen exposure. The aim of the study was to examine the association between 2D:4D and women's general and reproductive health. This analysis was conducted within a prospective pregnancy cohort stud...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62599-3
更新日期:2020-04-14 00:00:00
abstract::In utero and upon delivery, neonates are exposed to a wide array of microorganisms from various sources, including maternal bacteria. Prior studies have proposed that the mode of feeding shapes the gut microbiota and, subsequently the child's health. However, the effect of the mode of feeding and its influence on the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38309
更新日期:2016-12-06 00:00:00
abstract::In this study, an anatase/rutile mixed-phase titanium dioxide (TiO2) hierarchical network deposited with Au nanoparticles (Au/TiO2 ARHN) was synthesized using a facile hydrothermal method followed by a simple calcination step. Such a unique structure was designed for improving the light harvest, charge transportation/...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42524
更新日期:2017-02-10 00:00:00
abstract::Cyclophilin A (CyPA), secreted by vascular smooth muscle cells in response to oxidative stress, is important in the pathogenesis of progressive peripheral arterial occlusion disease (PAOD), which is common among chronic kidney disease. We explored the prevalence of PAOD in Taiwan's elderly (≥ 65 years old) population ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09937
更新日期:2015-04-24 00:00:00
abstract::Human learners can generalize a new concept from a small number of samples. In contrast, conventional machine learning methods require large amounts of data to address the same types of problems. Humans have cognitive biases that promote fast learning. Here, we developed a method to reduce the gap between human beings...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25679-z
更新日期:2018-05-09 00:00:00
abstract::Recent studies suggest that mRNAs may be differentially expressed between males and females. This study aimed to perform expression analysis of mRNA and its main regulatory molecule, microRNA (miRNA), to discuss the potential sex-specific expression patterns using abnormal expression profiles from The Cancer Genome At...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39812
更新日期:2017-01-03 00:00:00
abstract::Ti-24Nb-4Zr-8Sn (Ti2448), a new β-type Ti alloy, consists of nontoxic elements and exhibits a low uniaxial tensile elastic modulus of approximately 45 GPa for biomedical implant applications. Nevertheless, the bio-corrosion resistance and biocompatibility of Ti2448 alloys must be improved for long-term clinical use. I...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24590-x
更新日期:2018-04-26 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-58755-4
更新日期:2020-01-30 00:00:00
abstract::Motor symptoms are defining traits in the diagnosis of Parkinson's disease (PD). A crucial component in motor function is the integration of afferent proprioceptive sensory feedback. Previous studies have indicated abnormal movement-related cortical oscillatory activity in PD, but the role of the proprioceptive affere...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39204-3
更新日期:2019-02-22 00:00:00
abstract::Deformable elastomeric spheres are evaluated experimentally as they skip multiple times over a lake surface. Some spheres are embedded with small inertial measurement units to measure the acceleration experienced during water surface impact. A model for multiple impact events shows good agreement between measured acce...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42453-x
更新日期:2019-04-15 00:00:00
abstract::Colour polymorphism may be maintained within a population by disruptive-selection. One hypothesis proposes that different morphs are adapted to different ambient light conditions, with lighter morphs having a selective advantage in bright conditions and darker morphs having advantages in darker conditions. The mechani...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07829-x
更新日期:2017-08-22 00:00:00
abstract::To study the influence of the position of the double bond and ring size on the stability of hydrogen bonded complexes, the 1:1 complexes formed between 2,2,2-trifluoroethanol (TFE) and three heterocyclic compounds including 2,3-dihydrofuran (2,3-DHF), 2,5-dihydrofuran (2,5-DHF) and 3,4-dihydropyran (3,4-DHP) were inve...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11921-7
更新日期:2017-09-12 00:00:00
abstract::Cartilage tissue is avascular and hypoxic which regulates chondrocyte phenotype via stabilization of HIFs. Here, we investigated the role of hypoxia and HIFs in regulation of Rho and canonical Wnt signaling in chondrocytes. Our data demonstrates that hypoxia controls the expression of RhoA in chondrocytes in a context...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09505-6
更新日期:2017-08-22 00:00:00
abstract::Human female germline stem cells (FGSCs) have opened new opportunities for understanding human oogenesis, delaying menopause, treating infertility, and providing a new strategy for preserving fertility. However, the shortage of adult human ovaries tissues available impedes their future investigations and clinical appl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28218
更新日期:2016-06-30 00:00:00
abstract::Magnetron sputtering techniques were used to prepare molecularly smooth titanium thin films possessing an average roughness between 0.18 nm and 0.52 nm over 5 μm × 5 μm AFM scanning areas. Films with an average roughness of 0.52 nm or lower were found to restrict the extent of P. aeruginosa cell attachment, with less ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00165
更新日期:2011-01-01 00:00:00
abstract::Giardia is a worldwide spread protozoan parasite colonizing in small intestines of vertebrates, causing Giardiasis. The controversy about whether it is an extremely primitive eukaryote or just a highly evolved parasite has become a fetter to its uses as a model for both evolutionary and parasitological studies for yea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10054-1
更新日期:2017-08-25 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-49306-7
更新日期:2019-09-03 00:00:00
abstract::Alzheimer's disease (AD), an irreversible progressive neurodegenerative disease, causes characteristic cognitive impairment, and no curative treatments are currently available. Stem cell transplantation offers a powerful tool for the treatment of AD. We conducted a systematic review and meta-analysis of data from cont...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析,评审
doi:10.1038/srep12134
更新日期:2015-07-10 00:00:00
abstract::Telomerase is a ribonucleoprotein enzyme, which maintains genome integrity in eukaryotes and ensures continuous cellular proliferation. Telomerase holoenzyme from the thermotolerant yeast Hansenula polymorpha, in addition to the catalytic subunit (TERT) and telomerase RNA (TER), contains accessory proteins Est1 and Es...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68107-x
更新日期:2020-07-06 00:00:00
abstract::We demonstrate an experimental methodology for measuring the temporal distribution of pico-second level electron bunch with low energy using radial electric and azimuthal magnetic fields of an accelerating ([Formula: see text] mode) radio frequency (RF) cavity that is used for accelerating electron beams in a linear a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76054-w
更新日期:2020-11-03 00:00:00
abstract::Groundwater systems affected by various factors can exhibit complex fractal behaviors, whose reliable characterization however is not straightforward. This study explores the fractal scaling behavior of the groundwater systems affected by plant water use and river stage fluctuations in the riparian zone, using multifr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51657-0
更新日期:2019-10-28 00:00:00