Abstract：
:Recent studies suggest that mRNAs may be differentially expressed between males and females. This study aimed to perform expression analysis of mRNA and its main regulatory molecule, microRNA (miRNA), to discuss the potential sex-specific expression patterns using abnormal expression profiles from The Cancer Genome Atlas database. Generally, deregulated miRNAs and mRNAs had consistent expression between males and females, but some miRNAs may be oppositely expressed in specific diseases: up-regulated in one group and down-regulated in another. Studies of miRNA gene families and clusters further confirmed that these sequence or location related miRNAs might have opposing expression between sexes. The specific miRNA might have greater expression divergence across different groups, suggesting flexible expression across different individuals, especially in tumor samples. The typical analysis regardless of the sex will ignore or balance these sex-specific deregulated miRNAs. Compared with flexible miRNAs, their targets of mRNAs showed relative stable expression between males and females. These relevant results provide new insights into miRNA-mRNA interaction and sex difference.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Guo L,Zhang Q,Ma X,Wang J,Liang Tdoi
10.1038/srep39812subject
Has Abstractpub_date
2017-01-03 00:00:00pages
39812issn
2045-2322pii
srep39812journal_volume
7pub_type
杂志文章abstract：:Tetrastatin, a 230 amino acid sequence from collagen IV, was previously demonstrated to inhibit melanoma progression. In the present paper, we identified the minimal active sequence (QKISRCQVCVKYS: QS-13) that reproduced the anti-tumor effects of whole Tetrastatin in vivo and in vitro on melanoma cell proliferation, m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28003-x
更新日期：2018-06-29 00:00:00
abstract：:We show that ATM kinase inhibition using AZ31 prior to 9 or 9.25 Gy total body irradiation (TBI) reduced median time to moribund in mice to 8 days. ATR kinase inhibition using AZD6738 prior to TBI did not reduce median time to moribund. The striking finding associated with ATM inhibition prior to TBI was increased cry...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41892
更新日期：2017-02-01 00:00:00
abstract：:Liquid pumping can occur along the outer surface of an electrode under a DC electric field. For biological applications, a better understanding of the ionic solution pumping mechanism is required. Here, we fabricated CNT wire electrodes (CWEs) and tungsten wire electrodes (TWEs) of various diameters to assess an ionic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11799
更新日期：2015-07-02 00:00:00
abstract：:Nearly half of the world's population obtains its daily calories from rice grains, which lack or have insufficient levels of essential micronutrients. The deficiency of micronutrients vital for normal growth is a global health problem, and iron, zinc and vitamin A deficiencies are the most prevalent ones. We developed...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07198-5
更新日期：2017-07-31 00:00:00
abstract：:Parkinson's disease is a neurodegenerative disorder, and no treatment has been yet established to prevent disease progression. Coenzyme Q10, an antioxidant, has been considered a promising neuroprotective agent; however, conventional oral administration provides limited efficacy due to its very low bioavailability. In...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66493-w
更新日期：2020-06-12 00:00:00
abstract：:Climate change vulnerability assessment (CCVA) has become a mainstay conservation decision support tool. CCVAs are recommended to incorporate three elements of vulnerability - exposure, sensitivity and adaptive capacity - yet, lack of data frequently leads to the latter being excluded. Further, weighted or unweighted ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13245-y
更新日期：2017-10-11 00:00:00
abstract：:Intracellular ion channels are involved in multiple signaling processes, including such crucial ones as regulation of cellular motility and fate. With 95% of the cellular membrane belonging to intracellular organelles, it is hard to overestimate the importance of intracellular ion channels. Multiple studies have been ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13968-y
更新日期：2017-10-26 00:00:00
abstract：:The bacterial stringent response is a key regulator of bacterial virulence, biofilm formation and antibiotic tolerance, and is a promising target for the development of new antibacterial compounds. The intracellular nucleotide (p)ppGpp acts as a messenger orchestrating the stringent response. A synthetic peptide 1018 ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36549
更新日期：2016-11-07 00:00:00
abstract：:Recently, mesoporous carbon nitride (MCN) has aroused extensive interest for its potential applications in organocatalysis, photo- and electrochemistry and CO2 capture. However, further surface functionalization of MCN for advanced nanomaterials and catalysis still remains very challenging. Here we show that acidic ca...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12901
更新日期：2015-08-05 00:00:00
abstract：:The DEAD-box RNA helicase DDX3 plays divergent roles in tumorigenesis, however, its function in mitosis is unclear. Immunofluorescence indicated that DDX3 localized to centrosome throughout the cell cycle and colocalized with centrosome-associated p53 during mitosis in HCT116 and U2OS cells. DDX3 depletion promoted ch...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09779-w
更新日期：2017-08-25 00:00:00
abstract：:Lipoprotein associated phospholipase A2 (Lp-PLA2) has been characterized for its interfacial activation as well as inhibition by detergent micelles and lipoprotein particles. The enzyme has been shown to bind on the surfaces of hydrophobic aggregates, such as detergent micelles, lipoprotein particles and even polystyr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74236-0
更新日期：2020-10-14 00:00:00
abstract：:This study aimed to quantify arterial volume distensibility in patients with branch retinal vein occlusion (BRVO) in comparison with normal subjects and to investigate factors associated with their differences. 40 normal subjects and 30 BRVO patients were studied. Brachial-ankle pulse wave velocity (baPWV) was measure...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06685
更新日期：2014-10-20 00:00:00
abstract：:Thymocyte and T cell trafficking relies on signals initiated by G-protein coupled receptors. To address the importance of the G-proteins Gαi2 and Gαi3 in thymocyte and T cell function, we developed several mouse models. Gαi2 deficiency in hematopoietic progenitors led to a small thymus, a double negative (DN)1/DN2 thy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04537-4
更新日期：2017-06-23 00:00:00
abstract：:Silicon Carbide (SiC) is a promising cladding material for accident-tolerant fuel in light water reactors due to its excellent resistance to chemical attacks at high temperatures, which can prevent severe accident-induced environmental disasters. Although it has been known for decades that radiation-induced swelling a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15037-w
更新日期：2017-11-07 00:00:00
abstract：:Non-invasive investigation of physiological changes and metabolic events associated with brain activity in mice constitutes a major challenge. Conventionally, fMRI assesses neuronal activity by evaluating activity-evoked local changes in blood oxygenation levels (BOLD). In isoflurane-anaethetized mice, however, we fou...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46477-1
更新日期：2019-07-22 00:00:00
abstract：:We report here that CYB5D2 is associated with tumor suppression function in breast cancer (BC). CYB5D2 expression was significantly reduced in tamoxifen resistant MCF7 cells and in MCF7 cell-derived xenografts treated with TAM. CYB5D2 overexpression induced apoptosis in MCF7 cells; CYB5D2 knockdown enhanced MCF7 cell ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43006-y
更新日期：2019-04-29 00:00:00
abstract：:CD8+ T cells directed against beta cell autoantigens are considered relevant for the pathogenesis of type 1 diabetes. Using single cell T cell receptor sequencing of CD8+ T cells specific for the IGRP265-273 epitope, we examined whether there was expansion of clonotypes and sharing of T cell receptor chains in autorea...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44661
更新日期：2017-03-16 00:00:00
abstract：:Routine immunizations and supplementary immunization activities (SIAs) have significantly improved measles control over the past two decades in China. Progress towards eliminating measles currently faces multiple challenges as the infection age increases, and adult-targeted SIA strategies are being considered. This st...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34461-0
更新日期：2018-10-31 00:00:00
abstract：:Habitat fragmentation is considered as major threat to biodiversity worldwide. Biodiversity can be described as taxonomic, functional and phylogenetic diversity. However, the effect of forest fragmentation on taxonomic, phylogenetic and functional diversity is barely understood. We compare the response of taxonomic (s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76917-2
更新日期：2020-11-23 00:00:00
abstract：:High mortality and dependent living after hip fracture pose a significant public health concern. Retrospective study was conducted with 481 hip fracture patients (≥65 years of age) undergoing surgery from March 2009 to May 2014. The Hip-MFS was calculated by Comprehensive Geriatric Assessment (CGA). The primary outcom...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42966
更新日期：2017-02-24 00:00:00
abstract：:CRISPR/Cas9 is a valuable tool for both basic and applied research that has been widely applied to different plant species. Nonetheless, a systematical assessment of the efficiency of this method is not available for the allotetraploid Brassica napus-an important oilseed crop. In this study, we examined the mutation e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07871-9
更新日期：2017-08-08 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41598-017-16210-x
更新日期：2017-11-23 00:00:00
abstract：:Globally breast cancer is the leading cause of cancer death among women. The breast consists of epithelium, stroma and a mucosal immune system that make up a complex microenvironment. Growing awareness of the role of microbes in the microenvironment recently has led to a series of findings important for human health. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30751
更新日期：2016-08-03 00:00:00
abstract：:Hair regenerative medicine has emerged as a promising approach for the treatment of severe hair loss. Recent advances in three-dimensional tissue engineering, such as formation of hair follicle germs (HFGs), have considerably improved hair regeneration after transplantation in animal models. Here, we proposed an appro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79722-z
更新日期：2021-01-12 00:00:00
abstract：:The spontaneous activity of sinoatrial node (SAN) pacemaker cells is generated by a functional interplay between the activity of ionic currents of the plasma membrane and intracellular Ca2+ dynamics. The molecular correlate of a dihydropyridine (DHP)-sensitive sustained inward Na+ current (I st), a key player in SAN a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08191-8
更新日期：2017-08-11 00:00:00
abstract：:Microscopic plastic (microplastic, 0.1 µm-5 mm) is a widespread pollutant impacting upon aquatic ecosystems across the globe. Environmental sampling has revealed synthetic fibers are prevalent in seawater, sediments and biota. However, microplastic fibers are rarely used in laboratory studies as they are unavailable f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34519
更新日期：2016-10-03 00:00:00
abstract：:Exposure to light at night (LAN) is associated with insomnia in humans. Light provides the main input to the master clock in the hypothalamic suprachiasmatic nucleus (SCN) that coordinates the sleep-wake cycle. We aimed to develop a rodent model for the effects of LAN on sleep. Therefore, we exposed male Wistar rats t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35662
更新日期：2016-10-20 00:00:00
abstract：:Glutathione-S-transferases mu 2 (GSTM2), a kind of important Phase II antioxidant enzyme of eukaryotes, is degraded by nonsense mediated mRNA decay due to a C27T substitution in the fifth exon of pigs. As a reproductive performance-related gene, GSTM2 is involved in embryo implantation, whereas, functional deficiency ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38254
更新日期：2016-12-01 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-44354-5
更新日期：2019-05-23 00:00:00
abstract：:Coupling between dynamical heterogeneity of ionic liquids and their structural periodicity on different length-scales can be directly probed by quasielastic neutron scattering with polarization analysis. The technique provides the tools to investigate single-particle and cooperative ion motions separately and, thus, d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34481-w
更新日期：2018-11-06 00:00:00
